Analysis of Machine Learning Techniques for Breast Cancer Prediction

The most frequently happening cancer among Indian women is breast cancer, which is the second most exposed cancer in the world. Here is a chance of fifty percent for fatality in a case as one of two women diagnosed with breast cancer die in the cases of Indian women.  With the rapid population growth, the risk of death incurred by breast cancer is rising exponentially. [2] Breast cancer is the second most severe cancer among all of the cancers already unveiled. A machine learning technique discovers illness which helps clinical staffs in sickness analysis and offers dependable, powerful, and quick reaction just as diminishes the danger of death. In this paper, we look at five administered AI methods named Support vector machine (SVM), K-closest neighbours, irregular woodlands, fake/ Artificial neural organizations (ANNs). The performance of the study is measured with respect to accuracy, sensitivity, specificity, precision, negative predictive value. Furthermore, these strategies were evaluated on exactness review region under bend and beneficiary working trademark bend. At last in this paper we analysed some of different papers to find how they are predicted and what are all the techniques they were used and finally we study the complete research of machine learning techniques for breast cancer

Acute toxicity study of seeds of Achyranthes aspera, bark of Berberis aristata and roots of Coleus forskohlii in Wistar rats

Background: Achyranthes aspera is a species of plant in the family Amaranthaceae. Berberis aristata is a shrub belonging to the family Berberidaceae and the genus Berberis. Plectranthus barbatus is a tropical perennial plant related to the typical coleus species. It produces forskolin, an extract useful for pharmaceutical preparations and research in cell biology. It is belonging to Lamiaceae. The present study has been undertaken to study the toxic effects of hydro alcoholic extracts of A. aspera, B. aristata, C. forskohlii in albino Wistar rats and to establish the hazardous safety category of hydro alcoholic extracts of these plants as per organization for economic cooperation and development (OECD-423) guidelines and GHS classification system respectively.Methods: In acute toxicity study, the hydro-alcoholic extracts of all the above three plants were given orally at the dose of 2000 mg/kg b. w. to three rats in each group respectively in step I. Then, all the animals were observed for initial 4 hours and followed by fourteen days for their clinical signs and mortality in step II.Results: In step I, all the animals were normal and there was no mortality after 48 hours. In step II with the same dose, all the animals showed no adverse effects and no mortality when followed up to 14 days observation period.Conclusions: The result indicates that the hydro alcoholic extracts of A. aspera, B. aristata, C. forskohlii plants can be utilized safely for therapeutic use in pharmaceutical formulations and it falls under category ‘5’ or ‘unclassified’ of GHS system

Think-aloud evaluation of mobile information technology for older adults with chronic heart failure

poster abstractChronic heart failure (CHF) is a complex disease that often requires continuous medical attention.CHF is globally prevalent, especially among older adults. With more healthcare taking place in homes, controlling and managing the symptoms and progression of CHF depends critically on self-care behaviors such as medication taking and nutrition management by elderly patients. Based on Human Factors analysis of data gathered from interviews, surveys and in-home observations, our team designed Engage, a mobile, health information technology (HIT) tool customized for use by older adults with CHF. Engage is primarily envisioned to provide support for self-care and includes functionality designed and evaluated such as the: (1) logging daily values; (2) setting and monitoring daily self-management goals related to food intake and physical activities; (3) learning more information on self-care topics such as nutrition; and (4) visualizing collected information. Our team conducted an initial exploratory evaluation of Engage used think-aloud testing (in a controlled lab setting) with 5 older patients with CHF. Evaluation sessions involved patients using Engage’s functionalities based on hypothetical scenarios. Patients completed tasks guided by scripted instructions with each evaluation session being video recorded to capture user expectations and Engage’s usability. Results revealed design recommendations that will be tested in subsequent iterations of Engage. Our initial evaluation also pointed to the patients’ perceived benefits and barriers in using Engage over a 30-day period

