210 research outputs found
Risk of criminal victimisation in outpatients with common mental health disorders
Crime victimisation is a serious problem in psychiatric patients. However, research has focused on patients with severe mental illness and few studies exist that address victimisation in other outpatient groups, such as patients with depression. Due to large differences in methodology of the studies that address crime victimisation, a comparison of prevalence between psychiatric diagnostic groups is hard to make. Objectives of this study were to determine and compare one-year prevalence of violent and non-violent criminal victimisation among outpatients from different diagnostic psychiatric groups and to examine prevalence differences with the general population.Criminal victimisation prevalence was measured in 300 outpatients living in Amsterdam, The Netherlands. Face-to-face interviews were conducted with outpatients with depressive disorder (n = 102), substance use disorder (SUD, n = 106) and severe mental illness (SMI, n = 92) using a National Crime Victimisation Survey, and compared with a matched general population sample (n = 10865).Of all outpatients, 61% reported experiencing some kind of victimisation over the past year; 33% reported violent victimisation (3.5 times more than the general population) and 36% reported property crimes (1.2 times more than the general population). Outpatients with depression (67%) and SUD (76%) were victimised more often than SMI outpatients (39%). Younger age and hostile behaviour were associated with violent victimisation, while being male and living alone were associated with non-violent victimisation. Moreover, SUD was associated with both violent and non-violent victimisation.Outpatients with depression, SUD, and SMI are at increased risk of victimisation compared to the general population. Furthermore, our results indicate that victimisation of violent and non-violent crimes is more common in outpatients with depression and SUD than in outpatients with SMI living independently in the community
Reversing non-local transport through a superconductor by electromagnetic excitations
Superconductors connected to normal metallic electrodes at the nanoscale
provide a potential source of non-locally entangled electron pairs. Such states
would arise from Cooper pairs splitting into two electrons with opposite spins
tunnelling into different leads. In an actual system the detection of these
processes is hindered by the elastic transmission of individual electrons
between the leads, yielding an opposite contribution to the non-local
conductance. Here we show that electromagnetic excitations on the
superconductor can play an important role in altering the balance between these
two processes, leading to a dominance of one upon the other depending on the
spatial symmetry of these excitations. These findings allow to understand some
intriguing recent experimental results and open the possibility to control
non-local transport through a superconductor by an appropriate design of the
experimental geometry.Comment: 6 pages, 3 figure
Формування світогляду О. Кониського
Crime victimisation is a serious problem in psychiatric patients. However, research has focused on patients with severe mental illness and few studies exist that address victimisation in other outpatient groups, such as patients with depression. Due to large differences in methodology of the studies that address crime victimisation, a comparison of prevalence between psychiatric diagnostic groups is hard to make. Objectives of this study were to determine and compare one-year prevalence of violent and non-violent criminal victimisation among outpatients from different diagnostic psychiatric groups and to examine prevalence differences with the general population.Criminal victimisation prevalence was measured in 300 outpatients living in Amsterdam, The Netherlands. Face-to-face interviews were conducted with outpatients with depressive disorder (n = 102), substance use disorder (SUD, n = 106) and severe mental illness (SMI, n = 92) using a National Crime Victimisation Survey, and compared with a matched general population sample (n = 10865).Of all outpatients, 61% reported experiencing some kind of victimisation over the past year; 33% reported violent victimisation (3.5 times more than the general population) and 36% reported property crimes (1.2 times more than the general population). Outpatients with depression (67%) and SUD (76%) were victimised more often than SMI outpatients (39%). Younger age and hostile behaviour were associated with violent victimisation, while being male and living alone were associated with non-violent victimisation. Moreover, SUD was associated with both violent and non-violent victimisation.Outpatients with depression, SUD, and SMI are at increased risk of victimisation compared to the general population. Furthermore, our results indicate that victimisation of violent and non-violent crimes is more common in outpatients with depression and SUD than in outpatients with SMI living independently in the community
Synthetic long peptide booster immunization in rhesus macaques primed with replication-competent NYVAC-C-KC induces a balanced CD4/CD8 T-cell and antibody response against the conserved regions of HIV-1.
