Crusted (Norwegian) scabies treated with oral ivermectin : a case report and overview

Crusted (Norwegian) scabies is a severe and highly contagious form of infestation caused by the mite Sarcoptes scabiei var. hominis. It occurs in a subgroup of patients who are either immunocompromised or physically or mentally debilitated. Due to its atypical clinical presentation as well as difficulties associated with its management it presents a number of challenges both from a therapeutic aspect as well as from public health perspective. Failure to diagnose this condition may give rise to a massive epidemic when the patient is in an institutional setting. We describe a case of crusted scabies which occurred in a nursing home leading to an institutional outbreak. She received a combination of oral ivermectin and topical scabicidal with good results. This case highlights the importance of being alert to the possible diagnosis of crusted scabies and gives an overview of the condition as well as management strategies.peer-reviewe

New records of the genus Pachygrapsus (Crustacea : Decapoda) from the central Mediterranean Sea with a review of its Mediterranean zoogeography

The occurrence of Pachygrapsus maurus and Pachygrapsus transversus is reported from the Maltese Islands for the first time on the basis of one specimen of P. maurus collected in 1990 and numerous recent specimens, and the distribution of the two species is mapped. The controversial presence of P. maurus in Italy is confirmed and two new sites for this species are reported, including the first for the mainland of Italy. The examination of the historical specimen of P. maurus from the Genova area revealed a misidentification of P. transversus; this record could be a result of ship-mediated transport. First notes on the habitat of P. maurus in the central Mediterranean Sea are given. Updated maps of the distribution of P. maurus and P. transversus in the Mediterranean are provided and the zoogeography of these species is revisited.peer-reviewe

LA RED DEL VALOR, EL MODELO DELTA Y LA INDUSTRIA AERONÁUTICA

Este artigo pretende analisar as possibilidades de aplicação de estratégias baseadas na rede de valores na indústria aeronáutica. Para este fim, usamos as dimensões sugeridas no Modelo Delta, visto que este tipo de estratégia não considera apenas a companhia, os clientes e fornecedores, mas também seus complementadores. Por meio de um estudo de caso único, porém altamente representativo na indústria aeronáutica global (Embraer), verificou-se que estratégias baseadas na rede de valores sustentam fortemente o modelo de negócios da companhia pesquisada. Essas estratégias são os meios pelos quais a organização estudada obtém e sustenta vantagens competitivas. As estratégias baseadas na rede de valores parecem se adequar ao modelo de negócios de compartilhamento de riscos adotado pela Embraer. O gerenciamento efetivo da rede de valores simultaneamente permite que cada participante aproveite o sistema ao máximo e contribui incisivamente para incrementar o desempenho do sistema. Além de trazerem aos participantes retorno econômico acima da média, tais estratégias fortalecem a ligação entre eles enquanto mantém fora os competidores.DOI:10.5585/riae.v11i2.1872This article intends to analyze the possibilities of applying strategies based upon the value net to the aeronautics industry. To do so, we have employed the dimensions suggested by the Delta Model since this typology of strategy considers not only the company, its customers and suppliers, but also its complementors. By studying a single although highly representative case in the global aeronautics industry, we have found out that strategies focused on the value net strongly support the business model of the company under investigation. Moreover, these strategies are the means by which the organization studied obtains and sustains competitive advantages. Strategies focused on the value net seem to fit well into the risk-sharing business model employed by Embraer, and the effective management of the value net simultaneously allows each participant to get the most out of the system and strongly contribute to increase system performance. Besides providing all participants with above average economic returns, strategies based upon the value net strengthen the bonding among them while locking them in and competitors out.Este artículo tiene como objetivo analizar las posibilidades de implementar estrategias basadas en la red de valor en la industria aeronáutica. Para ello, utilizamos las dimensiones sugeridas en el Modelo Delta, ya que este tipo de estrategia tiene en cuenta no sólo la empresa, clientes y proveedores, sino también sus complementarias. A través de un estudio de caso único, pero muy representativa de la industria mundial de la aviación (Embraer), se encontró que las estrategias basadas en los valores de red, apoyamos firmemente el modelo de negocio de la empresa investigada. Estas estrategias son el medio por el cual la organización estudiada obtiene y mantiene una ventaja competitiva. Las estrategias basadas en los valores de la red parecen encajar en el modelo de negocio de distribución de riesgos adoptada por Embraer. La gestión eficaz de la red de valores al mismo tiempo permite que cada participante al máximo disfrutar del sistema y contribuye decisivamente a aumentar el rendimiento del sistema. Además de llevar a los participantes sobre el rendimiento económico promedio, estas estrategias fortalecer el vínculo entre ellos, manteniendo a sus competidores

