Preferential Treatment Impacts Organizational Commitment: Evidence from Public Universities of Pakistan

Preferential treatment is detrimental. Keeping in view this important perspective, this study intends to capture the impact of preferential treatment via favoritism, nepotism, and cronyism on employee commitment in Public Universities of Pakistan. To seek the objectives of the study 400 questionnaires were distributed to employees of different Public Universities. The findings of the study revealed the negative impact of favoritism, nepotism, and cronyism on employees’ commitment. The results of the study confirmed the moderating role of LMX in the relation between favoritism-organizational commitment as well between nepotism-organizational commitment relation whereas, contrary to expectations LMX did not moderate the relation between cronyism and organizational commitment. Practical implications, limitations as well future directions are discusse

Assessment of Self-medication Practices During COVID-19 Pandemic in Hyderabad and Karachi, Pakistan

Background: Lack of appropriate treatment for COVID-19 infection led the general population of Pakistan toward self-medication and symptomatic treatment; almost 80% of the population collected medications for future use during pandemic. Thus, the current study aimed to assess the use of medication as symptomatic treatment preventive strategy. Methods: This descriptive cross–sectional study was conducted on a local population of Hyderabad and Karachi, Sindh, Pakistan. The study duration was six months (April– September 2020). A total of 698 responders were selected via random sampling method. The number of participants were recruited based on 95% confidence interval with 5% margin error. Data were transferred into analysis sheet descriptively. Results: Most participants responded to the use of different over-the-counter (OTC) products for headache. The use of antibiotics with prescription due to allergic conditions, cough, respiratory tract infections including sore throat, and urinary tract infections was also found among the majority. Few respondents had self-medication practice with sedatives due to difficulty in falling asleep, and 9.5% had self-medication practice due to pain. About 20.8% of the population agreed that lockdown was a contributing factor in the self-medication practice. Conclusion: Pharmacists and healthcare professionals are advised to counsel the general public regarding the use of medication. A close collaboration is required at this stage to fight against COVID-19 and preventing the situation from worsening. Keywords: self-medication, covid-19, Hyderabad, Karachi, Pakista

SOCIO- DEMOGRAPHIC AND DIETARY DETERMINANTS OF OVERWEIGHT AND OBESITY IN MALE PAKISTANI ADULTS

The aim of this study was to identify potential socio-demographic and dietary determinants of overweight and obesity in men to provide basis for effective prevention strategies. A stratified random sample of 897 men (aged >30 years and free from any chronic / congenital diseases) were selected for the study from Mardan city located in the North West of Pakistan. Height and weight of the subjects were measured using standard anthropometric methods; body mass index (BMI) was calculated. Data on dietary intake, overweight /obesity trend in the families, physical activity and socio-economic status were collected by interview. Pearson’s chi square statistic and chi square trend were used to determine the differences in prevalence of overweight and obesity between different groups. Multiple logistic regressions were used to identify potential socio-demographic and dietary factors associated with overweight / obesity. Using BMI, subjects were identified as normal (<25), overweight (25-29.9) and obese (≥30). Overall, prevalence of overweight and obesity was 33% and 9% respectively. There was an increasing trend in the prevalence of overweight and obesity with increasing age (OR: 1.15, 95% CI: 1.12-1.18). Among socio-economic factors; occupation, family history of overweight/obesity, monthly income and physical activity were found to be significant predictors of overweight/obesity in study subjects. In contrast to developed countries, increased income was associated with increased levels of overweight/obesity. Among dietary factors, daily energy intake and subjects’ preferences for fried meat and fatty foods were evident as significant correlates of overweight/obesity. Strong predictors of overweight and obesity included income level, physical inactivity and poor dietary preferences in the study population

Effectiveness of thrombolytic therapy in patients with acute myocardial infarction within 12 hours of symptoms

Background: Atherosclerotic coronary artery disease particularly myocardial infarction is the leading cause of morbidity and mortality all over the world and its incidence is also on the rise in Pakistan. This study was done to assess the effectiveness of thrombolytic therapy in patients with acute myocardial infarction and comparison between diabetics and non- diabetics.Methods: This cross sectional study was conducted at Department of Cardiology, Bahawal Victoria Hospital, Bahawalpur from January to June 2019. Total 380 patients of aged 30-70 years either male or female with diagnosis of acute ST-elevation myocardial infarction presenting within 12 hours of the onset of chest pain were selected. Patients were given thrombolytic therapy with Streptokinase 1.5 MIU over 1 hour and post therapy, efficacy was assessed.Results: Mean age of the patients was 51.37±10.08 years. Mean duration of diabetes mellitus was 5.99±3.47 years. Duration of chest pain ranged from 1 hour to 12 hours with mean duration of 4.66±2.98 hours. Out of 380 patients of MI, treatment was found effective in 202 (53.2%) patients. Female gender, type of MI, and duration of chest pain were significantly associated with reduced efficacy (p value 0.05) while patients having diabetes had significantly reduced efficacy (p value < 0.001).Conclusions: There is reduced effectiveness of thrombolytic therapy in diabetic patients with ST elevation myocardial infarction

