Introduction to Human-Environment Geography: A Laboratory Manual

A laboratory manual designed for use in introductory college courses as an Open Educational Resource. Each of the ten laboratory experiments are presented as stand-alone chapters within this book to increase accessibility and potential adoptability by instructors seeking only some of the provided content.https://digitalcommons.unomaha.edu/geoggeolfacbooks/1004/thumbnail.jp

Feshbach blockade: single-photon nonlinear optics using resonantly enhanced cavity-polariton scattering from biexciton states

We theoretically demonstrate how the resonant coupling between a pair of cavity-polaritons and a biexciton state can lead to a large single-photon Kerr nonlinearity in a semiconductor solid-state system. A fully analytical model of the scattering process between a pair of cavity-polaritons is developed, which explicitly includes the biexcitonic intermediate state. A dramatic enhancement of the polariton-polariton interactions is predicted in the vicinity of the biexciton Feshbach resonance. Application to the generation of non-classical light from polariton dots is discussed

Dr. J. Robert Suriano interview (2) conducted on December 5, 1984 about the Boonshoft School of Medicine at Wright State University

This is the second in a series with Dr. J. Robert Suriano, Associate Dean for Admissions and Student Affairs of the Wright State University School of Medicine. In the first part of the interview Dr. Suriano examines the functions of the Office of Admissions and Student Affairs and how these functions affect the medical student. In the second part of the interview Dr. Suriano discusses the admissions philosophy of the School of Medicine and reflects on the extent of the integration of the School of Medicine into the university community

Discharge responses associated with rapid snow cover ablation events in the Susquehanna and Wabash River basins

In the mid-latitudes, snow plays a critical role in regional hydroclimate, with snow ablation variability in ephemeral regions representing an area of essential research. Due to a lack of historical snow-water-equivalent data in the eastern United States, recent research has substituted daily snow depth changes for ablation. These studies, however, do not explicitly examine if such a substitution yields a snowmelt hydrological signal, an important component of water resource management. As such, this study evaluates if ablation events, as defined as a daily snow depth decrease, subsequently result in increased river discharge within two similarly sized watersheds in the eastern United States: the Wabash and Susquehanna River basins. For both basins, \u3e75% of snow ablation events resulted in a positive river discharge response (increase in discharge) at a 3-day lag. Furthermore, results show a significant and positive relationship between ablation event frequency and seasonal discharge response, such that an increase (decrease) in seasonal snow ablation event frequency yields an increase (decrease) in associated seasonal river discharge at a 3-day lag. These relationships indicate that inter-diurnal decreases in snow depth do carry hydrological implications, adding confidence that such a definition of ablation is appropriate for climatological applications

Changes in the architecture of fluvial deposits in the Paganzo Basin (Upper Paleozoic of San Juan province) : an example of sea level and climatic controls on the development of coastal fluvial environments

Paganzo Group exposures (Tupe Formation) in the Huaco area provide an excellent opportunity for assessing the role of sea level and climatic changes on the morphology and nature of coastal fluvial systems deposited in areas of limited tectonic activity. The paleogeographic position of Huaco, close to a coastal region within the Paganzo Basin, allows identification of the effects of sea level change on fluvial architecture. Despite the fact that the Huaco area was dominated by coastal fluvial systems, three marine incursions flooded this part of the basin during the Namurian, Early Pennsylvanian and Late Pennsylvanian respectively. During deposition of the Paganzo Group, climatic conditions evolved from glacial (Namurian) to hot and dry (Late Cisuralian). Five types of fluvial deposits were recognized on the basis of architectural element analysis, lithofacies distribution and type of fluvial bounding surfaces present. Fluvial system 1 (FS1) constitutes the lower part of the Tupe Formation and consists of stacked multi-storey channel-fill complexes formed on large braided alluvial plains dominated by channel-avulsion processes. FS2 consists of multi-storey channels alternating with floodplain deposits including coal beds and organic-rich mudstones. This fluvial system is interpreted as the deposit of an anastomosed network of sandy channels. FS3 occurs between the Early Pennsylvanian and Late Pennsylvanian marine transgressions and consists of sandstones and some conglomerates that form stacked channel complexes. Sporadically, very fine-grained sandstone and mudstone floodplain deposits appear as thin intercalations. FS3 likely formed on braided alluvial plains with channels dominated by transversal bars. FS 4 corresponds to an anastomosed fluvial system that was dominated by two types of braided channel belts that were separated by narrow floodplains. Finally, FS5 is composed of fining-upward cycles ranging from gravely sandstones at the bottom of channels to muddy floodplain deposits at the top. The whole FS5 succession was deposited by high-sinuosity meandering rivers. Detailed stratigraphic analyses clearly suggest that both, sea level and climate changes were first-order controls on fluvial system configurations. In this way, braided systems belonging to FS1 correspond to a low-accommodation system tract. Whereas, coal beds of FS2, which resulted from high water-tables, correspond to a high accommodation system tract that was likely associated with advanced stages of the Late Pennsylvanian transgression. A significant change in the nature of fluvial deposits took place prior to the Late Pennsylvanian sea level rise when braided fluvial systems (FS3) with very scarce floodplain deposits prevailed. Towards the top of the Late Pennsylvanian transgressive deposits, a high relief fluvial incision surface was carved into the underlying marine deposits. This surface was later mantled by anastomosed rivers (FS4) corresponding to low-accommodation deposits formed in a lowstand or during the early stages of the ensuing sea level rise. In later phases of this transgression, high accommodation conditions prevailed and fluvial sedimentation was dominated by high-sinuosity rivers (FS5). These fluvial deposits are considered as an inland equivalent to the shallow-marine deposits exposed in the neighboring Agua Negra Formation located to the west

