4-D Computational Modeling of Cardiac Outflow Tract Hemodynamics over Looping Developmental Stages in Chicken Embryos

Cardiogenesis is interdependent with blood flow within the embryonic system. Recently, a number of studies have begun to elucidate the effects of hemodynamic forces acting upon and within cells as the cardiovascular system begins to develop. Changes in flow are picked up by mechanosensors in endocardial cells exposed to wall shear stress (the tangential force exerted by blood flow) and by myocardial and mesenchymal cells exposed to cyclic strain (deformation). Mechanosensors stimulate a variety of mechanotransduction pathways which elicit functional cellular responses in order to coordinate the structural development of the heart and cardiovascular system. The looping stages of heart development are critical to normal cardiac morphogenesis and have previously been shown to be extremely sensitive to experimental perturbations in flow, with transient exposure to altered flow dynamics causing severe late stage cardiac defects in animal models. This paper seeks to expand on past research and to begin establishing a detailed baseline for normal hemodynamic conditions in the chick outflow tract during these critical looping stages. Specifically, we will use 4-D (3-D over time) optical coherence tomography to create in vivo geometries for computational fluid dynamics simulations of the cardiac cycle, enabling us to study in great detail 4-D velocity patterns and heterogeneous wall shear stress distributions on the outflow tract endocardium. This information will be useful in determining the normal variation of hemodynamic patterns as well as in mapping hemodynamics to developmental processes such as morphological changes and signaling events during and after the looping stages examined here

Semantic Modelling of Citation Contexts for Context-Aware Citation Recommendation

Contents The four CSV files are the data used for the evaluation in: Saier T., Färber M. (2020) Semantic Modelling of Citation Contexts for Context-Aware Citation Recommendation. In: Advances in Information Retrieval. ECIR 2020. Lecture Notes in Computer Science, vol 12035. DOI: 10.1007/978-3-030-45439-5_15 Code: github.com/IllDepence/ecir2020 The evaluation was conducted in a citation re-prediction setting. CSV Format 7 columns divided by \u241E cited document ID for *_nomarker.csv: citation marker position ambiguous for *_withmarker.csv: citation marker position at 'MAINCIT' in citation context adjacent cited document IDs only given in citrec_unarxive_*.csv divided by \u241F order matches 'CIT' markers in citation context citing document ID citation context MAG field of study IDs divided by \u241F predicate:argument tuples generated based on PredPatt JSON noun phrases for *_nomarker.csv: divided by \u241F for *_withmarker.csv: divided by \u241D into noun phrases noun phrase directly preceding citation marker Data Sources citrec_unarxive_cs_withmarker.csv data set unarXive Paper DOI: 10.1007/s11192-020-03382-z Data DOI: 10.5281/zenodo.2553522 filter citing doc from computer science cited doc is cited at least 5 times citrec_mag_cs_en.csv data set Microsoft Academic Graph (MAG) Paper DOI: 10.1145/2740908.2742839 filter citing doc from computer science and in English citing doc abstract in MAG given cited doc is cited at least 50 times citrec_refseer.csv data set RefSeer Paper URL: ojs.aaai.org/index.php/AAAI/article/view/9528 Data URL: psu.app.box.com/v/refseer filter for citing and cited docs title, venue, venuetype, abstract, and year not NULL citrec_acl-arc_withmarker.csv data set ACL ARC Paper URL: aclanthology.org/L08-1005 Data URL: acl-arc.comp.nus.edu.sg/ filter cited doc has a DBLP ID Paper Citation @inproceedings{Saier2020ECIR, author = {Tarek Saier and Michael F{\"{a}}rber}, title = {{Semantic Modelling of Citation Contexts for Context-aware Citation Recommendation}}, booktitle = {Proceedings of the 42nd European Conference on Information Retrieval}, pages = {220--233}, year = {2020}, month = apr, doi = {10.1007/978-3-030-45439-5_15},

Research Paper Recommender System with Serendipity Using Tweets vs. Diversification

21st International Conference on Asia-Pacific Digital Libraries, ICADL 2019, Kuala Lumpur, Malaysia, November 4–7, 2019. Part of the Lecture Notes in Computer Science book series (LNCS, volume 11853), also part of the Information Systems and Applications, incl. Internet/Web, and HCI book sub series (LNISA, volume 11853).So far, a lot of works have studied research paper recommender systems. However, most of them have focused only on the accuracy and ignored the serendipity, which is an important aspect for user satisfaction. The serendipity is concerned with the novelty of recommendations and to which extent recommendations positively surprise users. In this paper, we investigate a research paper recommender system focusing on serendipity. In particular, we examine (1) whether a user’s tweets lead to a generation of serendipitous recommendations and (2) whether the use of diversification on a recommendation list improves serendipity. We have conducted an online experiment with 22 subjects in the domain of computer science. The result of our experiment shows that tweets do not improve the serendipity, despite their heterogeneous nature. However, diversification delivers serendipitous research papers that cannot be generated by a traditional strategy

