The auditory perceived aperture position of the transition between rooms

Funding Information: This research was supported by the Human Optimised XR (HumOR) Project. The authors appreciate the contribution of Aleksi Öyry in the listening test design. Publisher Copyright: © 2022 Author(s).This exploratory study investigates the phenomenon of the auditory perceived aperture position (APAP): the point at which one feels they are in the boundary between two adjoined spaces, judged only using auditory senses. The APAP is likely the combined perception of multiple simultaneous auditory cue changes, such as energy, reverberation time, envelopment, decay slope shape, and the direction, amplitude, and colouration of direct and reverberant sound arrivals. A framework for a rendering-free listening test is presented and conducted in situ, avoiding possible inaccuracies from acoustic simulations, impulse response measurements, and auralisation to assess how close the APAP is to the physical aperture position under blindfold conditions, for multiple source positions and two room pairs. Results indicate that the APAP is generally within ± 1 m of the physical aperture position, though reverberation amount, listener orientation, and source position affect precision. Comparison to objective metrics suggests that the APAP generally falls within the period of greatest acoustical change. This study illustrates the non-trivial nature of acoustical room transitions and the detail required for their plausible reproduction in dynamic rendering and game audio engines.Peer reviewe

Afforesting former agricultural lands with high value hardwoods in southern Ontario

Paper presented at the 11th North American Agroforesty Conference, which was held May 31-June 3, 2009 in Columbia, Missouri.In Gold, M.A. and M.M. Hall, eds. Agroforestry Comes of Age: Putting Science into Practice. Proceedings, 11th North American Agroforestry Conference, Columbia, Mo., May 31-June 3, 2009.With the onset of another environmental revolution, interest in establishing afforested plantations on marginal farmland in southern Ontario has been renewed. To supply private landowners with the tools needed to afforest their land in a successful, cost effective manner, we must first address the technical knowledge gap that exists in a regional context. This study was a side by side comparison between traditional afforestation practices and alternative techniques that we feel may address some of the common obstacles to modern afforestation. The study investigated the influence of two planting types (planted and seeded) and three vegetation management regimes (plastic mulch, herbicide and control) on the growth and development of black cherry (Prunus serotina Ehrh.), bur oak (Quercus macrocarpa Michx.) and red oak (Quercus rubra L.) plantations in the London Ontario region. The analysis of the three year results found plastic mulch to be an effective alternative to herbicide use, without the annual application commitment. Red oak was identified as an appropriate tree species for afforestation. However, the success of bur oak was limited by site quality and hydrology. Planted black cherry was identified as an appropriate candidate for afforestation because it can quickly occupy and persist in an open field environment. Although the seeded oak species did produce a high proportion of successful germination, a clear conclusion on the success of direct seeding was unable to be formed due to the age of our plantations.Patrick J. Howe (1), Jian Wang (1) and Reino Pulkki (1) ; 1. Faculty of Forestry and the Forest Environment, Lakehead University, Thunder Bay, On, Canada, P7B 5E1.Includes bibliographical references

Resynthesis of Spatial Room Impulse Response tails With anisotropic multi-slope decays

Spatial room impulse responses (SRIRs) capture room acoustics with directional information. SRIRs measured in coupled rooms and spaces with non-uniform absorption distribution may exhibit anisotropic reverberation decays and multiple decay slopes. However, noisy measurements with low signal-to-noise ratios pose issues in analysis and reproduction in practice. This paper presents a method for resynthesis of the late decay of anisotropic SRIRs, effectively removing noise from SRIR measurements. The method accounts for both multi-slope decays and directional reverberation. A spherical filter bank extracts directionally constrained signals from Ambisonic input, which are then analyzed and parameterized in terms of multiple exponential decays and a noise floor. The noisy late reverberation is then resynthesized from the estimated parameters using modal synthesis, and the restored SRIR is reconstructed as Ambisonic signals. The method is evaluated both numerically and perceptually, which shows that SRIRs can be denoised with minimal error as long as parts of the decay slope are above the noise level, with signal-to-noise ratios as low as 40 dB in the presented experiment. The method can be used to increase the perceived spatial audio quality of noise-impaired SRIRs.Peer reviewe

Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study

BACKGROUND: Social isolation and loneliness have been associated with increased risk of dementia, but it is not known whether this risk is modified or confounded by genetic risk of dementia. METHODS: We used the prospective UK Biobank study with 155 070 participants (mean age 64.1 years), including self-reported social isolation and loneliness. Genetic risk was indicated using the polygenic risk score for Alzheimer's disease and the incident dementia ascertained using electronic health records. RESULTS: Overall, 8.6% of participants reported that they were socially isolated and 5.5% were lonely. During a mean follow-up of 8.8 years (1.36 million person years), 1444 (0.9% of the total sample) were diagnosed with dementia. Social isolation, but not loneliness, was associated with increased risk of dementia (HR 1.62, 95% CI 1.38 to 1.90). There were no interaction effects between genetic risk and social isolation or between genetic risk and loneliness predicting incident dementia. Of the participants who were socially isolated and had high genetic risk, 4.4% (95% CI 3.4% to 5.5%) were estimated to developed dementia compared with 2.9% (95% CI 2.6% to 3.2%) of those who were not socially isolated but had high genetic risk. Comparable differences were also in those with intermediate and low genetic risk levels. CONCLUSIONS: Socially isolated individuals are at increased risk of dementia at all levels of genetic risk

Structural and functional aspects of social support as predictors of mental and physical health trajectories: Whitehall II cohort study

BACKGROUND: Social support is associated with better health. However, only a limited number of studies have examined the association of social support with health from the adult life course perspective and whether this association is bidirectional. METHODS: Participants (n=6797; 30% women; age range from 40 to 77 years) who were followed from 1989 (phase 2) to 2006 (phase 8) were selected from the ongoing Whitehall II Study. Structural and functional social support was measured at follow-up phases 2, 5 and 7. Mental and physical health was measured at five consecutive follow-up phases (3–8). RESULTS: Social support predicted better mental health, and certain functional aspects of social support, such as higher practical support and higher levels of negative aspects in social relationships, predicted poorer physical health. The association between negative aspects of close relationships and physical health was found to strengthen over the adult life course. In women, the association between marital status and mental health weakened until the age of approximately 60 years. Better mental and physical health was associated with higher future social support. CONCLUSIONS: The strength of the association between social support and health may vary over the adult life course. The association with health seems to be bidirectional

Effectiveness of an Internet-Based and Telephone-Assisted Training for Parents of 4-Year-Old Children With Disruptive Behavior : Implementation Research

Background: There is a lack of effectiveness studies when digital parent training programs are implemented in real-world practice. The efficacy of the internet-based and telephone-assisted Finnish Strongest Families Smart Website (SFSW) parent training intervention on the disruptive behavior of 4-year-old children was studied in a randomized controlled trial setting in Southwest Finland between 2011 and 2013. After that, the intervention was implemented nationwide in child health clinics from 2015 onwards. Objective: The main aim of this study was to compare the treatment characteristics and effectiveness of the SFSW parent training intervention between the families who received the intervention when it was implemented as a normal practice in child health clinics and the families who received the same intervention during the randomized controlled trial. Methods: The implementation group comprised 600 families who were recruited in the SFSW intervention between January 2015 and May 2017 in real-world implementation. The RCT intervention group comprised 232 families who were recruited between October 2011 and November 2013. The same demographic and child and parent measures were collected from both study groups and were compared using linear mixed-effect models for repeated measurements. The child psychopathology and functioning level were measured using the Child Behavior Checklist (CBCL) version 1.5-5 for preschool children, the Inventory of Callous-Unemotional Traits (ICU), and a modified version of the Barkley Home Situations Questionnaire. Parenting skills were measured using the 31-item Parenting Scale and the shorter 21-item Depression, Anxiety and Stress Scale (DASS-21). The estimated child and parent outcomes were adjusted for CBCL externalizing scores at baseline, maternal education, duration of the behavior problems, and paternal age. The baseline measurements of each outcome were used as covariates. Results: The implementation group was more likely to complete the intervention than the RCT intervention group (514/600, 85.7% vs 176/232, 75.9%, respectively; P Conclusions: The internet-based and telephone-assisted SFSW parent training intervention was effectively implemented in real-world settings. These findings have implications for addressing the unmet needs of children with disruptive behavior problems. Our initiative could also provide a quick socially distanced solution for the considerable mental health impact of the COVID-19 pandemic.Peer reviewe

Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB).

Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation

Biomarkers and Long-term Labour Market Outcomes: The Case of Creatine

Using the Young Finns Study (YFS) combined with the Finnish Linked Employer-Employee Data (FLEED) we show that quantities of creatine measured in 1980 prior to labour market entry affect labour market outcomes over the period 1990–2010. Those with higher levels of creatine (proxied by urine creatinine) prior to labour market entry spend more time in the labour market in the subsequent two decades and earn more. The associations between creatine and labour market outcomes are robust to controlling for other biomarkers, educational attainment and parental background. Creatine is a naturally occurring nitrogenous organic acid which supplies energy to body cells, including muscles. Our findings are consistent with high energy levels, induced by creatine, leading to productivity-enhancing traits such as a high propensity for effort, perseverance, and high-commitment

Hypoalbuminemia is a frequent marker of increased mortality in cardiogenic shock

Altres ajuts: VPH was supported by the Aarne Koskelo Foundation (no grant number): http://www. aarnekoskelonsaatio.fi/, and the Finnish Cardiac Foundation (no grant number): https://www. fincardio.fi/. Laboratory kits were provided by Roche Diagnostics. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Introduction The prevalence of hypoalbuminemia, early changes of plasma albumin (P-Alb) levels, and their effects on mortality in cardiogenic shock are unknown. Materials and methods P-Alb was measured from serial blood samples in 178 patients from a prospective multinational study on cardiogenic shock. The association of hypoalbuminemia with clinical characteristics and course of hospital stay including treatment and procedures was assessed. Theprimary outcome was all-cause 90-day mortality. Results Hypoalbuminemia (P-Alb < 34g/L) was very frequent (75%) at baseline in patients with cardiogenic shock. Patients with hypoalbuminemia had higher mortality than patients with normal albumin levels (48% vs. 23%, p = 0.004). Odds ratio for death at 90 days was 2.4 [95% CI 1.5-4.1] per 10 g/L decrease in baseline P-Alb. The association with increased mortality remained independent in regression models adjusted for clinical risk scores developed for cardiogenic shock (CardShock score adjusted odds ratio 2.0 [95% CI 1.1-3.8], IABPSHOCK II score adjusted odds ratio 2.5 [95%CI 1.2-5.0]) and variables associated with hypoalbuminemia at baseline (adjusted odds ratio 2.9 [95%CI 1.2-7.1]). In serial measurements,albumin levels decreased at a similar rate between 0h and 72h in both survivors andnonsurvivors (ΔP-Alb -4.6 g/L vs. 5.4 g/L, p = 0.5). While the decrease was higher for patients with normal P-Alb at baseline (p 0.001 compared to patients with hypoalbuminemia at baseline), the rate of albumin decrease was not associated with outcome. Conclusions Hypoalbuminemia was a frequent finding early in cardiogenic shock, and P-Alb levels decreased during hospital stay. Low P-Alb at baseline was associated with mortality independently of other previously described risk factors. Thus, plasma albumin measurement should be part of the initial evaluation in patients with cardiogenic shock