E-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer

E-cadherin is critical for the maintenance of tissue architecture due to its role in cell-cell adhesion. E-cadherin mutations are the genetic cause of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations represent a clinical burden, due to the uncertainty of their pathogenic role. In vitro and in vivo, most mutations lead to loss-of-function, although the causal factor is unknown for the majority. We hypothesized that destabilization could account for the pathogenicity of E-cadherin missense mutations in HDGC, and tested our hypothesis using in silico and in vitro tools. FoldX algorithm was used to calculate the impact of each mutation in E-cadherin native-state stability, and the analysis was complemented with evolutionary conservation, by SIFT. Interestingly, HDGC patients harbouring germline E-cadherin destabilizing mutants present a younger age at diagnosis or death, suggesting that the loss of native-state stability of E-cadherin accounts for the disease phenotype. To elucidate the biological relevance of E-cadherin destabilization in HDGC, we investigated a group of newly identified HDGC-associated mutations (E185V, S232C and L583R), of which L583R is predicted to be destabilizing. We show that this mutation is not functional in vitro, exhibits shorter half-life and is unable to mature, due to premature proteasome-dependent degradation, a phenotype reverted by stabilization with the artificial mutation L583I (structurally tolerated). Herein we report E-cadherin structural models suitable to predict the impact of the majority of cancer-associated missense mutations and we show that E-cadherin destabilization leads to loss-of-function in vitro and increased pathogenicity in vivo

Sedimentologic and stratigraphic evolution of the Cacheuta basin: Constraints on the development of the Miocene retroarc foreland basin, south-central Andes

Retroarc foreland basins in contractional arc settings contain evidence of temporal and spatial variations in magmatic activity, deformation, and exhumation along the continental margin and serve as excellent recorders of subduction dynamics through time. The Cacheuta basin, northwestern Mendoza Province, Argentina, is situated within the transition zone between the Pampean flat-slab subduction segment north of 33°S and the normal-dipping slab segment of the Southern Volcanic Zone to the south, and it records a detailed history of Andean orogenic exhumation at this latitude. The integration of sedimentologic, stratigraphic, geochronologic, and sediment provenance data from the Cacheuta basin constrains orogenic exhumation patterns and basin evolution during basin development. Cacheuta basin strata record at least a 12 m.y. period of basin evolution (ca. 20 Ma to younger than 7.5 Ma), based on new geochronology. The timing of initial basin subsidence is constrained by the lowermost sample in the Mariño Formation, which yielded a maximum depositional age of 19.2 ± 0.26 Ma, ∼4 m.y. earlier than previous interpretations. Conglomerate clast counts, thin section petrography, and detrital zircon analyses, coupled with distinct sedimentologic variations, record progressive orogenic exhumation of the Cordillera Principal, Cordillera Frontal, and Precordillera during early to middle Miocene time. Examination of basinal strata demonstrate that uplift of the Cordillera Principal, Cordillera Frontal, and Precordillera, and simultaneous development of the Cacheuta retroarc foreland basin, in the early to mid-Miocene was the result of contractional deformation and crustal thickening during normal subduction-related orogenic processes and did not result from the development of the flat slab in late Miocene time.Fil: Buelow, E. K.. University of Wisconsin; Estados UnidosFil: Suriano, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Mahoney, J. B.. University of Wisconsin; Estados UnidosFil: Kimbrough, D. L.. San Diego State University; Estados UnidosFil: Mescua, Jose Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Giambiagi, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Hoke, Gregory D.. Syracuse University; Estados Unido

