12 research outputs found
Experience with continuous venovenous hemofiltration (CVVH) in the ICU: a report from a single center
- Publication venue
- BioMed Central
- Publication date
- 01/01/2001
- Field of study
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
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- Andrews E
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- Angus K
- Anillo V
- Antal O
- Antill P
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- Apostolou K
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- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
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- Arnaoutoglou E
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- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
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- Asudo F
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- Attrill E
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- Avila Sanchez FJ
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- Xiong X
- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study
- Author
- Abdelaty M.
- Abed Maillard S.
- Ahmed H.
- Albrecht L.
- Alsudani A.
- Amundarain E. D.
- Anand S.
- Andersen J. B.
- Anglada M.
- Arabi Y.
- Aragao I.
- Arias Verdu M. D.
- Asehnoune K.
- Assuncao F.
- Audibert G.
- Badenes R.
- Bajracharya T.
- Banco P.
- Batista D.
- Bertellini E.
- Berty Gutierrez H.
- Besch G.
- Biston P.
- Blandino Ortiz A.
- Blazquez V.
- Bloria S.
- Bonetti C.
- Bresil P.
- Brunetti I.
- Buldini V.
- Caillard A.
- Calamai I.
- Carbonara M.
- Caricato A.
- Casadio M. C.
- Casanova M.
- Cavaleiro P.
- Celaya Lopez M.
- Chan C. Y.
- Chauhan R.
- Cinotti R.
- Citerio G.
- Corral L.
- Cortegiani A.
- Cotoia A.
- Crippa I. A.
- Davidovich V.
- Del Bianco S.
- Diakaki C.
- Dibu J.
- Dimoula A.
- Domeniconi G.
- Dominguez L. J. Y.
- Dovbysh N.
- Duque P.
- Eddelien H. S.
- Efthymiou A.
- Egmose Larsen T.
- Elhadi M.
- Elli F.
- Favre Eva E.
- Fencl M.
- Forjan P.
- Freitas R.
- Fuest K.
- Fumale M.
- Gakuba C.
- Galarza L.
- Garcia M. F.
- Gasca Lopez G. A.
- Gelormini C.
- Gempeler A.
- Giannopoulos A.
- Gimenez M. E.
- Giugni A.
- Giussani C.
- Glorieux D.
- Gonzalez Perez M. I.
- Gradisek P.
- Grandis M.
- Graziano F.
- Griesdale D.
- Gritsan A.
- Grotheer S.
- Gupta D.
- Hallt E. D.
- Hawthorne C.
- Helbok R.
- Helbok R.
- Holm M. O.
- Iasonidou C.
- Idowu O.
- Ioannoni E.
- Izzi A.
- Jibaja M.
- Kafle P.
- Kandamby D. H.
- Khan M. M.
- Khomiakov S.
- Kilapong B.
- Kletecka J.
- Kojder K.
- Kolias A.
- Kontoudaki E.
- Koukoulitsios G.
- Kovac N.
- Kozar S.
- Krieg S. M.
- Kurtz P.
- Kyriazopoulos G.
- Lamperti M.
- Lavicka P.
- Lencastre L.
- Levin M.
- Lightfoot R.
- Lindner A.
- Lopez Ojeda P.
- Lores A.
- Lucca M.
- Luthra A.
- Magni F.
- Majholm B.
- Makris D.
- Maldonado F.
- Marudi A.
- Maskey S.
- Mebis L.
- Mejia-Mantilla J. H.
- Mendoza R.
- Meyfroidt G.
- Milivojevic N.
- Miroz J. P.
- Monleon B.
- Montes J. M.
- Morelli P.
- Motta A.
- Mouloudi E.
- Muehlschlegel S.
- Namendys Silva S. A.
- Nardai G.
- Nilam K.
- Oddo M.
- Olson D.
- Olson Z.
- Ozair A.
- Pacheco C.
- Padilla Juan J.
- Palli E.
- Panda N.
- Pantelas N.
- Pariente L.
- Pearson D.
- Perez-Araos R.
- Picetti E.
- Pinedo Portilla J. L.
- Pons B.
- Pozzi F.
- Prisco L.
- Provaznikova E.
- Quartarone M. C.
- Quintard H.
- Rajbanshi L.
- Reade M.
- Rebora P.
- Ribaric S. F.
- Rigamonti A.
- Rivera L. L.
- Robba C.
- Roberts J.
- Roka Y. B.
- Sabelnikovs O.
