СОВЕРШЕНСТВОВАНИЕ МЕТОДИКИ ВЫБОРА НАПРАВЛЕНИЯ ИННОВАЦИОННОГО РАЗВИТИЯ ПРЕДПРИЯТИЯ НА ОСНОВЕ АНАЛИЗА ПОКАЗАТЕЛЕЙ ФИНАНСОВОЙ И СТАТИСТИЧЕСКОЙ ОТЧЕТНОСТИ

An analysis of the indexes of the financial and innovation activity of industrial enterprises is given, six of them are identified. The methods of calculation of the indicators based on the financial and statistical reporting of enterprises is proposed. Practical testing of these methods is made by the example of Russian air entities. The appropriate recommendations for participation in the innovative activity are introduced.Представлен анализ показателей финансово-инновационной активности промышленных предприятий, из которых были выделены шесть основных. Предложена методика расчета показателей, основанная на финансовой и статистической отчетности предприятий. Произведена практическая апробация предлагаемой методики на примере российских предприятий авиационной отрасли, приведены соответствующие рекомендации по участию в инновационной деятельности

Comic Text as a Tool to Discredit Orthodoxy

Исследование выполнено в русле современного направления – лингвистика информационно-психологической войны, основной задачей которого является вскрытие в текстах смыслов, разрушающих национальные ценности. Православная вера, будучи одной из таких ценностей русского человека, занимает ведущую позицию в перечне мишеней информационного воздействия. В работе анализируется комический поликодовый текст стендап-комедии, способный эффективно влиять на сознание людей и выступать тем самым инструментом дискредитации Православия. Эмпирическим материалом явилась стендап-комедия А. Долгополова «Новый час шуток», где стратегия дискредитации Православия реализуется через тему «вера в Бога». Применение метода тематического расслоения позволило раскрыть систему образов персонажей с целью обнаружения содержательных компонентов (интродукция, портретная и речевая характеристика, авторское отношение), заложенных автором текста в эти образы. Выявленный спектр коммуникативных тактик и лингвопсихологических приемов программирования сознания дал возможность установить языковые средства достижения манипулятивного воздействия на аудиторию с целью формирования к Православию отрицательного отношения и отказу от православной веры. Результаты исследования могут быть применены в сфере обеспечения национальной безопасностиThe research is carried out in line with the modern direction – linguistics of information and psychological warfare with the main task to reveal the meanings in texts that destroy national values. The Orthodox faith, being one of such values of the Russian man, takes a leading position in the list of targets of information influence. The paper analyzes the comic polycode text of a stand-up comedy that can effectively influence people’s minds and act, thereby, as a tool to discredit Orthodoxy. The empiric material is A. Dolgopolov’s stand-up comedy “The New Hour of Jokes”, where the strategy of discrediting Orthodoxy is implemented through the theme “faith in God». The application of the thematic stratification method made it possible to reveal the system of characters’ images in order to discover the meaningful components (introduction, portrait and speech characteristics, author’s attitude) embedded in these images by the author of the text. The revealed spectrum of communicative tactics and linguistic-psychological techniques of programming the consciousness made it possible to establish the linguistic means of achieving manipulative impact on the audience in order to form a negative attitude towards Orthodoxy and rejection of the Orthodox faith. The results of the study can be applied in the field of national securit

People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population

There is a great deal of interest in fine scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to play a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. Here we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK control population that can be used as a resource by the research community as well as providing fine scale genetic information on the British population. So far, some 4,000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3,865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1,057 samples demonstrates the value of these samples for investigating fine scale population structure within the UK, and shows how this can be enhanced by the use of surnames

BSHI guideline: HLA matching and donor selection for haematopoietic progenitor cell transplantation

A review of the British Society for Histocompatibility and Immunogenetics (BSHI) Guideline ‘HLA matching and donor selection for haematopoietic progenitor cell transplantation’ published in 2016 was undertaken by a BSHI appointed writing committee. Literature searches were performed and the data extracted were presented as recommendations according to the GRADE nomenclature

Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations

Background: The genetic origins of Uralic speakers from across a vast territory in the temperate zone of North Eurasia have remained elusive. Previous studies have shown contrasting proportions of Eastern and Western Eurasian ancestry in their mitochondrial and Y chromosomal gene pools. While the maternal lineages reflect by and large the geographic background of a given Uralic-speaking population, the frequency of Y chromosomes of Eastern Eurasian origin is distinctively high among European Uralic speakers. The autosomal variation of Uralic speakers, however, has not yet been studied comprehensively.Results: Here, we present a genome-wide analysis of 15 Uralic-speaking populations which cover all main groups of the linguistic family. We show that contemporary Uralic speakers are genetically very similar to their local geographical neighbours. However, when studying relationships among geographically distant populations, we find that most of the Uralic speakers and some of their neighbours share a genetic component of possibly Siberian origin. Additionally, we show that most Uralic speakers share significantly more genomic segments identity-by-descent with each other than with geographically equidistant speakers of other languages. We find that correlated genome-wide genetic and lexical distances among Uralic speakers suggest co-dispersion of genes and languages. Yet, we do not find long-range genetic ties between Estonians and Hungarians with their linguistic sisters that would distinguish them from their non-Uralic-speaking neighbours.Conclusions: We show that most Uralic speakers share a distinct ancestry component of likely Siberian origin, which suggests that the spread of Uralic languages involved at least some demic component

Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations.

