Исследование пенетрационной способности адгезивных систем на временных зубах методом конфокальной микроскопии

In this work, the authors evaluate the effectiveness of various adhesive systems (AS) in the temporary teeth restoration with composite materials. For this study, the authors used temporary teeth extracted for orthodontic reasons or lost due to a physiological change. Enamel samples with dentin were made from these teeth. Rhodamine B fluorochrome was added to each of the adhesive systems used. For the greater practical significance of research results, adhesive systems of several generations (IV, V, and VII) were chosen. In each sample, a cavity was prepared, and adhesive preparation was carried out according to the AS manufacturer instructions, followed by restoration with a composite material. Then, longitudinal slits were made so that the areas of enamel and dentin for which an adhesive protocol and restoration were performed could be observed in their entirety. The effectiveness of various generations was determined by the depth of penetration of AS components into the dentinal tubules. Fluorescent confocal microscopy was used to visualize the penetration ability of AS. Based on the results of the study, the authors concluded that IV and V generations of AS are the most effective.В работе представлены результаты исследования эффективности применения различных адгезивных систем (АС) при реставрации временных зубов композитными материалами. Для проведения исследования авторы использовали временные зубы, удаленные по ортодонтическим показаниям или утраченные вследствие физиологической смены. Из таких зубов были изготовлены образцы эмали с подлежащим дентином. В каждую из использованных АС был добавлен флуорохром (родамин В). Для большей практической значимости результатов были выбраны АС нескольких поколений: IV, V и VII. Далее в каждом образце отпрепарировали полость и провели адгезивную подготовку согласно инструкциям производителей соответствующих систем с последующей реставрацией композитным материалом. Затем для каждого образца изготавливали продольные шлифы с учетом полного попадания в область шлифа участков эмали и дентина, для которых проводили адгезивный протокол и реставрацию. Эффективность различных поколений определялась глубиной проникновения компонентов АС в дентинные трубочки. Для визуализации пенетрационной способности АС был использован метод флуоресцентной конфокальной микроскопии. По результатам исследования авторы делают вывод, что наибольшей эффективностью обладают АС IV и V поколения

ИТОГИ РЕАЛИЗАЦИИ МЕРОПРИЯТИЙ, НАПРАВЛЕННЫХ НА СОВЕРШЕНСТВОВАНИЕ ОКАЗАНИЯ МЕДИЦИНСКОЙ ПОМОЩИ БОЛЬНЫМ С СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ НА ТЕРРИТОРИИ ТОМСКОЙ ОБЛАСТИ В 2012 г.

Acute disorders of cerebral circulation remain serious medical and social problem associated with high disability and mortality rates. Since 2011 Tomsk oblast is a participating member of the medical campaign aimed at improved medical services to the vascular patients. The preliminary implementation data analysis for 2012 revealed improvement of most of the indices of medical support to patients suffering from acute cerebral circulation; increased number of the in-patient cases (Regional Vascular Center and primary vascular department), decreased lethality rates from strokes, specifically hemorrhagic cases. Strict observance of the Regulations on Medical Assistance for stroke patients and the using of modern methods of therapy allowed to decrease hospital mortality in the Primary Vascular Departments and early mortality in the Regional Vascular Center. The active implementation of neurorehabilitation approaches resulted in the increased number of patients who do not require third parties’ assistance. Analysis of the work of the departments helped to identifying current problems and perspectives of further development of special medical care for stroke patients.Острые нарушения мозгового кровообращения (ОНМК) остаются актуальной медицинской и социальной проблемой с высокими показателями смертности и инвалидизации населения. С 2011 Томская область вошла в число участников мероприятий, направленных на совершенствование оказания медицинской помощи больным с сосудистыми заболеваниями. Анализ предварительных результатов реализации данных мероприятий за 2012 показал улучшение большинства показателей, характеризующих состояние медицинской помощи больным с ОНМК: повысился процент пациентов, госпитализированных в специализированные отделения (региональный сосудистый центр и первичные сосудистые отделения), снизилась летальность от инсультов, особенно от геморрагических типов. Строгое выполнение утвержденных порядков помощи больным с ОНМК и использование современных методик лечения инсульта в сосудистых отделениях позволило снизить госпитальную летальность в первичных сосудистых отделениях и раннюю летальность в региональном сосудистом центре. Активное применение нейрореабилитационных мероприятий привело к повышению доли пациентов, не зависимых от окружающих при выписке. Анализ показателей работы отделений позволил обозначить существующие проблемы и перспективы дальнейшего развития специализированной медицинской помощи данной категории больных.

Development of 100^{100}Mo-containing scintillating bolometers for a high-sensitivity neutrinoless double-beta decay search

We report recent achievements in the development of scintillating bolometers to search for neutrinoless double-beta decay of $^{100}$Mo. The presented results have been obtained in the framework of the LUMINEU, LUCIFER and EDELWEISS collaborations, and are now part of the R\&D activities towards CUPID (CUORE Update with Particle IDentification), a proposed next-generation double-beta decay experiment based on the CUORE experience. We have developed a technology for the production of large mass ($\sim$1 kg), high optical quality, radiopure zinc and lithium molybdate crystal scintillators (ZnMoO$_4$ and Li$_2$MoO$_4$, respectively) from deeply purified natural and $^{100}$Mo-enriched molybdenum. The procedure is applied for a routine production of enriched crystals. Furthermore, the technology of a single detector module consisting of a large-volume ($\sim 100$~cm$^3$) Zn$^{100}$MoO$_4$ and Li$_2$$^{100}$MoO$_4$ scintillating bolometer has been established, demonstrating performance and radiopurity that are close to satisfy the demands of CUPID. In particular, the FWHM energy resolution of the detectors at 2615 keV --- near the $Q$-value of the double-beta transition of $^{100}$Mo (3034~keV) --- is $\approx$ 4--10~keV. The achieved rejection of $\alpha$-induced dominant background above 2.6~MeV is at the level of more than 99.9\%. The bulk activity of $^{232}$Th ($^{228}$Th) and $^{226}$Ra in the crystals is below 10 $\mu$Bq/kg. Both crystallization and detector technologies favor Li$_2$MoO$_4$, which was selected as a main element for the realization of a CUPID demonstrator (CUPID-0/Mo) with $\sim$7 kg of $^{100}$Mo

