Dwarf novae in the Hamburg quasar survey : rarer than expected

Aims. We report the discovery of five new dwarf novae that were spectroscopically identified in the Hamburg Quasar Survey (HQS),and discuss the properties of the sample of new dwarf novae from the HQS. Methods. Follow-up time-resolved spectroscopy and photometry have been obtained to characterise the new systems. Results. The orbital periods determined from analyses of the radial velocity variations and/or orbital photometric variability are Porb 105.1min or Porb 109.9min for HS 0417+7445, Porb = 114.3 ± 2.7min for HS 1016+3412, Porb = 92.66 ± 0.17 min for HS 1340+1524, Porb = 272.317 ± 0.001 min for HS 1857+7127, and Porb = 258.02 ± 0.56 min for HS 2214+2845. HS 1857+7127 is found to be partially eclipsing. In HS 2214+2845 the secondary star of spectral type M3 ± 1 is clearly detected, and we estimate the distance to the system to be d = 390 ± 40 pc. We recorded one superoutburst of HS 0417+7445, identifying the system as a SUUMatype dwarf nova. HS 1016+3412 and HS 1340+1524 have rare outbursts, and their subtype is yet undetermined. HS 1857+7127 frequently varies in brightness and may be a ZCam-type dwarf nova. HS 2214+2845 is a UGem-type dwarf nova with a most likely cycle length of 71 d. Conclusions. To date, 14 new dwarf novae have been identified in the HQS. The ratio of short-period (3 h)systems of this sample is 1.3, much smaller compared to the ratio of 2.7 found for all known dwarf novae. The HQS dwarf novae display typically infrequent or low-amplitude outburst activity, underlining the strength of spectroscopic selection in identifying new CVs independently of their variability. The spectroscopic properties of short-period CVs in the HQS, newly identified and previously known, suggest that most, or possibly all of them are still evolving towards the minimum period. Their total number agrees with the predictions of population models within an order of magnitude. However, the bulk of all CVs is predicted to have evolved past the minimum period, and those systems remain unidentified. This suggests that those post-bounce systems have markedly weaker Hβ emission lines compared to the average known short-period CVs, and undergo no or extremely rare outbursts

Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis

International audienceCaspases are aspartate-specific cysteine proteases that play a pivotal role in drug-induced cell death. We designed RT-PCR assays to analyse the expression of CASP-3, CASP-4, CASP-6 and the long and short isoforms of CASP-2 genes in human cells. These genes heterogeneously coexpress in leukemic cell lines and bone marrow samples from patients with de novo acute myelogenous leukemia at diagnosis. Treatment of U937 and HL60 leukemic cells and HT29 colon carcinoma cells with the topoisomerase II inhibitor etoposide upregulates CASP-2 and CASP-3 genes in these cells before inducing their apoptosis. This effect of etoposide is not observed in K562 cells and bcl-2-transfected U937 cells which are less sensitive to drug-induced apoptosis. Nuclear run-on experiments demonstrate that etoposide increases CASP gene transcription in U937 cells, an effect that is prevented by Bcl-2 overexpression. Upregulation of CASP genes is associated with an enhanced synthesis of related procaspases that precedes the appearance of apoptosis markers including caspase-3 activation, poly(ADP-ribose) polymerase cleavage and internucleosomal DNA fragmentation. These results suggest that the ability of tumor cells to upregulate CASP-2 and CASP-3 genes in response to cytotoxic drugs could be predictive of their sensitivity to drug-induced apoptosis

SDSS unveils a population of intrinsically faint cataclysmic variables at the minimum orbital period

We discuss the properties of 137 cataclysmic variables (CVs) which are included in the Sloan Digital Sky Survey (SDSS) spectroscopic data base, and for which accurate orbital periods have been measured. 92 of these systems are new discoveries from SDSS and were followed-up in more detail over the past few years. 45 systems were previously identified as CVs because of the detection of optical outbursts and/or X-ray emission, and subsequently re-identified from the SDSS spectroscopy. The period distribution of the SDSS CVs differs dramatically from that of all the previously known CVs, in particular it contains a significant accumulation of systems in the orbital period range 80-86 min. We identify this feature as the elusive 'period minimum spike' predicted by CV population models, which resolves a long-standing discrepancy between compact binary evolution theory and observations. We show that this spike is almost entirely due to the large number of CVs with very low accretion activity identified by SDSS. The optical spectra of these systems are dominated by emission from the white dwarf photosphere, and display little or no spectroscopic signature from the donor stars, suggesting very low mass companion stars. We determine the average absolute magnitude of these low-luminosity CVs at the period minimum to be > = 11.6 +/- 0.7. Comparison of the SDSS CV sample to the CVs found in the Hamburg Quasar Survey and the Palomar Green Survey suggests that the depth of SDSS is the key ingredient resulting in the discovery of a large number of intrinsically faint short-period systems