21,910 research outputs found
Lupus nephritis management guidelines compared
In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis. These guidelines are European, American and internationally based, with one separate guideline for children. They offer information on different aspects of the management of lupus nephritis including induction and maintenance treatment of the different histological classes, adjunctive treatment, monitoring of the patient, definitions of response and relapse, indications for (repeat) renal biopsy, and additional challenges such as the presence of vascular complications, the pregnant SLE patient, treatment in children and adolescents and considerations about end-stage renal disease and transplantation. In this review, we summarize the guidelines, determine the common ground between them, highlight the differences and discuss recent literature
Homological algebra for osp(1/2n)
We discuss several topics of homological algebra for the Lie superalgebra
osp(1|2n). First we focus on Bott-Kostant cohomology, which yields classical
results although the cohomology is not given by the kernel of the Kostant
quabla operator. Based on this cohomology we can derive strong
Bernstein-Gelfand-Gelfand resolutions for finite dimensional osp(1|2n)-modules.
Then we state the Bott-Borel-Weil theorem which follows immediately from the
Bott-Kostant cohomology by using the Peter-Weyl theorem for osp(1|2n). Finally
we calculate the projective dimension of irreducible and Verma modules in the
category O
Transcranial electric stimulation and neurocognitive training in clinically depressed patients: a pilot study of the effects on rumination
Order reduction approaches for the algebraic Riccati equation and the LQR problem
We explore order reduction techniques for solving the algebraic Riccati
equation (ARE), and investigating the numerical solution of the
linear-quadratic regulator problem (LQR). A classical approach is to build a
surrogate low dimensional model of the dynamical system, for instance by means
of balanced truncation, and then solve the corresponding ARE. Alternatively,
iterative methods can be used to directly solve the ARE and use its approximate
solution to estimate quantities associated with the LQR. We propose a class of
Petrov-Galerkin strategies that simultaneously reduce the dynamical system
while approximately solving the ARE by projection. This methodology
significantly generalizes a recently developed Galerkin method by using a pair
of projection spaces, as it is often done in model order reduction of dynamical
systems. Numerical experiments illustrate the advantages of the new class of
methods over classical approaches when dealing with large matrices
Early signatures of ozone trend reversal over the Antarctic
We report on a detailed time series analysis of long total column ozone (TO) records based on multi-satellite observations of daily resolution. We concentrate on three geographic latitudes over and around the Antarctic area, specifically on three circles at 58.5 degrees S, 59.5 degrees S, and 79.5 degrees S. Almost continuous observations are available at the two former latitudes; however, data are lacking during the polar winter periods at 79.5 degrees S, because the measurement technique requires sunlight. The methodology is motivated by level-crossing statistics, where subsets of the records above or below particular threshold levels are evaluated. Long-term trend reversal at around the turn of the century is already detectable for low TO levels in the raw time series in the "ozone-hole" region (79.5 degrees S). In order to overcome the apparent non-stationarities of the time series, we determined daily TO differences (Delta TO) belonging to the same geographic longitudes between the different latitudinal circles. The result is a stable, stationary behavior for small (absolute) Delta TO values in the period January-February-March without any significant detectable trends. The high absolute value Delta TO subsets (September-October-November) indicate a robust trend reversal in the middle of the 1990s. The observed trend reversal in the total column ozone time series is consistent with the temporal development of the stratospheric halogen loading. However, a close correspondence of ozone and halogen turnaround years is not expected because of the statistical uncertainties in the determination of the ozone turnaround, and the many factors contributing to ozone depletion processes
PULMONARY FUNCTION IN RHEUMATOID ARTHRITIS TREATED WITH LOW-DOSE METHOTREXATE: A LONGITUDINAL STUDY
