Calidad del agua residual urbana depurada para su uso en riego. Experimento de invernadero

El agua residual urbana depurada proveniente de la planta depuradora de argiva (Granada) puede ser utilizada, sin restricciones, para el riego de la mayoría de los cultivos, ya que su contenido en sales, elementos tóxicos y sólidos en suspensión es escaso. Su aporte, en un experimento de invernadero, ál sistema suelo-planta provocó un aumento de la conductivdad del extracto de saturación del suelo y de los niveles de Na y B en suelo y planta, aunque ellos no resultaron perjudiciales para un cultivo de tomate.Reclaimed municipal wastewater from the argiva treatment plant can be used, without restrictions, for agricultural irrigation, because of its low concentracion of salts, toxic elements and suspended solids. Its application to the soil-plant system in a greenhouse experiment increased electrical conductivity of the saturated extract of the soil, and levels of Na and B in soil anct plant However, no adverse effect was observed in a tomato crop

Calidad del agua residual urbana depurada para su uso en riego. Experimento de invernadero

Reclaimed municipal wastewater from the argiva treatment plant can be used, without restrictions, for agricultural irrigation, because of its low concentracion of salts, toxic elements and suspended solids. Its application to the soil-plant system in a greenhouse experiment increased electrical conductivity of the saturated extract of the soil, and levels of Na and B in soil anct plant. However, no adverse effect was observed in a tomato crop.El agua residual urbana depurada proveniente de la planta depuradora de Órgiva (Granada) puede ser utilizada, sin restricciones, para el riego de la mayoría de los cultivos, ya que su contenido en sales, elementos tóxicos y sólidos en suspensión es escaso. Su aporte, en un experimento de invernadero, al sistema suelo-planta provocó un aumento de la conductivdad del extracto de saturación del suelo y de los niveles de Na y B en suelo y planta, aunque ellos no resultaron perjudiciales para un cultivo de tomate

LOS PORIFEROS DE LA PROVINCIA DE ALICANTE (ESPANA)

A total of 36 species of Porifera have been found in some localities of the coast of Alicante, southeastem of Spain, from O to 50 m deep. Adreus fascicularis (Bowerbank, 1866) is new for the mediterranean coast, Samus anonyma Gray, 1867 for the Iberian Peninsula, and 24 of them for the Alicante province.Se han encontrado 36 especies de esponjas en muestreos realizados en la provincia de Alicante, sudeste de España. La axinélida Adreus fascicularis (Bowerbank, 1866) se cita por primera vez para el Mediterráneo y Samus anonyma Gray, 1867, es primera cita para la península ibérica

Portuguese Version of the Questionnaire About Interpersonal Difficulties for Adolescents: Reliability and Validity

[Resumen] El objetivo de este estudio fue validar la versión portuguesa del Cuestionario de Evaluación de Dificultades Interpersonales para Adolescentes (CEDIA) usando una muestra de 369 estudiantes de 12 a 18 años (51 % chicas; M = 14.50; SD = 1.60). El análisis factorial exploratorio de componentes principales y rotación oblimin, identificó 4 factores relacionados (Asertividad, Relaciones Familiares y Amigos, Relaciones Heterosexuales y Hablar en Público) que explicaron el 43.45 % de la varianza. En el análisis factorial confirmatorio se analizaron tres modelos predefinidos: el modelo nulo (M0), el modelo de un factor (M1) y el modelo de cuatro factores relacionados (M4). M4 fue el modelo que mejor se ajustó a los datos. La consistencia interna y la fiabilidad test-retest para la puntuación total del CEDIA fueron apropiadas. La correlación del CEDIA con la puntuación total del Inventario de Ansiedad Escolar (IAES) fue positiva y con un tamaño del efecto moderado. Este resultado fue similar para los tres sistemas de respuesta de ansiedad escolar medidos por el IAES y algo más variable para las cinco subescalas situacionales del IAES. Además, la correlación del CEDIA con la Social Anxiety Scale for Adolescents (SASA) fue positiva y pequeña para la subescala Aprensión y Miedo a la Evaluación Negativa (AFNE y moderada para la subescala Tensión e Inhibición en Situaciones Sociales (TISC). Finalmente, la correlación del CEDIA con el Internet Personality Inventory (IPI) fue positiva y moderada para la escala de Neuroticismo y negativa y pequeña para la escala Extraversión.[Abstract] The aim of this study was to translate and adapt the Portuguese version of the Questionnaire about Interpersonal Difficulties for Adolescents (QIDA) using a sample of 369 students aged 12 to 18 years (51 % girls; M = 14.50; SD = 1.60). The exploratory factor analysis of main components and oblimin rotation, identified four related factors (Assertiveness, Relations with family and friends, Heterosexual relationships and Public speaking) that explained 43.45 % of the variance. In the confirmatory factor analysis (CFA), three predefined models were analyzed: the null model (M0), the one-factor model (M1) and the four-factor model (M4). CFA showed that M4 fit the data best, and internal consistency and test-retest reliability for the total score of the QIDA were appropriate. The correlation of the QIDA with the total score of the School Anxiety Questionnaire (SAI) was positive and with a moderate effect size. This result was similar for the three school anxiety response systems measured by the SAI and slightly more variable for the five situational subscales of the SAI. In addition, the correlation of the QIDA with the Social Anxiety Scale for Adolescents (SASA) was positive and low with the Apprehension and Fear of Negative Evaluation subscale (AFNE) and moderate with the Tension and Inhibition in Social Situations subscale (TISC). Finally, the correlation of the QIDA with the Internet Personality Inventory (IPI) was positive and moderate for the Neuroticism scale, and negative and low with the Extraversion scale

