Improved design of a high response slotted plate overboard bypass valve for supersonic inlets

The electrohydraulically actuated slotted-plate bypass valve used to control the position of the normal shock during wind-tunnel investigations of supersonic inlets also has proven to be a valuable device for determining inlet dynamics and creating airflow disturbances. Operation of previous valves at high frequencies (to 100 Hz) for extended testing has resulted in numerous failures. An improved bypass-valve design is presented which increases the cyclic tolerance of the device considerably over past designs. The use of dynamic limit criteria to obtain an optimum actuator-piston size results in a frequency response which is flat within + or - 3 decibels to 120 Hz for a peak-to-peak variation of 20 percent of full area

Viral RNA at two stages of reovirus infection is required for the induction of necroptosis

Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis. We find that necroptosis requires sensing of the genomic RNA within incoming virus particles via cytoplasmic RNA sensors to produce type I interferon (IFN). While these events that occur prior to the de novo synthesis of viral RNA are required for the induction of necroptosis, they are not sufficient. The induction of necroptosis also requires late stages of reovirus infection. Specifically, efficient synthesis of double-stranded RNA (dsRNA) within infected cells is required for necroptosis. These data indicate that viral RNA interfaces with host components at two different stages of infection to induce necroptosis. This work provides new molecular details about events in the viral replication cycle that contribute to the induction of necroptosis following infection with an RNA virus. IMPORTANCE An appreciation of how cell death pathways are regulated following viral infection may reveal strategies to limit tissue destruction and prevent the onset of disease. Cell death following virus infection can occur by apoptosis or a regulated form of necrosis known as necroptosis. Apoptotic cells are typically disposed of without activating the immune system. In contrast, necroptotic cells alert the immune system, resulting in inflammation and tissue damage. While apoptosis following virus infection has been extensively investigated, how necroptosis is unleashed following virus infection is understood for only a small group of viruses. Here, using mammalian reovirus, we highlight the molecular mechanism by which infection with a dsRNA virus results in necroptosis

Dark Matter, Muon g-2 and Other SUSY Constraints

Recent developments constraining the SUSY parameter space are reviewed within the framework of SUGRA GUT models. The WMAP data is seen to reduce the error in the density of cold dark matter by about a factor of four, implying that the lightest stau is only 5 -10 GeV heavier than the lightest neutralino when m_0, m_{1/2} < 1 TeV. The CMD-2 re-analysis of their data has reduced the disagreement between the Standard Model prediction and the Brookhaven measurement of the muon magnetic moment to 1.9 sigma, while using the tau decay data plus CVC, the disagreement is 0.7 sigma. (However, the two sets of data remain inconsistent at the 2.9 sigma level.) The recent Belle and BABAR measurements of the B -> phi K CP violating parameters and branching ratios are discussed. They are analyzed theoretically within the BBNS improved factorization method. The CP parameters are in disagreement with the Standard Model at the 2.7 sigma level, and the branching ratios are low by a factor of two or more over most of the parameter space. It is shown that both anomalies can naturally be accounted for by adding a non-universal cubic soft breaking term at M_G mixing the second and third generations.Comment: 16 pages, 7 figures, plenary talk at Beyond The Desert '03, Castle Ringberg, Germany, June 9, 2003. Typos correcte

Casimir energy of a compact cylinder under the condition ϵμ=c−2\epsilon\mu = c^{-2}

The Casimir energy of an infinite compact cylinder placed in a uniform unbounded medium is investigated under the continuity condition for the light velocity when crossing the interface. As a characteristic parameter in the problem the ratio $\xi^2=(\epsilon_1-\epsilon_2)^2/ (\epsilon_1+\epsilon_2)^-2 = (\mu_1-\mu_2)^2/(\mu_1+ \mu_2)^2 \le 1$ is used, where $\epsilon_1$ and $\mu_1$ are, respectively, the permittivity and permeability of the material making up the cylinder and $\epsilon_2$ and $\mu_2$ are those for the surrounding medium. It is shown that the expansion of the Casimir energy in powers of this parameter begins with the term proportional to $\xi^4$. The explicit formulas permitting us to find numerically the Casimir energy for any fixed value of $\xi^2$ are obtained. Unlike a compact ball with the same properties of the materials, the Casimir forces in the problem under consideration are attractive. The implication of the calculated Casimir energy in the flux tube model of confinement is briefly discussed.Comment: REVTeX, 12 pages, 1 figure in a separate fig1.eps file, 1 table; minor corrections in English and misprints; version to be published in Phys. Rev. D1

Casimir Energy for a Spherical Cavity in a Dielectric: Applications to Sonoluminescence

In the final few years of his life, Julian Schwinger proposed that the ``dynamical Casimir effect'' might provide the driving force behind the puzzling phenomenon of sonoluminescence. Motivated by that exciting suggestion, we have computed the static Casimir energy of a spherical cavity in an otherwise uniform material. As expected the result is divergent; yet a plausible finite answer is extracted, in the leading uniform asymptotic approximation. This result agrees with that found using zeta-function regularization. Numerically, we find far too small an energy to account for the large burst of photons seen in sonoluminescence. If the divergent result is retained, it is of the wrong sign to drive the effect. Dispersion does not resolve this contradiction. In the static approximation, the Fresnel drag term is zero; on the mother hand, electrostriction could be comparable to the Casimir term. It is argued that this adiabatic approximation to the dynamical Casimir effect should be quite accurate.Comment: 23 pages, no figures, REVTe