DESIGN AND ACCOMPLISHMENT OF GLASS FIBER REINFORCED GYPSUM WALL PANELS

Glass fabric assisted mortar (GFRG) barricade bureau have got to in actuality of cement stucco assisted amidst mirror substances. The bureaus are gorge and might be nearly new as responsibility pertinence bars. The ditch cores contained in the sides may be full upon in-situ meadow or augmented dried. This card presents guidelines for the use of GFRG embankment bureau as an oblique stuff disobedient segment in huts in line with an analytical opinion scheme to reach its facility appraisal less than essential confining, confining including in jet twisting and mow. Variation of buckling lades of unfurl GFRG barricade bureaus for different widths gets out. The significant stuff carrying facility of 1.02 m away and 2.85 m strong side jury, obtained by the analytical search and the check results are akin to that responsibility fact. While fixing the significant stuff capability for device lower than confining, a margin you can foible (causing out-of jet twining) is suspect for. A metallurgy mode is planned to fix the vigor of permeated and caked full GFRG side bureaus in multi-storied house technique withstand sidelong lade comparable to the earthquake

Understanding of Samhanana based on Ayurvedic Concepts

In Ayurveda, Daśavida Parīkṣha helps in assessing the patient in all aspects. All Prakṛthyadi examination except Vikṛtaparīkṣa is to assess the Śarīra Bala of a person in a Svasta (Healthy condition). By assessing Svasta condition abnormality easily can be perceived. Saṁhanana is an examination which included Carakācārya in Daśavidaparīkṣha. Saṁhanana can relate with the different Ayurvedic concepts like Praśastha Puruṣa, Vyādhi Kṣamatva, Bala, Prakriti, Dhatu Saratha, Pramana, Guru Vyādhita and Laghu Vyādhita and it can be relate with the some of the modern concepts. This paper aims to understand the Saṁhanana in different aspects

Wound healing activity of topical application of Aloe vera gel in experimental animal models

Aloe vera gel of 50% and 96.4% were tested for its wound healing activity by topical application in experimental rats. The effect of Aloe vera gel on wound healing was evaluated by wound excision model and histopathology was used to study the effect on wound healing. The effect produced by Aloe vera gel with reference to wound contraction, wound closure, decrease in surface area of wound, tissue regeneration at the wound site and histopathological characteristics were significant in treated rats. The effect of Aloe vera gel on biochemical studies revealed significant increase in collagen and decreased hexosamine content and malondialdehyde levels when compared with control. The present study thus provided scientific rationale for the traditional use of Aloe vera gel for management of wounds

To Study of Artemisia nilagirica Leaves for their Antithyroid, Oxidative and Antihyperglycemic Properties

The tiny, fragrant shrub Artemisia nilagirica (Clarke) is a member of the Asteraceae family. This plant's leaves and flowering top have been used in traditional medicine as an antimalarial, nerve tonic, and anticancer drug, and there is evidence of anti-leishmanial efficacy. Material and Methods: The plant specimen was obtained from the Ooty district in Tamil Nadu, India, during the month of December. It was subsequently authenticated by NMKRV College for Women, Bengaluru, Karnataka, India. The plant specimens were stored in the herbarium of the NMKRV College for Women, Bengaluru, Karnataka, India. Results: The morphological, microscopic, organoleptic, and other WHO-recommended procedures for standardization were investigated in a powdered sample of Artemisia nilagirica (Clarke) leaf. Phytochemical investigation revealed the existence of numerous elements such as alkaloids, amino acids, carbohydrates, flavonoids, glycosides, terpenoids, steroids, saponins, essential oils, tannins and phenol in diverse extracts. Conclusion: Pharmacognostic and phytochemical analysis of Artemisia nilagirica (Clarke) leaves would be useful for authenticating raw material or crude medication

Preliminary assessment, restoration and aquaculture support for a small wetland

In line with the strategy of regional wetland datasets integration to a common national digital platform, map of small wetlands less than 2.2 ha in Kochi Taluk was prepared. A representative small wetland at Edakochi village of Kerala was selected through maps and field visits for preliminary assessment and restoration. Shuttle Radar Topography Mission’s Digital Elevation Model (DEM) was used to assess the general elevation, slope and flow accumulation pattern of the selected wetland along with assessment of the catchment area and drainage pattern. Restoration works of the selected wetland was carried out vis-a-vis side bund strengthening and sluice gate fortification. The comparative analysis of water quality assessment of wetland before and after restoration revealed improvement in water quality parameters as well as increase in water level. The Dissolved Oxygen level of the aquatic system was found to have increased substantially along with other several favourable changes in water parameters due to the restoration activities. The restored wetland at Edakochi was further utilised for multispecies farming of prawns, Pearl spot, Milk fish and Grey mullet and the harvest indicated sustainable yield. Aquaculture practice in wetlands with real time scientific advisories could ensure continuous data generation and village level climate resilience

What can a morphometric study of unoperated children teach us about the natural history of metopic synostosis?

