Male Contraceptives: A New Frontier in Contraception Medicine

In the field of contraceptive studies, discussions primarily focus on the practice of women’s health and contraception. While it is true that unintended pregnancies and sexually transmitted diseases/infections (STI) pose major challenges in global public health, historically the burden of preventing these has largely fallen on women. Assuming that sexual intercourse requires an equal contribution between two partners, we hold that contraception and STI prevention should be a shared responsibility. Additionally, the ideal contraceptive method should prevent both unplanned pregnancies and STIs simultaneously. While abstinence remains the only 100% proven method of achieving such goals, it is not always practical or achievable in sexually active consenting or nonconsenting individuals. Because pregnancy occurs in a woman’s body, contraception has been regarded as a women’s health issue and not a general health issue. This dynamic is shifting. There is currently a paucity of male contraceptives and STI prevention methods on the market, but current trends in research and clinical practice promise to equally enable both women and men when making contraception choices. This paper aims to provide a comprehensive review of the male contraceptive methods currently available, as well as to highlight some of the most recently published work in the area of male contraceptive research

\u3cem\u3eIn Vitro\u3c/em\u3e Gas Production and Bacterial Biomass Estimation for Lucerne Silage Inoculated With One of Three Lactic Acid Bacterial Inoculants

Silages inoculated with microbial inoculants frequently have a lower pH than non-inoculated crops. Less often inoculated crops have a positive effect on milk production (Weinberg & Muck, 1996). One hypothesis is that bacterial inoculants produce a probiotic effect that could enhance animal performance (Weinberg & Muck, 1996). Our objective was to use the method of Blümmel et al. (1997) to study differences in in vitro fermentation among lucerne silages inoculated with three microbial inoculants

Interpretación constitucional: El cambio de la Doctrina Tradicional de la función jurisdiccional en el Estado Constitucional.

The paper analyses changes in constitutional interpretation since the postwar constitutional paradigm. Specifically, focuses on interpretation of human rights and changes with the traditional view of the jurisdictional function. El trabajo aborda la problemática de la interpretación constitucional desde un aspecto de neoconstitucionalismo metodológico, en el que da cuenta de un cambio en la función jurisdiccional, de manera específica, cuando realizan interpretación en materia de Derechos Humano

VOLUMEN 14, NÚMERO 28 (1980)

ACTIVIDAD SÍSMICA EN EL DEPARTAMENTO DE SANTANDER. Gómez Padilla, J. A.EVOLUCIÓN GEOLÓGICA DE LA CUENCA PACÍFICA (GEOSINCLINAL DE BOLÍVAR), SECTOR NOROCCIDENTAL DE SURAMÉRICA. Pérez Téllez, G.GEOLOGÍA DE LA CUENCA DEL PUTUMAYO. Govea, R. C., Aguilera, H

VOLUMEN 14, NÚMERO 28 (1980)

ACTIVIDAD SÍSMICA EN EL DEPARTAMENTO DE SANTANDER. Gómez Padilla, J. A.EVOLUCIÓN GEOLÓGICA DE LA CUENCA PACÍFICA (GEOSINCLINAL DE BOLÍVAR), SECTOR NOROCCIDENTAL DE SURAMÉRICA. Pérez Téllez, G.GEOLOGÍA DE LA CUENCA DEL PUTUMAYO. Govea, R. C., Aguilera, H

Production and quality of meat from hair sheep grazing on Tanzania grass and supplemented with different protein levels

Objective: To evaluate the effect of a supplementary feeding (with different crude protein (CP) levels) in the yield and growth performance and meat characteristics of hair lambs grazed on Tanzania grass. Design/Methodology/Approach: A 120-d-1 experiment was conducted; it included four treatments and seven replications in a completely randomized design. Twenty-eight hair lambs (22.6 ± 1.6 kg LW) were allowed to graze on Tanzania grass (Panicum maximum) and were provided concentrate feeds (with 10, 12, 14, and 16% crude protein). The aim was to assess the effects of the latter food on growth, carcass characteristics, and meat quality. Results: Compared with the lambs fed with 10, 12, and 14% CP, the heaviest carcasses (P<0.05) were obtained from lambs fed with 16% CP. The percentage of crude protein and fat of the biceps femoris linearly increased (P<0.05) as the CP percentage increased in the concentrate feed. Meat color, water retention capacity, and cutting force were not impacted by the CP percentage of the concentrate feeds. Compared with the lambs fed with 10, 12, and 14%, the lowest palmitic acid percentage and the highest oleic acid percentage were found in the meat of lambs fed with 16% CP. Study Limitations/Implications: A high area was selected to avoid excessive rain. Findings/Conclusions: Compared with the lambs fed with 10, 12, and 14% CP, the lambs grazed on Tanzania grass and supplemented with 16% CP grew more, recorded a higher carcass yield, and their meat had a better unsaturated fatty acids ratio

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions

Análisis de experiencia previa y propuestas de mejora en el Máster Universitario en Gestión de la Edificación

Tras los acontecimientos ocurridos en el sector edificatorio durante los últimos años, es preciso establecer ciertas mejoras en la estructura del Máster Universitario en Gestión de la Edificación, perteneciente a la Escuela Politécnica Superior de la Universidad de Alicante, tanto en relación a la organización de los estudios a nivel de programa así como a los conceptos específicos estudiados en cada materia. Por ello, el propósito del presente trabajo es reflexionar sobre la experiencia previa desarrollada en el Máster con el fin de establecer determinadas medidas que proporcionen una mayor coordinación y seguimiento entre los departamentos implicados. Así, esta situación permitirá desarrollar las acciones propuestas en el Plan de Acciones de Mejora para la Renovación de la Acreditación del citado Máster en relación a su estructura organizativa, introducción de mejoras tecnológicas, así como la propuesta de innovaciones metodológicas y de evaluación docente adaptadas a los condicionantes actuales del sector de la edificación. Se propone mantener una metodología docente basada en la Evaluación Continua, mediante un temario donde los conocimientos adquiridos por el estudiante sean graduales y de aplicación sucesiva en prácticas y temas teóricos de actualidad en el sector, apostando por la clase participativa como estrategia de aprendizaje