The Thai trial (RV144) indicates that a prime-boost vaccine combination that induces both T-cell and antibody responses may be desirable for an effective HIV vaccine. We have previously shown that immunization with synthetic long peptides (SLP), covering the conserved parts of SIV, induced strong CD4 T-cell and antibody responses, but only modest CD8 T-cell responses. To generate a more balanced CD4/CD8 T-cell and antibody response, this study evaluated a pox-vector prime/SLP boost strategy in rhesus macaques. Priming with a replication-competent NYVAC, encoding HIV-1 clade C gag, pol and nef, induced modest IFNγ T-cell immune responses, predominantly directed against HIV-1 Gag. Booster immunization with SLP, covering the conserved parts of HIV-1 Gag, Pol and Env, resulted in a more than 10-fold increase in IFNγ ELISpot responses in four of six animals, which were predominantly HIV-1 Pol-specific. The animals showed a balanced polyfunctional CD4 and CD8 T-cell response and high Ab titres.This project was conducted under the auspices of of the Poxvirus T-cell Vaccine Discovery Consortium (PTVDC) as part of the Collaboration for AIDS Vaccine Discovery (CAVD) with support from the Bill and Melinda Gates Foundation.This is the accepted manuscript of a paper published in the Journal of General Virology (Mooij P, et al., Journal of General Virology, 2015, 96, 1478-1483, doi:10.1099/vir.0.000074). The final version is available at http://dx.doi.org/10.1099/vir.0.00007
Electrical detection of 31P spin quantum states
In recent years, a variety of solid-state qubits has been realized, including
quantum dots, superconducting tunnel junctions and point defects. Due to its
potential compatibility with existing microelectronics, the proposal by Kane
based on phosphorus donors in Si has also been pursued intensively. A key issue
of this concept is the readout of the P quantum state. While electrical
measurements of magnetic resonance have been performed on single spins, the
statistical nature of these experiments based on random telegraph noise
measurements has impeded the readout of single spin states. In this letter, we
demonstrate the measurement of the spin state of P donor electrons in silicon
and the observation of Rabi flops by purely electric means, accomplished by
coherent manipulation of spin-dependent charge carrier recombination between
the P donor and paramagnetic localized states at the Si/SiO2 interface via
pulsed electrically detected magnetic resonance. The electron spin information
is shown to be coupled through the hyperfine interaction with the P nucleus,
which demonstrates the feasibility of a recombination-based readout of nuclear
spins
Quantum non-demolition measurement of a superconducting two-level system
In quantum mechanics, the process of measurement is a subtle interplay
between extraction of information and disturbance of the state of the quantum
system. A quantum non-demolition (QND) measurement minimizes this disturbance
by using a particular system - detector interaction which preserves the
eigenstates of a suitable operator of the quantum system. This leads to an
ideal projective measurement. We present experiments in which we perform two
consecutive measurements on a quantum two -level system, a superconducting flux
qubit, by probing the hysteretic behaviour of a coupled nonlinear resonator.
The large correlation between the results of the two measurements demonstrates
the QND nature of the readout method. The fact that a QND measurement is
possible for superconducting qubits strengthens the notion that these
fabricated mesoscopic systems are to be regarded as fundamental quantum
objects. Our results are also relevant for quantum information processing,
where projective measurements are used for protocols like state preparation and
error correction.Comment: 14 pages, 4 figure
Adult Patients with Congenital Adrenal Hyperplasia Have Elevated Blood Pressure but Otherwise a Normal Cardiovascular Risk Profile
Contains fulltext :
96615.pdf (publisher's version ) (Open Access)OBJECTIVE: Treatment with glucocorticoids and mineralocorticoids has changed congenital adrenal hyperplasia (CAH) from a fatal to a chronic lifelong disease. Long-term treatment, in particular the chronic (over-)treatment with glucocorticoids, may have an adverse effect on the cardiovascular risk profile in adult CAH patients. The objective of this study was to evaluate the cardiovascular risk profile of adult CAH patients. DESIGN: Case-control study. PATIENTS AND MEASUREMENTS: In this case-control study the cardiovascular risk profile of 27 adult CAH patients and 27 controls, matched for age, sex and body mass index was evaluated by measuring ambulatory 24-hour blood pressure, insulin sensitivity (HOMA-IR), lipid profiles, albuminuria and circulating cardiovascular risk markers (PAI-1, tPA, uPA, tPA/PAI-1 complex, hsCRP, adiponectin, IL-6, IL-18 and leptin). RESULTS: 24-Hour systolic (126.3 mmHg+/-15.5 vs 124.8 mmHg+/-15.1 in controls, P = 0.019) and diastolic (76.4 mmHg+/-12.7 vs 73.5 mmHg+/-12.4 in controls, P<0.001) blood pressure was significantly elevated in CAH patients compared to the control population. CAH patients had higher HDL cholesterol levels (P<0.01), lower hsCRP levels (P = 0.03) and there was a trend toward elevated adiponectin levels compared to controls. Other cardiovascular risk factors were similar in both groups. CONCLUSION: Adult CAH patients have higher ambulatory blood pressure compared to healthy matched controls. Other cardiovascular risk markers did not differ, while HDL-cholesterol, hsCRP and adiponectin levels tended to be more favorable
An absolute sodium abundance for a cloud-free 'hot Saturn' exoplanet.