Outcomes of surgical repair of trigonocephaly are well reported in the literature, but there is a paucity of information on the natural history of unoperated children. The authors evaluated a group of unoperated children with metopic synostosis to describe the natural change in head shape over time. A database was screened for scans of children with unoperated trigonocephaly (2010-2021). Multisuture cases and those with a metopic ridge were excluded. Three-dimensional surface scans (3D stereophotogrammetry/CT) were used for morphological analysis. Nine previously published parameters were used: frontal angle (FA30°), anteroposterior (AP) volume ratio (APVR), AP area ratio (APAR), AP width ratios 1 and 2 (APWR1 and APWR2), and 4 AP diagonal ratios (30° right APDR [rAPDR30], 30° left APDR [lAPDR30], 60° right APDR [rAPDR60], and 60° left APDR [lAPDR60]). Ninety-seven scans were identified from a cohort of 316 patients with a single metopic suture, in which the male-to-female ratio was 2.7:1. Ages at the time of the scan ranged from 9 days to 11 years and were stratified into 4 groups: group 1, 3 years. Significant improvements were detected in 5 parameters (APVR, APAR, APWR1, rAPDR30, and lAPDR30) over time, whereas no significant differences were found in FA30, APWR2, rAPDR60, and lAPDR60 between age groups. Forehead shape (surface area and volume), as well as narrowing and anterolateral contour at the frontal points, differed significantly over time without surgery. However, forehead angulation, narrowing, and anterolateral contour at temporal points did not show significant differences. This knowledge will aid in surgical and parental decision-making

The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer: study design

Aims Cachexia, the wasting disorder associated with a wide range of serious illnesses including cancer, is a major cause of morbidity and mortality. There is currently no widely approved therapeutic agent for treating or preventing cancer-associated cachexia. Colorectal cancer and nonsmall cell lung cancer have relatively high incidences of cachexia, approximately 28% and 34%, respectively. Neurohormonal overactivity has been implicated in the genesis and progression of cachexia and beta receptor antagonism has been proposed as a potential therapy. MT-102, a novel anabolic/catabolic transforming agent, has a multi-functional effect upon three potential pharmacological targets in cancer cachexia, namely reduced catabolism through non-selective β-blockade, reduced fatigue, and thermogenesis through central 5-HT1a antagonism and increased anabolism through partial β-2 receptor agonism. Methods At least 132 male and female patients, aged between 25 and 80 years with a confirmed diagnosis of late-stage non-small cell lung cancer or colorectal cancer, with cachexia will be randomised to either one of the two MT-102 doses or placebo in a 3:1:2 ratio (MT-102 10 mg BD−1/MT-102 2.5 mg BD/placebo). Patients will continue on study treatment for maximally 16 weeks. The primary endpoint, to be analysed by assigned treatment group, will be body weight change over 16 weeks. For this endpoint, the study has 85% power (0.05% significance level) to detect per 4-week period a mean change of −0.8 kg in the placebo group and 0 kg in the high-dose MT-102 arm. The first patient was randomised in February 2011 and patient recruitment is expected to continue until mid-2012. Perspective The ACT-ONE trial is designed to test whether the anabolic/catabolic transforming agent MT-102 will positively impact on the rate of change of body weight in cancer cachexia, thereby evaluating a novel therapeutic strategy in this hitherto poorly treatable condition. A separate ACT-TWO trial will recruit patients who complete the ACT-ONE trial and remain on randomised double-blind medication. Participants in ACT-TWO will be followed for an additional period with a separate primary endpoint