Efectos de un programa de actividad física vigorosa en la tensión arterial y frecuencia cardiaca de escolares de 8-9 años

Nowadays, research aimed at improving the cardiovascular health of people is of the utmost importance. Objective: This paper focuses on studying the effects of a vigorous-intensity physical activity program on the blood pressure (BP) and heart rate (HR) of a group of school children. Methods: This investigation involved 41 children (19 boys and 22 girls), aged between 8 and 9 years (average age=8.49 and standard deviation=0.51). The variables considered were: blood pressure (systolic and diastolic) and resting heart rate. Blood pressure and heart rate were measured by arm sphygmomanometer Visomat Comfort 20/40. The procedure was as follows: pre-test, intervention and post-test. The intervention consisted of 3 days per week of high-intensity physical activity, 15 minutes per day, during 12 weeks. Results: Data analysis was performed through SPSS 22 and significant improvements were obtained in systolic blood pressure and heart rate (Sig p < 0.05). Conclusions: The physical activity program implemented in this study may be useful to improve systolic blood pressure and heart rate in 8- and 9-year-old school children.En la actualidad, las investigaciones encaminadas a mejorar la salud cardiovascular de las personas son de suma importancia. Objetivo: Este artículo se centra en estudiar los efectos de un programa de actividad física sobre la tensión arterial (TA) y frecuencia cardiaca (FC) de un grupo de escolares. Métodos: Participaron 41 escolares (19 niños y 22 niñas), entre los 8 y los 9 años de edad (media de edad 8,49 y DE 0,51). Las variables estudiadas fueron: tensión arterial (sistólica y diastólica) y frecuencia cardiaca en reposo. La tensión arterial y la frecuencia cardiaca se midieron con el tensiómetro de brazo Visomat Comfort 20/40. El procedimiento ha sido: pre-test, intervención y pos-test. La intervención ha consistido en 3 días a la semana de actividad física de alta intensidad, 15 minutos al día, durante 12 semanas. Resultados: Se ha realizado un análisis de datos por medio del SPSS 22 y se han obtenido mejoras significativas en la tensión arterial sistólica y la frecuencia cardiaca (Sig. p < 0.05). Conclusiones: El programa de actividad física empleado en este estudio puede ser de utilidad para mejorar la tensión arterial sistólica y la frecuencia cardiaca de escolares de 8-9 años

Numerical approximations of second-order matrix differential equations using higher-degree splines