BACKGROUND: The genetic origins of Uralic speakers from across a vast territory in the temperate zone of North Eurasia have remained elusive. Previous studies have shown contrasting proportions of Eastern and Western Eurasian ancestry in their mitochondrial and Y chromosomal gene pools. While the maternal lineages reflect by and large the geographic background of a given Uralic-speaking population, the frequency of Y chromosomes of Eastern Eurasian origin is distinctively high among European Uralic speakers. The autosomal variation of Uralic speakers, however, has not yet been studied comprehensively. RESULTS: Here, we present a genome-wide analysis of 15 Uralic-speaking populations which cover all main groups of the linguistic family. We show that contemporary Uralic speakers are genetically very similar to their local geographical neighbours. However, when studying relationships among geographically distant populations, we find that most of the Uralic speakers and some of their neighbours share a genetic component of possibly Siberian origin. Additionally, we show that most Uralic speakers share significantly more genomic segments identity-by-descent with each other than with geographically equidistant speakers of other languages. We find that correlated genome-wide genetic and lexical distances among Uralic speakers suggest co-dispersion of genes and languages. Yet, we do not find long-range genetic ties between Estonians and Hungarians with their linguistic sisters that would distinguish them from their non-Uralic-speaking neighbours. CONCLUSIONS: We show that most Uralic speakers share a distinct ancestry component of likely Siberian origin, which suggests that the spread of Uralic languages involved at least some demic component

Genomic analyses inform on migration events during the peopling of Eurasia.

High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.Support was provided by: Estonian Research Infrastructure Roadmap grant no 3.2.0304.11-0312; Australian Research Council Discovery grants (DP110102635 and DP140101405) (D.M.L., M.W. and E.W.); Danish National Research Foundation; the Lundbeck Foundation and KU2016 (E.W.); ERC Starting Investigator grant (FP7 - 261213) (T.K.); Estonian Research Council grant PUT766 (G.C. and M.K.); EU European Regional Development Fund through the Centre of Excellence in Genomics to Estonian Biocentre (R.V.; M.Me. and A.Me.), and Centre of Excellence for Genomics and Translational Medicine Project No. 2014-2020.4.01.15-0012 to EGC of UT (A.Me.) and EBC (M.Me.); Estonian Institutional Research grant IUT24-1 (L.S., M.J., A.K., B.Y., K.T., C.B.M., Le.S., H.Sa., S.L., D.M.B., E.M., R.V., G.H., M.K., G.C., T.K. and M.Me.) and IUT20-60 (A.Me.); French Ministry of Foreign and European Affairs and French ANR grant number ANR-14-CE31-0013-01 (F.-X.R.); Gates Cambridge Trust Funding (E.J.); ICG SB RAS (No. VI.58.1.1) (D.V.L.); Leverhulme Programme grant no. RP2011-R-045 (A.B.M., P.G. and M.G.T.); Ministry of Education and Science of Russia; Project 6.656.2014/K (S.A.F.); NEFREX grant funded by the European Union (People Marie Curie Actions; International Research Staff Exchange Scheme; call FP7-PEOPLE-2012-IRSES-number 318979) (M.Me., G.H. and M.K.); NIH grants 5DP1ES022577 05, 1R01DK104339-01, and 1R01GM113657-01 (S.Tis.); Russian Foundation for Basic Research (grant N 14-06-00180a) (M.G.); Russian Foundation for Basic Research; grant 16-04-00890 (O.B. and E.B); Russian Science Foundation grant 14-14-00827 (O.B.); The Russian Foundation for Basic Research (14-04-00725-a), The Russian Humanitarian Scientific Foundation (13-11-02014) and the Program of the Basic Research of the RAS Presidium “Biological diversity” (E.K.K.); Wellcome Trust and Royal Society grant WT104125AIA & the Bristol Advanced Computing Research Centre (http://www.bris.ac.uk/acrc/) (D.J.L.); Wellcome Trust grant 098051 (Q.A.; C.T.-S. and Y.X.); Wellcome Trust Senior Research Fellowship grant 100719/Z/12/Z (M.G.T.); Young Explorers Grant from the National Geographic Society (8900-11) (C.A.E.); ERC Consolidator Grant 647787 ‘LocalAdaptatio’ (A.Ma.); Program of the RAS Presidium “Basic research for the development of the Russian Arctic” (B.M.); Russian Foundation for Basic Research grant 16-06-00303 (E.B.); a Rutherford Fellowship (RDF-10-MAU-001) from the Royal Society of New Zealand (M.P.C.)

The Concept of Stolby Nature Reserve in the Aspect of Linguoimageology

The article examines the concept of Stolby Nature Reserve in the aspect of the theory of linguoimageology, the tasks of which include the study and the development of technologies for creating the image of someone / something through the use of linguistic means that effectively influence the creation of a positive image of an object. The main purpose of this research is to model the image of a national park based on the exclusive properties of this object. In the course of the linguo-cognitive analysis of empirical material (publicistic texts about the reserve), the authors identified the components of the concept under study; built a frame-type model, providing for the conceptual, pragmatic and evaluative characteristics of the frame slots; determined the types of estimates that prevail in the texts about the reserve; found out the frequency of linguistic means – artistic tropes used for creating a positive image of the object under study. The identified components of the concept of Stolby Nature Reserve were used as the basis for a frame model, the creation of which made it possible to highlight the gaps in the texts about the reserve. The developed methodology can be applied to the analysis of the image component of other iconic regional sites. The study offers recommendations to improve the image of the nature reserve, which can be taken into account when creating new texts by the management of the reserve and travel agencie

IMPROVEMENT OF THE METHODS OF ROUTE SELECTION OF INNOVATIVE DEVELOPMENT OF AN ENTERPRISE ON THE BASIS OF THE ANALYSIS OF FINANCIAL AND STATISTICAL REPORTING

An analysis of the indexes of the financial and innovation activity of industrial enterprises is given, six of them are identified. The methods of calculation of the indicators based on the financial and statistical reporting of enterprises is proposed. Practical testing of these methods is made by the example of Russian air entities. The appropriate recommendations for participation in the innovative activity are introduced