The Appearance of Four Basement Membrane Zone Antigens in Developing Human Fetal Skin

In order to study the ontogeny of various structural and antigenic components of the basement membrane zone of human skin, we have examined skin specimens from 20 aborted fetuses ranging in gestational ages from 6 to 25 weeks, utilizing light microscopy, transmission electron microscopy, and indirect immunofluorescence with antibodies to bullous pemphigoid antigen, laminin, type IV collagen, and to the antigen defined by KF-1 monoclonal antibody. Both laminin and type IV collagen were detectable as early as 6 weeks of gestational age. In contrast, bullous pemphigoid antigen and the antigen defined by KF- 1 antibody were not detectable before 10 weeks and 16 weeks, respectively. The appearance of bullous pemphigoid antigen correlated with stratification of the epidermis and the formation of hemidesmosomes and anchoring fibrils at the basement membrane zone. KF- 1 antigen is first expressed when the epidermis is further stratified, hemidesmosomes and anchoring fibrils are present in greater numbers and with increased frequency at the dermal-epidermal junction, and hair follicles have begun to bud downward from the basal layer of the epidermis. Our findings suggest an orderly sequence to the appearance of these basement membrane zone components within human skin

Taboo Or Not Taboo: (In)visibilities Of Death, Dying And Bereavement

The notion that ‘death is a taboo’ pervades private, public and academic discourses around death, dying and bereavement in contemporary Western societies. The rise of digital media within the last decades further complicates the appreciation of the stance that death is a taboo, given the increased opportunities afforded in social media environments for embracing death, fostering new intimacies with strangers and semi-strangers but also for turning death into a spectacle (Jakobsen, 2016). The study of death-related practices online and the tensions they raise has rapidly been growing in the interdisciplinary field of Death online studies. However, in this field there is a need for developing shared conceptual and analytical frameworks and ensure methodological and theoretical robustness in line with developments in the study of social media communication. There is a need to synthesize insights from death sociology and interdisciplinary death online studies in order to shape an agenda for an integrated study of the offline and the online that can capture continuities and shifts in death-related practices (see also Borgstrom and Ellis, 2017). This panel collects four papers presented by six interdisciplinary scholars from Denmark, Sweden, Israel and the UK. Focusing on the (in)visibilities of death, dying and bereavement across contexts - online and offline - the papers critically revisit the ‘death is taboo’ thesis by investigating the particular conditions under which death, dying and bereavement are talked about, storied, and made socially visible and the ways in which technology plays a vital part in coping with mortality

Statistical Characterization of Temperature Patterns in Anisotropic Cosmologies

We consider the issue of characterizing the coherent large-scale patterns from CMB temperature maps in globally anisotropic cosmologies. The methods we investigate are reasonably general; the particular models we test them on are the homogeneous but anisotropic relativistic cosmologies described by the Bianchi classification. Although the temperature variations produced in these models are not stochastic, they give rise to a "non-Gaussian" distribution of temperature fluctuations over the sky that is a partial diagnostic of the model. We explore two methods for quantifying non-Gaussian and/or non-stationary fluctuation fields in order to see how they respond to the Bianchi models.We first investigate the behavior of phase correlations between the spherical harmonic modes of the maps. Then we examine the behavior of the multipole vectors of the temperature distribution which, though defined in harmonic space, can indicate the presence of a preferred direction in real space, i.e. on the 2-sphere. These methods give extremely clear signals of the presence of anisotropy when applied to the models we discuss, suggesting that they have some promise as diagnostics of the presence of global asymmetry in the Universe.Comment: 14 pages, 10 figures, 4 tables, accepted by MNRA

Extreme hyponatremia with moderate metabolic acidosis during hysteroscopic myomectomy -A case report-

Excess absorption of fluid distention media remains an unpredictable complication of operative hysteroscopy and may lead to lethal conditions. We report an extreme hyponatremia, caused by using an electrolyte-free 5 : 1 sorbitol/mannitol solution as distention/irrigation fluid for hysteroscopic myomectomy. A 34-year-old female developed severe pulmonary edema and extreme hyponatremia (83 mmol/L) during transcervical endoscopic myomectomy. A brain computed tomography showed mild brain swelling without pontine myelinolysis. The patient almost fully recovered in two days. Meticulous attention should be paid to intraoperative massive absorption of fluid distention media, even during a simple hysteroscopic procedure

An interactive course to enhance self-efficacy of family practitioners to treat obesity

BACKGROUND: Physicians' awareness of their important role in defusing the obesity epidemic has increased. However, the number of family practitioners who treat obesity problems continues to be low. Self-efficacy refers to the belief in one's ability to organize and execute the courses of action required to produce given attainments. Thus, practitioners who judge themselves incapable of managing obesity do not even try. We hypothesized that practitioners' self-efficacy and motivation would be enhanced as a result of participating in an interactive course designed to enrich their knowledge of obesity management. METHODS: Twenty-nine family practitioners participated in the course, which was accompanied by qualitative interviews. The difference between the physicians' pre-course and post-course appraisals was tested by paired t-test. The interviews were analyzed by qualitative methods. RESULTS: Post-course efficacy appraisals were significantly higher than pre-course appraisals (p < 0.0005). A deeper insight on the practitioners' self-efficacy processes was gained through reflection of the practitioners on their self-efficacy during the interviews. CONCLUSIONS: Up-to-date information and workshops where skills, attitudes and social support were addressed were important in making the program effective

