Caracterização da Carne Marinhoa DOP

Este trabalho resultou da análise de dados existentes na Associação dos Criadores de Bovinos da Raça Marinhoa (ACRM), no matadouro de Aveiro, obtidos durante a recria de vitelos em parceria e da análise das respostas a inquéritos feitos a uma amostra da população residente no solar de origem da raça Marinhoa. Teve como objectivo caracterizar as primeiras 56 carcaças de bovinos que foram comercializadas pelo Agrupamento de Produtores CARMARDOP e avaliar a importância e o reconhecimento que esta DOP tem na região solar da raça. Determinou-se: a idade média ao abate (494,0 dias ±173,35); o sexo dos animais abatidos (82,0% machos); a classe dos animais abatidos (60,3% da classe novilho); o peso médio de carcaça (194,4 kg ±63,95); o ganho de peso diário entre os 150 e os 285 dias de idade (0,528kg/dia). Verificou-se que 44,2% das carcaças obtiveram a classificação P1 e 30,7% a classificação P2, a vazia é a peça mais abundante na categoria Extra, que no seu total representa 13,9 % do peso da carcaça, as peças de 1ª Categoria constituem 38,8 % da carcaça, sendo o acém a peça com maior peso e na 2ª Categoria, com 23,11% do peso da carcaça, a aba é a peça mais representativa. Em relação ao inquérito efectuado apurou-se que: 13% dos inquiridos consome carne de bovino (gosto pessoal, confiança no produto criado em casa); 60% conhece o significado da expressão “Denominação de Origem Protegida”, sobretudo os inquiridos do sexo masculino e na faixa etária dos 31-40 anos; 48,9% já provou carne com DOP e apenas 20% já provou Carne Marinhoa DOP. Embora esteja a ser importante o trabalho de divulgação do produto que tem sido desenvolvido pela ACRM e pelo agrupamento de produtores, consideramos fundamental a divulgação desta carne pelas entidades políticas competentes, por se tratar de um produto de qualidade, exclusivo da região, e que poderá constituir uma mais valia para a sua população e para a preservação desta raça autóctone

Adaptive Optimization of Chemical Reactions with Minimal Experimental Information

Optimizing reaction conditions depends on expert chemistry knowledge and laborious exploration of reaction parameters. To automate this task and augment chemical intuition, we here report a computational tool to navigate search spaces. Our approach (LabMate.ML) integrates random sampling of 0.03%–0.04% of all search space as input data with an interpretable, adaptive machine-learning algorithm. LabMate.ML can optimize many real-valued and categorical reaction parameters simultaneously, with minimal computational resources and time. In nine prospective proof-of-concept studies pursuing distinctive objectives, we demonstrate how LabMate.ML can identify optimal goal-oriented conditions for several different chemistries and substrates. Double-blind competitions and the conducted expert surveys reveal that its performance is competitive with that of human experts. LabMate.ML does not require specialized hardware, affords quantitative and interpretable reactivity insights, and autonomously formalizes chemical intuition, thereby providing an innovative framework for informed, automated experiment selection toward the democratization of synthetic chemistry.D.R. is a Swiss National Science Foundation Fellow (grant nos. P2EZP3_168827 and P300P2_177833). E.A.H. is supported by the Herchel Smith Fellowship awarded by Williams College. G.J.L.B. is a Royal Society URF (URF\R\180019). T.R. is an Investigador Auxiliar supported by FCT Portugal (CEECIND/00887/2017). T.R. acknowledges the H2020 (TWINN-2017 ACORN, grant no. 807281), FCT/FEDER (02/SAICT/2017, grant no. 28333). D.R. acknowledges the MIT-IBM Watson AI Lab and the MIT SenseTime coalition for funding. The authors are extremely grateful to several colleagues for suggesting Ugi reaction conditions, and to Prof. R. Langer and Prof. G. Traverso, who provided invaluable comments on the research and manuscript. The authors are indebted to Prof. R. Moreira for access to the CEM microwave reactor; Dr. F. Corzana for technical assistance with HRMS; and the 13 graduate students, 17 postdoctoral researchers, and eight principal investigators across Austria, Denmark, Portugal, Spain, the United Kingdom, and the United States who took part in the survey. We thank R. Rodrigues for help in producing Figure 1. The survey was approved by the iMM and MIT (COUHES protocol 1809514426). The authors also thank the four anonymous reviewers for their most insightful comments.info:eu-repo/semantics/publishedVersio

VIP enhances TRH-stimulated prolactin secretion of pituitary tumours Studies with 31P NMR