Probabilistic Modeling of Digital Detectors with Correlated Input Effects

Most modern radio systems use digital signal processing. To debug algorithms of digital signal processing, most often is used simulation modelling, which has a number of significant drawbacks, since most modern programmes that generate random sequences of numbers begin to repeat previously obtained combinations of values with a large number of measurements. In addition, simulation modelling does not allow us to obtain very small probabilities of detector states. Consequently, the problem of mathematical modelling of digital devices remains relevant. Therefore, to study the operation of digital detectors when there are correlated input effects there is an article’s proposal to apply a probabilistic simulation method, using the Markov chain apparatus, based on a recurrent procedure and a concept of the extended digital automaton.The simulation modelling to debug digital detector operation is as follows: a generated correlated signal comes to the threshold device to give at the output a sequence of binary signals arriving at the counter. Since in real conditions a digital detector has to have high accuracy, an error emerges when debugging based on simulation modelling. The article shows that with a probabilistic modelling method it is necessary to use the multidimensional Markov chains and the extended digital automaton to reach the higher accuracy. The article also compares the results obtained by various types of mathematical modelling to analyse the effect of the input signal correlation on the probability of detector false response.The analysis has shown that probabilistic modelling in debugging the digital detector operation with a correlated input signal of high accuracy corresponds to the simulation model with the same specified parameters. With increasing input signal correlation there is a significantly raising probability of false response. Thus, it is fair to say that Markov chains-based probabilistic simulation can be used to study operation of radar signal processors.</p

Nodular mastocytosis: a case study

A case study of nodular mastocytosis is described. Tacrolimus was used to treat skin manifestations of mastocytosis

Study of penetration ability of adhesive systems on temporary teeth by confocal microscopy

In this work, the authors evaluate the effectiveness of various adhesive systems (AS) in the temporary teeth restoration with composite materials. For this study, the authors used temporary teeth extracted for orthodontic reasons or lost due to a physiological change. Enamel samples with dentin were made from these teeth. Rhodamine B fluorochrome was added to each of the adhesive systems used. For the greater practical significance of research results, adhesive systems of several generations (IV, V, and VII) were chosen. In each sample, a cavity was prepared, and adhesive preparation was carried out according to the AS manufacturer instructions, followed by restoration with a composite material. Then, longitudinal slits were made so that the areas of enamel and dentin for which an adhesive protocol and restoration were performed could be observed in their entirety. The effectiveness of various generations was determined by the depth of penetration of AS components into the dentinal tubules. Fluorescent confocal microscopy was used to visualize the penetration ability of AS. Based on the results of the study, the authors concluded that IV and V generations of AS are the most effective

The low thermal gradient Czochralski crystal growth and microstructural properties of a Pb2MoO5(20-1) cleaved surface

Optical quality Pb2MoO5 single crystals were grown by the Low Thermal Gradient Czochralski (LTG Cz) technique. The resulting Pb2MoO5 crystals had diameters of 40–50 mm and lengths of ~100 mm. The phase composition of the grown crystals was identified by X-ray single crystal structure analysis; the space group is C2/m and a = 14.2221(11), b = 5.7852(5), c = 7.3262(6) Å, β = 114.168(2)° and Z = 4 (R1 = 0.0336). Pb2MoO5(20−1) substrates were prepared by cleavage, and the surface properties were evaluated by RHEED and AFM. The superposition of wide Kikuchi lines and crystal reflexes was found by RHEED. The AFM measurements indicate a surface roughness as low as ~0.2 nm. Thus, atomically smooth surfaces of Pb2MoO5 were formed by cleavage

Study of the effectiveness of supplementary feeding in patients with inherited enzyme deficiency

The successful provision of optimal nutrition in children with serious diseases depends on the right diet, as well as the addition of specialized mixtures for its correction. The aim of the study was to study the effectiveness of supplemental nutrition in hereditary fermentopathy (cystic fibrosis) in children. The work included a three-year follow-up of 69 children aged 3 to 15 years suffering from cystic fibrosis. Patients were divided into two groups: 37 patients with cystic fibrosis group 1, receiving a modified version of treatment with additional enteral nutrition and 32 patients with cystic fibrosis group 2, receiving traditional treatment. The study conducted a comparative analysis of changes in trophic status in patients using nutritional support mixture produced in the Russian Federation – "Nutrien-standard"in diet therapy. Laboratory, functional and anthropometric parameters were monitored once a month. A significant increase in the physical development of patients was obtained only in the second year of use in the diet of supplementary nutrition, p&lt;0.05. At the 3rd year of treatment, the results of positive dynamics of nutritional status in both groups were confirmed, while the increase in body mass index in the main group was 6.7%, and in the control group-only 1% (p&lt;0.05). It is noted that the use of this mixture allows to achieve positive dynamics of nutritional status in 27% of patients and in 73% of cases to completely eliminate it. The obtained results prove the expediency of additional use of "Nutrient-standard" mixture in the complex therapy of patients with hereditary pancreatic enzyme deficiency, cystic fibrosi