- Sapra H.
- Schaller S. J.
- Sekhon M.
- Sellami W.
- Seppelt I.
- Serrano A.
- Sharma K.
- Shrestha G. S.
- Shum H. P.
- Silva S.
- Simoes M.
- Sivakumar S.
- Siviter R.
- Skola J.
- Skoti M.
- Smitt M.
- Soley R.
- Sonneville R.
- Soragni A.
- Soyer B.
- Spatenkova V.
- Stamou E. E.
- Stival E.
- Stocchetti N.
- Suarez J. I.
- Taccone F. S.
- Tanczos K.
- Thompson C.
- Thomsen J.
- Tsikriki S.
- Van De Velde S.
- Videtta W.
- Villa F.
- Vincent J. -L.
- Vrbica K.
- Vrettou C.
- Westy Hoffmeyer H.
- Wolf S.
- Yasin Wayhs S.
- Zerbi S. M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: The indications for intracranial pressure (ICP) monitoring in patients with acute brain injury and the effects of ICP on patients’ outcomes are uncertain. The aims of this study were to describe current ICP monitoring practises for patients with acute brain injury at centres around the world and to assess variations in indications for ICP monitoring and interventions, and their association with long-term patient outcomes. Methods: We did a prospective, observational cohort study at 146 intensive care units (ICUs) in 42 countries. We assessed for eligibility all patients aged 18 years or older who were admitted to the ICU with either acute brain injury due to primary haemorrhagic stroke (including intracranial haemorrhage or subarachnoid haemorrhage) or traumatic brain injury. We included patients with altered levels of consciousness at ICU admission or within the first 48 h after the brain injury, as defined by the Glasgow Coma Scale (GCS) eye response score of 1 (no eye opening) and a GCS motor response score of at least 5 (not obeying commands). Patients not admitted to the ICU or with other forms of acute brain injury were excluded from the study. Between-centre differences in use of ICP monitoring were quantified by using the median odds ratio (MOR). We used the therapy intensity level (TIL) to quantify practice variations in ICP interventions. Primary endpoints were 6 month mortality and 6 month Glasgow Outcome Scale Extended (GOSE) score. A propensity score method with inverse probability of treatment weighting was used to estimate the association between use of ICP monitoring and these 6 month outcomes, independently of measured baseline covariates. This study is registered with ClinicalTrial.gov, NCT03257904. Findings: Between March 15, 2018, and April 30, 2019, 4776 patients were assessed for eligibility and 2395 patients were included in the study, including 1287 (54%) with traumatic brain injury, 587 (25%) with intracranial haemorrhage, and 521 (22%) with subarachnoid haemorrhage. The median age of patients was 55 years (IQR 39–69) and 1567 (65%) patients were male. Considerable variability was recorded in the use of ICP monitoring across centres (MOR 4·5, 95% CI 3·8–4·9 between two randomly selected centres for patients with similar covariates). 6 month mortality was lower in patients who had ICP monitoring (441/1318 [34%]) than in those who were not monitored (517/1049 [49%]; p<0·0001). ICP monitoring was associated with significantly lower 6 month mortality in patients with at least one unreactive pupil (hazard ratio [HR] 0·35, 95% CI 0·26–0·47; p<0·0001), and better neurological outcome at 6 months (odds ratio 0·38, 95% CI 0·26–0·56; p=0·0025). Median TIL was higher in patients with ICP monitoring (9 [IQR 7–12]) than in those who were not monitored (5 [3–8]; p<0·0001) and an increment of one point in TIL was associated with a reduction in mortality (HR 0·94, 95% CI 0·91–0·98; p=0·0011). Interpretation: The use of ICP monitoring and ICP management varies greatly across centres and countries. The use of ICP monitoring might be associated with a more intensive therapeutic approach and with lower 6-month mortality in more severe cases. Intracranial hypertension treatment guided by monitoring might be considered in severe cases due to the potential associated improvement in long-term clinical results. Funding: University of Milano-Bicocca and the European Society of Intensive Care Medicine
Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study
- Author
- Abdelaty M.
- Abed Maillard S.
- Ahmed H.
- Albrecht L.
- Alsudani A.
- Amundarain E. D.
- Anand S.
- Andersen J. B.
- Anglada M.
- Arabi Y
- Aragao I.
- Arias Verdu M. D.
- Asehnoune K.
- Assunção F.
- Audibert G.
- Badenes R.
- Bajracharya T.
- Banco P.
