Recent advances in pharmaceutical sciences VII

The E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences. This seventh volume consists of nine chapters, mainly dealing with the fields of botany, physiology, food science, biochemistry & molecular biology, plant physiology, microbiology, parasitology, pharmacology, and medicinal chemistry

¿Existen diferencias en las cales apagadas por distintos métodos tradicionales?: la experiencia de Zone (BS)

Caracterización de muestras de cal apagadas por distintos métodos tradicionales, en una experiencia realizada en Zone (Brescia, Italia)Peer Reviewe

Addition of microencapsulated PCM into single layer mortar: physical and thermal properties and fire resistance

The energy consumption in buildings has increased in the last years due to the energy demand for thermal comfort. The improvement of thermal properties in building materials is one of the key points to achieve a reduction of the energy demand. Thermal energy storage (TES) is an alternative to save energy that has been investigated extensively in recent years. The addition of phase change materials (PCM) in a material increases its thermal inertia because PCM are able to store and release energy in sensible and latent heat. In this paper coatings used in the outer walls of buildings are studied, in particular single layer mortar. Microencapsulated paraffin PCM is added into the material to improve the thermal properties of the building envelope. The use of PCM combined with thermal insulation can reduce the energy consumption of buildings by absorbing heat gains and reducing the heat flow. Two types of single layer mortar Weber.Therm.Mineral commerzialized by Weber Saint Gobain incorporating different percentages of microencapsulated PCM type Micronal® DS5001 (20%, 10% and 0%) in their formulations are studied in this paper. The main objective of this work is to analyze the effect of PCM addition on the properties of two single layer mortars. Fresh mortar properties, as well as fire behavior, physical, mechanical and thermal properties of hardened mortar have been evaluated. The results show that physical and mechanical properties of single layer mortar are affected by the addition of microencapsulated PCM. Compressive strength decreases 60% with the addition of 20% of PCM in the formulation while the formulation with 10% of PCM has approximately the same compressive strength than a single layer mortar without PCM. The addition of PCM in the formulation decreases in 35% the adherence of the single layer mortar to a concrete surface. The presence of PCM in the mortar formulation worsens the fire behavior, due to the organic, and therefore flammable, composition of Micronal® DS5001. Flammability increases according to the percentage of PCM added. As a general conclusion, physical and mechanical properties of the single layer mortar become worse when the percentage of the added microencapsulated PCM is increased. Nevertheless, an improvement of thermal properties is expected and the quantification will be done that could justify the addition of PCM to some extent.Peer ReviewedPostprint (published version

Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research

Muscle loss alone, or in the context of sarcopenia or cachexia, is a prevalent condition and a predictor of negative outcomes in aging and disease. As adequate nutrition is essential for muscle maintenance, a growing number of studies has been conducted to explore the role of specific nutrients on muscle mass or function. Nonetheless, more research is needed to guide evidence-based recommendations. This scoping review aimed to compile and document ongoing clinical trials investigating nutrition interventions as a strategy to prevent or treat low muscle mass or function (strength and physical performance), sarcopenia, or cachexia. ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform were searched up to 21 April 2021 for planned and ongoing trials. Randomized controlled trials with ≥20 participants per arm were included based on intent to explore the effects of nutrition interventions on muscle-related outcomes (i.e. muscle mass or strength, physical performance, or muscle synthesis rate) in both clinical and non-clinical conditions (i.e. aging). Two reviewers independently screened records for eligibility, and a descriptive synthesis of trials characteristics was conducted. A total of 113 trials were included in the review. Most trials (69.0%) enroll adults with clinical conditions, such as cancer (19.5%), obesity and metabolic diseases (16.8%), and musculoskeletal diseases (10.7%). The effects of nutrition interventions on age-related muscle loss are explored in 31% of trials. Although nutrition interventions of varied types were identified, food supplements alone (48.7%) or combined with dietary advice (11.5%) are most frequently reported. Protein (17.7%), amino acids (10.6%), and β-hydroxy-β-methylbutyrate (HMB, 6.2%) are the top three food supplements' nutrients under investigation. Primary outcome of most trials (54.9%) consists of measures of muscle mass alone or in combination with muscle strength and/or performance (as either primary or secondary outcomes). Muscle strength and physical performance are primary outcomes of 38% and 31.9% of the trials, respectively. These measurements were obtained using a variety of techniques. Only a few trials evaluate muscle synthesis rate either as a primary or secondary outcome (5.3%). Several nutrition studies focusing on muscle, sarcopenia, and cachexia are underway and can inform future research in this area. Although many trials have similar type of interventions, methodological heterogeneity may challenge study comparisons, and future meta-analyses aiming to provide evidence-based recommendations. Upcoming research in this area may benefit from guidelines for the assessment of therapeutic effects of nutrition interventions

