From the Attic to the Cosmos: Myth in the Art of Anselm Kiefer 1973-2007

Anselm Kiefer was born in Germany, 1945—the year of Adolf Hitler’s suicide, and subsequently, the end of World War II. His own beginnings were shrouded by a national “repression” of history. This repression was at odds with Kiefer’s needs to establish his own origin. For this reason, the spirituality in his earlier work is often overshadowed by its subject—Nazi Germany. This thesis will look back on Kiefer’s work through the lens of mythology in an effort to re-evaluate his earlier art within the context of his works since 1990. From the 1970s to the present, Kiefer has drawn from mythology to find links between personal and universal human experience. We begin by examining Kiefer’s controversial Attic Paintings of 1973. In the Attic Paintings, German and Christian mythology helped Kiefer understand his origin as a post-war German artist. Kiefer then turned his attention to myths from outside cultures throughout the 1980s. We will look closely at three paintings from the 1980s that incorporate Greek, Judaic, and Egyptian mythology in an effort to understand Kiefer’s larger goals in broadening his mythological base. Following this discussion, we will examine two paintings from the 1990s and his 2007 permanent installation at the Louvre Museum. These selected works serve to illustrate how Kiefer presented his own cultivated, personal mythology under the stars in his still ongoing cosmic series. The 1990s mark Kiefer’s broadest expansion yet; in a sense, he went from “the attic to the universe” over the course of three decades

Parental investment and immune dynamics in sex-role reversed pipefishes

Parental care elevates reproductive success by allocating resources into the upbringing of the offspring. However, it also imposes strong costs for the care-giving parent and can foster sexual dimorphism. Trade-offs between the reproductive system and the immune system may result in differential immunological capacities between the care-providing and the non-care-providing parent. Usually, providing care is restricted to the female sex making it impossible to study a sex-independent influence of parental investment on sexual immune dimorphism. The decoupling of sex-dependent parental investment and their influences on the parental immunological capacity, however, is possible in syngnathids, which evolved the unique male pregnancy on a gradient ranging from a simple carrying of eggs on the trunk (Nerophinae, low paternal investment) to full internal pregnancy (Syngnathus, high paternal investment). In this study, we compared candidate gene expression between females and males of different gravity stages in three species of syngnathids (Syngnathus typhle, Syngnathus rostellatus and Nerophis ophidion) with different male pregnancy intensities to determine how parental investment influences sexual immune dimorphism. While our data failed to detect sexual immune dimorphism in the subset of candidate genes assessed, we show a parental care specific resource-allocation trade-off between investment into pregnancy and immune defense when parental care is provided

Parental investment matters for maternal and offspring immune defense in the mouthbrooding cichlid Astatotilapia burtoni

Background: Parental care, while increasing parental fitness through offspring survival, also bears cost to the care-giving parent. Consequentially, trade offs between parental care and other vitally important traits, such as the immune system seem evident. In co-occurring phases of parental care and immunological challenges negative consequences through a resource allocation trade off on both the parental and the offspring conditions can be predicted. While the immune system reflects parental stress conditions, parental immunological investments also boost offspring survival via the transfer of immunological substances (trans-generational immune priming). We investigated this relationship in the mouthbrooding East African cichlid Astotatilapia burtoni. Prior to mating, females were exposed to an immunological activation, while others remained immunologically naïve. Correspondingly, the immunological status of females was either examined directly after reproduction or after mouthbrooding had ceased. Offspring from both groups were exposed to immunological challenges to assess the extent of trans-generational immune priming. As proxy for immune status, cellular immunological activity and gene expression were determined. Results: Both reproducing and mouthbrooding females allocate their resources towards reproduction. While upon reproduction the innate immune system was impeded, mouthbrooding females showed an attenuation of inflammatory components. Juveniles from immune challenged mouthbrooding females showed downregulation of immune and life history candidate genes, implying a limitation of trans-generational plasticity when parents experience stress during the costly reproductive phase. Conclusion: Our results provide evidence that both parental investment via mouthbrooding and the rise of the immunological activity upon an immune challenge are costly traits. If applied simultaneously, not only mothers seem to be impacted in their performance, but also offspring are impeded in their ability to react upon a potentially virulent pathogen exposure