Domain-independent Extraction of Scientific Concepts from Research Articles

We examine the novel task of domain-independent scientific concept extraction from abstracts of scholarly articles and present two contributions. First, we suggest a set of generic scientific concepts that have been identified in a systematic annotation process. This set of concepts is utilised to annotate a corpus of scientific abstracts from 10 domains of Science, Technology and Medicine at the phrasal level in a joint effort with domain experts. The resulting dataset is used in a set of benchmark experiments to (a) provide baseline performance for this task, (b) examine the transferability of concepts between domains. Second, we present two deep learning systems as baselines. In particular, we propose active learning to deal with different domains in our task. The experimental results show that (1) a substantial agreement is achievable by non-experts after consultation with domain experts, (2) the baseline system achieves a fairly high F1 score, (3) active learning enables us to nearly halve the amount of required training data.Comment: Accepted for publishing in 42nd European Conference on IR Research, ECIR 202

Reproducibility of experiments in recommender systems evaluation

© IFIP International Federation for Information Processing 2018 Published by Springer International Publishing AG 2018. All Rights Reserved. Recommender systems evaluation is usually based on predictive accuracy metrics with better scores meaning recommendations of higher quality. However, the comparison of results is becoming increasingly difficult, since there are different recommendation frameworks and different settings in the design and implementation of the experiments. Furthermore, there might be minor differences on algorithm implementation among the different frameworks. In this paper, we compare well known recommendation algorithms, using the same dataset, metrics and overall settings, the results of which point to result differences across frameworks with the exact same settings. Hence, we propose the use of standards that should be followed as guidelines to ensure the replication of experiments and the reproducibility of the results

The Rural Digital Economy

Retailers in remote rural areas face competition from online retailers that can offer superior product availability and variety. This paper explores the issues stores in Scottish small island communities face due to the residents’ increased opportunities for ‘virtual mobility’, and highlights strategies for their economically sustainable operation. Eight semi-structured interviews were conducted with shop owners on seven islands in the council areas of Orkney, Argyll and Bute, and Highland. The research has found that while online retailers are frequently used by the islanders, the small shops on the islands are vital for the communities, particularly for elderly residents. Their close connection with the community enables shop owners to flexibly respond to demand, but elevated transport cost and lack of economies of scale lead to high prices. Shops stay competitive by offering additional services to the community, for example, they frequently incorporate the post office. Local produce is available in many shops, but is not distributed beyond the island community, as none of the retailers sell via the Internet. There is very little evidence of cooperation with other businesses, despite an acknowledged opportunity to create valuable economies of scale to cut transport cost. Any attempt to tackle this issue will have to focus primarily on the creation of trust amongst local businesses

Immune profiling in Puerto Rican injection drug users with and without HIV-1 infection

Antiretroviral therapy has been effective in suppressing HIV viral load and enabling people living with HIV to experience longer, more conventional lives. However, as people living with HIV are living longer, they are developing aging-related diseases prematurely and are more susceptible to comorbidities that have been linked to chronic inflammation. Coincident with HIV infection and aging, drug abuse has also been independently associated with gut dysbiosis, microbial translocation, and inflammation. Here, we hypothesized that injection drug use would exacerbate HIV-induced immune activation and inflammation, thereby intensifying immune dysfunction. We recruited 50 individuals not using injection drugs (36/50 HIV+) and 47 people who inject drugs (PWID, 12/47 HIV+). All but 3 of the HIV+ subjects were on antiretroviral therapy. Plasma immune profiles were characterized by immunoproteomics, and cellular immunophenotypes were assessed using mass cytometry. The immune profiles of HIV+/PWID−, HIV−/PWID+, and HIV+/PWID+ were each significantly different from controls; however, few differences between these groups were detected, and only 3 inflammatory mediators and 2 immune cell populations demonstrated a combinatorial effect of injection drug use and HIV infection. In conclusion, a comprehensive analysis of inflammatory mediators and cell immunophenotypes revealed remarkably similar patterns of immune dysfunction in HIV-infected individuals and in people who inject drugs with and without HIV-1 infection