680 research outputs found
Misaligned spin and orbital axes cause the anomalous precession of DI Herculis
The orbits of binary stars precess as a result of general relativistic
effects, forces arising from the asphericity of the stars, and forces from
additional stars or planets in the system. For most binaries, the theoretical
and observed precession rates are in agreement. One system, however -- DI
Herculis -- has resisted explanation for 30 years. The observed precession rate
is a factor of four slower than the theoretical rate, a disagreement that once
was interpreted as evidence for a failure of general relativity. Among the
contemporary explanations are the existence of a circumbinary planet and a
large tilt of the stellar spin axes with respect to the orbit. Here we report
that both stars of DI Herculis rotate with their spin axes nearly perpendicular
to the orbital axis (contrary to the usual assumption for close binary stars).
The rotationally induced stellar oblateness causes precession in the direction
opposite to that of relativistic precession, thereby reconciling the
theoretical and observed rates.Comment: Nature, in press [11 pg
A new concept for the combination of optical interferometers and high-resolution spectrographs
The combination of high spatial and spectral resolution in optical astronomy
enables new observational approaches to many open problems in stellar and
circumstellar astrophysics. However, constructing a high-resolution
spectrograph for an interferometer is a costly and time-intensive undertaking.
Our aim is to show that, by coupling existing high-resolution spectrographs to
existing interferometers, one could observe in the domain of high spectral and
spatial resolution, and avoid the construction of a new complex and expensive
instrument. We investigate in this article the different challenges which arise
from combining an interferometer with a high-resolution spectrograph. The
requirements for the different sub-systems are determined, with special
attention given to the problems of fringe tracking and dispersion. A concept
study for the combination of the VLTI (Very Large Telescope Interferometer)
with UVES (UV-Visual Echelle Spectrograph) is carried out, and several other
specific instrument pairings are discussed. We show that the proposed
combination of an interferometer with a high-resolution spectrograph is indeed
feasible with current technology, for a fraction of the cost of building a
whole new spectrograph. The impact on the existing instruments and their
ongoing programs would be minimal.Comment: 27 pages, 9 figures, Experimental Astronomy; v2: accepted versio
The Rossiter-McLaughlin effect in Exoplanet Research
The Rossiter-McLaughlin effect occurs during a planet's transit. It provides
the main means of measuring the sky-projected spin-orbit angle between a
planet's orbital plane, and its host star's equatorial plane. Observing the
Rossiter-McLaughlin effect is now a near routine procedure. It is an important
element in the orbital characterisation of transiting exoplanets. Measurements
of the spin-orbit angle have revealed a surprising diversity, far from the
placid, Kantian and Laplacian ideals, whereby planets form, and remain, on
orbital planes coincident with their star's equator. This chapter will review a
short history of the Rossiter-McLaughlin effect, how it is modelled, and will
summarise the current state of the field before describing other uses for a
spectroscopic transit, and alternative methods of measuring the spin-orbit
angle.Comment: Review to appear as a chapter in the "Handbook of Exoplanets", ed. H.
Deeg & J.A. Belmont
Kank Is an EB1 Interacting Protein that Localises to Muscle-Tendon Attachment Sites in Drosophila
Little is known about how microtubules are regulated in different cell types during development. EB1 plays a central role in the regulation of microtubule plus ends. It directly binds to microtubule plus ends and recruits proteins which regulate microtubule dynamics and behaviour. We report the identification of Kank, the sole Drosophila orthologue of human Kank proteins, as an EB1 interactor that predominantly localises to embryonic attachment sites between muscle and tendon cells. Human Kank1 was identified as a tumour suppressor and has documented roles in actin regulation and cell polarity in cultured mammalian cells. We found that Drosophila Kank binds EB1 directly and this interaction is essential for Kank localisation to microtubule plus ends in cultured cells. Kank protein is expressed throughout fly development and increases during embryogenesis. In late embryos, it accumulates to sites of attachment between muscle and epidermal cells. A kank deletion mutant was generated. We found that the mutant is viable and fertile without noticeable defects. Further analysis showed that Kank is dispensable for muscle function in larvae. This is in sharp contrast to C. elegans in which the Kank orthologue VAB-19 is required for development by stabilising attachment structures between muscle and epidermal cells
Experiences in the development of a data management system for genomics