- Batista D.
- Bertellini E.
- Berty Gutiérrez H.
- Besch G.
- Biston P.
- Blandino Ortiz A.
- Blazquez V.
- Bloria S.
- Bonetti C.
- Bresil P.
- Brunetti I.
- Buldini V.
- Caillard A.
- Calamai I.
- Carbonara M.
- Caricato A.
- Casadio M. C.
- Casanova M.
- Cavaleiro P.
- Celaya Lopez M.
- Chan C. Y.
- Chauhan R.
- Cinotti R.
- Citerio Giuseppe
- Corral L.
- Cortegiani A.
- Cotoia A.
- Crippa I. A.
- Davidovich V.
- Del Bianco S.
- Diakaki C.
- Dibu J.
- Dimoula A.
- Domeniconi G.
- Dominguez L. J. Y.
- Dovbysh N.
- Duque P.
- Eddelien H. S.
- Efthymiou A.
- Egmose Larsen T.
- Elhadi M.
- Elli Francesca
- Favre Eva E.
- Fencl M.
- Forjan P.
- Freitas R.
- Fuest K.
- Fumale M.
- Gakuba C.
- Galarza L.
- García M. F.
- Gasca López G. A.
- Gelormini C.
- Gempeler A.
- Giannopoulos A.
- Giménez M. E.
- Giugni A.
- Giussani Carlo
- Glorieux D.
- Gonzalez Perez M. I.
- Gradisek P.
- Grandis M.
- Graziano Francesca
- Griesdale D.
- Gritsan A.
- Grotheer S.
- Gupta D.
- Hallt E. D.
- Hawthorne C.
- Helbok R.
- Helbok Raimund
- Holm M. O.
- Iasonidou C.
- Idowu O.
- Ioannoni E.
- Izzi A.
- Jibaja M.
- Kafle P.
- Kandamby D. H.
- Khan M. M.
- Khomiakov S.
- Kilapong B.
- Kletecka J.
- Kojder K.
- Kolias A.
- Kontoudaki E.
- Koukoulitsios G.
- Kovac N.
- Kozar S.
- Krieg S. M.
- Kurtz P.
- Kyriazopoulos G.
- Lamperti M.
- Lavicka P.
- Lencastre L.
- Levin M.
- Lightfoot R.
- Lindner A.
- Lores A.
- Lucca M.
- Luthra A.
- López Ojeda P.
- Magni F.
- Majholm B.
- Makris D.
- Maldonado F.
- Marudi A.
- Maskey S.
- Mebis L.
- Mejia-Mantilla J. H.
- Mendoza R.
- Meyfroidt Geert
- Milivojevic N.
- Miroz J. P.
- Monleon B.
- Montes J. M.
- Morelli P.
- Motta A.
- Mouloudi E.
- Muehlschlegel S.
- Nardai G.
- Nilam K.
- Oddo Mauro
- Olson D.
- Olson Z.
- Ozair A.
- Pacheco C.
- Padilla Juan J.
- Palli E.
- Panda N.
- Pantelas N.
- Pariente L.
- Pearson D.
- Picetti E.
- Pinedo Portilla J. L.
- Pons B.
- Pozzi F.
- Prisco Lara
- Provaznikova E.
- Pérez-Araos R.
- Quartarone M. C.
- Quintard H.
- Rajbanshi L.
- Reade M.
- Rebora Paola
- Ribaric S. F.
- Rigamonti A.
- Rivera L. L.
- Robba Chiara
- Roberts J.
- Roka Y. B.
- Sabelnikovs O.
- Sapra H.
- Schaller S. J.
- Sekhon M.
- Sellami W.
- Seppelt I.
- Serrano A.
- Sharma K.
- Shrestha G. S.
- Shum H. P.
- Silva S.
- Simoes M.
- Sivakumar S.
- Siviter R.
- Skola J.
- Smitt M.
- Soley R.
- Sonneville R.
- Soragni A.
- Soyer B.
- Spatenkova V.
- Stamou E. E.
- Stival E.
- Stocchetti Nino
- Suarez Jose I
- Taccone Fabio S
- Thompson C.
- Thomsen J.
- Tsikriki S.
- Tánczos K.
- Van De Velde S.
- Videtta W.
- Villa F.
- Vincent Jean-Louis
- Vrbica K.
- Vrettou C.
- Westy Hoffmeyer H.
- Wolf S.
- Wolf S.
- Yasin Wayhs S.
- Zerbi S. M.
