A nonhomogeneous boundary value problem in mass transfer theory

We prove a uniqueness result of solutions for a system of PDEs of Monge-Kantorovich type arising in problems of mass transfer theory. The results are obtained under very mild regularity assumptions both on the reference set $\Omega\subset\mathbf{R}^n$, and on the (possibly asymmetric) norm defined in $\Omega$. In the special case when $\Omega$ is endowed with the Euclidean metric, our results provide a complete description of the stationary solutions to the tray table problem in granular matter theory.Comment: 22 pages, 2 figure

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy. Currently, there are only a limited number of targeted therapies that act by increasing senescence in cancers, but the majority of them are not selective and also target healthy cells. Here we developed a chemogenomic screening to identify compounds that enhance senescence in PTEN-deficient cells without affecting normal cells. By using this approach, we identified casein kinase 2 (CK2) as a pro-senescent target. Mechanistically, we show that Pten loss increases CK2 levels by activating STAT3. CK2 upregulation in Pten null tumours affects the stability of Pml, an essential regulator of senescence. However, CK2 inhibition stabilizes Pml levels enhancing senescence in Pten null tumours. Taken together, our screening strategy has identified a novel STAT3-CK2-PML network that can be targeted for pro-senescence therapy for cancer

Enhancing phosphorus and zinc acquisition efficiency in rice: a critical review of root traits and their potential utility in rice breeding

Background: Rice is the world's most important cereal crop and phosphorus (P) and zinc (Zn) deficiency are major constraints to its production. Where fertilizer is applied to overcome these nutritional constraints it comes at substantial cost to farmers and the efficiency of fertilizer use is low. Breeding crops that are efficient at acquiring P and Zn from native soil reserves or fertilizer sources has been advocated as a cost-effective solution, but would benefit from knowledge of genes and mechanisms that confer enhanced uptake of these nutrients by roots. Scope: This review discusses root traits that have been linked to P and Zn uptake in rice, including traits that increase mobilization of P/Zn from soils, increase the volume of soil explored by roots or root surface area to recapture solubilized nutrients, enhance the rate of P/Zn uptake across the root membrane, and whole-plant traits that affect root growth and nutrient capture. In particular, this review focuses on the potential for these traits to be exploited through breeding programmes to produce nutrient-efficient crop cultivars. Conclusions: Few root traits have so far been used successfully in plant breeding for enhanced P and Zn uptake in rice or any other crop. Insufficient genotypic variation for traits or the failure to enhance nutrient uptake under realistic field conditions are likely reasons for the limited success. More emphasis is needed on field studies in mapping populations or association panels to identify those traits and underlying genes that are able to enhance nutrient acquisition beyond the level already present in most cultivars.T. J. Rose, S. M. Impa, M. T. Rose, J. Pariasca-Tanaka, A. Mori, S. Heuer, S. E. Johnson-Beebout and M. Wissuw

Giant sandbur (Cenchrus palmeri, Poaceae) new for Arizona and the United States

Volume: 2013-91Start Page: 1End Page:

Ajo Peak to Tinajas Altas: Flora of southwestern Arizona: Part 8, Eudicots: Acanthaceae–Apocynaceae

Volume: 2014-85Start Page: 1End Page: 7

Ajo Peak to Tinajas Altas: A flora of southwestern Arizona. Part 6. Poaceae – grass family

Volume: 2014-35Start Page: 1End Page: 13

Ajo Peak to Tinajas Altas: A flora of southwestern Arizona. Part 12. Eudicots: Campanulaceae to Cucurbitaceae

Volume: 2015-21Start Page: 1End Page: 3