Internet gaming disorder clustering based on personality traits in adolescents, and its relation with comorbid psychological symptoms

Altres ajuts: This work was funded by an AIS (Atención e Investigación en Socioaddiciones) intramural research program. This research is partially supported by the Marsden grant E2987-3648 (Royal Society of New Zealand).In recent years, the evidence regarding Internet Gaming Disorder (IGD) suggests that some personality traits are important risk factors for developing this problem. The heterogeneity involved in problematic online gaming and differences found in the literature regarding the comorbid psychopathology associated with the problem could be explained through different types of gamers. Clustering analysis can allow organization of a collection of personality traits into clusters based on similarity. The objectives of this study were: (1) to obtain an empirical classification of IGD patients according to personality variables and (2) to describe the resultant groups in terms of clinical and sociodemographic variables. The sample included 66 IGD adolescent patients who were consecutive referrals at a mental health center in Barcelona, Spain. A Gaussian mixture model cluster analysis was used in order to classify the subjects based on their personality. Two clusters based on personality traits were detected: type I "higher comorbid symptoms" (n = 24), and type II "lower comorbid symptoms" (n = 42). The type I included higher scores in introversive, inhibited, doleful, unruly, forceful, oppositional, self-demeaning and borderline tendency traits, and lower scores in histrionic, egotistic and conforming traits. The type I obtained higher scores on all the Symptom Check List-90 items-Revised, all the State-Trait Anxiety Index scales, and on the DSM-5 IGD criteria. Differences in personality can be useful in determining clusters with different types of dysfunctionality

Qualidade de vida relacionada à saúde em espanholas com osteoporose

OBJECTIVE: To analyze the health-related quality of life in patients with osteoporosis and to compare it with the overall population. METHODS: A cross-sectional descriptive study was carried out with 60 female patients of the rheumatology service at a university hospital, in Spain, from April to October 2003. The Short Form-36 (SF-36) questionnaire was applied in order to obtain demographic data, clinical characteristics and data about lifestyles related to health. Patients were classified in age groups. The statistics tests performed were Chi-square, general linear model, Student's t-test. RESULTS: The interviewees' average age was 65.57 years old (SD: ±9.7 years), and average time interval for diagnosis was 3.4±2.84 years. The best scores were in social functioning (89), emotional aspects (72.2), mental health (63), and vitality (53.7). The lowest scores were in general health (45.1), physical capacity (47.7), pain (52.3) and physical aspects (59.9). The patients' average scores were lower than the general Spanish population's scores in the following dimensions: functional capacity, physical aspects, pain and overall health status. The greatest differences between the average SF-36 scores for patients and for the overall Spanish population were in the age group ranging from 55 to 64 years old. Scores were lower or similar to the general Spanish population in all other dimensions of the questionnaire. No significant associations were found between the dimensions of the SF-36 contemplated in this study and the clinical, demographic and lifestyle data. CONCLUSIONS: The patients presented bad quality of life, particularly with respect to those dimensions that are most relevant with respect to osteoporosis, when compared with the overall Spanish population. The physical dimensions were the ones most affected.OBJETIVO: Analisar a qualidade de vida relacionada à saúde de pacientes com osteoporose e compará-la com a população geral. MÉTODOS: Foi realizado um estudo descritivo transversal com 60 pacientes do sexo feminino no serviço de reumatologia de um hospital universitário na Espanha, de abril a outubro de 2003. Foi aplicado o questionário Short Form-36, abordando dados demográficos, características clínicas e dados sobre estilos de vida relacionados à saúde. As pacientes foram classificadas em grupos etários. Foram utilizados os seguintes testes estatísticos: qui-quadrado, modelo linear geral, t de Student. RESULTADOS: As entrevistadas tinham idade média de 65,57 (DP: ±9,7 anos), e tempo de diagnóstico médio de 3,4±2,84 anos. As melhores pontuações foram obtidas nas dimensões aspectos sociais (89), aspectos emocionais (72,2) e saúde mental (63). As mais baixas foram em estado geral de saúde (45,1), capacidade funcional (47,7), dor (52,3) e aspectos físicos (59,9). As pontuações médias dos pacientes resultaram inferiores às pontuações conhecidas da população geral espanhola nas dimensões capacidade funcional, aspectos físicos, dor e estado geral de saúde. As máximas diferenças entre as pontuações médias do SF-36 dos pacientes e os valores populacionais espanhóis correspondem ao grupo de idade de 55 a 64 anos. Nas demais dimensões do SF-36, as pontuações foram inferiores ou similares aos valores populacionais espanhóis. Não se encontraram associações significativas entre as dimensões do SF-36 estudadas e os dados clínicos, demográficos e de estilos de vida analisados. CONCLUSÕES: Os pacientes apresentaram baixa qualidade de vida, sobretudo nas dimensões mais relevantes da enfermidade, quando comparada com valores da população espanhola em geral. As áreas físicas foram as mais afetadas