Lung volumes and gas exchange were investigated prospectively in 96 patients with rheumatoid arthritis selected without regard to pulmonary disorders and treated with i.m. methotrexate (MTX) injections [mean weekly dose 13.0 mg (5th-95th percentile (5-95 PC) 7.6-20.8)]. Individual changes over time during MTX treatment [mean duration 2.9 yr (5-95 PC 0.4-5.3)] were assessed by regression analyses in each individual. Forced vital capacity (FVQ remained stable in the majority of patients [mean annual change +0.8% (5-95 PC −8.1 to +14.0) of calculated normal value]. In addition, transfer factor using the indicator gas CO (TLCO) was unaltered in most patients [mean annual change − 2.1% (5-95 PC −16.2 to +11.8) of predicted value]. However, there were significant decreases in the forced expiratory volume in 1 s (FEV1) before and after inhalation of 0.2 mg salbutamol [mean annual change - 0.8% (5-;95 PC −8.4 to +3.2) and −1.3% (5-95 PC −7.8 to +3.9) of the FVC measured, respectively]. In addition, there were significant increases in alveolar-arterial Po2, gradients (P(A-a), O2) at rest and after exercise [mean annual change +1.7 mmHg (5-;95 PC −5.2 to +12.2) and +1.8 mmHg (5-95 PC −3.5 to 9.0), respectively]. Nevertheless, the amounts were small in view of the reliability of the methods applied and reflect, at least in part, the normal process of ageing. The annual change in FEV1 /FVC was negatively correlated with FEV1 /FVC at baseline (Rs = − 0.46, P < 0.001). The annual change in TL, co was also negatively correlated with TL, co at baseline (Rs = − 0.31, P = 0.028). No other risk factors for deterioration of lung volumes or gas exchange were found, including mean weekly MTX dose, age, gender, smoking, presence of rheumatoid factor and pulmonary function at baseline. We conclude that MTX has no major effect on pulmonary function in the majority of patients and that there is no evidence that patients with pre-existing pulmonary disease are at increased risk for further deterioration of lung functio
Topical Hpmc/s-nitrosoglutathione Solution Decreases Inflammation And Bone Resorption In Experimental Periodontal Disease In Rats
Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico (CNPq)S-nitrosoglutathione (GSNO) is a nitric oxide (NO) donor, which exerts antioxidant, anti-inflammatory, and microbicidal actions. Intragingival application of GSNO was already shown to decrease alveolar bone loss, inflammation and oxidative stress in an experimental periodontal disease (EPD) model. In the present study, we evaluated the potential therapeutic effect of topical applications of hydroxypropylmethylcellulose (HPMC)/GSNO solutions on EPD in Wistar rats. EPD was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the animals, which received topical applications of a HPMC solutions containing GSNO 2 or 10 mM or vehicle (HPMC solution), 1 h prior to the placement of the ligature and then twice daily until sacrifice on day 11. Treatment with HPMC/ GSNO 10 mM solution significantly reduced alveolar bone loss, oxidative stress and TNF-alpha e IL-1 beta levels in the surrounding gingival tissue, and led to a decreased transcription of RANK and TNF-alpha genes and elevated bone alkaline phosphatase, compared to the HPMC group. In conclusion, topical application of HPMC/GSNO solution is a potential treatment to reduce inflammation and bone loss in periodontal disease.11National Council for Scientific and Technological Development - CNPq [478380/2011-9, 309390/2011-7]Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico (CNPq
Modulation of a surface plasmon-polariton resonance by sub-terahertz diffracted coherent phonons
Coherent sub-THz phonons incident on a gold grating that is deposited on a
dielectric substrate undergo diffraction and thereby induce an alteration of
the surface plasmon-polariton resonance. This results in efficient
high-frequency modulation (up to 110 GHz) of the structure's reflectivity for
visible light in the vicinity of the plasmon-polariton resonance. High
modulation efficiency is achieved by designing a periodic nanostructure which
provides both plasmon-polariton and phonon resonances. Our theoretical analysis
shows that the dynamical alteration of the plasmon-polariton resonance is
governed by modulation of the slit widths within the grating at the frequencies
of higher-order phonon resonances.Comment: 5 pages, 4 figure
Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization.
The human gut microbiota can restrict the growth of pathogens to prevent them from colonizing the intestine ('colonization resistance'). However, antibiotic treatment can kill members of the gut microbiota ('gut commensals') and reduce competition for nutrients, making these nutrients available to support the growth of pathogens. This disturbance can lead to the growth and expansion of pathogens within the intestine (including antibiotic-resistant pathogens), where these pathogens can exploit the absence of competitors and the nutrient-enriched gut environment. In this review, we discuss nutrient competition between the gut microbiota and pathogens. We also provide an overview of how nutrient competition can be harnessed to support the design of next-generation microbiome therapeutics to restrict the growth of pathogens and prevent the development of invasive infections
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