Transformation of the concept of "power" as a basic cultural value in the media discourse of modern times in metagraphic representation

The relevance is due to the fact that new geopolitical realities cause the transformation of basic concepts, which include the concept of "power", which has an internal conflict of content, where there is power as self-possession and power as the management of others. At the same time, the concept of "power" itself is built in various linguistic and philosophical coordinate systems. The research is based on an ethnic-psycholinguistic scientific paradigm, within which the concept of "power" is analyzed from the point of view of structure and semantics as a separate element of linguistic consciousness, actively represented in the speech activity of representatives of various linguistic cultures (Kazakh, Russian, Anglo-American, Chinese). The appeal to this concept is predetermined by the acuteness of the experience of the problem of power itself as a constantly evolving socio-political institution. The aim of the study is to model the concept of "power" in the modern linguistic consciousness of modern times with the establishment of its structural and content specificity. The complexity of the claimed topic is predetermined by the initial ambiguity of power as a social phenomenon, which includes a binary of oppositions: "I" individual and "We" collective, the ability to control oneself and the ability to control others, legitimate power and illegitimate power, ethical power due to respect and authority and the power of oppression and pressure due to fear. The metagraph of the complex socio-political basic value "power" perfectly illustrates the representation of this complex concept, demonstrating qualitative transformations in the structure of the meaning of this concept at different levels of lexico-semantic, neurasthenic and symbolic-semiological hierarchy

Biliary Microbiota, Gallstone Disease and Infection with Opisthorchis felineus.

BACKGROUND: There is increasing interest in the microbiome of the hepatobiliary system. This study investigated the influence of infection with the fish-borne liver fluke, Opisthorchis felineus on the biliary microbiome of residents of the Tomsk region of western Siberia. METHODOLOGY/PRINCIPAL FINDINGS: Samples of bile were provided by 56 study participants, half of who were infected with O. felineus, and all of who were diagnosed with gallstone disease. The microbiota of the bile was investigated using high throughput, Illumina-based sequencing targeting the prokaryotic 16S rRNA gene. About 2,797, discrete phylotypes of prokaryotes were detected. At the level of phylum, bile from participants with opisthorchiasis showed greater numbers of Synergistetes, Spirochaetes, Planctomycetes, TM7 and Verrucomicrobia. Numbers of \u3e 20 phylotypes differed in bile of the O. felineus-infected compared to non-infected participants, including presence of species of the genera Mycoplana, Cellulosimicrobium, Microlunatus and Phycicoccus, and the Archaeans genus, Halogeometricum, and increased numbers of Selenomonas, Bacteroides, Rothia, Leptotrichia, Lactobacillus, Treponema and Klebsiella. CONCLUSIONS/SIGNIFICANCE: Overall, infection with the liver fluke O. felineus modified the biliary microbiome, increasing abundance of bacterial and archaeal phylotypes

Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: Potential applications for vaccine development

Cryptococcosis caused by C. neoformans and C. gattii affects a large population and is a cause of significant morbidity and mortality. Despite its public health burden, there are currently no vaccines against cryptococcosis and new strategies against such infections are needed. In this study, we demonstrate that C. neoformans has the biochemical ability to metabolize sterylglucosides (SGs), a class of immunomodulatory glycolipids. Genetic manipulations that eliminate cryptococccal sterylglucosidase lead to the accumulation of SGs and generate a mutant strain (Îsgl1) that is non-pathogenic in the mouse models of cryptococcosis. Interestingly, this mutant strain acts as a vaccine strain and protects mice against cryptococcosis following infection with C. neoformans or C. gattii. The immunity induced by the Îsgl1 strain is not CD4+ T-cells dependent. Immunocompromised mice, which lack CD4+ T-cells, are able to control the infection by Îsgl1 and acquire immunity against the challenge by wild-type C. neoformans following vaccination with the Îsgl1 strain. These findings are particularly important in the context of HIV/AIDS immune deficiency and suggest that the Îsgl1 strain might provide a potential vaccination strategy against cryptococcosis