Association of aromatase and estrogen receptor gene polymorphisms with hip fractures

Producción CientíficaSummary Two polymorphisms of the aromatase and estrogen receptor genes appeared to interact to influence the risk of hip fractures in women. Introduction Allelic variants of the aromatase gene have been associated with bone mineral density and vertebral fractures. Our objective was to analyze the relationship between two polymorphisms of the aromatase and estrogen receptor genes and hip fracture

COEDU-IN Project: an inclusive co-educational project for teaching computational thinking and digital skills at early ages

Learning to program is the new literacy of the 21st century. Computational thinking, closely related to programming, requires thinking and solving problems with different levels of abstraction and is independent of hardware devices. The early childhood education stage provides teachers with the opportunity to lay the foundations for a comprehensive quality education using innovative tools and technologies. Educational robotics in early childhood education becomes a tool that facilitates the acquisition of knowledge to children, playfully, based on the principles of interactivity, social interrelationships, collaborative work, creativity, constructivist and constructionist learning, and a student-centered didactic approach, allowing in turn that student can acquire digital competencies and develop logical and computational thinking in an underlying way. This project explores the current state of teaching and learning computational thinking and programming in early childhood education in an inclusive manner. Moreover, the lack of diversity and inequality is particularly latent in science, Technology, Engineering, and Mathematics (STEM) fields. Therefore, this work considers this problem and presents an inclusive coeducation approach to this new literacy, eliminating gender stereotypes and extending them to people with Down syndrome and hospitalized minors

GA-NIFS: co-evolution within a highly star-forming galaxy group at z=3.7 witnessed by JWST/NIRSpec IFS

We present NIRSpec IFS observations of a galaxy group around the massive GS_4891 galaxy at z=3.7 in GOODS-South that includes two other two systems, GS_4891_n to the north and GS_28356 to the east. These observations, obtained as part of the GTO GA-NIFS program, allow for the first time to study the spatially resolved properties of the interstellar medium (ISM) and ionized gas kinematics of a galaxy at this redshift. Leveraging the wide wavelength range spanned with the high-dispersion grating (with resolving power R=2700) observations, covering from [OII]$\lambda$$\lambda$3726,29 to [SII]$\lambda$$\lambda$6716,31, we explore the spatial distribution of star-formation rate, nebular attenuation and gas metallicity, together with the mechanisms responsible for the excitation of the ionized gas. GS_4891 presents a clear gradient of gas metallicity (as traced by 12 + log(O/H)) by more than 0.2dex from the south-east (where a star-forming clump is identified) to the north-west. The gas metallicity in the less-massive northern system, GS_4891_n, is also higher by 0.2 dex than at the center of GS_4891, suggesting that inflows of lower-metallicity gas might be favoured in higher-mass systems. The kinematic analysis shows that GS_4891 presents velocity gradients in the ionized gas consistent with rotation. The region between GS_4891 and GS_4891_n does not present high gas turbulence which, together with the difference in gas metallicities, suggests that these two systems might be in a pre-merger stage. Finally, GS_4891 hosts an ionized outflow that extends out to r_out=1.2 kpc from the nucleus and reaches maximum velocities v_out of approximately 400 km/s. Despite entraining an outflowing mass rate of M_out$\sim$2Msun/yr, the low associated mass-loading factor, $\eta$=0.05, implies that the outflow does not have a significant impact on the star-formation activity of the galaxy.Comment: Submitted to Astronomy & Astrophysics on September 25th, 202

Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation

Brain’s metals accumulation is associated with toxic proteins, like amyloid-proteins (Aβ), formation, accumulation, and aggregation, leading to neurodegeneration. Metals downregulate the correct folding, disaggregation, or degradation mechanisms of toxic proteins, as heat shock proteins (HSPs) and proteasome. The 7-amino-phenanthridin-6(5H)-one derivatives (APH) showed neuroprotective effects against metal-induced cell death through their antioxidant effect, independently of their chelating activity. However, additional neuroprotective mechanisms seem to be involved. We tested the most promising APH compounds (APH1-5, 10–100 μM) chemical ability to prevent metal-induced Aβ proteins aggregation; the APH1-5 effect on HSP70 and proteasome 20S (P20S) expression, the metals effect on Aβ formation and the involvement of HSP70 and P20S in the process, and the APH1-5 neuroprotective effects against Aβ proteins (1 μM) and metals in SN56 cells. Our results show that APH1-5 compounds chemically avoid metal-induced Aβ proteins aggregation and induce HSP70 and P20S expression. Additionally, iron and cadmium induced Aβ proteins formation through downregulation of HSP70 and P20S. Finally, APH1-5 compounds protected against Aβ proteins-induced neuronal cell death, reversing partially or completely this effect. These data may help to provide a new therapeutic approach against the neurotoxic effect induced by metals and other environmental pollutants, especially when mediated by toxic proteins