Many studies of mechanical systems in engineering are based on second-order matrix models. This work discusses the second-order generalization of previous research on matrix differential equations dealing with the construction of approximate solutions for non-stiff initial problems Y 00(x) = f(x, Y (x), Y 0 (x)) using higher-degree matrix splines without any dimensional increase. An estimation of the approximation error for some illustrative examples are presented by using Mathematica. Several MatLab functions have also been developed, comparing, under equal conditions, accuracy and execution times with built-in MatLab functions. Experimental results show the advantages of solving the above initial problem by using the implemented MatLab functions.The authors wish to thank for financial support by the Universidad Politecnica de Valencia [grant number PAID-06-11-2020].Defez Candel, E.; Tung ., MM.; Solis Lozano, FJ.; Ibáñez González, JJ. (2015). Numerical approximations of second-order matrix differential equations using higher-degree splines. Linear and Multilinear Algebra. 63(3):472-489. https://doi.org/10.1080/03081087.2013.873427S472489633Loscalzo, F. R., & Talbot, T. D. (1967). Spline Function Approximations for Solutions of Ordinary Differential Equations. SIAM Journal on Numerical Analysis, 4(3), 433-445. doi:10.1137/0704038Al-Said, E. A. (2001). The use of cubic splines in the numerical solution of a system of second-order boundary value problems. Computers & Mathematics with Applications, 42(6-7), 861-869. doi:10.1016/s0898-1221(01)00204-8Al-Said, E. A., & Noor, M. A. (2003). Cubic splines method for a system of third-order boundary value problems. Applied Mathematics and Computation, 142(2-3), 195-204. doi:10.1016/s0096-3003(02)00294-1Kadalbajoo, M. K., & Patidar, K. C. (2002). Numerical solution of singularly perturbed two-point boundary value problems by spline in tension. Applied Mathematics and Computation, 131(2-3), 299-320. doi:10.1016/s0096-3003(01)00146-1Micula, G., & Revnic, A. (2000). An implicit numerical spline method for systems for ODEs. Applied Mathematics and Computation, 111(1), 121-132. doi:10.1016/s0096-3003(98)10111-xDefez, E., Soler, L., Hervás, A., & Santamaría, C. (2005). Numerical solution ofmatrix differential models using cubic matrix splines. Computers & Mathematics with Applications, 50(5-6), 693-699. doi:10.1016/j.camwa.2005.04.012Defez, E., Hervás, A., Soler, L., & Tung, M. M. (2007). Numerical solutions of matrix differential models using cubic matrix splines II. Mathematical and Computer Modelling, 46(5-6), 657-669. doi:10.1016/j.mcm.2006.11.027Ascher, U., Pruess, S., & Russell, R. D. (1983). On Spline Basis Selection for Solving Differential Equations. SIAM Journal on Numerical Analysis, 20(1), 121-142. doi:10.1137/0720009Brunner, H. (2004). On the Divergence of Collocation Solutions in Smooth Piecewise Polynomial Spaces for Volterra Integral Equations. BIT Numerical Mathematics, 44(4), 631-650. doi:10.1007/s10543-004-3828-5Tung, M. M., Defez, E., & Sastre, J. (2008). Numerical solutions of second-order matrix models using cubic-matrix splines. Computers & Mathematics with Applications, 56(10), 2561-2571. doi:10.1016/j.camwa.2008.05.022Defez, E., Tung, M. M., Ibáñez, J. J., & Sastre, J. (2012). Approximating and computing nonlinear matrix differential models. Mathematical and Computer Modelling, 55(7-8), 2012-2022. doi:10.1016/j.mcm.2011.11.060Claeyssen, J. R., Canahualpa, G., & Jung, C. (1999). A direct approach to second-order matrix non-classical vibrating equations. Applied Numerical Mathematics, 30(1), 65-78. doi:10.1016/s0168-9274(98)00085-3Froese, C. (1963). NUMERICAL SOLUTION OF THE HARTREE–FOCK EQUATIONS. Canadian Journal of Physics, 41(11), 1895-1910. doi:10.1139/p63-189Marzulli, P. (1991). Global error estimates for the standard parallel shooting method. Journal of Computational and Applied Mathematics, 34(2), 233-241. doi:10.1016/0377-0427(91)90045-lShore, B. W. (1973). Comparison of matrix methods applied to the radial Schrödinger eigenvalue equation: The Morse potential. The Journal of Chemical Physics, 59(12), 6450-6463. doi:10.1063/1.1680025ZHANG, J. F. (2002). OPTIMAL CONTROL FOR MECHANICAL VIBRATION SYSTEMS BASED ON SECOND-ORDER MATRIX EQUATIONS. Mechanical Systems and Signal Processing, 16(1), 61-67. doi:10.1006/mssp.2001.1441Flett, T. M. (1980). Differential Analysis. doi:10.1017/cbo978051189719

Superficial radiotherapy as haemostatic treatment in breast cancer

Poster Session [EP-1661] Purpose or Objective Breast cancer is a common pathology in which o = 25% in tumor size and absence of bleeding was observed. Conclusion Surface radiotherapy is a treatment modality that should be taken into account in patients with breast cancer who present bleeding as a consequence of local tumor growth, given that this is a treatment comfortable for the patient, non invasive and increases the quality of patient’s life

Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk.

PURPOSE: To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). METHODS: We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. RESULTS: Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). CONCLUSIONS: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. TRIAL REGISTRATION NUMBER: ISRCTN89898870 (Data of registration: 2014)

Opposite cannabis-cognition associations in psychotic patients depending on family history

The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis

Bright light therapy versus physical exercise to prevent co-morbid depression and obesity in adolescents and young adults with attention-deficit/hyperactivity disorder: study protocol for a randomized controlled trial

