146 research outputs found
Mass Loss, Destruction and Detection of Sun-grazing and -impacting Cometary Nuclei
[Abridged] Sun-grazing comets almost never re-emerge, but their sublimative
destruction near the sun has only recently been observed directly, while
chromospheric impacts have not yet been seen, nor impact theory developed.
Employing simple analytic models to describe comet destruction near the Sun and
to enable the estimation of observable signatures, we find analytic solutions
for the mass as a function of distance from the Sun, for insolation
sublimation, impact ablation and explosion. Sun-grazers are found to fall into
three regimes based on initial mass and perihelion: sublimation-, ablation-,
and explosion-dominated. Most sun-grazers are destroyed sublimatively, and our
analytic results are similar to numerical models. Larger masses (>10^11g) with
small perihelion (q<1.01Rsun) ablation dominates but results are sensitive to
nucleus strength, Pc, and entry angle to the vertical, phi.
Nuclei with initial mass >~10^10g (Pc/10^6 (dyne/cm^2) sec (phi))^3 are fully
ablated before exploding, though the hot wake itself explodes. For most
sun-impactors sec(phi)~1. For small perihelion the ablation regime applies to
moderate masses ~10^13-16 g impactors unless Pc is very low. For higher masses,
or smaller perihelia, nuclei reach higher densities where ram pressure causes
catastrophic explosion. For perihelion 10^11 g
nuclei are destroyed by ablation or explosion (depending on phi and Pc) in the
chromosphere, producing flare-like events with cometary abundance spectra. For
all plausible masses and physical parameters, nuclei are destroyed above the
photosphere.Comment: 12 pages, 5 figures, Accepted A&
Spitzer Space Telescope Observations of the Magnetic Cataclysmic Variable AE Aqr
The magnetic cataclysmic variable AE Aquarii hosts a rapidly rotating white
dwarf which is thought to expel most of the material streaming onto it.
Observations of AE Aqr have been obtained in the wavelength range of 5 - 70
microns with the IRS, IRAC, and MIPS instruments on board the Spitzer Space
Telescope. The spectral energy distribution reveals a significant excess above
the K4V spectrum of the donor star with the flux increasing with wavelength
above 12.5 microns. Superposed on the energy distribution are several hydrogen
emission lines, identified as Pf alpha and Hu alpha, beta, gamma. The infrared
spectrum above 12.5 microns can be interpreted as synchrotron emission from
electrons accelerated to a power-law distribution dN=E^{-2.4}dE in expanding
clouds with an initial evolution timescale in seconds. However, too many
components must then be superposed to explain satisfactorily both the
mid-infrared continuum and the observed radio variability. Thermal emission
from cold circumbinary material can contribute, but it requires a disk
temperature profile intermediate between that produced by local viscous
dissipation in the disk and that characteristic of a passively irradiated disk.
Future high-time resolution observations spanning the optical to radio regime
could shed light on the acceleration process and the subsequent particle
evolution.Comment: 15 pages, 3 figures, accepted for publication in Ap
Innovating carbon-capture biotechnologies through ecosystem-inspired solutions
Rising atmospheric carbon concentrations affect global health, the economy, and overall quality of life. We are fast approaching climate tipping points that must be addressed, not only by reducing emissions but also through new innovation and action toward carbon capture for sequestration and utilization (CCSU). In this perspective, we delineate next-generation biotechnologies for CCSU supported by engineering design principles derived from ecological processes inspired by three major biomes (plant-soil, deep biosphere, and marine). These are to interface with existing industrial infrastructure and, in some cases, tap into the carbon sink potential of nature. To develop ecosystem-inspired biotechnology, it is important to identify accessible control points of CO2 and CH4 within a given system as well as value-chain opportunities that drive innovation. In essence, we must supplement natural biogeochemical carbon sinks with new bioengineering solutions
Are the health messages in schoolbooks based on scientific evidence? A descriptive study
<p>Abstract</p> <p>Background</p> <p>Most textbooks contains messages relating to health. This profuse information requires analysis with regards to the quality of such information. The objective was to identify the scientific evidence on which the health messages in textbooks are based.</p> <p>Methods</p> <p>The degree of evidence on which such messages are based was identified and the messages were subsequently classified into three categories: Messages with high, medium or low levels of evidence; Messages with an unknown level of evidence; and Messages with no known evidence.</p> <p>Results</p> <p>844 messages were studied. Of this total, 61% were classified as messages with an unknown level of evidence. Less than 15% fell into the category where the level of evidence was known and less than 6% were classified as possessing high levels of evidence. More than 70% of the messages relating to "Balanced Diets and Malnutrition", "Food Hygiene", "Tobacco", "Sexual behaviour and AIDS" and "Rest and ergonomics" are based on an unknown level of evidence. "Oral health" registered the highest percentage of messages based on a high level of evidence (37.5%), followed by "Pregnancy and newly born infants" (35%). Of the total, 24.6% are not based on any known evidence. Two of the messages appeared to contravene known evidence.</p> <p>Conclusion</p> <p>Many of the messages included in school textbooks are not based on scientific evidence. Standards must be established to facilitate the production of texts that include messages that are based on the best available evidence and which can improve children's health more effectively.</p