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as evidenced by an increase in dendritic density of pyramidal neurons in organotypic hippocampal culture. The additional conjugation of the Angiopep-2 targeting moiety enhanced nanoconjugate passage through the blood-brain barrier and modulated brain distribution with nanoconjugate accumulation in neurogenic areas, including the olfactory bulb. Nanoconjugate treatment effectively reduced neurotoxic amyloid aggregate levels and rescued impairments to olfactory memory and object recognition in APP/PS1 transgenic AD model mice. Overall, this study provides a description of a targeted multimodal polyglutamate-based nanoconjugate with neuroprotective and neurotrophic potential for AD treatment. Copyrigh

Tobacco and alcohol consumption: academic goals, school self-concept and academic performance in portuguese adolescents

Introducción. La adolescencia incluye la búsqueda y adquisición de una identidad o la experimentación de nuevas sensaciones, incluyendo el consumo de drogas legales, como el alcohol y el tabaco. Objetivos. El objetivo principal de este estudio fue analizar si el consumo de alcohol y tabaco está relacionado con variables psicoeducativas (e.g., metas académicas, autoconcepto escolar y rendimiento académico). Método. Se usó un muestreo aleatorio de 1 197 alumnos/as pertenecientes a nueve centros escolares en Portugal. Resultados. Los resultados del presente estudio encontraron que las personas consumidoras de tabaco y alcohol presentan resultados significativamente más bajos en las variables psicoeducativas, en comparación con las personas no consumidoras. Cabe destacar que en el autoconcepto verbal no se encontraron diferencias entre personas consumidoras y no consumidoras en relación tanto con el alcohol como el tabaco. Conclusiones. Por tanto, es posible concluir que existe una relación entre el consumo de tabaco y alcohol y las variables psicoeducativas examinadas en este estudio en una muestra de adolescentes portugueses.Introduction. Adolescence is a phase of the human life cycle including the use of drugs such as alcohol and tobacco. Objectives. The main objective of this study was to analyze whether alcohol and tobacco use is related to psychoeducational variables (e.g., school goals, academic self-concept, and school performance). Method. A random sampling of 1 197 students selected from nine schools in Portugal was used. Results. The results of the present study found that tobacco and alcohol users had significantly lower scores on psychoeducational variables compared to non-users. It should be noted that in verbal self-concept no differences were found between users and non-users in relation to both alcohol and tobacco. Conclusions. For all these reasons, it can be established that there is a relationship between tobacco and alcohol consumption and the psychoeducational variables examined in this study of Portuguese adolescents

Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding

Evolution involves not only adaptation, but also the degradation of superfluous features. Many examples of degradation at the morphological level are known (vestigial organs, for instance). However, the impact of degradation on molecular evolution has been rarely addressed. Thioredoxins serve as general oxidoreductases in all cells. Here, we report extensive mutational analyses on the folding of modern and resurrected ancestral bacterial thioredoxins. Contrary to claims from recent literature, in vitro folding rates in the thioredoxin family are not evolutionarily conserved, but span at least a ∼100-fold range. Furthermore, modern thioredoxin folding is often substantially slower than ancestral thioredoxin folding. Unassisted folding, as probed in vitro, thus emerges as an ancestral vestigial feature that underwent degradation, plausibly upon the evolutionary emergence of efficient cellular folding assistance. More generally, our results provide evidence that degradation of ancestral features shapes, not only morphological evolution, but also the evolution of individual proteins.This research was supported by FEDER Funds, grant BIO2015-66426-R from the Spanish Ministry of Economy and Competitiveness ( J.M.S.-R.), grant RGP0041/2017 from the Human Frontier Science Program ( J.M.S.-R. and E.A.G.) and National Institutes of Health 1R01AR069137 (E.A.G.), Department of Defence MURI W911NF-16-1-0372 (E.A.G.)

Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary fibroblasts isolated from a patient with activated PI3 kinase delta syndrome (APDS2)

APDS2 is caused by mutations in PIK3R1 gene resulting in constitutive PI3Kδ activation. PI3Kδ is predominantly expressed in leukocytes and plays critical roles in regulating immune responses. Here we first derived fibroblast primary cells from a skin biopsy of a patient carrying a heterozygous single T deletion in intron 11 of the PIK3R1 gene. We next present the derivation of an induced pluripotent stem cell (iPS) line using a non-integrative reprogramming technology. Pluripotent-related hallmarks are further shown, including: iPSCs self-renewal and expression of pluripotent and differentiation markers after in vitro differentiation towards embryonic germ layers, assessed by RT-PCR and immunofluorescence

Relación entre el comportamiento de rechazo a la escuela y el funcionamiento social: un enfoque de análisis de clúster

On the basis of the heterogeneous casuistry that characterizes the students who refuse going to school, it is useful to have a classification of this population in homogeneous groups. For this, the aim of this study was, first, to identify by cluster analysis the profiles of school refusal behavior based on the functional model evaluated through the School Refusal Assessment Scale-Revised (SRAS-S). Secondly, it is intended to analyze if there are differences in social functioning scores according to the school refusal profiles identified. This study involved 1212 Spanish children between 8 and 11 years old (M=9.12, SD=1.05) who completed the SRAS-R to evaluate the school refusal behavior and the Child and Adolescent Social Adaptive Functioning Scale (CASAFS) to assess social functioning. Four profiles were identified: Non-school refusers, School refusers by mixed reinforcements, School refusers by tangible reinforcements and School refusers by negative reinforcements. The profile of Non-school refusers achieved the highest average scores in social functioning, while School refusers by mixed reinforcements group obtained the lowest average scores in social functioning. In general, the profiles found support the clusters identified in previous studies. The implications of social functioning on school refusal behavior are discussed.Partiendo de la heterogénea casuística que caracteriza a los estudiantes que rechazan la escuela, resulta útil disponer de una clasificación de esta población en conjuntos homogéneos. Para ello, el objetivo de este estudio fue, en primer lugar, identificar mediante análisis clúster los perfiles de estudiantes que rechazan la escuela en base al modelo funcional evaluado a través de la School Refusal Assessment Scale-Revised (SRAS-S). En segundo lugar, se pretende analizar si existen diferencias en las puntuaciones de funcionamiento social en función del perfil de estudiante que rechaza la escuela. En este estudio participaron 1212 niños españoles entre 8 y 11 años (M=9.12; DE=1.05) quienes cumplimentaron la SRAS-R para evaluar el rechazo escolar y la Child and Adolescent Social Adaptive Functioning Scale (CASAFS) para evaluar el funcionamiento social. Fueron cuatro los perfiles identificados: No rechazo escolar, Rechazo escolar por reforzamiento mixto, Rechazo escolar por refuerzos tangibles y Rechazo escolar por reforzamiento negativo. El perfil de No rechazo escolar alcanzó las puntuaciones medias más altas en funcionamiento social, mientras que el perfil de Rechazo escolar por reforzamiento mixto obtuvo las puntuaciones medias más bajas en funcionamiento social. En general, los perfiles hallados apoyan los clústeres identificados en estudios previos. Las implicaciones del funcionamiento social sobre el rechazo escolar se discuten