414 research outputs found
Boundary Asymptotic Analysis for an Incompressible Viscous Flow: Navier Wall Laws
We consider a new way of establishing Navier wall laws. Considering a bounded
domain of R N , N=2,3, surrounded by a thin layer ,
along a part 2 of its boundary , we consider a
Navier-Stokes flow in with
Reynolds' number of order 1/ in . Using
-convergence arguments, we describe the asymptotic behaviour of the
solution of this problem and get a general Navier law involving a matrix of
Borel measures having the same support contained in the interface 2. We
then consider two special cases where we characterize this matrix of measures.
As a further application, we consider an optimal control problem within this
context
A chemical, microbiological and (eco)toxicological scheme to understand the efficiency of UV-C/HO oxidation on antibiotic-related microcontaminants in treated urban wastewater
Next-to-leading order QCD corrections to Higgs boson production in association with a photon via weak-boson fusion at the LHC
Higgs boson production in association with a hard central photon and two
forward tagging jets is expected to provide valuable information on Higgs boson
couplings in a range where it is difficult to disentangle weak-boson fusion
processes from large QCD backgrounds. We present next-to-leading order QCD
corrections to Higgs production in association with a photon via weak-boson
fusion at a hadron collider in the form of a flexible parton-level Monte Carlo
program. The QCD corrections to integrated cross sections are found to be small
for experimentally relevant selection cuts, while the shape of kinematic
distributions can be distorted by up to 20% in some regions of phase space.
Residual scale uncertainties at next-to-leading order are at the few-percent
level.Comment: 17 pages, 7 figures, 1 tabl
Systematic study of the pp -> pp omega reaction
A systematic study of the production of omega-mesons in
proton-proton-collisions was carried out in a kinematically complete experiment
at three excess energies(epsilon= 92, 128, 173MeV). Both protons were detected
using the large-acceptance COSY-TOF spectrometer at an external beam line at
the Cooler Synchrotron COSY at Forschungszentrum J\"ulich. The total cross
section, angular distributions of both omega-mesons and protons were measured
and presented in various reference frames such as the overall CMS, helicity and
Jackson frame. In addition, the orientation of the omega-spin and invariant
mass spectra were determined. We observe omega-production to take place
dominantly in Ss and Sp final states at epsilon = 92, 128 MeV and,
additionally, in Sd at epsilon= 173 MeV. No obvious indication of resonant
omega-production via N^*-resonances was found, as proton angular distributions
are almost isotropic and invariant mass spectra are compatible with phase space
distributions. A dominant role of ^3P_1 and ^1S_0 initial partial waves for
omega-production was concluded from the orientation of the decay plane of the
omega-meson. Although the Jackson angle distributions in the omega-p-Jackson
frame are anisotropic we argue that this is not an indication of a resonance
but rather a kinematical effect reflecting the anisotropy of the omega angular
distribution. The helicity angle distribution in the omega-p-helicity frame
shows an anisotropy which probably reflects effects of the omega angular
momenta in the final state; this observable may be, in addition to the
orientation of the omega decay plane, the most sensitive one to judge the
validity of theoretical descriptions of the production process.Comment: 17 pages, 16 figures, accepted for publication in EPJ
Production of Lambda and Sigma^0 hyperons in proton-proton collisions
This paper reports results on simultaneous measurements of the reaction
channels pp -> pK+\Lambda and pp -> pK+\Sigma^0 at excess energies of 204, 239,
and 284 MeV (\Lambda) and 127, 162, and 207 MeV (\Sigma^0). Total and
differential cross sections are given for both reactions. It is concluded from
the measured total cross sections that the high energy limit of the cross
section ratio is almost reached at an excess energy of only about 200 MeV. From
the differential distributions observed in the overall CMS as well as in the
Jackson and helicity frames, a significant contribution of interfering nucleon
resonances to the \Lambda production mechanism is concluded while resonant
\Sigma^0-production seems to be of lesser importance and takes place only
through specific partial waves of the entrance channel. The data also indicate
that kaon exchange plays a minor role in the case of \Lambda- but an important
role for \Sigma^0-production. Thus the peculiar energy dependence of the
\Lambda-to-\Sigma^0 cross section ratio appears in a new light as its
explanation requires more than mere differences between the p\Lambda and the
p\Sigma^0 final state interaction. The data provide a benchmark for theoretical
models already available or yet to come.Comment: 18 pages, 10 figures; accepted by The European Physical Journal A
(EPJ A
A randomized phase II trial of 5-fluorouracil, with or without human interferon-β, for advanced colorectal cancer
Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestinal failure with high-mortality. Mechanistically, autoreactive-pathogenic CD4+ T cells accumulated at specific vessels of boundary area of third-ventricle, thalamus, and dentate-gyrus to establish brain micro-inflammation via stress-gateway reflex. Importantly, induction of brain micro-inflammation at specific vessels by cytokine injection was sufficient to establish fatal gastrointestinal failure. Resulting micro-inflammation activated new neural pathway including neurons in paraventricular-nucleus, dorsomedial-nucleus-of-hypothalamus, and also vagal neurons to cause fatal gastrointestinal failure. Suppression of the brain micro-inflammation or blockage of these neural pathways inhibited the gastrointestinal failure. These results demonstrate direct link between brain micro-inflammation and fatal gastrointestinal disease via establishment of a new neural pathway under stress. They further suggest that brain micro-inflammation around specific vessels could be switch to activate new neural pathway(s) to regulate organ homeostasis
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors
IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation
The features that define autoreactive T helper (Th) cell pathogenicity remain obscure. We have previously shown that Th cells require the transcription factor Bhlhe40 to mediate experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Here, using Bhlhe40 reporter mice and analyzing both polyclonal and TCR transgenic Th cells, we found that Bhlhe40 expression was heterogeneous after EAE induction, with Bhlhe40-expressing cells displaying marked production of IFN-γ, IL-17A, and granulocyte-macrophage colony-stimulating factor. In adoptive transfer EAE models, Bhlhe40-deficient Th1 and Th17 cells were both nonencephalitogenic. Pertussis toxin (PTX), a classical co-adjuvant for actively induced EAE, promoted IL-1β production by myeloid cells in the draining lymph node and served as a strong stimulus for Bhlhe40 expression in Th cells. Furthermore, PTX co-adjuvanticity was Bhlhe40 dependent. IL-1β induced Bhlhe40 expression in polarized Th17 cells, and Bhlhe40-expressing cells exhibited an encephalitogenic transcriptional signature. In vivo, IL-1R signaling was required for full Bhlhe40 expression by Th cells after immunization. Overall, we demonstrate that Bhlhe40 expression identifies encephalitogenic Th cells and defines a PTX–IL-1–Bhlhe40 pathway active in EAE
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