GMQL is a high-level query language for genomics, which operates on datasets described through GDM, a unifying data model for processed data formats. They are ingredients for the integration of processed genomic datasets, i.e. of signals produced by the genome after sequencing and long data extraction pipelines. While most of the processing load of today’s genomic platforms is due to data extraction pipelines, we anticipate soon a shift of attention towards processed datasets, as such data are being collected by large consortia and are becoming increasingly available. In our view, biology and personalized medicine will increasingly rely on data extraction and analysis methods for inferring new knowledge from existing heterogeneous repositories of processed datasets, typically augmented with the results of experimental data targeting individuals or small populations. While today’s big data are raw reads of the sequencing machines, tomorrow’s big data will also include billions or trillions of genomic regions, each featuring specific values depending on the processing conditions. Coherently, GMQL is a high-level, declarative language inspired by big data management, and its execution engines include classic cloud-based systems, from Pig to Flink to SciDB to Spark. In this paper, we discuss how the GMQL execution environment has been developed, by going through a major version change that marked a complete system redesign; we also discuss our experiences in comparatively evaluating the four platforms
Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches
Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.Fil: Romanowski, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Garavaglia, Matías Javier. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ing.genética y Biolog.molecular y Celular. Area Virus de Insectos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Goya, María Eugenia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ghiringhelli, Pablo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ing.genética y Biolog.molecular y Celular. Area Virus de Insectos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego Andres. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
On-line health companion contact among chronically ill in the Netherlands
A health companion is a patient who supports another patient or patient group with a similar health condition. Health companions deliver more and more support by the Internet. However, little is known about the characteristics of the users, their motivation, type of technology used and effects on health and the healthcare delivery process. The objective of the paper is to understand motivation, technology and effects of on-line health companion contact in the Netherlands concerning chronic diseases (DBM, COPD, CHF, CRD, CMD). The On-line Health Companion Contact Model was created to frame the research process. An extensive on-line questionnaire was taken from patients with various chronic disorders and using on-line health companion contact to obtain quantitative and qualitative data. Obtaining information was found the key motivation for applying on-line health companion contact and several characteristics play a role in the selection to use a specific website, including: closed access; the topics discussed; the easy use; the type of users and a clear structure. Respondents prefer website facilitated by a forum or social networking site. Other factors are the possibility to share experiences with other patients, to find recognition and understanding and to meet new people. These positive aspects are of greater importance than the perceived barriers including privacy concerns, negative stories and whining other users and concerns regarding the quality of information. On-line health companion contact can increase the quality of life and self-management because respondents perceived to be better informed, better able to accept their disease, better deal with their situation and to receive an increased amount of social support
The signature of orbital motion from the dayside of the planet tau Bootis b
The giant planet orbiting tau Bootis was among the first extrasolar planets
to be discovered through the reflex motion of its host star. It is one of the
brightest known and most nearby planets with an orbital period of just a few
days. Over the course of more than a decade, measurements of its orbital
inclination have been announced and refuted, and have subsequently remained
elusive until now. Here we report on the detection of carbon monoxide
absorption in the thermal day-side spectrum of tau Bootis b. At a spectral
resolution of R~100,000, we trace the change in the radial velocity of the
planet over a large range in phase, determining an orbital inclination of
i=44.5+-1.5 degrees and a true planet mass of 5.95+-0.28 MJup. This result
extends atmospheric characterisation to non-transiting planets. The strong
absorption signal points to an atmosphere with a temperature that is decreasing
towards higher altitudes. This is a stark contrast to the temperature inversion
invoked for other highly irradiated planets, and supports models in which the
absorbing compounds believed to cause such atmospheric inversions are destroyed
by the ultraviolet emission from the active host star.Comment: To appear in the June 28 issue of Nature: main article +
supplementary informatio
Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events
Measurement and Interpretation of Fermion-Pair Production at LEP energies above the Z Resonance
This paper presents DELPHI measurements and interpretations of
cross-sections, forward-backward asymmetries, and angular distributions, for
the e+e- -> ffbar process for centre-of-mass energies above the Z resonance,
from sqrt(s) ~ 130 - 207 GeV at the LEP collider. The measurements are
consistent with the predictions of the Standard Model and are used to study a
variety of models including the S-Matrix ansatz for e+e- -> ffbar scattering
and several models which include physics beyond the Standard Model: the
exchange of Z' bosons, contact interactions between fermions, the exchange of
gravitons in large extra dimensions and the exchange of sneutrino in R-parity
violating supersymmetry.Comment: 79 pages, 16 figures, Accepted by Eur. Phys. J.
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