Cyrillic Manuscript Heritage: Vol. 37

CMH 37 cover design based on the cover design of CMH 34 created by Eva Dujardin Dale.Note that in 2015, only one issue appeared of the biannual newsletter appeared: Cyrillic Manuscript Heritage 37 (December 2015). This issue contains information and photos of the Eighth Biennial Medieval Slavic Summer Institute, which was held during the summer of 2015.Biannual newsletter of the Hilandar Research Library (HRL) and the Resource Center for Medieval Slavic Studies (RCMSS), The Ohio State University. Includes: features by guest contributors, which appear under the column heading of "HRL Journal" – where Cyrillic Manuscript Heritage asks researchers who have used the resources of the HRL in the past year or so to describe their experience and work; a column, "Director's Desk," by the Director of RCMSS; Reports on recent visitors, research, events, exhibits, projects, updates, etc.; Contributors to both the Hilandar Endowment Fund and Hilandar's Friends of the Library Fund are listed, as are donors of "Gifts in Kind." Also included are seasonal announcements regarding the International Hilandar Conference series and the Medieval Slavic Summer Institute.Front cover image: Hodigetria Mosaic icon, 12th century, which Stefan Nemanja (canonized as St. Simeon) is said to have brought to Mount Athos after he took monastic vows in 1198. Image is from a set of slides donated to the HRL by A. Dean McKenzie, professor emeritus of Art History at the University of Oregon; table of contents, front cover; masthead and description of front cover image, p. 2; "From the Director's Desk," by Dr. Predrag Matejic, photos by M.A. Johnson and Jessi Jones, pp. 2-3, 5; "The 2015 Kalamazoo Conference," photos by M.A. Johnson, p. 4; "Welcome Ryan Perkins!," photo courtesy of Opic [the OSU Avatar Service], p. 4; "New Leadership at OSU Libraries," photos courtesy of OSU Libraries, p. 6; "Exploring the 'World's Desire,'" by Kevin Bloomfield, photos by Jessi Jones, p. 6; "Kopitar's Legacy of Slavic Manuscripts in Slovenia and Austria," by M.A. Johnson, photos by M.A. Johnson, p. 7; "HRL Journal: Traversing the Annals of Time," by Ezekiel Abodale Olagoke, photo by Jessi Jones, p. 8; "Getting 'Hands On' at Hilandar Research Library," by Tom Elvins, photos by Jessi Jones, p. 9; "MSSI 2015," photos by Nina Haviernikova, M.A. Johnson, and Jessi Jones, pp. 10-11; "Examining Exegesis and Hermeneutics at HRL," by Maria Ivanova, photo by Jessie Jones, p. 12; "Letter from Dr. Vlada Stanković," p. 12; "2015 Highlights," photos by Nina Haviernikova and courtesy of St. Vladimir's Orthodox Theological Seminary (SVOTS), p. 13; "HRL Acquires the Emilia Guergova-Veder & William R. Veder Collection," p. 13; "Edward Kasinec Request," photo courtesy of Edward Kasinec, p. 14; "Special Collections Donor Wall," photo by Jessi Jones, p. 14; Contributions to the Hilandar Endowment Fund, Gifts through Friends of the Library, Gifts in Kind to the Hilandar Research Library, p. 15; farewell to OSUL colleague Wes Boomgaarden (retired), photo by Eric Albrecht, and "Happy Holidays and Season's Greetings," back cover

CHEMICAL PROPERTIES AND APPLICATIONS OF NITROPYRIDINES

Background. Pyridines are one of the most common heterocycles, the derivatives of which are widely used in pharmaceuticals, agrochemistry, and also in the production of new materials. Therefore, a comprehensive study of the chemical behavior of various pyridine derivatives will continue to be an urgent task of organic chemistry. This literature review is devoted to the systematization and analysis of the chemical properties of pyridine nitro derivatives, starting from the first half of the 20th century and up to the present. The paper considers both reactions proceeding through the nitro group (reduction under the action of various chemical agents, substitution, condensation) and reactions through the pyridine cycle. The main areas of application of nitropyridines are also shown. Purpose. Generalize and systematize the main types of reactions characteristic of nitropyridines, show the features of their chemical properties associated with the transformation of the nitro group, its effect on the mobility of substituents in the pyridine ring, as well as on the activity of the heterocycle as a whole. Materials and methods. To achieve the goal of the study, a review of the scientific literature was made on the main types of chemical reactions characteristic of pyridine nitro derivatives and the most significant areas of their application. Results. This paper summarizes the results of experimental studies on the chemical properties and application of nitropyridines from the beginning of the last century to the present. Conclusion. Thus, as a result of the analysis of sources devoted to the chemical properties and application of nitropyridines, a brief literature review was compiled, including the main types of reactions characteristic of the compounds under study, and their main areas of application were identified

