Limited Contribution of Health Behaviours to Expanding Income-Related Chronic Disease Disparities Based on a Nationwide Cross-Sectional Study in China

This study estimated the association of income and prevalence of cardiovascular diseases (CVD) and hypertension, and then quantified the contribution of health behaviors to the association in China. Using the 2013 survey of the China Health and Retirement Longitudinal Study (CHARLS), a logit model was applied to examine income-related health disparities in relation to CVD and hypertension. A four-step regression method was then constructed to measure the role of health behaviors in income-related health disparities. Using indirect effects, mediation by health behaviors was examined. Income-related health disparities in chronic diseases were found to exist in China. Specifically, individuals in the high-income group had a 14% (OR = 0.86; 95% CI 0.73–1.02) and 14% (OR = 0.86; 95% CI 0.76–0.97) lower odds of suffering from CVD and hypertension than those in the low-income group. However, limited evidence shows this association was mediated by health behaviors. The Heaviness of Smoking Index (HSI), heavy drinking, irregular eating, and nap time did not significantly mediate the association of income and prevalence of CVD and hypertension. To curb the rising prevalence of CVD and hypertension in China, policies should focus on the low-income subpopulation. However, healthy behaviors interventions targeting smoking, heavy drinking, unhealthy napping and irregular eating habits among low-income people may be ineffective in reduction of income-related disparities in prevalence of CVD and hypertension

A new method for registrationbased medical image interpolation

Abstract—A new technique is presented for interpolating between grey-scale images in a medical data set. Registration between neighboring slices is achieved with a modified control grid interpolation algorithm that selectively accepts displacement field updates in a manner optimized for performance. A cubic interpolator is then applied to pixel intensities correlated by the displacement fields. Special considerations are made for efficiency, interpolation quality, and compression in the implementation of the algorithm. Experimental results show that the new method achieves good quality, while offering dramatic improvement in efficiency relative to the best competing method. Index Terms—Interpolation, reconstruction, registration. I

Orbital and CO 2 forcing of late Paleozoic continental ice sheets

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94883/1/grl23653.pd

An NF-κB - EphrinA5-Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates

SummarySkeletal muscle growth immediately following birth is critical for proper body posture and locomotion. However, compared with embryogenesis and adulthood, the processes regulating the maturation of neonatal muscles is considerably less clear. Studies in the 1960s predicted that neonatal muscle growth results from nuclear accretion of myoblasts preferentially at the tips of myofibers. Remarkably, little information has been added since then to resolve how myoblasts migrate to the ends of fibers. Here, we provide insight into this process by revealing a unique NF-κB-dependent communication between NG2+ interstitial cells and myoblasts. NF-κB in NG2+ cells promotes myoblast migration to the tips of myofibers through cell-cell contact. This occurs through expression of ephrinA5 from NG2+ cells, which we further deduce is an NF-κB target gene. Together, these results suggest that NF-κB plays an important role in the development of newborn muscles to ensure proper myoblast migration for fiber growth

Oligodendrocytes contribute to motor neuron death in ALS via SOD1 dependent mechanism

Oligodendrocytes have recently been implicated in the pathophysiology of ALS. Here we show that, in vitro, mutant SOD1 mouse oligodendrocytes induce wild-type motor neuron hyperexcitability and death. Moreover, we efficiently derived human oligodendrocytes from a large number of controls, sporadic and familial ALS patients using two different reprogramming methods. All ALS oligodendrocyte lines induced motor neuron death through conditioned medium and in co-culture. Conditioned medium-mediated motor neuron death was associated with decreased lactate production and release, while toxicity in co-culture was lactate independent, demonstrating that motor neuron survival is not only mediated by soluble factors. Remarkably, human SOD1 shRNA treatment resulted in motor neuron rescue in both mouse and human cultures when knockdown was achieved in progenitor cells, while it was ineffective in differentiated oligodendrocytes. Early SOD1 knockdown, in fact, rescued lactate impairment and cell toxicity in all lines tested with exclusion of samples carrying C9orf72 repeat expansions. These did not respond to SOD1 knockdown nor showed lactate release impairment. Our data indicate that SOD1 is directly or indirectly involved in ALS oligodendrocyte pathology and suggest that in this cell type some damage might be irreversible. In addition, we demonstrate that C9ORF72 patients represent an independent patient group that might not respond to the same treatment

The Spiral Structure of the Milky Way, Cosmic Rays, and Ice Age Epochs on Earth

The short term variability of the Galactic cosmic ray flux (CRF) reaching Earth has been previously associated with variations in the global low altitude cloud cover. This CRF variability arises from changes in the solar wind strength. However, cosmic ray variability also arises intrinsically from variable activity of and motion through the Milky Way. Thus, if indeed the CRF climate connection is real, the increased CRF witnessed while crossing the spiral arms could be responsible for a larger global cloud cover and a reduced temperature, thereby facilitating the occurrences of ice ages. This picture has been recently shown to be supported by various data (Shaviv, 2001). In particular, the variable CRF recorded in Iron meteorites appears to vary synchronously with the appearance ice ages. Here we expand upon the original treatment with a more thorough analysis and more supporting evidence. In particular, we discuss the cosmic ray diffusion model which considers the motion of the Galactic spiral arms. We also elaborate on the structure and dynamics of the Milky Way's spiral arms. In particular, we bring forth new argumentation using HI observations which imply that the galactic spiral arm pattern speed appears to be that which fits the glaciation period and the cosmic-ray flux record extracted from Iron meteorites. In addition, we show that apparent peaks in the star formation rate history, as deduced by several authors, coincides with particularly icy epochs, while the long period of 1 to 2 Gyr before present, during which no glaciations are known to have occurred, coincides with a significant paucity in the past star formation rate.Comment: 33 pages, 11 figures. To Appear in New Astronom