243 research outputs found
Proximity of Iron Pnictide Superconductors to a Quantum Tricritical Point
We determine the nature of the magnetic quantum critical point in the doped
LaFeAsO using a set of constrained density functional calculations that provide
ab initio coefficients for a Landau order parameter analysis. The system turns
out to be remarkably close to a quantum tricritical point, where the nature of
the phase transition changes from first to second order. We compare with the
effective field theory and discuss the experimental consequences.Comment: 4 pages, 4 figure
Giant phonon anomalies and central peak due to charge density wave formation in YBaCuO
The electron-phonon interaction is a major factor influencing the competition
between collective instabilities in correlated-electron materials, but its role
in driving high-temperature superconductivity in the cuprates remains poorly
understood. We have used high-resolution inelastic x-ray scattering to monitor
low-energy phonons in YBaCuO (superconducting
K), which is close to a charge density wave (CDW) instability. Phonons in a
narrow range of momentum space around the CDW ordering vector exhibit extremely
large superconductivity-induced lineshape renormalizations. These results imply
that the electron-phonon interaction has sufficient strength to generate
various anomalies in electronic spectra, but does not contribute significantly
to Cooper pairing. In addition, a quasi-elastic "central peak" due to CDW
nanodomains is observed in a wide temperature range above and below ,
suggesting that the gradual onset of a spatially inhomogeneous CDW domain state
with decreasing temperature is a generic feature of the underdoped cuprates
Nitrogenase Gene Amplicons from Global Marine Surface Waters Are Dominated by Genes of Non-Cyanobacteria
Cyanobacteria are thought to be the main N2-fixing organisms
(diazotrophs) in marine pelagic waters, but recent molecular analyses indicate
that non-cyanobacterial diazotrophs are also present and active. Existing data
are, however, restricted geographically and by limited sequencing depths. Our
analysis of 79,090 nitrogenase (nifH) PCR amplicons encoding
7,468 unique proteins from surface samples (ten DNA samples and two RNA samples)
collected at ten marine locations world-wide provides the first in-depth survey
of a functional bacterial gene and yield insights into the composition and
diversity of the nifH gene pool in marine waters. Great
divergence in nifH composition was observed between sites.
Cyanobacteria-like genes were most frequent among amplicons from the warmest
waters, but overall the data set was dominated by nifH
sequences most closely related to non-cyanobacteria. Clusters related to Alpha-,
Beta-, Gamma-, and Delta-Proteobacteria were most common and showed distinct
geographic distributions. Sequences related to anaerobic bacteria
(nifH Cluster III) were generally rare, but preponderant in
cold waters, especially in the Arctic. Although the two transcript samples were
dominated by unicellular cyanobacteria, 42% of the identified
non-cyanobacterial nifH clusters from the corresponding DNA
samples were also detected in cDNA. The study indicates that non-cyanobacteria
account for a substantial part of the nifH gene pool in marine
surface waters and that these genes are at least occasionally expressed. The
contribution of non-cyanobacterial diazotrophs to the global N2
fixation budget cannot be inferred from sequence data alone, but the prevalence
of non-cyanobacterial nifH genes and transcripts suggest that
these bacteria are ecologically significant
Iron and phosphorus co-limit nitrogen fixation in the eastern tropical North Atlantic
The role of iron in enhancing phytoplankton productivity in high nutrient, low chlorophyll oceanic regions was demonstrated first through iron-addition bioassay experiments1 and subsequently confirmed by large-scale iron fertilization experiments2. Iron supply has been hypothesized to limit nitrogen fixation and hence oceanic primary productivity on geological timescales3, providing an alternative to phosphorus as the ultimate limiting nutrient4. Oceanographic observations have been interpreted both to confirm and refute this hypothesis5, 6, but direct experimental evidence is lacking7. We conducted experiments to test this hypothesis during the Meteor 55 cruise to the tropical North Atlantic. This region is rich in diazotrophs8 and strongly impacted by Saharan dust input9. Here we show that community primary productivity was nitrogen-limited, and that nitrogen fixation was co-limited by iron and phosphorus. Saharan dust addition stimulated nitrogen fixation, presumably by supplying both iron and phosphorus10, 11. Our results support the hypothesis that aeolian mineral dust deposition promotes nitrogen fixation in the eastern tropical North Atlantic
Abundances of Iron-Binding Photosynthetic and Nitrogen-Fixing Proteins of Trichodesmium Both in Culture and In Situ from the North Atlantic
Marine cyanobacteria of the genus Trichodesmium occur throughout the oligotrophic tropical and subtropical oceans, where they can dominate the diazotrophic community in regions with high inputs of the trace metal iron (Fe). Iron is necessary for the functionality of enzymes involved in the processes of both photosynthesis and nitrogen fixation. We combined laboratory and field-based quantifications of the absolute concentrations of key enzymes involved in both photosynthesis and nitrogen fixation to determine how Trichodesmium allocates resources to these processes. We determined that protein level responses of Trichodesmium to iron-starvation involve down-regulation of the nitrogen fixation apparatus. In contrast, the photosynthetic apparatus is largely maintained, although re-arrangements do occur, including accumulation of the iron-stress-induced chlorophyll-binding protein IsiA. Data from natural populations of Trichodesmium spp. collected in the North Atlantic demonstrated a protein profile similar to iron-starved Trichodesmium in culture, suggestive of acclimation towards a minimal iron requirement even within an oceanic region receiving a high iron-flux. Estimates of cellular metabolic iron requirements are consistent with the availability of this trace metal playing a major role in restricting the biomass and activity of Trichodesmium throughout much of the subtropical ocean
Importance of salt fingering for new nitrogen supply in the oligotrophic ocean.
