Spin dynamics of quantum and classical Heisenberg dimers

Analytical solutions for the time-dependent autocorrelation function of the classical and quantum mechanical spin dimer with arbitrary spin are presented and compared. For large spin quantum numbers or high temperature the classical and the quantum dimer become more and more similar, yet with the major difference that the quantum autocorrelation function is periodic in time whereas the classical is not.Comment: 10 pages, 4 postscript figures, uses 'epsfig.sty'. Submitted to Physica A. More information available at http://www.physik.uni-osnabrueck.de/makrosysteme

primary prevention of cardiovascular disease and type 2 diabetes in patients at metabolic risk an endocrine society clinical practice guideline

Objective: The objective was to develop clinical practice guidelines for the primary prevention of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) in patients at metabolic risk. Conclusions: Healthcare providers should incorporate into their practice concrete measures to reduce the risk of developing CVD and T2DM. These include the regular screening and identification of patients at metabolic risk (at higher risk for both CVD and T2DM) with measurement of blood pressure, waist circumference, fasting lipid profile, and fasting glucose. All patients identified as having metabolic risk should undergo 10-yr global risk assessment for either CVD or coronary heart disease. This scoring will determine the targets of therapy for reduction of apolipoprotein B-containing lipoproteins. Careful attention should be given to the treatment of elevated blood pressure to the targets outlined in this guideline. The prothrombotic state associated with metabolic risk should be treated with lifestyle modification measures and in appropriate individuals with low-dose aspirin prophylaxis. Patients with prediabetes (impaired glucose tolerance or impaired fasting glucose) should be screened at 1- to 2-yr intervals for the development of diabetes with either measurement of fasting plasma glucose or a 2-h oral glucose tolerance test. For the prevention of CVD and T2DM, we recommend that priority be given to lifestyle management.Thisincludesantiatherogenicdietarymodification,aprogramofincreasedphysicalactivity, andweightreduction.Effortstopromotelifestylemodificationshouldbeconsideredanimportant component of the medical management of patients to reduce the risk of both CVD and T2DM. (J Clin Endocrinol Metab 93: 3671–3689, 2008

Impact of harness attachment point on kinetics and kinematics during sled towing.

Resisted sprint training is performed in a horizontal direction, and involves similar muscles, velocities and ranges of motion (ROM) to those of normal sprinting. Generally, sleds are attached to the athletes via a lead (3m) and harness; the most common attachment points are the shoulder or waist. At present, it is not known how the different harness point's impact on the kinematics and kinetics associated with sled towing (ST). The aim of the current investigation was to examine the kinetics and kinematics of shoulder and waist harness attachment points in relation to the acceleration phase of ST. Fourteen trained males completed normal and ST trials, loaded at 10% reduction of sprint velocity. Sagittal plane kinematics from the trunk, hip, knee and ankle were measured, together with stance phase kinetics (third foot-strike). Kinetic and kinematic parameters were compared between harness attachments using one-way repeated measures analysis of variance. The results indicated that various kinetic differences were present between the normal and ST conditions. Significantly greater net horizontal mean force, net horizontal impulses, propulsive mean force and propulsive impulses were measured (p>0.05). Interestingly, the waist harness also led to greater net horizontal impulse when compared to the shoulder attachment (p = 0.000). In kinematic terms, ST conditions significantly increased peak flexion in hip, knee and ankle joints compared to the normal trials (p<0.05). Results highlighted that the shoulder harness had a greater impact on trunk and knee joint kinematics when compared to the waist harness (p<0.05). In summary, waist harnesses appear to be the most suitable attachment point for the acceleration phase of sprinting. Sled towing with these attachments resulted in fewer kinematic alterations and greater net horizontal impulse when compared to the shoulder harness. Future research is necessary, in order to explore the long-term adaptations of these acute changes

Dynamics of Endoreplication during Drosophila Posterior Scutellar Macrochaete Development

Endoreplication is a variant type of DNA replication, consisting only of alternating G1 and S phases. Many types of Drosophila tissues undergo endoreplication. However, the timing and the extent to which a single endocycling macrochaete undergoes temporally programmed endoreplication during development are unclear. Here, we focused on the dynamics of endoreplication during posterior scutellar (pSC) macrochaete development. Quantitative analyses of C values in shaft cells and socket cells revealed a gradual rise from 8C and 4C at 8 hours after pupal formation (APF) to 72C and 24C at 29 hours APF, respectively. The validity of the values was further confirmed by the measurement of DNA content with a confocal laser microscope. BrdU incorporation assays demonstrated that shaft cells undergo four rounds of endoreplication from 18 to 29.5 hours APF. In contrast, socket cells undergo two rounds of endoreplication during the same period. Statistical analyses showed that the theoretical C values, based on BrdU assays, nearly coincide with the actually measured C values in socket cells, but not in shaft cells after 22 hours APF. These analyses suggest that socket cells undergo two rounds of endoreplication. However, the mechanism of endoreplication in the shaft cells may change from 22 hours APF, suggesting the possibility that shaft cells undergo two or four rounds of endoreplication during the periods. We also found that the timing of endoreplication differs, depending on the type of macrochaete. Moreover, endocycling in shaft cells of both the left and right sides of pSC bristle lineages occurs in the same pattern, indicating that the process is synchronized for specific types of macrochaete. Our findings suggest that endocycling in macrochaete cell lineages can be a model for understanding mechanisms of endoreplication at the single-cell level

Load absorption force-time characteristics following the second pull of weightlifting derivatives