Broad absorption signatures from alkali metals, such as the sodium (Na I) and potassium (K I) resonance doublets, have long been predicted in the optical atmospheric spectra of cloud-free irradiated gas giant exoplanets1-3. However, observations have revealed only the narrow cores of these features rather than the full pressure-broadened profiles4-6. Cloud and haze opacity at the day-night planetary terminator are considered to be responsible for obscuring the absorption-line wings, which hinders constraints on absolute atmospheric abundances7-9. Here we report an optical transmission spectrum for the 'hot Saturn' exoplanet WASP-96b obtained with the Very Large Telescope, which exhibits the complete pressure-broadened profile of the sodium absorption feature. The spectrum is in excellent agreement with cloud-free, solar-abundance models assuming chemical equilibrium. We are able to measure a precise, absolute sodium abundance of logεNa = [Formula: see text], and use it as a proxy for the planet's atmospheric metallicity relative to the solar value (Zp/Zʘ = [Formula: see text]). This result is consistent with the mass-metallicity trend observed for Solar System planets and exoplanets10-12
Quantum suppression of superconductivity in ultrathin nanowires
We report measurements on ultrathin (<10 nm) nanowires produced by coating
carbon nanotubes with a superconducting amorphous MoGe alloy. We find that
nanowires can be superconducting or insulating depending on their normal state
resistance compared to -- the quantum resistance for
Cooper pairs. If the tunneling of quantum phase slips (QPS) is
prohibited due to strong damping, and so the wires stay superconducting. The
insulating state, observed if , is explained in terms of
proliferation of quantum phase slips and corresponding localization of Cooper
pairs. The observed superconductor-insulator transition is analogous to the
dissipative phase transition which takes place in Josephson Junctions at
(Penttila et al., Phys. Rev. Lett. Vol.82, p.1004, 1999)Comment: 14 pages, 3 figures. Accepted for publication in Natur
A survey on independence-based Markov networks learning
This work reports the most relevant technical aspects in the problem of
learning the \emph{Markov network structure} from data. Such problem has become
increasingly important in machine learning, and many other application fields
of machine learning. Markov networks, together with Bayesian networks, are
probabilistic graphical models, a widely used formalism for handling
probability distributions in intelligent systems. Learning graphical models
from data have been extensively applied for the case of Bayesian networks, but
for Markov networks learning it is not tractable in practice. However, this
situation is changing with time, given the exponential growth of computers
capacity, the plethora of available digital data, and the researching on new
learning technologies. This work stresses on a technology called
independence-based learning, which allows the learning of the independence
structure of those networks from data in an efficient and sound manner,
whenever the dataset is sufficiently large, and data is a representative
sampling of the target distribution. In the analysis of such technology, this
work surveys the current state-of-the-art algorithms for learning Markov
networks structure, discussing its current limitations, and proposing a series
of open problems where future works may produce some advances in the area in
terms of quality and efficiency. The paper concludes by opening a discussion
about how to develop a general formalism for improving the quality of the
structures learned, when data is scarce.Comment: 35 pages, 1 figur
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