The input of new nitrogen into the euphotic zone constrains the export of organic carbon to
the deep ocean and thereby the biologically mediated long-term CO2 exchange between
the ocean and atmosphere. In low-latitude open-ocean regions, turbulence-driven nitrate
diffusion from the ocean’s interior and biological fixation of atmospheric N2 are the main
sources of new nitrogen for phytoplankton productivity. With measurements across the
tropical and subtropical Atlantic, Pacific and Indian oceans, we show that nitrate diffusion
(171±190 mmolm 2 d 1) dominates over N2 fixation (9.0±9.4 mmolm 2 d 1) at the time
of sampling. Nitrate diffusion mediated by salt fingers is responsible for ca. 20% of the new
nitrogen supply in several provinces of the Atlantic and Indian Oceans. Our results indicate
that salt finger diffusion should be considered in present and future ocean nitrogen budgets,
as it could supply globally 0.23–1.00 TmolNyr 1 to the euphotic zone.MALASPINA (CSD2008-00077)Versión del editor10,015
Development, Problem Behavior, and Quality of Life in a Population Based Sample of Eight-Year-Old Children with Down Syndrome
OBJECTIVE: Children with Down syndrome (DS) have delayed psychomotor development. We investigated levels of development, problem behavior, and Health-Related Quality of Life (HRQoL) in a population sample of Dutch eight-year-old children with DS. Developmental outcomes were compared with normative data of eight-year-old children from the general population. METHOD: Over a three-year-period all parents with an eight-year-old child with DS were approached by the national parent organization. Developmental skills were assessed by means of the McCarthy Scales of Children's Ability. To measure emotional and behavioral problems we used the Child Behavior Checklist. HRQoL was assessed with the TNO-AZL Children's Quality of Life questionnaire. Analyses of variance were applied to compare groups. RESULTS: A total of 337 children participated. Mean developmental age was substantially lower than mean calendar age (3.9 years, SD 0.87 and 8.1 years, SD 0.15 respectively). Mean developmental age was significantly lower among boys than girls (3.6 (SD 0.85) and 4.2 years (SD 0.82) respectively; p<0.001). Compared with the general population, children with DS had more emotional and behavioral problems (p<0.001). However on the anxious/depressed scale, they scored significantly more favorably (p<0.001). Significantly lower HRQoL scores for the scales gross motor skills, autonomy, social functioning and cognitive functioning were found (p-values<0.001). Hardly any differences were observed for the scales physical complaints, positive and negative emotions. CONCLUSION: Eight-year-old children with DS have an average developmental delay of four years, more often have emotional and behavioral problems, and have a less favorable HRQoL compared with children from the general population
Development and validation of the Arizona Cognitive Test Battery for Down syndrome
Neurocognitive assessment in individuals with intellectual disabilities requires a well-validated test battery. To meet this need, the Arizona Cognitive Test Battery (ACTB) has been developed specifically to assess the cognitive phenotype in Down syndrome (DS). The ACTB includes neuropsychological assessments chosen to 1) assess a range of skills, 2) be non-verbal so as to not confound the neuropsychological assessment with language demands, 3) have distributional properties appropriate for research studies to identify genetic modifiers of variation, 4) show sensitivity to within and between sample differences, 5) have specific correlates with brain function, and 6) be applicable to a wide age range and across contexts. The ACTB includes tests of general cognitive ability and prefrontal, hippocampal and cerebellar function. These tasks were drawn from the Cambridge Neuropsychological Testing Automated Battery (CANTAB) and other established paradigms. Alongside the cognitive testing battery we administered benchmark and parent-report assessments of cognition and behavior. Individuals with DS (n = 74, ages 7–38 years) and mental age (MA) matched controls (n = 50, ages 3–8 years) were tested across 3 sites. A subsample of these groups were used for between-group comparisons, including 55 individuals with DS and 36 mental age matched controls. The ACTB allows for low floor performance levels and participant loss. Floor effects were greater in younger children. Individuals with DS were impaired on a number ACTB tests in comparison to a MA-matched sample, with some areas of spared ability, particularly on tests requiring extensive motor coordination. Battery measures correlated with parent report of behavior and development. The ACTB provided consistent results across contexts, including home vs. lab visits, cross-site, and among individuals with a wide range of socio-economic backgrounds and differences in ethnicity. The ACTB will be useful in a range of outcome studies, including clinical trials and the identification of important genetic components of cognitive disability
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