A Rede de Valor, O Modelo Delta e a Indústria Aeronáutica

This article intends to analyze the possibilities of applying strategies based upon the value net to the aeronautics industry. To do so, we have employed the dimensions suggested by the Delta Model since this typology of strategy considers not only the company, its customers and suppliers, but also its complementors. By studying a single although highly representative case in the global aeronautics industry, we have found out that strategies focused on the value net strongly support the business model of the company under investigation. Moreover, these strategies are the means by which the organization studied obtains and sustains competitive advantages. Strategies focused on the value net seem to fit well into the risk-sharing business model employed by Embraer, and the effective management of the value net simultaneously allows each participant to get the most out of the system and strongly contribute to increase system performance. Besides providing all participants with above average economic returns, strategies based upon the value net strengthen the bonding among them while locking them in and competitors out.Este artículo tiene como objetivo analizar las posibilidades de implementar estrategias basadas en la red de valor en la industria aeronáutica. Para ello, utilizamos las dimensiones sugeridas en el Modelo Delta, ya que este tipo de estrategia tiene en cuenta no sólo la empresa, clientes y proveedores, sino también sus complementarias. A través de un estudio de caso único, pero muy representativa de la industria mundial de la aviación (Embraer), se encontró que las estrategias basadas en los valores de red, apoyamos firmemente el modelo de negocio de la empresa investigada. Estas estrategias son el medio por el cual la organización estudiada obtiene y mantiene una ventaja competitiva. Las estrategias basadas en los valores de la red parecen encajar en el modelo de negocio de distribución de riesgos adoptada por Embraer. La gestión eficaz de la red de valores al mismo tiempo permite que cada participante al máximo disfrutar del sistema y contribuye decisivamente a aumentar el rendimiento del sistema. Además de llevar a los participantes sobre el rendimiento económico promedio, estas estrategias fortalecer el vínculo entre ellos, manteniendo a sus competidores.Este artigo pretende analisar as possibilidades de aplicação de estratégias baseadas na rede de valores na indústria aeronáutica. Para este fim, usamos as dimensões sugeridas no Modelo Delta, visto que este tipo de estratégia não considera apenas a companhia, os clientes e fornecedores, mas também seus complementadores. Por meio de um estudo de caso único, porém altamente representativo na indústria aeronáutica global (Embraer), verificou-se que estratégias baseadas na rede de valores sustentam fortemente o modelo de negócios da companhia pesquisada. Essas estratégias são os meios pelos quais a organização estudada obtém e sustenta vantagens competitivas. As estratégias baseadas na rede de valores parecem se adequar ao modelo de negócios de compartilhamento de riscos adotado pela Embraer. O gerenciamento efetivo da rede de valores simultaneamente permite que cada participante aproveite o sistema ao máximo e contribui incisivamente para incrementar o desempenho do sistema. Além de trazerem aos participantes retorno econômico acima da média, tais estratégias fortalecem a ligação entre eles enquanto mantém fora os competidores.DOI:10.5585/riae.v11i2.187

A Robotic arm for optical and gamma radwaste inspection

We propose Radibot, a simple and cheap robotic arm for remote inspection, which interacts with the radwaste environment by means of a scintillation gamma detector and a video camera representing its light (< 1 kg) payload. It moves vertically thanks to a crane, while the other three degrees of freedom are obtained by means of revolute joints. A dedicated algorithm allows to automatically choose the best kinematics in order to reach a graphically selected position, while still allowing to fully drive the arm by means of a standard videogame joypad