Different but the Same: Common Themes in Illness Experience Among People With Diverse Long COVID Symptoms and the Potential Benefits of Virtual Group Medical Visits

Long coronavirus disease 2019 (COVID-19) is poorly understood, widespread and debilitating. Integrative medical group visits (IMGVs) provide group medical care virtually or in person and are reimbursed by insurance payors. IMGV introduces integrative modalities such as mindfulness, nutrition, and acupressure in a person-centered, supportive, and educational environment. To evaluate a telehealth IMGV program called Nourish to Flourish (N2F) for patients with long COVID, three researchers conducted a qualitative analysis of pre- and post-group individual interviews. Twenty-five patients provided interviews, of which fifteen included pre- and post-group individual interviews. Main themes were unpredictable symptom patterns, a common range of emotions associated with long COVID experience, reconceptualizing self-identity, multiple barriers to care in conventional settings, and connections formed in N2F. Although symptoms varied, N2F participants found commonalities in their experiences of living with long COVID. They empathized with one another regarding changing symptoms, inconsistent social support, shifting identities, and barriers to effective medical care

Measuring social desirability amongst men with intellectual disabilities: The psychometric properties of the Self- and Other-Deception Questionnaire—Intellectual Disabilities

Background Social desirability has been construed as either inaccurately attributing positive characteristics to oneself (self-deception), or inaccurately denying that one possesses undesirable characteristics to others (other-deception or impression management). These conceptualisations of social desirability have not been considered in relation to people with intellectual disabilities (IDs), but they are important constructs to consider when undertaking a psychological assessment of an individual, especially within forensic contexts. Therefore, we revised two existing measures of self- and other-deception and considered their psychometric properties. Methods Thirty-two men with mild IDs and 28 men without IDs completed the Self- and Other-Deception Questionnaires—Intellectual Disabilities (SDQ-ID and ODQ-ID) on two occasions, two weeks apart. Results Men with IDs scored significantly higher on the SDQ-ID and the ODQ-ID than men without IDs. However, these differences disappeared when Full Scale IQ, Verbal IQ and Performance IQ were controlled in relation to the SDQ-ID, and partially disappeared in relation to the ODQ-ID. The SDQ-ID and the ODQ-ID had substantial internal consistency in relation to men with IDs (k = 0.82 and 0.84 respectively). The test-retest reliability of the SDQ-ID was good (ri = 0.68), while the test-retest reliability of the ODQ-ID was moderate (ri = 0.56), for men with IDs. The SDQ-ID had moderate (k = 0.60) and the ODQ-ID had substantial (k = 0.70) internal consistency in relation to men without IDs, while the test-retest reliability of the SDQ-ID was excellent (ri = 0.87) as was the case for the ODQ-ID (ri = 0.85). Conclusions The SDQ-ID and the ODQ-ID have satisfactory psychometric properties in relation to men with and without IDs. Future research using these instruments is propose