Gravitino dark matter in the constrained next-to-minimal supersymmetric standard model with neutralino next-to-lightest superpartner

The viability of a possible cosmological scenario is investigated. The theoretical framework is the constrained next-to-minimal supersymmetric standard model (cNMSSM), with a gravitino playing the role of the lightest supersymmetric particle (LSP) and a neutralino acting as the next-to-lightest supersymmetric particle (NLSP). All the necessary constraints from colliders and cosmology have been taken into account. For gravitino we have considered the two usual production mechanisms, namely out-of equillibrium decay from the NLSP, and scattering processes from the thermal bath. The maximum allowed reheating temperature after inflation, as well as the maximum allowed gravitino mass are determined.Comment: 20 pages, 5 figure

Extended Tree-Level Gauge Mediation

Tree-level gauge mediation (TGM) is a scenario of SUSY breaking in which the tree-level exchange of heavy (possibly GUT) vector fields generates flavor-universal sfermion masses. In this work we extend this framework to the case of E_6 that is the natural extension of the minimal case studied so far. Despite the number of possible E_6 subgroups containing G_SM is large (we list all rank 6 subgroups), there are only three different cases corresponding to the number of vector messengers. As a robust prediction we find that sfermion masses are SU(5) invariant at the GUT scale, even if the gauge group does not contain SU(5). If SUSY breaking is mediated purely by the U(1) generator that commutes with SO(10) we obtain universal sfermion masses and thus can derive the CMSSM boundary conditions in a novel scenario.Comment: 22 pages, 2 figures, 3 table

Transmutations and spectral parameter power series in eigenvalue problems

We give an overview of recent developments in Sturm-Liouville theory concerning operators of transmutation (transformation) and spectral parameter power series (SPPS). The possibility to write down the dispersion (characteristic) equations corresponding to a variety of spectral problems related to Sturm-Liouville equations in an analytic form is an attractive feature of the SPPS method. It is based on a computation of certain systems of recursive integrals. Considered as families of functions these systems are complete in the $L_{2}$-space and result to be the images of the nonnegative integer powers of the independent variable under the action of a corresponding transmutation operator. This recently revealed property of the Delsarte transmutations opens the way to apply the transmutation operator even when its integral kernel is unknown and gives the possibility to obtain further interesting properties concerning the Darboux transformed Schr\"{o}dinger operators. We introduce the systems of recursive integrals and the SPPS approach, explain some of its applications to spectral problems with numerical illustrations, give the definition and basic properties of transmutation operators, introduce a parametrized family of transmutation operators, study their mapping properties and construct the transmutation operators for Darboux transformed Schr\"{o}dinger operators.Comment: 30 pages, 4 figures. arXiv admin note: text overlap with arXiv:1111.444

Light Stop Decay in the MSSM with Minimal Flavour Violation

In supersymmetric scenarios with a light stop particle $\tilde{t}_1$ and a small mass difference to the lightest supersymmetric particle (LSP) assumed to be the lightest neutralino, the flavour changing neutral current decay $\tilde{t}_1 \to c \tilde{\chi}_1^0$ can be the dominant decay channel and can exceed the four-body stop decay for certain parameter values. In the framework of Minimal Flavour Violation (MFV) this decay is CKM-suppressed, thus inducing long stop lifetimes. Stop decay length measurements at the LHC can then be exploited to test models with minimal flavour breaking through Standard Model Yukawa couplings. The decay width has been given some time ago by an approximate formula, which takes into account the leading logarithms of the MFV scale. In this paper we calculate the exact one-loop decay width in the framework of MFV. The comparison with the approximate result exhibits deviations of the order of 10% for large MFV scales due to the neglected non-logarithmic terms in the approximate decay formula. The difference in the branching ratios is negligible. The large logarithms have to be resummed. The resummation is performed by the solution of the renormalization group equations. The comparison of the exact one-loop result and the tree level flavour changing neutral current decay, which incorporates the resummed logarithms, demonstrates that the resummation effects are important and should be taken into account.Comment: 29 page

Alternative Splicing at a NAGNAG Acceptor Site as a Novel Phenotype Modifier

Approximately 30% of alleles causing genetic disorders generate premature termination codons (PTCs), which are usually associated with severe phenotypes. However, bypassing the deleterious stop codon can lead to a mild disease outcome. Splicing at NAGNAG tandem splice sites has been reported to result in insertion or deletion (indel) of three nucleotides. We identified such a mechanism as the origin of the mild to asymptomatic phenotype observed in cystic fibrosis patients homozygous for the E831X mutation (2623G>T) in the CFTR gene. Analyses performed on nasal epithelial cell mRNA detected three distinct isoforms, a considerably more complex situation than expected for a single nucleotide substitution. Structure-function studies and in silico analyses provided the first experimental evidence of an indel of a stop codon by alternative splicing at a NAGNAG acceptor site. In addition to contributing to proteome plasticity, alternative splicing at a NAGNAG tandem site can thus remove a disease-causing UAG stop codon. This molecular study reveals a naturally occurring mechanism where the effect of either modifier genes or epigenetic factors could be suspected. This finding is of importance for genetic counseling as well as for deciding appropriate therapeutic strategies