Cytochrome P450 induced differentially in endothelial cells cultured from different organs of Anguilla rostrata
Author Posting. © The Authors, 2004. This is the author's version of the work. It is posted here by permission of Society for In Vitro Biology for personal use, not for redistribution. The definitive version was published in In Vitro Cellular & Developmental Biology - Animal 41 (2005): 57-63, doi:10.1290/0409063.1.Endothelial cells are a structural barrier and an active regulator of many bodily
processes. CYP1A activity is induced in the endothelium of teleosts and mammals
exposed to lipophilic xenobiotics, such as polycyclic aromatic hydrocarbons, and can
have significant consequences for endothelial functions. We exposed cultures of
characterized endothelial cells from the heart, kidney and rete mirabile of the eel,
Anguilla rostrata, to AhR agonists. In heart endothelial cells the maximum response
(based on EROD activity) to TCDD, 113 pmol/mg-min, was at 1 nM TCDD and the peak
response to βNF, 135 pmol/mg-min, was at 3 μM βNF. The maximum response to
TCDD in the kidney endothelial cells is 12 pmol/mg-min at 0.3 nM TCDD. The rete
mirabile capillary endothelial cells responded minimally or not at all to exposure to
TCDD and βNF. Both the heart and kidney endothelial cells (but not the rete mirabile
capillary cells) have a low level of EROD activity (12.7 and 5.2 pmol/mg-min
respectively) in untreated or DMSO-treated cells. The robust response of the heart
endothelial cells to induction and the lack of response in the rete mirabile capillary
endothelial cells indicate that these cells are a good resource to use to investigate the
physiological consequences of AhR agonist exposure and CYP1A induction in different
areas of the vasculature.The Faculty Research Council of Fordham University provided partial support for
RAG. This research was supported by NIH grant 5-P42-ES07381 and by U.S.EPA grant
R827102-01-0
Origins of the Ambient Solar Wind: Implications for Space Weather
The Sun's outer atmosphere is heated to temperatures of millions of degrees,
and solar plasma flows out into interplanetary space at supersonic speeds. This
paper reviews our current understanding of these interrelated problems: coronal
heating and the acceleration of the ambient solar wind. We also discuss where
the community stands in its ability to forecast how variations in the solar
wind (i.e., fast and slow wind streams) impact the Earth. Although the last few
decades have seen significant progress in observations and modeling, we still
do not have a complete understanding of the relevant physical processes, nor do
we have a quantitatively precise census of which coronal structures contribute
to specific types of solar wind. Fast streams are known to be connected to the
central regions of large coronal holes. Slow streams, however, appear to come
from a wide range of sources, including streamers, pseudostreamers, coronal
loops, active regions, and coronal hole boundaries. Complicating our
understanding even more is the fact that processes such as turbulence,
stream-stream interactions, and Coulomb collisions can make it difficult to
unambiguously map a parcel measured at 1 AU back down to its coronal source. We
also review recent progress -- in theoretical modeling, observational data
analysis, and forecasting techniques that sit at the interface between data and
theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue
connected with a 2016 ISSI workshop on "The Scientific Foundations of Space
Weather." 44 pages, 9 figure
Little evidence for an epidemic of myopia in Australian primary school children over the last 30 years
BACKGROUND: Recently reported prevalences of myopia in primary school children vary greatly in different regions of the world. This study aimed to estimate the prevalence of refractive errors in an unselected urban population of young primary school children in eastern Sydney, Australia, between 1998 and 2004, for comparison with our previously published data gathered using the same protocols and other Australian studies over the last 30 years. METHODS: Right eye refractive data from non-cycloplegic retinoscopy was analysed for 1,936 children aged 4 to 12 years who underwent a full eye examination whilst on a vision science excursion to the Vision Education Centre Clinic at the University of New South Wales. Myopia was defined as spherical equivalents equal to or less than -0.50 D, and hyperopia as spherical equivalents greater than +0.50 D. RESULTS: The mean spherical equivalent decreased significantly (p < 0.0001) with age from +0.73 ± 0.1D (SE) at age 4 to +0.21 ± 0.11D at age 12 years. The proportion of children across all ages with myopia of -0.50D or more was 8.4%, ranging from 2.3% of 4 year olds to 14.7% of 12 year olds. Hyperopia greater than +0.50D was present in 38.4%. A 3-way ANOVA for cohort, age and gender of both the current and our previous data showed a significant main effect for age (p < 0.0001) but not for cohort (p = 0.134) or gender (p = 0.61). CONCLUSIONS: Comparison of our new data with our early 1990s data and that from studies of over 8,000 Australian non-clinical rural and urban children in the 1970's and 1980's provided no evidence for the rapidly increasing prevalence of myopia described elsewhere in the world. In fact, the prevalence of myopia in Australian children continues to be significantly lower than that reported in Asia and North America despite changing demographics. This raises the issue of whether these results are a reflection of Australia's stable educational system and lifestyle over the last 30 years