Crystal structure and location of gp131 in the bacteriophage phiKZ virion

Pseudomonas phage phi KZ and its two close relatives phi PA3 and 201 phi 2-1 are very large bacteriophages that form a separate branch in phage classification because their genomes are very different from the rest of GenBank sequence data. The contractile tail of phi KZ is built from at least 32 different proteins, but a definitive structural function is assigned to only one of them-the tail sheath protein. Here, we report the crystal structure of the C-terminal domain of another phiKZ tail protein, gene product 131 (gp131C). We show that gp131 is located at the periphery of the baseplate and possibly associates with fibers that emanate from the baseplate. Gp131C is a seven-bladed beta-propeller that has a shape of a skewed toroid. A small but highly conserved and negatively charged patch on the surface of gp131C might be important for substrate binding or for interaction with a different tail protein. (C) 2012 Elsevier Inc. All rights reserved

Innovation Contests with Entry Auction

We consider procurement of an innovation from heterogeneous sellers. Innovations are random but depend on unobservable effort and private information. We compare two procurement mechanisms where potential sellers first bid in an auction for admission to an innovation contest. After the contest, an innovation is procured employing either a fixed prize or a first-price auction. We characterize Bayesian Nash equilibria such that both mechanisms are payoff-equivalent and induce the same efforts and innovations. In these equilibria, signaling in the entry auction does not occur since contestants play a simple strategy that does not depend on rivals' private information

Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistance

Introduction: Among the various stromal cell types within the tumor microenvironment, cancer-associated fibroblasts (CAFs) emerge as the predominant constituent, exhibiting a diverse array of oncogenic functions not intrinsic to normal fibroblasts. Their involvement spans across all stages of tumorigenesis, encompassing initiation, progression, and metastasis. Current understanding posits the coexistence of distinct subpopulations of CAFs within the tumor microenvironment across a spectrum of solid tumors, showcasing both pro- and antitumor activities. Recent advancements in single-cell transcriptomics have revolutionized our ability to meticulously dissect the heterogeneity inherent to CAF populations. Furthermore, accumulating evidence underscores the pivotal role of CAFs in conferring therapeutic resistance to tumors against various drug modalities. Consequently, efforts are underway to develop pharmacological agents specifically targeting CAFs.Methods: This review embarks on a comprehensive analysis, consolidating data from 36 independent single-cell RNA sequencing investigations spanning 17 distinct human malignant tumor types.Results: Our exploration centers on elucidating CAF population markers, discerning their prognostic relevance, delineating their functional contributions, and elucidating the underlying mechanisms orchestrating chemoresistance.Discussion: Finally, we deliberate on the therapeutic potential of harnessing CAFs as promising targets for intervention strategies in clinical oncology

Measurement invariance of the phubbing scale across 20 countries

Mobile phone addiction is a robust phenomenon observed throughout the world. The social aspect of mobile phone use is crucial; therefore, phubbing is a part of the mobile phone addiction phenomenon. Phubbing is defined as ignoring an interlocutor by glancing at one's mobile phone during a face-to-face conversation. The main aim of this study was to investigate how the Phubbing Scale (containing 10 items) might vary across countries, and between genders. Data were collected in 20 countries: Belarus, Brazil, China, Croatia, Ecuador, India, Israel, Italy, Netherlands, Pakistan, Poland, Portugal, Serbia, Slovakia, Slovenia, Spain, Turkey, UK, Ukraine and USA. The mean age across the sample (N = 7696, 65.8% women, 34.2% men) was 25.32 years (SD = 9.50). The cross-cultural invariance of the scale was investigated using multigroup confirmatory factor analyses (MGCFA) as well as the invariance analyses. Additionally, data from each country were assessed individually via confirmatory factor analyses (CFAs). We obtained two factors, based on only eight of the items: (a) communication disturbances and (b) phone obsession. The 8 items Phubbing Scale