- Ñamendys Silva S. A.
- Škoti M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: The indications for intracranial pressure (ICP) monitoring in patients with acute brain injury and the effects of ICP on patients’ outcomes are uncertain. The aims of this study were to describe current ICP monitoring practises for patients with acute brain injury at centres around the world and to assess variations in indications for ICP monitoring and interventions, and their association with long-term patient outcomes. Methods: We did a prospective, observational cohort study at 146 intensive care units (ICUs) in 42 countries. We assessed for eligibility all patients aged 18 years or older who were admitted to the ICU with either acute brain injury due to primary haemorrhagic stroke (including intracranial haemorrhage or subarachnoid haemorrhage) or traumatic brain injury. We included patients with altered levels of consciousness at ICU admission or within the first 48 h after the brain injury, as defined by the Glasgow Coma Scale (GCS) eye response score of 1 (no eye opening) and a GCS motor response score of at least 5 (not obeying commands). Patients not admitted to the ICU or with other forms of acute brain injury were excluded from the study. Between-centre differences in use of ICP monitoring were quantified by using the median odds ratio (MOR). We used the therapy intensity level (TIL) to quantify practice variations in ICP interventions. Primary endpoints were 6 month mortality and 6 month Glasgow Outcome Scale Extended (GOSE) score. A propensity score method with inverse probability of treatment weighting was used to estimate the association between use of ICP monitoring and these 6 month outcomes, independently of measured baseline covariates. This study is registered with ClinicalTrial.gov, NCT03257904. Findings: Between March 15, 2018, and April 30, 2019, 4776 patients were assessed for eligibility and 2395 patients were included in the study, including 1287 (54%) with traumatic brain injury, 587 (25%) with intracranial haemorrhage, and 521 (22%) with subarachnoid haemorrhage. The median age of patients was 55 years (IQR 39–69) and 1567 (65%) patients were male. Considerable variability was recorded in the use of ICP monitoring across centres (MOR 4·5, 95% CI 3·8–4·9 between two randomly selected centres for patients with similar covariates). 6 month mortality was lower in patients who had ICP monitoring (441/1318 [34%]) than in those who were not monitored (517/1049 [49%]; p<0·0001). ICP monitoring was associated with significantly lower 6 month mortality in patients with at least one unreactive pupil (hazard ratio [HR] 0·35, 95% CI 0·26–0·47; p<0·0001), and better neurological outcome at 6 months (odds ratio 0·38, 95% CI 0·26–0·56; p=0·0025). Median TIL was higher in patients with ICP monitoring (9 [IQR 7–12]) than in those who were not monitored (5 [3–8]; p<0·0001) and an increment of one point in TIL was associated with a reduction in mortality (HR 0·94, 95% CI 0·91–0·98; p=0·0011). Interpretation: The use of ICP monitoring and ICP management varies greatly across centres and countries. The use of ICP monitoring might be associated with a more intensive therapeutic approach and with lower 6-month mortality in more severe cases. Intracranial hypertension treatment guided by monitoring might be considered in severe cases due to the potential associated improvement in long-term clinical results. Funding: University of Milano-Bicocca and the European Society of Intensive Care Medicine
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study
- Author
- Aalinezhad F.
- Abdulwahed E.
- Abed-Maillard S.
- Abidi K.
- Abilama F.
- Abousnina F. A.
- Abu-Sayf N.
- Acevedo J. O.
- Adeola F.
- Agalar C.
- Aguilar C. G.
- Ahmadi F.
- Ahmed A. K.
- Ahmed S.
- Akbas T.
- Akdogan O. O.
- Akerlund J.
- Akova M.
- Aksoy F.
- Aktas S. C.
- Akyol A.
- Al-Jadaan M.
- Aldhalia A.
- Alfandari S.
- Ali F.
- Ali S.
- AliAli A. M.
- Aljabbary A.
- Almekhlafi G. A.
- Almiqlash B.
- Almiroudi M. P.
- Alonzo M. I.
- Alsisi A.
- Altin N.
- Altintas N. D.
- Alves M.
- Amerigo J. A.
- Amiri F.
- Amro S.
- Anderzhanova A.
- Angell H.
- Antcliffe D.
- Antrolikar S.
- Aparicio C.
- Aparicio D. M.
- Apichatbutr Y.
- Aqeelah A.
- Arbelot C.
- Argaud L.
- Arias S. S.
- Armestar F.
- Arnillas M. P. G.
