Race, Place, and Family: Narratives of the Civil Rights Movement in Brownsville, Tennessee, and the Nation

This dissertation examines the Civil Rights Movement through the experiences of primarily two African American families with roots in Brownsville, Tennessee. This study, based on archival research and oral histories, chronicles three generations of citizens affiliated with the NAACP whose translocal civil rights struggles include both the South and urban North. It highlights various tactics individuals used to secure their rights and identifies African American entrepreneurship as a form of non-violent protest, focusing on the African American funeral home as a gateway enterprise which contributed to the establishment of other businesses or "staple institutions" that helped to sustain the Black community during segregation

What are nurse practice assessors’ priorities when assessing student mental health nurses? A qualitative content analysis

Background UK healthcare policy has observed over a decade of changes that has focussed on healthcare staffs’ professional values as a marker for safe, high-quality care In 2018 the regulatory body for nursing and midwifery introduced several new proficiencies, with an emphasis on physical health assessment. However, a global debate has since surfaced regarding the generification of nurse education, which has been thought to have eroded field specific skills in mental health nursing. Aim To explore the priorities of practice assessors, articulated within the open comments written within online practice assessment documents. Methods A qualitative study was conducted, with data collected from comments made within online practice assessment documents relating to the ongoing assessment of student mental health nurses at one UK University. 26 individual sets of assessor comments were collected. An inductive content analysis was used to explore the nature of qualitative feedback provided to student mental health nurses, generated by mental health practice assessors. The COREQ checklist was used for the reporting of the study. Results Findings demonstrated that practice assessors were prioritising two core areas or broad-based skills categories: ‘transactional’ and ‘transformational’ competencies. Transactional competencies related to the practical application of specific tasks. Transformational competencies were commented on more frequently and placed emphasis on the students’ personal attributes and characteristics, and how these contribute to ‘good’ mental health nursing practice. Conclusion Mental health nurses prioritise assessing student nurses in relation to their personal attributes, work ethic, and values that are congruent with humanist perceptions of mental health nursing

Zonal Modes of Cosmic Microwave Background Temperature Maps

All-sky maps of the cosmic microwave background temperature fluctuations are usually represented by a spherical harmonic decomposition involving modes labelled by their degree l and order m (where -l < m < +l). The zonal modes (i.e those with m = 0) are of particular interest because they vary only with galactic latitude; any anomalous behaviour in them might therefore be an indication of erroneous foreground substraction. We perform a simple statistical analysis of the modes with low l for sky maps derived via different cleaning procedures from the Wilkinson Microwave Anisotropy Probe (WMAP) and show that the zonal modes provide a useful diagnostic of possible systematics.Comment: 5 pages, 4 tables, 2 figures, accepted for publication in MNRA

The vertical motions of mono-abundance sub-populations in the Milky Way disk

We present the vertical kinematics of stars in the Milky Way's stellar disk inferred from SDSS/SEGUE G-dwarf data, deriving the vertical velocity dispersion, \sigma_z, as a function of vertical height |z| and Galactocentric radius R for a set of 'mono-abundance' sub-populations of stars with very similar elemental abundances [\alpha/Fe] and [Fe/H]. We find that all components exhibit nearly isothermal kinematics in |z|, and a slow outward decrease of the vertical velocity dispersion: \sigma_z (z,R|[\alpha/Fe],[Fe/H]) ~ \sigma_z ([\alpha/Fe],[Fe/H]) x \exp (-(R-R_0)/7 kpc}). The characteristic velocity dispersions of these components vary from ~ 15 km/s for chemically young, metal-rich stars, to >~ 50 km/s for metal poor stars. The mean \sigma_z gradient away from the mid plane is only 0.3 +/- 0.2 km/s/kpc. We find a continuum of vertical kinetic temperatures (~\sigma^2_z) as function of ([\alpha/Fe],[Fe/H]), which contribute to the stellar surface mass density as \Sigma_{R_0}(\sigma^2_z) ~ \exp(-\sigma^2_z). The existence of isothermal mono-abundance populations with intermediate dispersions reject the notion of a thin-thick disk dichotomy. This continuum of disks argues against models where the thicker disk portions arise from massive satellite infall or heating; scenarios where either the oldest disk portion was born hot, or where internal evolution plays a major role, seem the most viable. The wide range of \sigma_z ([\alpha/Fe],[Fe/H]) combined with a constant \sigma_z(z) for each abundance bin provides an independent check on the precision of the SEGUE abundances: \delta_[\alpha/Fe] ~ 0.07 dex and \delta_[Fe/H] ~ 0.15 dex. The radial decline of the vertical dispersion presumably reflects the decrease in disk surface-mass density. This measurement constitutes a first step toward a purely dynamical estimate of the mass profile the disk in our Galaxy. [abridged

Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid

BACKGROUND: Staphylococcal infection of the canine epidermis and hair follicle is amongst the commonest reasons for antimicrobial prescribing in small animal veterinary practice. Topical therapy with fusidic acid (FA) is an attractive alternative to systemic therapy based on low minimum inhibitory concentrations (MICs, commonly <0.03 mg/l) documented in canine pathogenic staphylococci, including strains of MRSA and MRSP (methicillin-resistant Staphylococcus aureus and S. pseudintermedius). However, permeation of canine skin by FA has not been evaluated in detail. This study aimed to define the degree and extent of FA permeation in canine skin in vitro from two sites with different hair follicle density following application of a licensed ophthalmic formulation that shares the same vehicle as an FA-betamethasone combination product approved for dermal application in dogs. Topical FA application was modelled using skin held in Franz-type diffusion cells. Concentrations of FA in surface swabs, receptor fluid, and transverse skin sections of defined anatomical depth were determined using high-performance liquid chromatography and ultraviolet (HPLC-UV) analysis. RESULTS: The majority of FA was recovered by surface swabs after 24 h, as expected (mean ± SEM: 76.0 ± 17.0%). FA was detected within 424/470 (90%) groups of serial sections of transversely cryotomed skin containing follicular infundibula, but never in 48/48 (100%) groups of sections containing only deeper follicular structures, nor in receptor fluid, suggesting that FA does not permeate beyond the infundibulum. The FA concentration (mean ± SEM) in the most superficial 240 μm of skin was 2000 ± 815 μg/g. CONCLUSIONS: Topically applied FA can greatly exceed MICs for canine pathogenic staphylococci at the most common sites of infection. Topical FA therapy should now be evaluated using available formulations in vivo as an alternative to systemic therapy for canine superficial bacterial folliculitis.Peer reviewedFinal Published versio

The use of YouTube for the self-management of arthritis and joint pain: a patient and public involvement study

This is an accepted manuscript of an article published by OUP in Rheumatology on 12/04/2019, available online: https://doi.org/10.1093/rheumatology/kez110.052 The accepted version of the publication may differ from the final published version

Breakdown of the adiabatic limit in low dimensional gapless systems

It is generally believed that a generic system can be reversibly transformed from one state into another by sufficiently slow change of parameters. A standard argument favoring this assertion is based on a possibility to expand the energy or the entropy of the system into the Taylor series in the ramp speed. Here we show that this argumentation is only valid in high enough dimensions and can break down in low-dimensional gapless systems. We identify three generic regimes of a system response to a slow ramp: (A) mean-field, (B) non-analytic, and (C) non-adiabatic. In the last regime the limits of the ramp speed going to zero and the system size going to infinity do not commute and the adiabatic process does not exist in the thermodynamic limit. We support our results by numerical simulations. Our findings can be relevant to condensed-matter, atomic physics, quantum computing, quantum optics, cosmology and others.Comment: 11 pages, 5 figures, to appear in Nature Physics (originally submitted version

Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders

Background Cerebral palsy (CP) is an heterogeneous group of neurological disorders of movement and/or posture, with an estimated incidence of 1 in 1000 live births. Non-progressive forms of symmetrical, spastic CP have been identified, which show a Mendelian autosomal recessive pattern of inheritance. We recently described the mapping of a recessive spastic CP locus to a 5 cM chromosomal region located at 2q24-31.1, in rare consanguineous families. Methods Here we present data that refine this locus to a 0.5 cM region, flanked by the microsatellite markers D2S2345 and D2S326. The minimal region contains the candidate gene GAD1, which encodes a glutamate decarboxylase isoform (GAD67), involved in conversion of the amino acid and excitatory neurotransmitter glutamate to the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Results A novel amino acid mis-sense mutation in GAD67 was detected, which segregated with CP in affected individuals. Conclusions This result is interesting because auto-antibodies to GAD67 and the more widely studied GAD65 homologue encoded by the GAD2 gene, are described in patients with Stiff-Person Syndrome (SPS), epilepsy, cerebellar ataxia and Batten disease. Further investigation seems merited of the possibility that variation in the GAD1 sequence, potentially affecting glutamate/GABA ratios, may underlie this form of spastic CP, given the presence of anti-GAD antibodies in SPS and the recognised excitotoxicity of glutamate in various contexts