Collusion through Joint R&D: An Empirical Assessment

This paper tests whether upstream R&D cooperation leads to downstream collusion. We consider an oligopolistic setting where firms enter in research joint ventures (RJVs) to lower production costs or coordinate on collusion in the product market. We show that a sufficient condition for identifying collusive behavior is a decline in the market share of RJV-participating firms, which is also necessary and sufficient for a decrease in consumer welfare. Using information from the US National Cooperation Research Act, we estimate a market share equation correcting for the endogeneity of RJV participation and R&D expenditures. We find robust evidence that large networks between direct competitors – created through firms being members in several RJVs at the same time – are conducive to collusive outcomes in the product market which reduce consumer welfare. By contrast, RJVs among non-competitors are efficiency enhancing

Agony at a Distance : Investigating Digital Witnessing on YouTube

Peer reviewe

Randomized Controlled Trial of a Computer-Based, Tailored Intervention to Increase Smoking Cessation Counseling by Primary Care Physicians

OBJECTIVE: The primary care visit represents an important venue for intervening with a large population of smokers. However, physician adherence to the Smoking Cessation Clinical Guideline (5As) remains low. We evaluated the effectiveness of a computer-tailored intervention designed to increase smoking cessation counseling by primary care physicians. METHODS: Physicians and their patients were randomized to either intervention or control conditions. In addition to brief smoking cessation training, intervention physicians and patients received a one-page report that characterized the patients’ smoking habit and history and offered tailored recommendations. Physician performance of the 5As was assessed via patient exit interviews. Quit rates and smoking behaviors were assessed 6 months postintervention via patient phone interviews. Intervention effects were tested in a sample of 70 physicians and 518 of their patients. Results were analyzed via generalized and mixed linear modeling controlling for clustering. MEASUREMENTS AND MAIN RESULTS: Intervention physicians exceeded controls on “Assess” (OR 5.06; 95% CI 3.22, 7.95), “Advise” (OR 2.79; 95% CI 1.70, 4.59), “Assist–set goals” (OR 4.31; 95% CI 2.59, 7.16), “Assist–provide written materials” (OR 5.14; 95% CI 2.60, 10.14), “Assist–provide referral” (OR 6.48; 95% CI 3.11, 13.49), “Assist–discuss medication” (OR 4.72;95% CI 2.90, 7.68), and “Arrange” (OR 8.14; 95% CI 3.98, 16.68), all p values being < 0.0001. Intervention patients were 1.77 (CI 0.94, 3.34,p = 0.078) times more likely than controls to be abstinent (12 versus 8%), a difference that approached, but did not reach statistical significance, and surpassed controls on number of days quit (18.4 versus 12.2, p < .05) but not on number of quit attempts. CONCLUSIONS: The use of a brief computer-tailored report improved physicians’ implementation of the 5As and had a modest effect on patients’ smoking behaviors 6 months postintervention

Inflammatory Cytokine Profiles of Semen Influence Cytokine Responses of Cervicovaginal Epithelial Cells

Genital inflammatory cytokine responses increase HIV risk. Since male partner semen is a complex mixture of immune-modulatory prostaglandins and cytokines, we hypothesized that exposure to semen may influence genital inflammation in women. Here, we investigated cytokine response kinetics of cervical cells following stimulation with seminal plasma from HIV-negative and HIV-positive men characterized as having low or high concentrations of inflammatory cytokines. Irrespective of the HIV status or semen cytokine profile, in vitro stimulation of cervical cells with seminal plasma resulted in significantly elevated concentrations of secreted IL-6, IL-8, TNF-β, MCP-1, GM-CSF, and VEGF within 8 h of stimulation, which tended to decline by 24 h, although this was only significant for TNF-β. Consistent with this, cervical cells responded to seminal plasma with increases in IL-8 and IL-1β mRNA expression of 10-fold. These findings suggest that the impact of semen on local female genital cytokines is likely transient. Although these findings suggest that the impact of semen on local female genital cytokines may not be sustained long-term, this heightened genital inflammation may have implications for HIV risk in women

Intrinsic vowel F0, the size of vowel inventories and second language acquisition

The phenomenon of intrinsic vowel F0 (IF0), in which high vowels exhibit higher F0 than low vowels, has been widely attested in languages of the world. Most often, IF0 is regarded as an automatic, physiologically determined phenomenon, whereas some claim that IF0 is a controlled feature, introduced to enhance vowel contrasts. This paper presents new evidence on this issue by means of a cross-linguistic investigation of the influence of vowel inventory size on IF0 and a study of IF0 in second language (L2) acquisition. IF0 was measured in three language varieties: Arabic (a language with 3 vowels), Dutch (a 12-vowel system), and Dutch spoken by native Arabic-speaking learners. IF0 was significantly larger in Dutch than Arabic, but did not differ significantly between Arabic and Dutch produced by L2 learners. No spectral differences between the corresponding vowels of the three language varieties were found. While confirming the universality of IF0, these results also suggest that the size of IF0 may be language-specific, depending on the need to enhance vowel contrasts. Thus, these results agree well with a mixed physiological-enhancement account, which assumes that IF0 is physiologically determined, but also at least in part the effect of an interacting, controlled mechanism