Single layer mortars with microencapsulated PCM: study of physical and thermal properties, and fire behaviour

tPhase change materials are a promising strategy to reduce energy consumption in a wide range of appli-cations including the building sector. Many studies have been done to evaluate the impact of PCM onthermal properties of building materials, however there exists little information on the influence ofPCM on other properties of the support materials. This knowledge is necessary to determine the fea-sibility to apply and use building materials containing PCM. In this paper, the effect of the addition ofdifferent percentages of microencapsulated phase change material on the properties of two commercialsingle layer mortars has been studied. Physical and thermal properties as well as fire reaction have beenevaluated.Peer ReviewedPostprint (author's final draft

Liderazgo, factores de riesgo psicosocial y estrés en la Dirección de Tránsito y Movilidad en Zapotlán el Grande, Jalisco

Objetivo: El presente trabajo se centra en evaluar algunos factores de riesgo psicosocial como son, organización del tiempo de trabajo, liderazgo y relación, ambiente de trabajo y factores propios de la actividad, así como el estrés y el liderazgo en trabajadores de la Dirección de Tránsito y Movilidad de Zapotlán el Grande. Métodos: Se aplicaron los instrumentos de factores de riesgo de la Norma 035 de México, el cuestionario de liderazgo (MQL) y el cuestionario de estrés de la Organización Internacional del Trabajo y la Organización Mundial para la Salud. Resultados: El nivel de estrés encontrado fue de M = 51.09 (D.E. = 20.97) y el nivel de factores de riesgo psicosociales fue de M = 66.19 (D.E. = 15.53) puntos. El estrés se encontró relacionado con la escala global de factores de riesgo (r = 0.422; p < 0.01). El liderazgo transformacional se correlacionó de manera inversa con factores de riesgo psicosocial (r = -0.642; p < 0.01). Conclusiones: Se encontraron niveles de estrés que pueden no ser dañinos y factores de riesgo propios de la actividad elevados. Los factores de riesgo de ambiente de trabajo, jornada de trabajo, interferencia familia-trabajo y violencia se correlación con el estrés. El liderazgo presentó una correlación inversa con factores de riesgo. Se recomienda realizar una intervención en la población con el fin de brindar un apoyo psicológico, emocional y consejería, con el fin de evitar el estrés y disminuir los factores de riesgo presentes en el trabajo

La incidencia del contexto en los discursos

Este volumen recoge diversos trabajos que abordan el estudio de la influencia del contexto en los discursos desde diversas perspectivas (sociolingüística, biolingüística, lingüística clínica, etc.) y en diferentes ámbitos comunicativos (conversación afásica, comunicación publicitaria, comunicación virtual, etc.)This book includes several works where the incidence of context into discourse is analyzed from diferent points of view (sociolinguistics, biolinguistics, clinical linguistics, …) and in diferents communicative frames (aphasic conversation, advertising communication, cybernetic communication, …

PHYLOPYR: The genetic information of Pyrenean plants accessible to society

Póster presentado en el IV Simposio Anual de la Sociedad Española de Botánica, Universidad de León, 17-18 de noviembre de 202

Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib

The most frequent BCR-ABL1-p210 transcripts in chronic myeloid leukemia (CML) are e14a2 and e13a2. Imatinib (IM) is the most common first-line tyrosine-kinase inhibitor (TKI) used to treat CML. Some studies suggest that BCR-ABL1 transcript types confer different responses to IM. The objective of this study was to correlate the expression of e14a2 or e13a2 to clinical characteristics, cumulative cytogenetic and molecular responses to IM, acquisition of deep molecular response (DMR) and its duration (sDMR), progression rate (CIP), overall survival (OS), and treatment-free remission (TFR) rate. We studied 202 CML patients, 76 expressing the e13a2 and 126 the e14a2, and correlated the differential transcript expression with the above-mentioned parameters. There were no differences in the cumulative incidence of cytogenetic responses nor in the acquisition of DMR and sDMR between the two groups, but the e14a2 transcript had a positive impact on molecular response during the first 6 months, whereas the e13a2 was associated with improved long-term OS. No correlation was observed between the transcript type and TFR rate

Medios de comunicación y derecho a la información en Jalisco, 2015

El octavo informe Q ITESO: Análisis Crítico de Medios revisa el funcionamiento del sistema de comunicación política durante el proceso electoral de 2015, así como diversos aspectos relevantes de unas elecciones que culminaron con un cambio radical en el panorama político en Jalisco. En el universo de los medios de comunicación, se analizan los cambios experimentados por estos en el marco de la coyuntura electoral local, la equidad y profundidad en la cobertura por parte de los periódicos y la difusión que hicieron de las encuestas, así como el discurso e impacto de la propaganda difundida a través de la televisión y la Internet, a lo que se suma los debates registrados en redes sociales como Twitter, y la percepción sobre las campañas por parte de la audiencia tapatía. El examen político se enfoca en la campaña realizada por los candidatos independientes, el planteamiento socioeconómico de los contendientes por la capital del estado y el impacto electoral de un personaje incómodo como el papá del gobernador, para culminar este informe con una reflexión general y un balance de quiénes perdieron y quiénes ganaron al término de las elecciones de 2015.ITESO, A.C