School-based high-intensity interval training programs in children and adolescents: A systematic review and meta-analysis

Purpose1) To investigate the effectiveness of school-based high-intensity interval training (HIIT) interventions in promoting health outcomes of children and adolescents compared with either a control group or other exercise modality; and 2) to explore the intervention characteristics and process outcomes of published school-based HIIT interventions.MethodsWe searched Medline, Embase, CINAHL, SPORTDiscus, and Web of Science from inception until 31 March 2021. Studies were eligible if 1) participants aged 5–17 years old; 2) a HIIT intervention within a school setting ≥ 2 weeks duration; 3) a control or comparative exercise group; 4) health-related, cognitive, physical activity, nutrition, or program evaluation outcomes; and 5) original research published in English. We conducted meta-analyses between HIIT and control groups for all outcomes with ≥ 4 studies and meta-regressions for all outcomes with ≥ 10 studies. We narratively synthesised results between HIIT and comparative exercise groups.ResultsFifty-four papers met eligibility criteria, encompassing 42 unique studies (35 randomised controlled trials; 36 with a high risk of bias). Meta-analyses indicated significant improvements in waist circumference (mean difference (MD) = -2.5cm), body fat percentage (MD = -1.7%), body mass index (standardised mean difference (SMD) = -1.0), cardiorespiratory fitness (SMD = +1.0), resting heart rate (MD = -5bpm), homeostatic model assessment–insulin resistance (MD = -0.7), and low-density lipoprotein cholesterol (SMD = -0.9) for HIIT compared to the control group. Our narrative synthesis indicated mixed findings between HIIT and other comparative exercise groups.ConclusionSchool-based HIIT is effective for improving several health outcomes. Future research should address the paucity of information on physical activity and nutrition outcomes and focus on the integration and long-term effectiveness of HIIT interventions within school settings

The SDSS-III Baryon Oscillation Spectroscopic Survey: Quasar Target Selection for Data Release Nine

The SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS), a five-year spectroscopic survey of 10,000 deg^2, achieved first light in late 2009. One of the key goals of BOSS is to measure the signature of baryon acoustic oscillations in the distribution of Ly-alpha absorption from the spectra of a sample of ~150,000 z>2.2 quasars. Along with measuring the angular diameter distance at z\approx2.5, BOSS will provide the first direct measurement of the expansion rate of the Universe at z > 2. One of the biggest challenges in achieving this goal is an efficient target selection algorithm for quasars over 2.2 < z < 3.5, where their colors overlap those of stars. During the first year of the BOSS survey, quasar target selection methods were developed and tested to meet the requirement of delivering at least 15 quasars deg^-2 in this redshift range, out of 40 targets deg^-2. To achieve these surface densities, the magnitude limit of the quasar targets was set at g <= 22.0 or r<=21.85. While detection of the BAO signature in the Ly-alpha absorption in quasar spectra does not require a uniform target selection, many other astrophysical studies do. We therefore defined a uniformly-selected subsample of 20 targets deg^-2, for which the selection efficiency is just over 50%. This "CORE" subsample will be fixed for Years Two through Five of the survey. In this paper we describe the evolution and implementation of the BOSS quasar target selection algorithms during the first two years of BOSS operations. We analyze the spectra obtained during the first year. 11,263 new z>2.2 quasars were spectroscopically confirmed by BOSS. Our current algorithms select an average of 15 z > 2.2 quasars deg^-2 from 40 targets deg^-2 using single-epoch SDSS imaging. Multi-epoch optical data and data at other wavelengths can further improve the efficiency and completeness of BOSS quasar target selection. [Abridged]Comment: 33 pages, 26 figures, 12 tables and a whole bunch of quasars. Submitted to Ap