Virus-Free CRISPR CAR T cells induce solid tumor regression

Chimeric antigen receptor (CAR) T cell therapy has shown promising efficacy in treating hematologic malignancies and has led to the FDA-approval of three CAR T cell products. However, there has been little success in treating solid tumors, as clinical trials to date have yielded little to no responses and no improvement in survival. Current methods of CAR T cell production typically involve the use of viral vectors which can give rise to complications such as insertional mutagenesis, leading to gene silencing or oncogene activation. In addition, GMP-grade viral vector manufacturing can be expensive with lengthy wait times for new batches. Here we have developed a virus-free strategy in primary T cells that has eliminated the use of viral vectors through the use of CRISPR-Cas9 to precisely edit the chimeric antigen receptor into the TRAC gene1. Our method of virus free production begins through the generation of a double stranded DNA (dsDNA) template produced by polymerase chain reaction (PCR). This template is then combined with a SpCas9-single guide RNA to create a ribonucleoprotein (RNP) complex. Isolated human primary T cells from adult healthy donors are then nucleofected with the RNP and dsDNA template on day 2 of ex vivo expansion. Flow cytometry is then utilized to immunophenotype the cell product and analyze the percent of efficiency of CAR gene transfer. Within the cell product, the editing efficiencies are \u3e95% TCR knockout and 35% CAR+. Transcriptional profiling indicates that the virus-free CART cells have a favorable memory-like phenotype. In addition to our in vitro work, in vivo mice studies with anti-GD2 CART products demonstrate regression of GD2+ solid tumors upon virus-free CART treatment, showing similar potency and survival to viral-produced CAR T cells. The production of virus-free CAR T cells has high potential to enable the rapid and flexible manufacturing of highly defined and highly potent CAR T cell products for the treatment of solid tumors. 1 Mueller, K. et al. CRISPR-mediated insertion of a chimeric antigen receptor produces nonviral T cell products capable of inducing solid tumor regression. bioRxiv preprint doi: https://doi.org/10.1101/2021.08.06.455489 (2021)

Updating the mediterranean diet pyramid towards sustainability: focus on environmental concerns

Background: Nowadays the food production, supply and consumption chain represent a major cause of ecological pressure on the natural environment, and diet links worldwide human health with environmental sustainability. Food policy, dietary guidelines and food security strategies need to evolve from the limited historical approach, mainly focused on nutrients and health, to a new one considering the environmental, socio-economic and cultural impact—and thus the sustainability—of diets. Objective: To present an updated version of the Mediterranean Diet Pyramid (MDP) to reflect multiple environmental concerns. Methods: We performed a revision and restructuring of the MDP to incorporate more recent findings on the sustainability and environmental impact of the Mediterranean Diet pattern, as well as its associations with nutrition and health. For each level of the MDP we provided a third dimension featuring the corresponding environmental aspects related to it. Conclusions: The new environmental dimension of the MDP enhances food intake recommendations addressing both health and environmental issues. Compared to the previous 2011 version, it emphasizes more strongly a lower consumption of red meat and bovine dairy products, and a higher consumption of legumes and locally grown eco-friendly plant foods as much as possible

Virus-Free CRISPR CAR T cells induce solid tumor regression

Chimeric antigen receptor (CAR) T cell therapy has shown promising efficacy in treating hematologic malignancies and has led to the FDA-approval of three CAR T cell products. However, there has been little success in treating solid tumors, as clinical trials to date have yielded little to no responses and no improvement in survival. Current methods of CAR T cell production typically involve the use of viral vectors which can give rise to complications such as insertional mutagenesis, leading to gene silencing or oncogene activation. In addition, GMP-grade viral vector manufacturing can be expensive with lengthy wait times for new batches. Here we have developed a virus-free strategy in primary T cells that has eliminated the use of viral vectors through the use of CRISPR-Cas9 to precisely edit the chimeric antigen receptor into the TRAC gene1. Our method of virus free production begins through the generation of a double stranded DNA (dsDNA) template produced by polymerase chain reaction (PCR). This template is then combined with a SpCas9-single guide RNA to create a ribonucleoprotein (RNP) complex. Isolated human primary T cells from adult healthy donors are then nucleofected with the RNP and dsDNA template on day 2 of ex vivo expansion. Flow cytometry is then utilized to immunophenotype the cell product and analyze the percent of efficiency of CAR gene transfer. Within the cell product, the editing efficiencies are \u3e95% TCR knockout and 35% CAR+. Transcriptional profiling indicates that the virus-free CART cells have a favorable memory-like phenotype. In addition to our in vitro work, in vivo mice studies with anti-GD2 CART products demonstrate regression of GD2+ solid tumors upon virus-free CART treatment, showing similar potency and survival to viral-produced CAR T cells. The production of virus-free CAR T cells has high potential to enable the rapid and flexible manufacturing of highly defined and highly potent CAR T cell products for the treatment of solid tumors. 1 Mueller, K. et al. CRISPR-mediated insertion of a chimeric antigen receptor produces nonviral T cell products capable of inducing solid tumor regression. bioRxiv preprint doi: https://doi.org/10.1101/2021.08.06.455489 (2021)

