3,863 research outputs found
Biomarkers in Kidney Transplantation: Translating to clinical practice
Improving long-term graft survival is a major challenge in kidney transplantation. Ischaemia-reperfusion
injury is a critical early allograft insult that enhances the risk of delayed graft function, which is common
in deceased-donor transplantation. Delayed graft function complicates the post-transplant management and
has a negative impact on both short and long-term outcomes. The development of effective interventions
to prevent and attenuate the injury caused by ischaemia-reperfusion is constricted by the limited ability of
early detection of kidney damage. In recent years, clinical and translational research has focused on improvements
in the diagnosis of acute kidney injury and provided prognostic information that is helpful in the
post-transplant care. Numerous biomarkers in kidney transplantation have been evaluated in the past
decade, but, so far, evidence to support their use in routine practice is limited. The purpose of this review
is to examine the current status of three biomarkers for early diagnosis and prognosis of delayed graft
function, namely urinary neutrophil gelatinase-associated lipocalin, oxidative stress and cystatin C. In addition,
the concept of a biomarker is addressed, as well as the existing challenges and perspectives for
developing a biomarker. This review discusses current literature and reflects the author’s own interpretation
and experience
Philip Morris International, Inc. : equity valuation
This dissertation is focused on the equity valuation of Philip Morris International, Inc.,
the leading publicly traded tobacco company. In other words, the work done on this
paper aims at determining how much the company is worth given its current assets
and position in the market. Such analysis is of great importance for shareholders and
potential investors, since the market is not always able to reflect the assets’ true value.
Underlying this challenge is an overview of the main equity valuation methodologies
and theories, along with other aspects considered as essential in a valuation process.
In this context, three methodologies were considered suitable. However, the
conclusions were more influenced by the adjusted present value methodology. Philip
Morris Int’ is found to be undervalued with 28.32% upside potential, a BUY
recommendation. Finally, the methodologies used and results obtained were
contrasted to those of UBS Investment Bank, in their report published on April 19th
2012. For a more detailed overview of the dissertation main findings, read the
executive summary on appendix O
O encontro clÃnico [PolÃtica Nacional de Saúde Integral da População Negra]
Unidade 2 do curso Saúde da População Negra, contendo 3 atividades. Tem como objetivo atuar pela perspectiva do cuidado centrado na pessoa e na famÃlia, para implementação da PolÃtica Nacional de Saúde Integral da População Negra, promovendo o acesso ao SUS e o cuidado de saúde equânime e culturalmente pertinentes à s necessidades da população negra na relação profissional da saúde-paciente
Development and validation of a protocol to analyse in STAR Q Punch reference samples collected with a swab
Juntas de Acción Comunal: construcción de caminos hacia la sostenibilidad: análisis de caso
- …