PIONEERED: Elaborating the link between social and educational policies for tackling educational inequalities in Europe

Peer reviewe

Surgical management of giant uterine leiomyoma

George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures,The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020Background. Uterine leiomyoma is the most common benign tumor encountered in female genital pathology. It originates from the level of the smooth muscle tissue, and from the morphological point of view, the tumor is well delimited, being surrounded by a pseudocapsule. Etiology is represented by a factors such as, genetic predisposition, sexual steroids and a number of growth factors with role in the processes of angio- and fibrogenesis which are the basis of this pathology, being found in 40-50% of the cases at the age of over 35 years. Case report. `We present the case of a 46-year-old patient who, following a CT scan performed for diffuse abdominal pain and intestinal transit disorders, showed a dense bulky tumor formation, with multiple hyperdense inclusions inside and well-defined areas of necrosis, with maximum axial diameters of 133/168/249 mm (LL / AP / CC), having as a starting point most likely the uterine upper pole A total hysterectomy is performed, with bilateral anexectomy, and the histopathological examination describes a giant subserosal leiomyofibroma of the uterus with signs of hyaline degeneration, left hydrosalpinx with strong stasis of the left tube, follicular hemorrhagic cysts of the left ovary, vascular stasis of the right tube, corpus albicans, corpus fibrosum and hemorrhagic follicular cyst of the right ovary. The objective of this study is to present the surgical management of giant uterine leiomyoma. The patient shows a favorable postoperative evolution and is discharged on 5th day in good general health, hemodynamically and respiratory stable. Conclusions. The annual gynecological screening of female patients leads to the early detection of uterine leiomyomas that can be surgically treated by myomectomy which preserves fertility and avoiding total hysterectomy instead of choosing laparoscopic approach that reduces the days of hospitalization and postop complications

Prevalence, economic impact and therapeutic efficacy in acute infectious pododermatitis in sheep

This study assessed seasonal incidence, economic losses, the efficacy of therapeutic protocols, the recovery time of affected animals and specific prophylactic measures applied to sheep with acute infectious pododermatitis. The studies were conducted over a period of 12 months in 3 different sheep farms from private units in the same area. The results of the study showed an increased incidence of the disease in all 3 farms, with an average of 26.94% of the sheep flock. The incidence of the disease was increased in the months of April-May-June-July and September-October (30%), when there were heavy rains. The high morbidity led to economic losses through the decrease in milk production by approximately 30% and the decrease in the weight of the sheep by 10.58% (4.2 kg) of their normal weight. The therapeutic protocol applied locally as well as parenterally, combined with a foot bath with 10% zinc sulphate solution, were effective in treating acute infectious pododermatitis of sheep. The average recovery time (days) was approximately the same in the three groups of sheep (5.25 ± 0.68 days for cases with moderate diseases and 10.2 ± 0.22 for cases with severe diseases)

Структура летальности от рецидива туберкулеза легких

From the existent data about the mortality through recedived pulmonary tuberculosis there were analyzed specific particularities of these in 2015-2017. So, the mortality through tuberculosis recidived and its complications constitution 1,26%000 in 2015, 1,38%ооо in 2016 and 1,42%000 in 2017. The mortality determined by the respiratory localization of the tuberculosis is much bigger (99,6%) than the one determined by the extrarespiratory localization of the disease (0,4%). The majority of the deaths through tuberculosis are produced in the period of 31-65 years (87,2%). The peak of the mortality curbe at men is the situated at the group of people at the age of 51-65 years and at women — at the group of people at the age of 41-65 yearsDin datele existente privind mortalitatea prin tuberculoza pulmonară recidivată s-au analizat anumite particularităţi ale acesteia în perioada 2015-2017. Astfel, mortalitatea prin tuberculoza recidivată şi complicaţiile ei, a constituit 1,26%000 în 2015, 1,38%000 în 2016 şi 1,42%000 în 2017. Mortalitatea determinată de localizarea respiratorie a tuberculozei este mult mai înaltă (99,6%) decât cea cauzată de localizările extrarespiratorii ale bolii (0,4%). Majoritatea deceselor prin tuberculoza recidivată se produc în perioada de vârstă de 31-65 de ani (87,2%). Nivelul cel mai înalt al letalităţii la bărbaţi, cât şi la femei s-a înregistrat la grupa de vârstă de 41-65 de aniИсходя из имеющихся данных о смертности от рецидивирующего туберкулеза легких, были проанализированы отдельные его особенности в период 2015-2017 гг. Так, смертность от рецидива туберкулеза и его осложнений составила 1,26%000 в 2015 г., 1,38%000в 2016 г. и 1,42%000 в 2017 г. Смертность, обусловленная респираторной локализацией туберкулеза, намного выше (99,6%), чем смертность от туберкулеза. экстрареспираторные локализации заболевания (0,4%). Большинство случаев смерти от рецидивирующего туберкулеза происходит в возрасте от 31 до 65 лет (87,2%). Самый высокий уровень летальности как у мужчин, так и у женщин был зафиксирован в возрастной группе 41-65 ле

SEM and EDS comparative studies about the homogeneity of some cements used for luting of posts

Objectives. The aim of the study was to evaluate comparatively by scanning electron microscope (SEM) and energy dispersive spectrophotometry (EDS) the physical and chemical homogeneity of some luting materials used for cementation of three types of posts. Materials and method. We selected 12 irretrievable monoradicular teeth extracted in our dental offices. After extraction, all teeth were prepared for cementation with 4 different cements (NANOCORE DUAL, CEMBEST, PANAVIA SA and CEMENT-ONE) of three types of posts: prefabricated titanium post, FibreKleer 4x fiberglass post (Pentron) and post cast from NiCrMo alloy. Afterwards, the samples were embedded in resin and prepared metallographically for examination with the Phenom ProX scanning electron microscope equipped with an energy dispersive spectrophotometer with X Rays. Results. SEM studies provide valuable ultrastructural information regarding the degree of filling with luting materials. The four studied cements do not present an inhomogeneous composition in the EDS analysis, not having significantly increased values between the 2 analyzed points for each of the 12 samples taken in the study. Conclusions. Among the four luting materials studied comparatively, PANAVIA SA seems to best fill the existing spaces between posts and the limits of dental preparations, being closely followed by CEMENT-One and CEMBEST. In last place is NANOCORE DUAL, which presents discontinuities in the mass of material and at the border with the preparations

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era

The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034 cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier

LHCb upgrade software and computing : technical design report

This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages