27,195 research outputs found
Nurses\u27 Alumnae Association Bulletin - Volume 3 Number 5
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Octopamine increases the excitability of neurons in the snail feeding system by modulation of inward sodium current but not outward potassium currents
Background: Although octopamine has long been known to have major roles as both transmitter and modulator in arthropods, it has only recently been shown to be functionally important in molluscs, playing a role as a neurotransmitter in the feeding network of the snail Lymnaea stagnalis. The synaptic potentials cannot explain all the effects of octopamine-containing neurons on the feeding network, and here we test the hypothesis that octopamine is also a neuromodulator. Results: The excitability of the B1 and B4 motoneurons in the buccal ganglia to depolarising current clamp pulses is significantly (P << 0.05) increased by (10 mu M) octopamine, whereas the B2 motoneuron becomes significantly less excitable. The ionic currents evoked by voltage steps were recorded using 2-electrode voltage clamp. The outward current of B1, B2 and B4 motoneurons had two components, a transient I-A current and a sustained I-K delayed-rectifier current, but neither was modulated by octopamine in any of these three buccal neurons. The fast inward current was eliminated in sodium - free saline and so is likely to be carried by sodium ions. 10 mu M octopamine enhanced this current by 33 and 45% in the B1 and B4 motoneurons respectively (P << 0.05), but a small reduction was seen in the B2 neuron. A Hodgkin-Huxley style simulation of the B1 motoneuron confirms that a 33% increase in the fast inward current by octopamine increases the excitability markedly. Conclusion: We conclude that octopamine is also a neuromodulator in snails, changing the excitability of the buccal neurons. This is supported by the close relationship from the voltage clamp data, through the quantitative simulation, to the action potential threshold, changing the properties of neurons in a rhythmic network. The increase in inward sodium current provides an explanation for the polycyclic modulation of the feeding system by the octopamine-containing interneurons, making feeding easier to initiate and making the feeding bursts more intense
Phillips CO-oxidation catalyts for long-lived CO2 lasers: Activity and initial characterization studies
Four different catalysts have been developed specifically for use in sealed carbon dioxide lasers. The catalysts have been designed to be low dusting, stable to shock and vibration, have high activity at low temperatures and have long active lifetimes. Measured global CO oxidation rates range from 1.4 to 2.2 cc CO converted per minute per gram of catalyst at ambient temperature. The catalysts also retain substantial activity at temperatures as low as -35 C. The Phillips laser catalysts are prepared in a variety of different shapes to meet the different pressure drop and gas flow profiles present in the many different styles of lasers. Each catalyst has been tested in sealed TEA lasers and has been shown to substantially increase the sealed life of the laser. Activity measurements made on the precious metal catalysts which were prepared with and without activity promoters showed that the promoter materials increase catalyst CO oxidation activity at least an order of magnitude at ambient temperature. Initial studies using H2 and CO chemisorption, X ray diffraction (XRD) and X ray photoelectron spectroscopy (XPS) have shown that the activity promoters do not significantly affect the precious metal crystallite size or the electronic structure around the precious metal. In addition, the formation or lack of formation of solid solutions between the precious metal and promoters has also been shown not to affect the activity of the promoted catalyst
Study of low gravity propellant transfer Quarterly progress report, 23 Dec. 1970 - 30 Apr. 1971
Bellows, metallic diaphragm, and paddle vortex subcritical transfer systems designs and high pressure systems analyses for orbital space station cryogen
The narrative potential of the British Birth Cohort Studies
This paper draws attention to the narrative potential of longitudinal studies such as the British Birth Cohort Studies (BBCS), and explores the possibility of creating narrative case histories and conducting narrative analysis based on information available from the studies. The BBCS have historically adopted a quantitative research design and used structured interviews and questionnaires to collect data from large samples of individuals born in specific years. However, the longitudinal nature of these studies means that they follow the same sample of individuals from birth through childhood into adult life, and this leads to the creation of data that can be understood as a quantitative auto/biography
Boundary maps for -crossed products with R with an application to the quantum Hall effect
The boundary map in K-theory arising from the Wiener-Hopf extension of a
crossed product algebra with R is the Connes-Thom isomorphism. In this article
the Wiener Hopf extension is combined with the Heisenberg group algebra to
provide an elementary construction of a corresponding map on higher traces (and
cyclic cohomology). It then follows directly from a non-commutative Stokes
theorem that this map is dual w.r.t.Connes' pairing of cyclic cohomology with
K-theory. As an application, we prove equality of quantized bulk and edge
conductivities for the integer quantum Hall effect described by continuous
magnetic Schroedinger operators.Comment: to appear in Commun. Math. Phy
Exact Solution of the Isovector Proton Neutron Pairing Hamiltonian
The complete exact solution of the T=1 neutron-proton pairing Hamiltonian is
presented in the context of the SO(5) Richardson-Gaudin model with
non-degenerate single-particle levels and including isospin-symmetry breaking
terms. The power of the method is illustrated with a numerical calculation for
Ge for a model space which is out of reach of modern
shell-model codes.Comment: To be published by Physical Review Letter
Narratives of fathering young children in Britain: linking quantitative and qualitative analyses
This is the final version of the article. Available from Taylor & Francis via the DOI in this record.The paper examines how in Britain the time fathers and couples spend in employment shifts in the first years of children’s lives, the conditions under which this happens and how fathers feel about and experience time with their families and time in paid work. In order to achieve these aims new longitudinal analysis of the UK Millennium Cohort Study (MCS) is carried out together with secondary analysis of narrative case studies drawn from a qualitative study of Fatherhood across the Generations. By linking these datasets the paper examines the potential for corroboration and complementarity between different types of data. Further, it seeks to show how qualitative cases corroborate, elaborate and expand on the main employment trajectories in the MCS population of fathers and how these extend understandings of fathers’ experience of time within families.This work was supported by the Economic and Social Research Council as a National Centre for Research Methods node, NOVELLA (Narratives of Varied Everyday Lives and Linked Approaches) [grant number ES/I025936/1]
Polarization of interacting bosons with spin
We demonstrate rigorously that in the absence of explicit spin-dependent
forces one of the ground states of interacting bosons with spin is always fully
polarized -- however complicated the many-body interaction potential might be.
Depending on the particle spin, the polarized ground state will generally be
degenerate with other states, but one can specify the exact degeneracy. For T>0
the magnetization and susceptibility necessarily exceed that of a pure
paramagnet. These results are relevant to recent experiments exploring the
relation between triplet superconductivity and ferromagnetism, and the
Bose-Einstein condensation of atoms with spin. They eliminate the possibility,
raised in some theoretical speculations, that the ground state or positive
temperature state might be antiferromagnetic.Comment: v4: as published in PR
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