459 research outputs found

    Vol. 1 Ch. 3 Between the Monuments: Landscape-Scale Geophysical Surveys at Hopewell Culture National Historical Park-Seip Earthworks

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    https://ideaexchange.uakron.edu/encountering_hopewell/1002/thumbnail.jp

    Low-Level Prenatal and Postnatal Blood Lead Exposure and Adrenocortical Responses to Acute Stress in Children

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    BACKGROUND: A few recent studies have demonstrated heightened hypothalamic–pituitary–adrenal (HPA) axis reactivity to acute stress in animals exposed to heavy metal contaminants, particularly lead. However, Pb-induced dysregulation of the HPA axis has not yet been studied in humans. OBJECTIVE: In this study, we examined children’s cortisol response to acute stress (the glucocorticoid product of HPA activation) in relation to low-level prenatal and postnatal Pb exposure. METHODS: Children’s prenatal blood Pb levels were determined from cord blood specimens, and postnatal lead levels were abstracted from pediatrician and state records. Children’s adrenocortical responses to an acute stressor were measured using assays of salivary cortisol before and after administration of a standard cold pressor task. RESULTS: Pb exposure was not associated with initial salivary cortisol levels. After an acute stressor, however, increasing prenatal and postnatal blood Pb levels were independently associated with significantly heightened salivary cortisol responses. CONCLUSIONS: Our results suggest that relatively low prenatal and postnatal blood lead levels— notably those below the 10 µg/dL blood lead level identified by the Centers for Disease Control and Prevention for public health purposes—can alter children’s adrenocortical responses to acute stress. The behavioral and health consequences of this Pb-induced HPA dysregulation in children have yet to be determined

    Using scale modelling to assess the prehistoric acoustics of stonehenge

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    With social rituals usually involving sound, an archaeological understanding of a site requires the acoustics to be assessed. This paper demonstrates how this can be done with acoustic scale models. Scale modelling is an established method in architectural acoustics, but it has not previously been applied to prehistoric monuments. The Stonehenge model described here allows the acoustics in the Late Neolithic and early Bronze Age to be quantified and the effects on musical sounds and speech to be inferred. It was found that the stone reflections create an average mid-frequency reverberation time of (0.64 ± 0.03) seconds and an amplification of (4.3 ± 0.9) dB for speech. The model has a more accurate representation of the prehistoric geometry, giving a reverberation time that is significantly greater than that measured in the current ruin and a full-size concrete replica at Maryhill, USA. The amplification could have aided speech communication and the reverberation improved musical sounds. How Stonehenge was used is much debated, but these results show that sounds were improved within the circle compared to outside. Stonehenge had different configurations, especially in terms of the positions of the bluestones. However, this made inaudible changes to the acoustics, suggesting sound is unlikely to be the underlying motivation for the various arrangements

    Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort

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    Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. We examined associations of maternal fish intake during pregnancy and maternal hair mercury at delivery with infant cognition among 135 mother–infant pairs in Project Viva, a prospective U.S. pregnancy and child cohort study. We assessed infant cognition by the percent novelty preference on visual recognition memory (VRM) testing at 6 months of age. Mothers consumed an average of 1.2 fish servings per week during the second trimester. Mean maternal hair mercury was 0.55 ppm, with 10% of samples > 1.2 ppm. Mean VRM score was 59.8 (range, 10.9–92.5). After adjusting for participant characteristics using linear regression, higher fish intake was associated with higher infant cognition. This association strengthened after adjustment for hair mercury level: For each additional weekly fish serving, offspring VRM score was 4.0 points higher [95% confidence interval (CI), 1.3 to 6.7]. However, an increase of 1 ppm in mercury was associated with a decrement in VRM score of 7.5 (95% CI, –13.7 to –1.2) points. VRM scores were highest among infants of women who consumed > 2 weekly fish servings but had mercury levels ≤1.2 ppm. Higher fish consumption in pregnancy was associated with better infant cognition, but higher mercury levels were associated with lower cognition. Women should continue to eat fish during pregnancy but choose varieties with lower mercury contamination
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