AbstractIntravenous thyrotrophin releasing hormone (TRH) caused a 6.5-fold increase in plasma prolactin (PRL) in rats carrying implanted pituitary tumours. Vasoactive intestinal polypeptide (VIP) had no effect, but TRH given after VIP raised TRH stimulated secretion 13-fold above basal. 31P NMR spectroscopy showed that VIP caused a decrease in high energy metabolites (depleted phosphocreatine, elevated inorganic phosphate and lowered intracellular pH). TRH alone caused a similar but smaller effect; given after VIP, it caused no detectable depletion. We suggest that the changes in high energy metabolite cencentrations reflect increased cellular energy consumption consistent with a priming process (stage 1) in PRL secretion, followed by hormone release (stage 2). VIP induces stage 1 whereas RTH induced both stages

Levantamento das patologias e monitorização do Arco-Cruzeiro da Igreja da Misericórdia de Aveiro

O estado de conservação das construções tradicionais motiva para um crescente interesse na recuperação e manutenção do património construído. Antes de mais, é importante obter uma visão geral da evolução temporal das construções permitindo assim a caracterização dos diversos aspectos estruturais e construtivos. Este trabalho foi desenvolvido com o objectivo de estudar as patologias associadas à nave principal da Igreja da Misericórdia de Aveiro e em particular as patologias associadas ao Arco-Cruzeiro que se encontra no interior desta, com o intuito de se estabelecer a melhor estratégia de monitorização dos danos estruturais a aplicar. Como resultado desta análise foi proposto e implementado um plano de monitorização, com o desenvolvimento de meios de instrumentação, que permitem monitorizar o comportamento estrutural do arco, de forma não intrusiva, garantindo a reversibilidade e a eventual futura extensão da instrumentação. Foi ainda desenvolvido um modelo numérico em elementos finitos que serviu de apoio à interpretação das causas dos danos estruturais encontrados

The last bastion? X-chromosome genotyping of Anopheles gambiae species-pair males from a hybrid zone reveals complex recombination within the major candidate ‘genomic island of speciation’

Speciation with gene flow may be aided by reduced recombination helping to build linkage between genes involved in the early stages of reproductive isolation. Reduced recombination on chromosome-X has been implicated in speciation within the Anopheles gambiae complex, species of which represent the major Afrotropical malaria vectors. The most recently diverged, morphologically-indistinguishable, species-pair, An. gambiae and An. coluzzii, ubiquitously display a ‘genomic island of divergence’ spanning over 4Mb from chromosome-X centromere, which represents a particularly promising candidate region for reproductive isolation genes, in addition to containing the diagnostic markers used to distinguish the species. Very low recombination makes the island intractable for experimental recombination studies, but an extreme hybrid zone in Guinea Bissau offers the opportunity for natural investigation of X-island recombination. SNP-analysis of chromosome-X hemizygous males revealed: (i) strong divergence in the X-island despite a lack of autosomal divergence; (ii) individuals with multiple-recombinant genotypes, including likely double crossovers and localized gene conversion; (iii) recombination-driven discontinuity both within and between the molecular species markers, suggesting that the utility of the diagnostics is undermined under high hybridization. The largely-, but incompletely-protected nature of the X-centromeric genomic island is consistent with a primary candidate area for accumulation of adaptive variants driving speciation with gene flow, whilst permitting some selective shuffling and removal of genetic variation

Fast building – increasing the geometrical freedom of textile reinforced concrete systems

Apresentação efetuada na 9th International Conference Mechanics and Materials in Design - Theory, Experiments and Applications in Engineering (M2D2021), no Funchal, Portugal, 2022[Excerpt] Introduction Textile technology is highly innovative, and several techniques are already being used to act as building parts for fast building, interior design, architectural details and offshore structures. However, such potential still fails when complex geometrical structures or multifunctionality are required.Fundação para a Ciência e a Tecnologia - grant SFRH/BD/144201/2019European Regional Development Fund (FEDER), Operational Program for Competitiveness Factors (COMPETE) POCI-01-0247-312 FEDER-03973

Two-dimensional superstrings and the supersymmetric matrix model

We present evidence that the supersymmetric matrix model of Marinari and Parisi represents the world-line theory of N unstable D-particles in type II superstring theory in two dimensions. This identification suggests that the matrix model gives a holographic description of superstrings in a two-dimensional black hole geometry.Comment: 22 pages, 2 figures; v2: corrected eqn 4.6; v3: corrected appendices and discussion of vacua, added ref

Primakoff effect in eta-photoproduction off protons

We analyse data on forward eta-meson photoproduction off a proton target and extract the eta to gamma gamma decay width utilizing the Primakoff effect. The hadronic amplitude that enters into our analysis is strongly constrained because it is fixed from a global fit to available gamma p to p eta data for differential cross sections and polarizations. We compare our results with present information on the two-photon eta-decay from the literature. We provide predictions for future PrimEx experiments at Jefferson Laboratory in order to motivate further studies.Comment: 5 pages, 6 figures, gamma-gamma*-eta form factor included, version to appear in Eur. Phys. J. A