Miocene deformation in the orogenic front of the Malargüe fold-and-thrust belt (35°30′–36° S): Controls on the migration of magmatic and hydrocarbon fluids

The integration of surface observations and sub-surface data (wellbore and seismic) from the orogenic front of the Malargüe fold-and-thrust belt allows us to study its kinematics and to interpret the local stress field and its control over fluid (magmatic and hydrocarbon) migration. Reverse faults correspond to inverted NNW-striking Mesozoic normal faults and N-S striking Cenozoic low-angle thrusts parallel to the orogen. Oblique structures with strike-slip movement are also present. The magmatic activity in the study area was strongly controlled by this structural framework and the in-situ stress field. Miocene dykes and sills were emplaced in relation to strike-slip and reverse faults, respectively. We propose an evolution of the study region from a foredeep sector, in the early-middle Miocene, to a peak in deformation in the late Miocene, and finally a waning of deformation from the Pliocene to the present. Our structural model suggests that during the evolution of the thrust front, the in-situ stress field changed from a compressional to strike-slip/compressional stress field, favouring the synchronous emplacement of sills and dykes. This alternation of stress regimes favours hydrocarbon migration through both thrusts and subvertical strike-slip faults. This exchange between both stress regimes is likely related to the similar values of the minimum (σ3) and intermediate (σ2) principal stress with an E-W oriented maximum principal stress (σ1) according to the plate convergence vector.Fil: Barrionuevo, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Giambiagi, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Mescua, Jose Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Suriano, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: de la Cal, Hernán Gabriel. Roch S.A.; ArgentinaFil: Soto, J. L.. Roch S.A.; ArgentinaFil: Lossada, Ana Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentin

Thermoresponsive polymer micropatterns fabricated by dip-pen nanolithography for a highly controllable substrate with potential cellular applications

We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). The direct writing of micron-sized thermoresponsive polymer spots was achieved with efficient control over feature size. A Jeffamine-based ink prepared through the combination of organic polymers, such as DEAAm, in an inorganic silica network was used to print thermosensitive arrays on a thiol-silanised silicon oxide substrate. The use of a Jeffamine hydrogel, acting as a carrier matrix, allowed a reduction in the evaporation of ink molecules with high volatility, such as DEAAm, and facilitated the transfer of ink from tip to substrate. The thermoresponsive behaviour of polymer arrays which swell/de-swell in aqueous solution in response to a change in temperature was successfully characterised by atomic force microscopy (AFM) and Raman spectroscopy: a thermally-induced change in height and hydration state was observed, respectively. Finally, we demonstrate that cells can adhere to and interact with these dynamic features and exhibit a change in behaviour when cultured on the substrates above and below the transition temperature of the Jeffamine/DEAAm thermoresponsive hydrogels. This demonstrates the potential of these micropatterned hydrogels to act as a controllable surface for cell growth

Atezolizumab-Induced Psoriasiform Drug Eruption Successfully Treated with Ixekizumab: A Case Report and Literature Review

Immune-related cutaneous adverse events (ircAE) are commonly seen with immune checkpoint inhibitors such as atezolizumab. Atezolizumab-induced psoriasis has been previously reported as an ircAE, especially in patients with pre-existing psoriasis. The severity of the reaction influences treatment of the cutaneous eruption. Biologics should be considered as a treatment option for severe refractory psoriasiform eruptions even in patients with complex medical conditions like chronic infections and malignancy. This is the first reported case of successful treatment of atezolizumab-induced psoriasiform eruption with ixekizumab, a neutralizing IL17A monoclonal antibody, to the best of our knowledge. Herein, we present a 63-year-old man with a history of human immunodeficiency virus and psoriasis who presented with atezolizumab-induced psoriasiform eruption while being treated for metastatic hepatocellular carcinoma. After initiating ixekizumab, atezolizumab was restarted without cutaneous eruption