The Potential Role of Lipopeptide Biosurfactant Generated by Acinetobacter junii B6 on Leishmania Tropica: The Synergy of Lipopeptide Biosurfactant and Glucantime

An in vitro investigation was carried out to assess how the lipopeptide biosurfactant (LPB) produced by Acinetobacter junii B6 affects Leishmania tropica infection and the associated cytokine gene expression in macrophages infected with L. tropica. Glucantime® (meglumine antimoniate, MA) and LPB were investigated for their leishmanicidal effect, alone and in combination (LPB + MA), using a colorimetric test and a macrophage model. Immunomodulatory impact was also evaluated through analysis of Th1 and Th2 cytokine gene expression in infected macrophages after treatment with MA and LPB, individually and in combination. The MA/LPB combination showed higher inhibitory impacts on L. tropica amastigotes and promastigotes than each alone. Cytokine gene expression confirmed LPB’s affinity to IFN-γ, affirming the elevated IL-12p40 and IFN- γ concentrations in addition to a reduction in the secretion of IL-10 in a dose-dependent manner, particularly in combined treatment. The results indicated higher effectiveness of LPB along with MA in the reduction of the parasite growth and promoting the immune reaction level, which may be considered as a possible therapeutic strategy to treat those with anthroponotic cutaneous leishmaniasis

Public-Private-People Partnerships (4P) for Improving the Response to COVID-19 in Iran

Public-Private-People Partnership is a significant element in disaster response. COVID-19 as a pandemic has been the worst disaster in the last decades in Iran in terms of exposure and magnitude. In order to respond effectively, the Iranian government needs an extra capacity which may be provided by the private sector and people. This study aims to collect evidences of Public-Private-People partnerships pertaining to COVID-19 response in Iran from February to April 2020. Partnership case studies are classified into three categories as follows: 1) Public-private partnerships; 2) public-people partnerships; and 3) private-people partnerships. It was found that the Iranian government has removed or diminished some of the barriers to cooperation. There was also more cooperation between the people, the private sector, and the public sector than during normal times (vs disasters). People participated in the response procedure through some associations or groups, such as religious and ethnic communities, as well as through non-governmental organizations. It is showed that 4P is vital in disasters response and in particular to epidemics. The government can be more active in partnerships with private sector, and people in emergencies such as COVID-19 Pandemic. Enhancing social capital, institutionalization, and developing required infrastructures by the government will improve public-private partnerships

Web application security by SQL injection detection tools

SQL injection is a type of attack which the attacker adds Structured Query Language code to a web form input box to gain access or make changes to data. SQL injection vulnerability allows an attacker to flow commands directly to a web application's underlying database and destroy functionality or confidentiality. Researchers have proposed different tools to detect and prevent this vulnerability. In this paper we present all SQL injection attack types and also current tools which can detect or prevent these attacks. Finally we evaluate these tools

Comparative Study of Mystic Thoughts of Khajeh Ahmad Kasani in Naqshbandiah Dynasty

Khajeh Kasani is known to have been one of the influential figures in Naqshbandi school, who was influenced by the sages of this school in theoretical and practical mysticism. Explaining the principles of Khawjegan school, he enriched the nature of the school with his works and influenced the school with critical and enlightening views. This research aims to compare the formative principles of Naqshbandi Ahrari school with those of Khajeh Ahmad in a descriptive-analytical method relying on library resources and manuscripts. It is shown that the main doctrine of this school is based on attaining awareness and consciousness considered to be available in all eleven principles of this school. The principles of belief are consciousness at the moment, glance at paving, paving in the innateness, isolation in community, reminiscence, returning, maintenance, storing, numerical mastery, temporal mastery, and heartfelt mastery. Kasani explained seven principles of consciousness at the moment, glance at paving, paving in the innateness, isolation in community, reminiscence, returning, and maintenance, and regarded the four other principles dependent on those seven. Although Kasani described the teaching of Naghshbandi to express these seven principles, adhering to his predecessors, he made subtle differences in explaining these principles, the theme of which originates from his view on innate transference

Research Article Novel Security Conscious Evaluation Criteria for Web Service Composition

Abstract: This study aims to present a new mathematical based evaluation method for service composition with respects to security aspects. Web service composition as complex problem solver in service computing has become one of the recent challenging issues in today's web environment. It makes a new added value service through combination of available basic services to address the problem requirements. Despite the importance of service composition in service computing, security issues have not been addressed in this area. Considering the dazzling growth of number of service based transactions, making a secure composite service from candidate services with different security concerns is a demanding task. To deal with this challenge, different techniques have been employed which have direct impacts on secure service composition efficiency. Nonetheless, little work has been dedicated to deeply investigate those impacts on service composition outperformance. Therefore, the focus of this study is to evaluate the existing approaches based on their applied techniques and QoS aspects. A mathematicalbased security-aware evaluation framework is proposed wherein Analytic Hierarchy Process (AHP), a multiple criteria decision making technique, is adopted. The proposed framework is tested on state-of-the-art approaches and the statistical analysis of the results presents the efficiency and correctness of the proposed work

Recent Applications of Ultrasonic Waves in Improved Oil Recovery : A Review of Techniques and Results

Peer reviewedPostprin

Global, regional, and national burden of chronic kidney disease, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI

The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality

Background Most diarrhoeal deaths can be prevented through the prevention and treatment of dehydration. Oral rehydration solution (ORS) and recommended home fluids (RHFs) have been recommended since 1970s and 1980s to prevent and treat diarrhoeal dehydration. We sought to estimate the effects of these interventions on diarrhoea mortality in children aged <5 years

Environmental assessment schemes for non-domestic building refurbishment in the Malaysian context

The increase in global warming, energy consumption and greenhouse gas emissions has gained attention in various regions. In Malaysia, the government announced a voluntary commitment to reduce 40% of CO 2 emissions by 2020 and to refurbish 100 government buildings. Existing buildings make a large contribution to energy consumption and CO 2 emissions, therefore refurbishing existing buildings is an essential strategy to achieve the commitment. There is no single assessment scheme for building refurbishment in Malaysia and hence, this study aims to develop a comprehensive list of assessment themes and sub-themes for building refurbishment purposes. It examines and compares 10 assessment schemes from various countries: BREEAM, LEED, CASBEE, BEAM Plus, GBLS, Green Star, HQE, Green Mark, GBI and MyCrest. The findings revealed fourteen themes that were considered for assessment: management, sustainable site, transport, indoor environmental quality (IEQ), water, waste, material, energy, pollution, innovation, economic, social, culture and quality of services. Energy and IEQ are dominant themes in all assessment schemes. Most of the schemes are considered relatively weak in evaluating economic and social aspects, in comparison to environmental aspects. The assessment of quality of services is overlooked in most of the schemes, including GBI and MyCrest in Malaysia. Outcomes from this paper will form the baseline for a new environmental assessment scheme that aimed at non-domestic building refurbishments in Malaysia. A new model is proposed for the development of an environmental assessment scheme in the further stage