Search for Large Rapidity Gap Events in e^+ e^- Annihilation

We investigate the cross-section for the production of a low-mass colour-singlet cluster in $e^+e^-$ annihilation with a large rapidity gap between the colour-singlet cluster and the other jets. It is argued that such events are the cross-channel analogue of large-rapidity-gap events in deep-inelastic scattering, and therefore could in principle be used to investigate the analytic continuation of the BFKL pomeron to the positive-$t$ kinematic regime, where one would expect the trajectory to pass through glueball states. The cross section can be calculated in perturbative QCD, so that the infrared scale arising from non-perturbative effects, which prevents an exponential fall-off with rapidity gap in the case of deep-inelastic scattering, is absent in $e^+ e^-$ annihilation. Correspondingly, the cross section for such events decreases rapidly with increasing rapidity gap.Comment: LATEX file - 21 pages + 15 figure

Is it possible to recover information from the black-hole radiation?

In the framework of communication theory, we analyse the gedanken experiment in which beams of quanta bearing information are flashed towards a black hole. We show that stimulated emission at the horizon provides a correlation between incoming and outgoing radiations consisting of bosons. For fermions, the mechanism responsible for the correlation is the Fermi exclusion principle. Each one of these mechanisms is responsible for the a partial transfer of the information originally coded in the incoming beam to the black--hole radiation. We show that this process is very efficient whenever stimulated emission overpowers spontaneous emission (bosons). Thus, black holes are not `ultimate waste baskets of information'.Comment: 9 pages (2 figures available upon request), CERN-TH 6811/93, (LateX file

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function

Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A. By contrast, constitutive expression of the human cannabinoid CB1 receptor resulted in a predominantly punctate, intracellular distribution pattern consistent with spontaneous, agonistindependent internalization. Expression of the orexin-1 receptor in the presence of the CB1 receptor resulted in both receptors displaying the spontaneous internalization phenotype. Single cell fluorescence resonance energy transfer imaging indicated the two receptors were present as heterodimers/oligomers in intracellular vesicles. Addition of the CB1 receptor antagonist SR-141716A to cells expressing only the CB1 receptor resulted in re-localization of the receptor to the cell surface. Although SR-141716A has no significant affinity for the orexin-1 receptor, in cells co-expressing the CB1 receptor, the orexin-1 receptor was also re-localized to the cell surface by treatment with SR-141716A. Treatment of cells co-expressing the orexin-1 and CB1 receptors with the orexin-1 receptor antagonist SB-674042 also resulted in re-localization of both receptors to the cell surface. Treatment with SR-141716A resulted in decreased potency of orexin A to activate the mitogen-activated protein kinases ERK1/2 only in cells co-expressing the two receptors. Treatment with SB-674042 also reduced the potency of a CB1 receptor agonist to phosphorylate ERK1/2 only when the two receptors were co-expressed. These studies introduce an entirely novel pharmacological paradigm, whereby ligands modulate the function of receptors for which they have no significant inherent affinity by acting as regulators of receptor heterodimers

Note on Varying Speed of Light Cosmologies

The various requirements on a consistent varying speed of light (`VSL') theory are surveyed, giving a short check-list of issues that should be satisfactorily handled by such theories.Comment: 6 pages; to appear in the GRG Journa

Use of apomorphine in Parkinsonian patients with neuropsychiatric complications to oral treatment

Neuropsychiatric side effects often complicate anti-Parkinsonian therapy and pose a significant problem in the optimal management of idiopathic Parkinson's disease. Several publications report a relative lack of neuropsychiatric side effects in Parkinsonian patients treated with subcutaneous apomorphine. To investigate this further, we have used subcutaneous apomorphine to treat 12 non-demented IPD patients with previous oral drug-related neuropsychiatric problems. Treatment with apomorphine allowed alteration of anti-Parkinsonian medication and led to the abolition or reduction of neuropsychiatric complications in all patients. The mechanism remains unclear but may be due, in part, to a reduction in oral medication or a psychotropic action of apomorphine, possibly due to the piperidine moiety in its structure, or both

Cold Dark Matter detection in SUSY models at large tan(beta)

We study the direct detection rate for SUSY cold dark matter (CDM) predicted by the minimal supersymmetric standard model with universal boundary conditions and large values for tan(beta). The relic abundance of the lightest supersymmetric particle (LSP), assumed to be approximately a bino, is obtained by including its coannihilations with the next-to-lightest supersymmetric particle (NLSP), which is the lightest s-tau. The cosmological constraint on this quantity severely limits the allowed SUSY parameter space, especially in the case the CP-even Higgs has mass of around 114 GeV. We find that for large tan(beta) it is possible to find a subsection of the allowed parameter space, which yields detectable rates in the currently planned experiments.Comment: Changes in text and figure

On the Meaning of the Principle of General Covariance

We present a definite formulation of the Principle of General Covariance (GCP) as a Principle of General Relativity with physical content and thus susceptible of verification or contradiction. To that end it is useful to introduce a kind of coordinates, that we call quasi-Minkowskian coordinates (QMC), as an empirical extension of the Minkowskian coordinates employed by the inertial observers in flat space-time to general observers in the curved situations in presence of gravitation. The QMC are operationally defined by some of the operational protocols through which the inertial observers determine their Minkowskian coordinates and may be mathematically characterized in a neighbourhood of the world-line of the corresponding observer. It is taken care of the fact that the set of all the operational protocols which are equivalent to measure a quantity in flat space-time split into inequivalent subsets of operational prescriptions under the presence of a gravitational field or when the observer is not inertial. We deal with the Hole Argument by resorting to de idea of the QMC and show how it is the metric field that supplies the physical meaning of coordinates and individuates point-events in regions of space-time where no other fields exist. Because of that the GCP has also value as a guiding principle supporting Einstein's appreciation of its heuristic worth in his reply to Kretschmann in 1918

Higher Dimensional Cosmology with Some Dark Energy Models in Emergent, Logamediate and Intermediate Scenarios of the Universe

We have considered N-dimensional Einstein field equations in which four-dimensional space-time is described by a FRW metric and that of extra dimensions by an Euclidean metric. We have chosen the exponential forms of scale factors a and d numbers of b in such a way that there is no singularity for evolution of the higher dimensional Universe. We have supposed that the Universe is filled with K-essence, Tachyonic, Normal Scalar Field and DBI-essence. Here we have found the nature of potential of different scalar field and graphically analyzed the potentials and the fields for three scenario namely Emergent Scenario, Logamediate Scenario and Intermediate Scenario. Also graphically we have depicted the geometrical parameters named statefinder parameters and slow-roll parameters in the higher dimensional cosmology with the above mentioned scenarios.Comment: 21 pages, 36 figure

Scaling Solutions and reconstruction of Scalar Field Potentials

Starting from the hypothesis of scaling solutions, the general exact form of the scalar field potential is found. In the case of two fluids, it turns out to be a negative power of hyperbolic sine. In the case of three fluids the analytic form is not found, but is obtained by quadratures.Comment: 5 pages, 2 figures, some changes in references and figures caption