Virgin almond oil: Extraction methods and composition

In this paper the extraction methods of virgin almond oil and its chemical composition are reviewed. The most common methods for obtaining oil are solvent extraction, extraction with supercritical fluids (CO₂) and pressure systems (hydraulic and screw presses). The best industrial performance, but also the worst oil quality is achieved by using solvents. Oils obtained by this method cannot be considered virgin oils as they are obtained by chemical treatments. Supercritical fluid extraction results in higher quality oils but at a very high price. Extraction by pressing becomes the best option to achieve high quality oils at an affordable price. With regards chemical composition, almond oil is characterized by its low content in saturated fatty acids and the predominance of monounsaturated, especially oleic acid. Furthermore, almond oil contains antioxidants and fat-soluble bioactive compounds that make it an oil with interesting nutritional and cosmetic properties.<br><br>En este trabajo se revisan los métodos de extracción del aceite de almendra virgen y su composición química. Los métodos más habituales para la obtención del aceite son la extracción con disolventes, la extracción con fluidos supercríticos (CO₂) y los sistemas de presión (prensas hidráulica y de tornillo). El mayor rendimiento industrial, pero también la peor calidad de los aceites, se consigue mediante el uso de disolventes. Además, los aceites obtenidos por este método no se pueden considerar vírgenes, pues se obtienen por medio de tratamientos químicos. La extracción con fluidos supercríticos da lugar a aceites de mayor calidad pero a un precio muy elevado. La extracción mediante prensado se convierte en la mejor opción de extracción, al conseguir aceites de alta calidad a un precio asequible. En cuanto a su composición química, el aceite de almendra se caracteriza por su bajo contenido en ácidos grasos saturados y el predominio de los monoinsaturados, en especial en ácido oleico. Además, el aceite de almendra contiene compuestos bioactivos liposolubles y antioxidantes que lo convierten en un aceite con interesantes propiedades nutricionales y cosméticas

The effect of seasoning with herbs on the nutritional, safety and sensory properties of reduced-sodium fermented Cobrançosa cv. table olives

This study aimed at evaluating the effectiveness of seasoning Cobrancosa table olives in a brine with aromatic ingredients, in order to mask the bitter taste given by KCl when added to reduced-sodium fermentation brines. Olives were fermented in two different salt combinations: Brine A, containing 8% NaCl and, Brine B, a reduced-sodium brine, containing 4% NaCl + 4% KCl. After the fermentation the olives were immersed in seasoning brines with NaCl (2%) and the aromatic herbs (thyme, oregano and calamintha), garlic and lemon. At the end of the fermentation and two weeks after seasoning, the physicochemical, nutritional, organoleptic, and microbiological parameters, were determined. The olives fermented in the reduced-sodium brines had half the sodium concentration, higher potassium and calcium content, a lower caloric level, but were considered, by a sensorial panel, more bitter than olives fermented in NaCl brine. Seasoned table olives, previously fermented in Brine A and Brine B, had no significant differences in the amounts of protein (1.23% or 1.11%), carbohydrates (1.0% or 0.66%), fat (20.0% or 20.5%) and dietary fiber (3.4% or 3.6%). Regarding mineral contents, the sodium-reduced fermented olives, presented one third of sodium, seven times more potassium and three times more calcium than the traditional olives fermented in 8% NaCl. Additionally, according to the panelists' evaluation, seasoning the olives fermented in 4% NaCl + 4% KCl, resulted in a decrease in bitterness and an improvement in the overall evaluation and flavor. Escherichia coli and Salmonella were not found in the olives produced.info:eu-repo/semantics/publishedVersio