The ultra-dense, interacting environment of a dual AGN at z ∼\sim 3.3 revealed by JWST/NIRSpec IFS

LBQS 0302-0019 is a blue quasar (QSO) at z ~ 3.3, hosting powerful outflows, and residing in a complex environment consisting of an obscured AGN candidate, and multiple companions, all within 30 kpc in projection. We use JWST NIRSpec IFS observations to characterise the ionized gas in this complex system. We develop a procedure to correct for the spurious oscillations (or 'wiggles') in NIRSpec single-spaxel spectra, due to the spatial under-sampling of the point spread function. We perform a quasar-host decomposition with the QDeblend3D tools, and use multi-component kinematic decomposition of the optical emission line profiles to infer the physical properties of the emitting gas. The quasar-host decomposition allows us to identify i) a low-velocity component possibly tracing a warm rotating disk, with a dynamical mass Mdyn $\sim 10^{11}$ Msun and a rotation-to-random motion ratio $v_{rot}$/$\sigma_0 \sim 2$; ii) a spatially unresolved ionised outflow, with a velocity of $\sim$ 1000 km/s and an outflow mass rate of $\sim 10^4$ Msun/yr. We also detect eight interacting companion objects close to LBQS 0302-0019. Optical line ratios confirm the presence of a second, obscured AGN at $\sim 20$ kpc of the primary QSO; the dual AGN dominates the ionization state of the gas in the entire NIRSpec field-of-view. This work has unveiled with unprecedented detail the complex environment of this dual AGN, which includes nine interacting companions (five of which were previously unknown), all within 30 kpc of the QSO. Our results support a scenario where mergers can trigger dual AGN, and can be important drivers for rapid early SMBH growth.Comment: 23 pages, 23 figures; accepted for publication by A&

Evaluación de un tratamiento en base a prostaglandina para la sincronización del estro en cabras en diferentes estaciones del año

El objetivo del presente trabajo fue evaluar la respuesta de cabras expuestas a un tratamiento en base al uso de análogos sintéticos de prostaglandina para la sincronización del estro en dos estaciones contrapuestas, primavera y otoño. El ensayo se llevó a cabo en la primavera del 2008 y en otoño del año siguiente en el Campo Experimental Regional Leales del INTA (Instituto Nacional de Tecnología Agropecuaria), ubicado en la provincia de Tucumán (Argentina), con una majada experimental de la Facultad de Agronomía y Zootecnia (UNT).Instituto de Investigación Animal Chaco SemiaridoFil: Jorrat, Juan José. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: de la Vega, Adolfo Carlos. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Ghiggia, Luis Rodrigo. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Holgado, Fernando Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido; ArgentinaFil: Hernandez, María Emilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá. Agencia de Extensión Rural Trancas; ArgentinaFil: Aráoz, J. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: González del Pino, Francisco Javier. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Cruz, Maria Liliana. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentin

Identification and characterization of Cardiac Glycosides as senolytic compounds

Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and acidification. Senescent cells present a slightly depolarized plasma membrane and higher concentrations of H+, making them more susceptible to the action of CGs. These vulnerabilities can be exploited for therapeutic purposes as evidenced by the in vivo eradication of tumors xenografted in mice after treatment with the combination of a senogenic and a senolytic drug. The senolytic effect of CGs is also effective in the elimination of senescence-induced lung fibrosis. This experimental approach allows the identification of compounds with senolytic activity that could potentially be used to develop effective treatments against age-related diseases.We thank Matthias Drosten, Alejo Efeyan and Sean Morrison for plasmids. F.T-M. is a postdoctoral fellow from CONACYT (cvu 268632); P.P. is a predoctoral fellow from Xunta de Galicia; M.C. is a "Miguel Servet II" investigator (CPII16/00015). P.P.-R. receives support from a program by the Deputacion de Coruna (BINV-CS/2019). Work in the laboratory of M.C. is funded by grant RTI2018-095818-B-100 (MCIU/AEI/FEDER, UE). P.J.F.-M. is funded by the IMDEA Food Institute, the Ramon Areces Foundation, (CIVP18A3891), and a Ramon y Cajal Award (MICINN) (RYC-2017-22335). M.P.I. is funded by Talento Modalidad-1 Program Grant, Madrid Regional Government (#2018-T1/BIO-11262). F.P. was funded by a Long Term EMBO Fellowship (ALTF-358-2017) and F.H-G. was funded by the PhD4MD Programme of the IRB, Hospital Clinic and IDIBAPS. Work in the laboratory of M.S. was funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) (SAF2013-48256-R), the European Research Council (ERC-2014-AdG/669622), and "laCaixa" Foundation.S