Hand rehabilitation with sonification techniques in the subacute stage of stroke

After a stroke event, most survivors suffer from arm paresis, poor motor control and other disabilities that make activities of daily living difficult, severely affecting quality of life and personal independence. This randomized controlled trial aimed at evaluating the efficacy of a music-based sonification approach on upper limbs motor functions, quality of life and pain perceived during rehabilitation. The study involved 65 subacute stroke individuals during inpatient rehabilitation allocated into 2 groups which underwent usual care dayweek) respectively of standard upper extremity motor rehabilitation or upper extremity treatment with sonification techniques. The Fugl-Meyer Upper Extremity Scale, Box and Block Test and the Modified Ashworth Scale were used to perform motor assessment and the McGill Quality of Life-it and the Numerical Pain Rating Scale to assess quality of life and pain. The assessment was performed at baseline, after 2 weeks, at the end of treatment and at follow-up (1 month after the end of treatment). Total scores of the Fugl-Meyer Upper Extremity Scale (primary outcome measure) and hand and wrist sub scores, manual dexterity scores of the affected and unaffected limb in the Box and Block Test, pain scores of the Numerical Pain Rating Scale (secondary outcomes measures) significantly improved in the sonification group compared to the standard of care group (time*group interaction < 0.05). Our findings suggest that music-based sonification sessions can be considered an effective standardized intervention for the upper limb in subacute stroke rehabilitation

Conventional and algorithmic music listening before radiotherapy treatment: A randomized controlled pilot study

Music listening is a widespread approach in the field of music therapy. In this study, the effects of music listening on anxiety and stress in patients undergoing radiotherapy are investigated. Sixty patients with breast cancer who were candidates for postoperative curative radiotherapy were recruited and randomly assigned to three groups: Melomics-Health (MH) group (music listening algorithmically created, n = 20); individualized music listening (IML) group (playlist of preferred music, n = 20); no music group (n = 20). Music listening was administered for 15 min immediately before simulation and during the first five radiotherapy sessions. The State-Trait Anxiety Inventory (STAI) and the Psychological Distress Inventory (PDI) were administered before/after treatment. Cochran’s Q test and McNemar test for paired proportions were performed to evaluate if the proportion of subjects having an outcome score below the critical value by treatment and over time was different, and if there was a change in that proportion. The MH group improved in STAI and PDI. The IML group worsened in STAI at T1 and improved STAI-Trait at T2. The IML group worsened in PDI at T2. The No music group generally improved in STAI and PDI. Clinical and music listening-related implications are discussed defining possible research perspectives in this field

First measurement of the 14N(p,gamma)15O cross section down to 70 keV

In stars with temperatures above 20*10^6 K, hydrogen burning is dominated by the CNO cycle. Its rate is determined by the slowest process, the 14N(p,gamma)15O reaction. Deep underground in Italy's Gran Sasso laboratory, at the LUNA 400 kV accelerator, the cross section of this reaction has been measured at energies much lower than ever achieved before. Using a windowless gas target and a 4pi BGO summing detector, direct cross section data has been obtained down to 70 keV, reaching a value of 0.24 picobarn. The Gamow peak has been covered by experimental data for several scenarios of stable and explosive hydrogen burning. In addition, the strength of the 259 keV resonance has been remeasured. The thermonuclear reaction rate has been calculated for temperatures 90 - 300 *10^6 K, for the first time with negligible impact from extrapolations

Feasibility of low energy radiative capture experiments at the LUNA underground accelerator facility

The LUNA (Laboratory Underground for Nuclear Astrophysics) facility has been designed to study nuclear reactions of astrophysical interest. It is located deep underground in the Gran Sasso National Laboratory, Italy. Two electrostatic accelerators, with 50 and 400 kV maximum voltage, in combination with solid and gas target setups allowed to measure the total cross sections of the radiative capture reactions $^2$H(p,$\gamma$)3He and $^{14}$N(p,$\gamma$)$^{15}$O within their relevant Gamow peaks. We report on the gamma background in the Gran Sasso laboratory measured by germanium and bismuth germanate detectors, with and without an incident proton beam. A method to localize the sources of beam induced background using the Doppler shift of emitted gamma rays is presented. The feasibility of radiative capture studies at energies of astrophysical interest is discussed for several experimental scenarios.Comment: Submitted to Eur. Phys. J.

EU-DEMO divertor: Cassette design and PFCs integration at pre-conceptual stage

The pre-conceptual design of the DEMO divertor cassette with a novelty, alternative path of the main cooling pipes inside cassette body is presented in this paper, focusing on cassette design and Plasma Facing Components (PFC) integration. The divertor cassette design is reviewed, considering recent updates in the DEMO configuration model as presented by the Programme Management Unit (PMU) in 2018. The new configuration requires the cooling pipes to be integrated inside the cassette body. The components affected by these changes and the impact on the divertor design are analyzed. The study focuses on a new integration system between cassette and cooling pipes. The paper describes the integration on the new cassette geometry and the divertor sub-systems. The design activities related to this system are discussed in detail in terms of CAD modeling and considerations with respect to manufacturing such as welding technologies and non-destructive testing

267 Occupation and Multiple Sclerosis: an Italian case-control study

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First Measurement of the He3+He3-->He4+2p Cross Section down to the Lower Edge of the Solar Gamow Peak

We give the LUNA results on the cross section measurement of a key reaction of the proton-proton chain strongly affecting the calculated neutrino luminosity from the Sun: He3+He3-->He4+2p. Due to the cosmic ray suppression provided by the Gran Sasso underground laboratory it has been possible to measure the cross section down to the lower edge of the solar Gamow peak, i.e. as low as 16.5 keV centre of mass energy. The data clearly show the cross section increase due to the electron screening effect but they do not exhibit any evidence for a narrow resonance suggested to explain the observed solar neutrino flux.Comment: 5 pages, RevTeX, and 2 figures in PostScript Submitted for publicatio