30 research outputs found
Baryons as non-topological chiral solitons
The present review gives a survey of recent developments and applications of
the Nambu--Jona-Lasinio model with and quark flavors for the
structure of baryons. The model is an effective chiral quark theory which
incorporates the SU(N)SU(N)U(1) approximate
symmetry of Quantum chromodynamics. The approach describes the spontaneous
chiral symmetry breaking and dynamical quark mass generation. Mesons appear as
quark-antiquark excitations and baryons arise as non-topological solitons with
three valence quarks and a polarized Dirac sea. For the evaluation of the
baryon properties the present review concentrates on the non-linear
Nambu--Jona-Lasinio model with quark and Goldstone degrees of freedom which is
identical to the Chiral quark soliton model obtained from the instanton liquid
model of the QCD vacuum. In this non-linear model, a wide variety of
observables of baryons of the octet and decuplet is considered. These include,
in particular, electromagnetic, axial, pseudoscalar and pion nucleon form
factors and the related static properties like magnetic moments, radii and
coupling constants of the nucleon as well as the mass splittings and
electromagnetic form factors of hyperons. Predictions are given for the strange
form factors, the scalar form factor and the tensor charge of the nucleon.Comment: 104 pages, 27 figures as uuencoded and compressed postscript files ,
hardcopy available upon request; Prog.Part.Nucl.Phys. 37 (1996) (in print
A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene
Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders
The Mitochondrial Lon protease, also called LonP1 is a product of the nuclear gene LONP1. Lon is a major regulator of mitochondrial metabolism and response to free radical damage, as well as an essential factor for the maintenance and repair of mitochondrial DNA. Lon is an ATP-stimulated protease that cycles between being bound (at the inner surface of the inner mitochondrial membrane) to the mitochondrial genome, and being released into the mitochondrial matrix where it can degrade matrix proteins. At least three different roles or functions have been ascribed to Lon: 1) Proteolytic digestion of oxidized proteins and the turnover of specific essential mitochondrial enzymes such as aconitase, TFAM, and StAR; 2) Mitochondrial (mt)DNA-binding protein, involved in mtDNA replication and mitogenesis; and 3) Protein chaperone, interacting with the Hsp60âmtHsp70 complex. LONP1 orthologs have been studied in bacteria, yeast, flies, worms, and mammals, evincing the widespread importance of the gene, as well as its remarkable evolutionary conservation. In recent years, we have witnessed a significant increase in knowledge regarding Lon's involvement in physiological functions, as well as in an expanding array of human disorders, including cancer, neurodegeneration, heart disease, and stroke. In addition, Lon appears to have a significant role in the aging process. A number of mitochondrial diseases have now been identified whose mechanisms involve various degrees of Lon dysfunction. In this paper we review current knowledge of Lon's function, under normal conditions, and we propose a new classification of human diseases characterized by a either over-expression or decline or loss of function of Lon. Lon has also been implicated in human aging, and we review the data currently available as well as speculating about possible interactions of aging and disease. Finally, we also discuss Lon as potential therapeutic target in human disease
Japanese bioanalytical method validation guideline: the world's first regulatory guideline dedicated to ligand-binding assays
Evaluation of adverse events focusing on infection associated with infliximab originator and biosimilar using a spontaneous reporting system database
A new enantiornithine bird from the Late Cretaceous of the Gobi Desert
We report on a new species of enantiornithine bird from the Late Cretaceous of the Mongolian Gobi Desert, which adds to the meager record of birds from the latest part of the Mesozoic in this region. The exceptional, three-dimensional bones of the new fossil increase the known anatomical diversity of enantiornithine birds, providing information about previously unreported morphologies such as a pneumatised furcula. Several synapomorphies nest the new bird within an enantiornithine clade of proficient fliers, but the anatomy and proportions of its flight apparatus imply significant aerodynamic restrictions. The combination of phylogeny and our functional interpretation suggests that this new fossil bird is a representative of a flightless lineage. This discovery thus provides the first evidence of a trend towards more limited flying capabilities among Enantiornithes, a group of Cretaceous birds otherwise believed to be represented by competent flier