Development of chia plants in field conditions at different sowing-date

The objective of this study was to characterize the development of chia plants sown at different dates, and to determine the relation between the duration of the development cycle and the final number of leaves and the leaf appearance rate on the main stem. A field experiment was conducted in the agricultural year of 2016/2017 in five sowing dates (09/22/16, 10/28/16, 01/03/17, 02/08/17 and 03/24/17) in the edaphoclimatic conditions of the central region of the RS, Brazil. A randomized block design with four replicates was used. For each sowing date, the duration of the vegetative and reproductive phases in days and in °C day (Tb = 11 °C), the final number of leaves and the phyllochron of the main stem were determined. The duration of the vegetative phase of chia plants in days and in ºC day varies between the sowing dates, with shorter duration in late sowings in response to the photoperiod reduction. The vegetative phase represents the largest part of the total development cycle in early sowing dates, being overcome by the reproductive phase in late sowing dates (02/08/17 and 03/24/17). The phyllochron for chia varies from 36.23 (very late sowing) to 59.88 ºC day (early sowing). Later sowing has a smaller final number of leaves accumulated in the main stem due to the shorter duration of the vegetative phase.The objective of this study was to characterize the development of chia plants sown at different dates, and to determine the relation between the duration of the development cycle and the final number of leaves and the leaf appearance rate on the main stem. A field experiment was conducted in the agricultural year of 2016/2017 in five sowing dates (09/22/16, 10/28/16, 01/03/17, 02/08/17 and 03/24/17) in the edaphoclimatic conditions of the central region of the RS, Brazil. A randomized block design with four replicates was used. For each sowing date, the duration of the vegetative and reproductive phases in days and in °C day (Tb = 11 °C), the final number of leaves and the phyllochron of the main stem were determined. The duration of the vegetative phase of chia plants in days and in ºC day varies between the sowing dates, with shorter duration in late sowings in response to the photoperiod reduction. The vegetative phase represents the largest part of the total development cycle in early sowing dates, being overcome by the reproductive phase in late sowing dates (02/08/17 and 03/24/17). The phyllochron for chia varies from 36.23 (very late sowing) to 59.88 ºC day (early sowing). Later sowing has a smaller final number of leaves accumulated in the main stem due to the shorter duration of the vegetative phase

Study of Hillock and Zinc Whisker Evolution in Five Different Cable Tray Coatings

ABSTRACT: The main objective of this work is the study of the hillock and zinc whisker evolution of five different commercial zinc coatings applied on the same base steel wires of the patented EASYCONNECT system cable trays manufactured by VALDINOX Ltd.: white zinc alkaline electrolyte, yellow zinc trivalent electrolyte, acid zinc electrolyte, hot dip galvanized, and zinc nickel coating. The limited literature on the subject is summarized, and then the coating thickness, chemical composition, hardness and surface rugosity are characterized. The hillock and whisker density evolution are evaluated over a period of 12 months, considering the presence of compression bending stresses. It is concluded that the white alkaline and yellow trivalent coatings are the most affected, while the zinc-nickel shows the best behavior with no presence of whiskers; the acid zinc electrolyte also shows good results despite the delayed appearance of whiskers from the ninth month; the hot-dip galvanized coating does not show any presence of zinc whiskers or hillocks

Integrin control of the transforming growth factor-β pathway in glioblastoma

Transforming growth factor-β is a central mediator of the malignant phenotype of glioblastoma, the most common and malignant form of intrinsic brain tumours. Transforming growth factor-β promotes invasiveness and angiogenesis, maintains cancer cell stemness and induces profound immunosuppression in the host. Integrins regulate cellular adhesion and transmit signals important for cell survival, proliferation, differentiation and motility, and may be involved in the activation of transforming growth factor-β. We report that αvβ3, αvβ5 and αvβ8 integrins are broadly expressed not only in glioblastoma blood vessels but also in tumour cells. Exposure to αv, β3 or β5 neutralizing antibodies, RNA interference-mediated integrin gene silencing or pharmacological integrin inhibition using the cyclic RGD peptide EMD 121974 (cilengitide) results in reduced phosphorylation of Smad2 in most glioma cell lines, including glioma-initiating cell lines and reduced transforming growth factor-β-mediated reporter gene activity, coinciding with reduced transforming growth factor-β protein levels in the supernatant. Time course experiments indicated that the loss of transforming growth factor-β bioactivity due to integrin inhibition likely results from two distinct mechanisms: an early effect on activation of preformed inactive protein, and second, major effect on transforming growth factor-β gene transcription as confirmed by decreased activity of the transforming growth factor-β gene promoter and decreased transforming growth factor-β1 and transforming growth factor-β2 messenger RNA expression levels. In vivo, EMD 121974 (cilengitide), which is currently in late clinical development as an antiangiogenic agent in newly diagnosed glioblastoma, was a weak antagonist of pSmad2 phosphorylation. These results validate integrin inhibition as a promising strategy not only to inhibit angiogenesis, but also to block transforming growth factor-β-controlled features of malignancy including invasiveness, stemness and immunosuppression in human glioblastom