The purpose of this study was to compare the load absorption force-time characteristics of weightlifting catching and pulling derivatives. Twelve resistance-trained men performed repetitions of the hang power clean (HPC), jump shrug (JS), and hang high pull (HHP) on a force platform with 30, 45, 65, and 80% of their one repetition maximum (1RM) HPC. Load absorption phase duration, mean force, and work were calculated from the force-time data. The HHP produced a significantly longer load absorption phase duration compared to the HPC (p < 0.001, d = 3.77) and JS (p < 0.001, d = 5.48), while no difference existed between the HPC and JS (p = 0.573, d = 0.51). The JS produced significantly greater load absorption mean forces compared to the HPC (p < 0.001, d = 2.85) and HHP (p < 0.001, d = 3.75), while no difference existed between the HPC and HHP (p = 0.253, d = 0.37). Significantly more load absorption work was performed during the JS compared to the HPC (p < 0.001, d = 5.03) and HHP (p < 0.001, d = 1.69), while HHP load absorption work was also significantly greater compared to the HPC (p < 0.001, d = 4.81). The weightlifting pulling derivatives examined in the current study (JS and HHP) produced greater load absorption demands following the second pull compared to the weightlifting catching derivative (HPC). The JS and HHP may be used as effective training stimuli for load absorption during impact tasks such as jumping

Comparative effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors and human glucagon-like peptide-1 (GLP-1) analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region: a systematic review

The prevalence of diabetes mellitus is rising globally, and it induces a substantial public health burden to the healthcare systems. Its optimal control is one of the most significant challenges faced by physicians and policy-makers. Whereas some of the established oral hypoglycaemic drug classes like biguanide, sulphonylureas, thiazolidinediones have been extensively used, the newer agents like dipeptidyl peptidase-4 (DPP-4) inhibitors and the human glucagon-like peptide-1 (GLP-1) analogues have recently emerged as suitable options due to their similar efficacy and favorable side effect profiles. These agents are widely recognized alternatives to the traditional oral hypoglycaemic agents or insulin, especially in conditions where they are contraindicated or unacceptable to patients. Many studies which evaluated their clinical effects, either alone or as add-on agents, were conducted in Western countries. There exist few reviews on their effectiveness in the Asia-Pacific region. The purpose of this systematic review is to address the comparative effectiveness of these new classes of medications as add-on therapies to sulphonylurea drugs among diabetic patients in the Asia-Pacific countries. We conducted a thorough literature search of the MEDLINE and EMBASE from the inception of these databases to August 2013, supplemented by an additional manual search using reference lists from research studies, meta-analyses and review articles as retrieved by the electronic databases. A total of nine randomized controlled trials were identified and described in this article. It was found that DPP-4 inhibitors and GLP-1 analogues were in general effective as add-on therapies to existing sulphonylurea therapies, achieving HbA1c reductions by a magnitude of 0.59–0.90% and 0.77–1.62%, respectively. Few adverse events including hypoglycaemic attacks were reported. Therefore, these two new drug classes represent novel therapies with great potential to be major therapeutic options. Future larger-scale research should be conducted among other Asia-Pacific region to evaluate their efficacy in other ethnic groups

A comparison of catch phase force-time characteristics during clean derivatives from the knee

The aim of this study was to compare load-absorption force-time characteristics of the clean from the knee (CK), power clean from the knee (PCK) and clean pull from the knee (CPK). Ten collegiate athletes (age 27.5 ± 4.2 years; height 180.4 ± 6.7 cm; mass 84.4 ± 7.8 kg), performed three repetitions each of the CK, PCK and CPK with 90% of their 1RM power clean on a force platform. The CK load-absorption duration (0.95 ± 0.35 s) was significantly longer compared to the CPK (0.44 ± 0.15 s; p 0.05, d = 1.08), with no differences between PCK and CPK (p > 0.05, d = 0.91). The CPK demonstrated the greatest mean force (2039 ± 394 N), which was significantly greater than the PCK (1771 ± 325 N; p = 0.012, d = 0.83), but not significantly different to the CK (1830 ± 331 N; p > 0.05, d = 0.60); CK and PCK were not different (p > 0.05, d = 0.18). Significantly more load-absorption work was performed during the CK (655 ± 276 J) compared to the PCK (288 ± 109 J; d = 1.75, p 0.05). Additionally, more load-absorption work was performed during the CPK compared to the PCK (d = 1.90, p = 0.032). Inclusion of the catch phase during the CK does not provide any additional stimulus in terms of mean force or work during the load-absorption phase compared to the CPK, while the CPK may be beneficial in training rapid force absorption due to high force and a short duration

The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice

Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target. The plant polyphenol Curcumin has been proposed for dietary prevention of cancer. We therefore examined its effects on the human breast cancer cell line MDA-MB-231 in vitro and in a mouse metastasis model. Curcumin strongly induces apoptosis in MDA- MB- 231 cells in correlation with reduced activation of the survival pathway NF kappa B, as a consequence of diminished I kappa B and p65 phosphorylation. Curcumin also reduces the expression of major matrix metalloproteinases (MMPs) due to reduced NF kappa B activity and transcriptional downregulation of AP-1. NF kappa B/p65 silencing is sufficient to downregulate c-jun and MMP expression. Reduced NF kappa B/AP-1 activity and MMP expression lead to diminished invasion through a reconstituted basement membrane and to a significantly lower number of lung metastases in immunodeficient mice after intercardiac injection of 231 cells (p=0.0035). 68% of Curcumin treated but only 17% of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NF kappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases. Dietary chemoprevention of metastases appears therefore feasible. Copyright (c) 2007 S. Karger AG, Basel