Background: The risk for major depression and obesity is increased in adolescents and adults with attention-deficit / hyperactivity disorder (ADHD) and adolescent ADHD predicts adult depression and obesity. Non-pharmacological interventions to treat and prevent these co-morbidities are urgently needed. Bright light therapy (BLT) improves day– night rhythm and is an emerging therapy for major depression. Exercise intervention (EI) reduces obesity and improves depressive symptoms. To date, no randomized controlled trial (RCT) has been performed to establish feasibility and efficacy of these interventions targeting the prevention of co-morbid depression and obesity in ADHD. We hypothesize that the two manualized interventions in combination with mobile health-based monitoring and reinforcement will result in less depressive symptoms and obesity compared to treatment as usual in adolescents and young adults with ADHD. Methods: This trial is a prospective, pilot phase-IIa, parallel-group RCT with three arms (two add-on treatment groups [BLT, EI] and one treatment as usual [TAU] control group). The primary outcome variable is change in the Inventory of Depressive Symptomatology total score (observer-blinded assessment) between baseline and ten weeks of intervention. This variable is analyzed with a mixed model for repeated measures approach investigating the treatment effect with respect to all three groups. A total of 330 participants with ADHD, aged 14 – < 30 years, will be screened at the four study centers. To establish effect sizes, the sample size was planned at the liberal significance level of α = 0.10 (two-sided) and the power of 1-β = 80% in order to find medium effects. Secondary outcomes measures including change in obesity, ADHD symptoms, general psychopathology, health-related quality of life, neurocognitive function, chronotype, and physical fitness are explored after the end of the intervention and at the 12-week follow-up. This is the first pilot RCT on the use of BLT and EI in combination with mobile health-based monitoring and reinforcement targeting the prevention of co-morbid depression and obesity in adolescents and young adults with ADHD. If at least medium effects can be established with regard to the prevention of depressive symptoms and obesity, a larger scale confirmatory phase-III trial may be warranted.The trial is funded by the EU Framework Programme for Research and Innovation, Horizon 2020 (Project no. 667302). Funding period: January 2016–December 2020. This funding source had no role in the design of this study and will not have any role during its execution, analyses, interpretation of the data, or decision to submit results. Some local funds additionally contributed to carry out this study, especially for the preparation of the interventions: FBO research activity is by the Spanish Ministry of Economy and Competitiveness – MINECO (RYC-2011-09011) and by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Unit of Excellence on Exercise and Health (UCEES)

Selective Serotonin Reuptake Inhibitors and Gastrointestinal Bleeding: A Case-Control Study

BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) have been associated with upper gastrointestinal (GI) bleeding. Given their worldwide use, even small risks account for a large number of cases. This study has been conducted with carefully collected information to further investigate the relationship between SSRIs and upper GI bleeding. METHODS: We conducted a case-control study in hospitals in Spain and in Italy. Cases were patients aged ≥18 years with a primary diagnosis of acute upper GI bleeding diagnosed by endoscopy; three controls were matched by sex, age, date of admission (within 3 months) and hospital among patients who were admitted for elective surgery for non-painful disorders. Exposures to SSRIs, other antidepressants and other drugs were defined as any use of these drugs in the 7 days before the day on which upper gastrointestinal bleeding started (index day). RESULTS: 581 cases of upper GI bleeding and 1358 controls were considered eligible for the study; no differences in age or sex distribution were observed between cases and controls after matching. Overall, 4.0% of the cases and 3.3% of controls used an SSRI antidepressant in the week before the index day. No significant risk of upper GI bleeding was encountered for SSRI antidepressants (adjusted odds ratio, 1.06, 95% CI, 0.57-1.96) or for whichever other grouping of antidepressants. CONCLUSIONS: The results of this case-control study showed no significant increase in upper GI bleeding with SSRIs and provide good evidence that the magnitude of any increase in risk is not greater than 2

Modifiable risk factors associated with prediabetes in men and women: A cross-sectional analysis of the cohort study in primary health care on the evolution of patients with prediabetes

Background: Prediabetes is a high-risk state for diabetes development, but little is known about the factors associated with this state. The aim of the study was to identify modifiable risk factors associated with the presence of prediabetes in men and women. Methods: Cohort Study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS-Study) is a prospective study on a cohort of 1184 subjects with prediabetes and another cohort of 838 subjects without glucose metabolism disorders. It is being conducted by 125 general practitioners in Spain. Data for this analysis were collected during the baseline stage in 2012. The modifiable risk factors included were: smoking habit, alcohol consumption, low physical activity, inadequate diet, hypertension, dyslipidemia, and obesity. To assess independent association between each factor and prediabetes, odds ratios (ORs) were estimated using logistic regression models. Results: Abdominal obesity, low plasma levels of high-density lipoprotein cholesterol (HDL-cholesterol), and hypertension were independently associated with the presence of prediabetes in both men and women. After adjusting for all factors, the respective ORs (95% Confidence Intervals) were 1.98 (1.41-2.79), 1.88 (1.23-2.88) and 1.86 (1.39-2.51) for men, and 1.89 (1.36-2.62), 1.58 (1.12-2.23) and 1.44 (1.07-1.92) for women. Also, general obesity was a risk factor in both sexes but did not reach statistical significance among men, after adjusting for all factors. Risky alcohol consumption was a risk factor for prediabetes in men, OR 1.49 (1.00-2.24). Conclusions: Obesity, low HDL-cholesterol levels, and hypertension were modifiable risk factors independently related to the presence of prediabetes in both sexes. The magnitudes of the associations were stronger for men than women. Abdominal obesity in both men and women displayed the strongest association with prediabetes. The findings suggest that there are some differences between men and women, which should be taken into account when implementing specific recommendations to prevent or delay the onset of diabetes in adult population