1,428 research outputs found
Magnetothermal properties of molecule-based materials
We critically review recent results obtained by studying the low-temperature
specific heat of some of the most popular molecular magnets. Perspectives of
this field are discussed as well.Comment: 12 pages text + 14 pages figures, Submitted as "feature article" to
Journal of Materials Chemistr
Liquid Biopsy Biomarkers for Immunotherapy in Non-Small Cell Lung Carcinoma: Lessons Learned and the Road Ahead
Over the recent years, advances in the development of anti-cancer treatments, particularly the implementation of ICIs (immune checkpoint inhibitors), have resulted in increased survival rates in NSCLC (non-small cell lung cancer) patients. However, a significant proportion of patients does not seem respond to immunotherapy, and some individuals even develop secondary resistance to treatment. Therefore, it is imperative to correctly identify the patients that will benefit from ICI therapy in order to tailor therapeutic options in an individualised setting, ultimately benefitting both the patient and the health system. Many different biomarkers have been explored to correctly stratify patients and predict response to immunotherapy, but liquid biopsy approaches have recently arisen as an interesting opportunity to predict and monitor treatment response due to their logistic accessibility. This review summarises the current data and efforts in the field of ICI response biomarkers in NSCLC patients and highlights advantages and limitations as we discuss the road to clinical implementation
New hydrogen-like potentials
Using the modified factorization method introduced by Mielnik, we construct a
new class of radial potentials whose spectrum for l=0 coincides exactly with
that of the hydrogen atom. A limiting case of our family coincides with the
potentials previously derived by Abraham and MosesComment: 6 pages, latex, 2 Postscript figure
Light field geometry of a standard plenoptic camera
The Standard Plenoptic Camera (SPC) is an innovation in photography, allowing for acquiring two-dimensional images focused at different depths, from a single exposure. Contrary to conventional cameras, the SPC consists of a micro lens array and a main lens projecting virtual lenses into object space. For the first time, the present research provides an approach to estimate the distance and depth of refocused images extracted from captures obtained by an SPC. Furthermore, estimates for the position and baseline of virtual lenses which correspond to an equivalent camera array are derived. On the basis of paraxial approximation, a ray tracing model employing linear equations has been developed and implemented using Matlab. The optics simulation tool Zemax is utilized for validation purposes. By designing a realistic SPC, experiments demonstrate that a predicted image refocusing distance at 3.5 m deviates by less than 11% from the simulation in Zemax, whereas baseline estimations indicate no significant difference. Applying the proposed methodology will enable an alternative to the traditional depth map acquisition by disparity analysis.European commisio
Evaluation of Suboptimal Peak Inspiratory Flow in Patients with Stable COPD
OBJECTIVE: Although the importance of assessing inspiratory flow in the selection of treatments for chronic obstructive pulmonary disease (COPD) is understood, evaluation of this factor is not yet widespread or standardized. The objective of the present work was to evaluate the peak inspiratory flow (PIF) of patients with COPD and to explore the variables associated with a suboptimal PIF. METHODS: An observational, cross-sectional study was carried out at specialized nursing consultations over a period of 6 months. We collected clinical data as well as data on symptoms, treatment adherence, and patient satisfaction with their inhalers via questionnaires. PIF was determined using the In-Check Dial G16((R)) device (Clement Clarke International, Ltd., Harlow, UK). In each case, the PIF was considered suboptimal when it was off-target for any of the prescribed inhalers. The association with suboptimal PIF was evaluated using multivariate logistic regression and the results were expressed as the odds ratio (OR) with 95% confidence interval (CI). RESULTS: A total of 122 COPD patients were included in this study, of whom 34 (27.9%) had suboptimal PIF. A total of 229 inhalers were tested, of which 186 (81.2%) were dry powder devices. The multivariate analysis found an association between suboptimal PIF and age (OR = 1.072; 95% CI (1.019, 1.128); p = 0.007) and forced vital capacity (OR = 0.961; 95% CI (0.933, 0.989); p = 0.006). CONCLUSIONS: About a third of patients in complex specialized COPD care have suboptimal PIFs, which is related to age and forced vital capacity
Increasing Competitiveness through the Implementation of Lean Management in Healthcare
The main aim of this paper was two-fold: first, to design a participative methodology that facilitates lean management implementation in healthcare by adopting the action research approach; second, to illustrate the usefulness of this methodology by applying it to the sleep unit of a public hospital in Spain. This methodology proposes the implementation of lean management in its broadest sense: adopting both lean principles and some of its practical tools or practices in order to achieve competitive advantage. The complete service value chain was considered when introducing changes through lean management implementation. This implementation involved training and involving staff in the project (personnel pillar), detecting and analysing "waste" in value chain processes (processes pillar) and establishing control and measurement mechanisms in line with objectives (key performance indicators pillar) and putting in place improvement actions to achieve these objectives. The application of this methodology brought about an improvement in the management of patient flow in terms of effectiveness, efficiency and quality but also an internal transformation towards lean culture
Nonlinear Dynamics in Distributed Systems
We build on a previous statistical model for distributed systems and
formulate it in a way that the deterministic and stochastic processes within
the system are clearly separable. We show how internal fluctuations can be
analysed in a systematic way using Van Kanpen's expansion method for Markov
processes. We present some results for both stationary and time-dependent
states. Our approach allows the effect of fluctuations to be explored,
particularly in finite systems where such processes assume increasing
importance.Comment: Two parts: 8 pages LaTeX file and 5 (uuencoded) figures in Postscript
forma
Value of Serum NEUROG1 Methylation for the Detection of Advanced Adenomas and Colorectal Cancer
Aberrant DNA methylation detected in liquid biopsies is a promising approach for colorectal cancer (CRC) detection, including premalignant advanced adenomas (AA). We evaluated the diagnostic capability of serum NEUROG1 methylation for the detection of AA and CRC. A CpG island in NEUROG1 promoter was assessed by bisulfite pyrosequencing in a case-control cohort to select optimal CpGs. Selected sites were evaluated through a nested methylation-specific qPCR custom assay in a screening cohort of 504 asymptomatic family-risk individuals. Individuals with no colorectal findings and benign pathologies showed low serum NEUROG1 methylation, similar to non-advanced adenomas. Contrarily, individuals bearing AA or CRC (advanced neoplasia-AN), exhibited increased NEUROG1 methylation. Using >1.3518% as NEUROG1 cut-off (90.60% specificity), 33.33% of AN and 32.08% of AA were identified, detecting 50% CRC cases. Nonetheless, the combination of NEUROG1 with fecal immunochemical test (FIT), together with age and gender through a multivariate logistic regression resulted in an AUC = 0.810 for AN, and 0.796 for AA, detecting all cancer cases and 35-47% AA (specificity 98-95%). The combination of NEUROG1 methylation with FIT, age and gender demonstrated a convenient performance for the detection of CRC and AA, providing a valuable tool for CRC screening programs in asymptomatic individuals
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