Serological and Molecular Investigation of Brucella Species in Dogs in Pakistan

Brucellosis is an important bacterial zoonosis caused by B. abortus and B. melitensis in Pakistan. The status of canine brucellosis caused by B. canis remains obscure. In total, 181 serum samples were collected from stray and working dogs in two different prefectures viz. Faisalabad (n = 87) and Bahawalpur (n = 94). Presence of antibodies against B. canis and B. abortus/B. melitensis was determined using the slow agglutination test (SAT) and ELISA, respectively. Real-time PCR was performed to detect and differentiate Brucella DNA at the species level. In Faisalabad, the serological prevalence was found to be 9.2% (8/87) and 10.3% (9/87) by SAT and ELISA, respectively. Only one of the ELISA positive samples (1.15%) yielded amplification for B. abortus DNA. In Bahawalpur, 63.8% (60/94) samples were found positive by SAT; however, none of the samples was positive by ELISA or by real-time PCR. Location, age (≥1 year) and body condition (weak) were found to be associated with B. canis infection, whereas presence of wounds was found to be associated with B. abortus infection only. These findings point towards a risk of transmission from dog to livestock and humans and vice versa. The study expects to draw the attention of concerned authorities towards infection prevention and animal welfare. This study warrants further epidemiological investigation on brucellosis in pet dogs and their owners. To the best of our knowledge, this is first ever report on B. canis and B. abortus in dogs in Pakistan

Analysis of occludin trafficking, demonstrating continuous endocytosis, degradation, recycling and biosynthetic secretory trafficking

© 2014 Fletcher et al. Tight junctions (TJs) link adjacent cells and are critical for maintenance of apicalbasolateral polarity in epithelial monolayers. The TJ protein occludin functions in disparate processes, including wound healing and Hepatitis C Virus infection. Little is known about steady-state occludin trafficking into and out of the plasma membrane. Therefore, we determined the mechanisms responsible for occludin turnover in confluent Madin-Darby canine kidney (MDCK) epithelial monolayers. Using various biotin-based trafficking assays we observed continuous and rapid endocytosis of plasma membrane localised occludin (the majority internalised within 30 minutes). By 120 minutes a significant reduction in internalised occludin was observed. Inhibition of lysosomal function attenuated the reduction in occludin signal post-endocytosis and promoted co-localisation with the late endocytic system. Using a similar method we demonstrated that ∼20% of internalised occludin was transported back to the cell surface. Consistent with these findings, significant co-localisation between internalised occludin and recycling endosomal compartments was observed. We then quantified the extent to which occludin synthesis and transport to the plasma membrane contributes to plasma membrane occludin homeostasis, identifying inhibition of protein synthesis led to decreased plasma membrane localised occludin. Significant co-localisation between occludin and the biosynthetic secretory pathway was demonstrated. Thus, under steady-state conditions occludin undergoes turnover via a continuous cycle of endocytosis, recycling and degradation, with degradation compensated for by biosynthetic exocytic trafficking. We developed a mathematical model to describe the endocytosis, recycling and degradation of occludin, utilising experimental data to provide quantitative estimates for the rates of these processes

Leadership Characteristics and Quality Prevalence in Higher Education

The QUAL PRVLANC of advanced learning grounded on the policies made by the organization and leadership is considered significant for implementing these policies. The investigation was led to understand the association among governance features as well as QUAL PRVLANC in advanced learning. The characteristics includes the adoption of innovation, continuous observing of the surrounding, honesty to new thoughts, communiqué of the significance of applying new thoughts, the endowment of monetary capitals, and teaching and suitably satisfying the execution of new plans. The assessment technique was utilizing toward gather the information and questionnaire was the tool of research. Further, together descriptive plus inferential statistic techniques were utilized aimed at examining the information collected by the business schools. Moreover, study described that there is an optimistic association among the features of the governance of the professional colleges and receptiveness to QUAL PRVLANC

Evaluation of the effectiveness of English language teaching in English language institutes in Mardan

AbstractThe scope of English language is widening day by day. There are various English language institutes working in Mardan city. The aim of the present study was to evaluate the effectiveness of the course content, class activities and adopted teaching methods in these language institutes. For this purpose, we distributed questionnaires among 76 students of different language institutes seeking their perception regarding the courses. We came to know that the courses were least effective due to the teachers’ ineptness, their focusing more on the content than on the students’ needs, and because of the unavailability of the proper resources for effective language practices at the institutes. However, some of the students at these institutes were found quite satisfied with their improvement in accent and pronunciation. As a whole, the language institutes in Mardan need to do a thorough overhauling of their practices to help students’ achieve their language goals satisfactorily

Interventional Study on Adherence to Pharmacotherapy and Drug Pattern in Elderly Patients at Civil Hospital of Badin, Pakistan

Background: To assess the contributing factors to adherence of pharmacotherapy and perception of elderly patients. Methods: This prospective cross-sectional study was conducted in the outpatient clinic of Civil Hospital Badin, Pakistan from January to June 2019. A total of 300 samples were selected to analyze the results. A self-designed proforma (prescribing indicator form) was used for collecting data including patient demographics, diagnosis, and the current medications prescribed for each patient. Results: Of the 300 selected participants, 221(73.7%) were male, while 79 (26.3%) were female. Majority of the subjects in the age group of 60–69 (52%) and 70–79 years (27%) followed by those aged &gt;79 (21%). Antibiotics were prescribed to 17.2% and vitamins to 14.7%. Patients’ responses related to nonadherence factor were 92.7% for the cost, 32.7% for the long treatment duration, and 24% for the lack of knowledge. Out of the total patients, 28% were forgetful, 26.7% complained about complex therapy, 26.3% blamed financial problems, 19.7% patients had side effects, and 14.3% were negligent in taking the medication. Conclusion: Patient conformity can be enhanced by dropping polypharmacy and simplifying complex management, use of extended formulations, rate of medications, and by creating awareness among elderly patients. Keywords: elderly, polypharmacy, pharmacotherapy, adherenc