olaparib maintenance therapy in patients pts with platinum sensitive relapsed psr ovarian cancer oc and stable disease sd following platinum based chemotherapy

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Nanostructured corrosion sensing coatings for aeronautical applications

It is critical for the aeronautical industry that the next generation of smart coatings allows the early detection and continuous monitoring of corrosion. Once corrosion is detected, preventive actions can be taken in order to mitigate its costs. Our strategy relies on functional coatings capable of detecting metallic corrosion early on. After appropriate selection of sensing compounds and subsequent loading into nanostructured materials, these are incorporated into coating formulations giving them corrosion sensing functionality. Based on this concept we focused on the compatibility between nanocontainers and coating formulations. Thus, a new sensing coating was investigated using immersion and salt-spray tests, release and leaching studies, viscoelastic properties, curing, thermal stability, hardness, mechanical properties and corrosion resistance. The results embody a new generation of coatings with sensing ability, and have implications for self-healing and anti-fouling coatings as well.publishe

Dynamic changes in genomic and social structures in third millennium BCE central Europe

Europe’s prehistory oversaw dynamic and complex interactions of diverse societies, hitherto unexplored at detailed regional scales. Studying 271 human genomes dated ~4900 to 1600 BCE from the European heartland, Bohemia, we reveal unprecedented genetic changes and social processes. Major migrations preceded the arrival of “steppe” ancestry, and at ~2800 BCE, three genetically and culturally differentiated groups coexisted. Corded Ware appeared by 2900 BCE, were initially genetically diverse, did not derive all steppe ancestry from known Yamnaya, and assimilated females of diverse backgrounds. Both Corded Ware and Bell Beaker groups underwent dynamic changes, involving sharp reductions and complete replacements of Y-chromosomal diversity at ~2600 and ~2400 BCE, respectively, the latter accompanied by increased Neolithic-like ancestry. The Bronze Age saw new social organization emerge amid a ≥40% population turnover.Peer reviewe

Determination of fission barrier height of Fr 210 and Ra 210 via neutron measurement

Fission barrier heights of short-lived nuclei away from line of β stability are not known reliably. Low-energy fission of Fr210 and Ra210, produced by (d,p) and (d,n) transfer reaction on the re-accelerated unstable beam Fr209 was investigated at HIE-ISOLDE. Four Timepix3 pixel detectors were installed on the body of the ACTAR TPC demonstrator chamber. Polyethylene converters were used for the detection of fast neutrons. Since no significant background was observed, it was possible to measure the spatial distribution of emitted neutrons reflecting the fission excitation function. Subsequent simulations employing the results of the talys code and available data on fission fragment distributions allowed to estimate directly the value of the fission barrier height for the neutron-deficient nucleus Fr210. This first direct measurement confirmed the reduction of the fission barrier compared to available theoretical calculations by 15-30%

Measuring the gravitational free-fall of antihydrogen

Antihydrogen holds the promise to test, for the first time, the universality of free-fall with a system composed entirely of antiparticles. The AEgIS experiment at CERN's antiproton decelerator aims to measure the gravitational interaction between matter and antimatter by measuring the deflection of a beam of antihydrogen in the Earths gravitational field ( g ¯ $\overline {\textrm {g}}$ ). The principle of the experiment is as follows: cold antihydrogen atoms are synthesized in a Penning-Malberg trap and are Stark accelerated towards a moiré deflectometer, the classical counterpart of an atom interferometer, and annihilate on a position sensitive detector. Crucial to the success of the experiment is the spatial precision of the position sensitive detector. We propose a novel free-fall detector based on a hybrid of two technologies: emulsion detectors, which have an intrinsic spatial resolution of 50 nm but no temporal information, and a silicon strip / scintillating fiber tracker to provide timing and positional information. In 2012 we tested emulsion films in vacuum with antiprotons from CERN's antiproton decelerator. The annihilation vertices could be observed directly on the emulsion surface using the microscope facility available at the University of Bern. The annihilation vertices were successfully reconstructed with a resolution of 1-2 μmon the impact parameter. If such a precision can be realized in the final detector, Monte Carlo simulations suggest of order 500 antihydrogen annihilations will be sufficient to determine g ¯ $\overline {\textrm {g}}$ with a 1 % accuracy. This paper presents current research towards the development of this technology for use in the AEgIS apparatus and prospects for the realization of the final detector

Syntéza hvězdicovitých polymerů pro polyurethanové nátery pomocí iontové polymerace

Star polymers were prepared by ionic polymerization. As the star core polyols served e.g.: trimethylol propane (TMP), pentaerythrythol (PETP) and dipentaerythrythol (DPETP) and the star arms were built up from ε-caprolactame, lactide in different ratios of both components. Coatings based on TMP have often anti-slip properties high gloss but lower hardness. On the contrary, coatings based on PETP and DPETP have high hardness, but no anti-slip properties.Hviezdicovité polyméry boli pripravené ionovou polymerizáciou. Ako jadro hviezdy, bol použitý napr. trimetylol propán (TMP), pentaerytritol (PETP), dipentaerytritol (DPETP) a ramená boli syntetizivané z ε-kaprolaktámu a laktidu v roznych pomeroch. Nátery založené na TMP majú proti šmykové vlastnosti, vysoký lesk ale nižšiu tvrdosť. Pre porovnanie, nátery založene na PETP a DPETP majú vysokú tvrdosť, ale žiadne protišmykové vlastnosti