Biparental inheritance of plastidial and mitochondrial DNA and hybrid variegation in Pelargonium
Plastidial (pt) and mitochondrial (mt) genes usually show maternal inheritance. Non-Mendelian, biparental inheritance of plastids was first described by Baur (Z Indukt Abstamm Vererbungslehre 1:330–351, 1909) for crosses between Pelargonium cultivars. We have analyzed the inheritance of pt and mtDNA by examining the progeny from reciprocal crosses of Pelargoniumzonale and P. inquinans using nucleotide sequence polymorphisms of selected pt and mt genes. Sequence analysis of the progeny revealed biparental inheritance of both pt and mtDNA. Hybrid plants exhibited variegation: our data demonstrate that the inquinans chloroplasts, but not the zonale chloroplasts bleach out, presumably due to incompatibility of the former with the hybrid nuclear genome. Different distribution of maternal and paternal sequences could be observed in different sectors of the same leaf, in different leaves of the same plant, and in different plants indicating random segregation and sorting-out of maternal and paternal plastids and mitochondria in the hybrids. The substantial transmission of both maternal and paternal mitochondria to the progeny turns Pelargonium into a particular interesting subject for studies on the inheritance, segregation and recombination of mt genes
A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases
Several recent discoveries of the hallmark features of programmed cell death (PCD) in Plasmodium falciparum have presented the possibility of revealing novel targets for antimalarial therapy. Using a combination of cell-based assays, flow cytometry and fluorescence microscopy, we detected features including mitochondrial dysregulation, activation of cysteine proteases and in situ DNA fragmentation in parasites induced with chloroquine (CQ) and staurosporine (ST). The use of the pan-caspase inhibitor, z-Val-Ala-Asp-fmk (zVAD), and the mitochondria outer membrane permeabilization (MOMP) inhibitor, 4-hydroxy-tamoxifen, enabled the characterization of a novel CQ-induced pathway linking cysteine protease activation to downstream mitochondrial dysregulation, amplified protease activity and DNA fragmentation. The PCD features were observed only at high (μM) concentrations of CQ. The use of a new synthetic coumarin-labeled chloroquine (CM-CQ) showed that these features may be associated with concentration-dependent differences in drug localization. By further using cysteine protease inhibitors z-Asp-Glu-Val-Asp-fmk (zDEVD), z-Phe-Ala-fmk (zFA), z-Phe-Phe-fmk (zFF), z-Leu-Leu-Leu-fmk (zLLL), E64d and CA-074, we were able to implicate clan CA cysteine proteases in CQ-mediated PCD. Finally, CQ induction of two CQ-resistant parasite strains, 7G8 and K1, reveals the existence of PCD features in these parasites, the extent of which was less than 3D7. The use of the chemoreversal agent verapamil implicates the parasite digestive vacuole in mediating CQ-induced PCD
Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites
Apoptosis-like programmed cell death (PCD) has recently been described in multiple taxa of unicellular protists, including the protozoan parasites Plasmodium, Trypanosoma and Leishmania. Apoptosis-like PCD in protozoan parasites shares a number of morphological features with programmed cell death in multicellular organisms. However, both the evolutionary explanations and mechanisms involved in parasite PCD are poorly understood. Explaining why unicellular organisms appear to undergo 'suicide' is a challenge for evolutionary biology and uncovering death executors and pathways is a challenge for molecular and cell biology. Bioinformatics has the potential to integrate these approaches by revealing homologies in the PCD machinery of diverse taxa and evaluating their evolutionary trajectories. As the molecular mechanisms of apoptosis in model organisms are well characterised, and recent data suggest similar mechanisms operate in protozoan parasites, key questions can now be addressed. These questions include: which elements of apoptosis machinery appear to be shared between protozoan parasites and multicellular taxa and, have these mechanisms arisen through convergent or divergent evolution? We use bioinformatics to address these questions and our analyses suggest that apoptosis mechanisms in protozoan parasites and other taxa have diverged during their evolution, that some apoptosis factors are shared across taxa whilst others have been replaced by proteins with similar biochemical activities
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