Harnessing genomics to improve health in the Eastern Mediterranean Region – an executive course in genomics policy

BACKGROUND: While innovations in medicine, science and technology have resulted in improved health and quality of life for many people, the benefits of modern medicine continue to elude millions of people in many parts of the world. To assess the potential of genomics to address health needs in EMR, the World Health Organization's Eastern Mediterranean Regional Office and the University of Toronto Joint Centre for Bioethics jointly organized a Genomics and Public Health Policy Executive Course, held September 20(th)–23(rd), 2003, in Muscat, Oman. The 4-day course was sponsored by WHO-EMRO with additional support from the Canadian Program in Genomics and Global Health. The overall objective of the course was to collectively explore how to best harness genomics to improve health in the region. This article presents the course findings and recommendations for genomics policy in EMR. METHODS: The course brought together senior representatives from academia, biotechnology companies, regulatory bodies, media, voluntary, and legal organizations to engage in discussion. Topics covered included scientific advances in genomics, followed by innovations in business models, public sector perspectives, ethics, legal issues and national innovation systems. RESULTS: A set of recommendations, summarized below, was formulated for the Regional Office, the Member States and for individuals. • Advocacy for genomics and biotechnology for political leadership; • Networking between member states to share information, expertise, training, and regional cooperation in biotechnology; coordination of national surveys for assessment of health biotechnology innovation systems, science capacity, government policies, legislation and regulations, intellectual property policies, private sector activity; • Creation in each member country of an effective National Body on genomics, biotechnology and health to: - formulate national biotechnology strategies - raise biotechnology awareness - encourage teaching and training of biotechnology - devise integration of biotechnology within national health systems. CONCLUSION: The recommendations provide the basis for a road map for EMR to take steps to harness biotechnology for better and more equitable health. As a result of these recommendations, health ministers from the region, at the 50th Regional Committee Meeting held in October 2003, have urged Member States to establish national bodies of biotechnology to formulate a strategic vision for developing biotechnology in the service of the region's health. These efforts promise to raise the profile of genomics in EMR and increase regional cooperation in this exciting new field

Introduction: is it possible to create pro-poor agriculture-related biotechnology?

Biotechnology represents hope for those who believe that new technology can contribute to overcoming a range of pressing productivity and environmental constraints facing poor farmers. Pouring money into the science and technology however without recognizing institutional and systemic complexities associated with creating 'pro-poor' technologies is unlikely to deliver much for those farmers. Moreover, there are a range of economic and political contextual factors which further complicate efforts to put the technology to use for poorer farmers. This article outlines some of the issues and possible new approaches which are discussed in more detail in later articles in this special issue. Copyright © 2005 John Wiley & Sons, Ltd.

Sources and implications of deep uncertainties surrounding sea-level projections

International audienceLong-term flood risk management often relies on future sea-level projections. Projected uncertainty ranges are however widely divergent as a result of different methodological choices. The IPCC has condensed this deep uncertainty into a single uncertainty range covering 66% probability or more. Alternatively, structured expert judgment summarizes divergent expert opinions in a single distribution. Recently published uncertainty ranges that are derived from these ``consensus'' assessments appear to differ by up to a factor four. This might result in overconfidence or overinvestment in strategies to cope with sea-level change. Here we explore possible reasons for these different interpretations. This is important for (i) the design of robust strategies and (ii) the exploration of pathways that may eventually lead to some kind of consensus distributions that are relatively straightforward to interpret