- Arvaniti K.
- Asensio D. M.
- Asiyanbi G.
- Aslan A. T.
- Athanasa Z.
- Atobe K.
- Attokaran A. G.
- Attwood B.
- Auchabie J.
- Awad A. K.
- Awad M.
- Ayestaran J. I.
- Azman A. H.
- Babashev B.
- Baby S. K.
- Badre G.
- Baghbanian R.
- Baig N.
- Baikady R. R.
- Bajaj M.
- Bakr L.
- Banach D.
- Barbier F.
- Baronia A.
- Barsoum M.
- Bassetti M.
- Batirel A.
- Battaglini D.
- Baudry T.
- Baumer T.
- Bayindir Y.
- Baykam N. N.
- Bazhykayeva Y.
- Belkhadir Z.
- Bellina D.
- Belman D.
- Belskiy V.
- Bermudez R. M.
- Beuzelin M.
- Bhadange N.
- Bilir Y.
- Bilkhayr H.
- Biradar V.
- Bisanti A.
- Biston P.
- Black E.
- Blasco-Navalpotro M. A.
- Bloos F.
- Bojko J.
- Borsi S. H.
- Bortolotti P.
- Bose P.
- Botelho I.
- Bouaziz M.
- Bouhuwaish A.
- Boukatta B.
- Bourenne J.
- Bourgeois M.
- Bracht H.
- Brajkovic A. V.
- Brewster D.
- Broda H.
- Bruel C.
- Bubenek-Turconi S.
- Buetti N.
- Buimsaedah A.
- Burma Y.
- Cakmak R.
- Carelli S.
- Cartoze N.
- Casares V.
- Castanera J.
- Castillo R. A.
- Catalan B.
- Centeno P.
- Cerman J.
- Ceyhun S.
- Chaaban M. K.
- Chandran J.
- Chantziara V.
- Chatzis M.
- Chen X.
- Chiewroongroj S.
- Chikungwa M.
- Chou N. -K.
- Chukina M.
- Cia C. -T.
- Cobb K.
- Cobilinschi C.
- Colak O.
- Colak S.
- Cole S.
- Conway Morris A.
- Cortegiani A.
- Costa V.
- Cotoia A.
- Coupez E.
- Covotta M.
- Cowton A.
- Cunha R. P.
- Custovic A.
- da Costa T.
- Dabiri G.
- Dahyot-Fizelier C.
- Daroui I.
- Datta A.
- Davalos-Alvarez A.
- De Bus L.
- de Figueiredo A. M. P.
- De Geer L.
- De La Rica A. S.
- De Pascale G.
- De Schryver N.
- De Waele E.
- De Waele J.
- Demeret S.
- Demiray E. K. D.
- Dendane T.
- Denys W.
- Desalu I.
- Dessap A. M.
- Di Gravio V.
- Di Guardo A.
- Diab A.
- Dimopoulos G.
- Djanikian F.
- Dolan R.
- Dominguez-Cherit J. G.
- Dsilva C.
- Duarte T.
- Dubler S.
- Duburcq T.
- Dulac T.
- Duprey M.
- Dwivedi J.
- Edin A.
- Efthymiou A.
- Elbadawy M. A.
- Elbahnasawy M.
- Elbuzidi A.
- Elhadi M.
- Elhadidy A.
- Elmandouh O.
- Elrabi O.
- Elsayed A.
- Ercole A.
- Erdogan C.
- Eremenko A.
- Eroglu A.
- Eroglu E.
- Erol C.
- Ersoy Y.
- Ersoz G.
- Escudier E.
- Espina L. F.
- Evik G.
- Fares A.
- Fartoukh M.
- Faulkner M.
- Fernandez R.
- Ferrer R.
- Fildisis G.
- Filipescu D. C.
- Filipovic-Grcic I.
- Finnis M.
- Finnis M.
- Fiorelli S.
- Flores M.
- Fong K. K.
- Foucrier A.
- Fourie C.
- Franke U.
- Fujitani S.
- Furman M.
- Gaigolnik D.
- Gainnier M.
- Gallego A. O.
- Gamra M.
- Garcon P.
- Geng N.
- Georgopoulou M.
- Ghannam A.
- Ghosh P.
- Giacobbe D. R.
- Goh K. J.
- Goh Q. Y.
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
PurposeIn the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials.MethodsWe carried out a prospective international cohort study of adult patients (>= 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021.Results2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28.ConclusionsHA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes
Kuluttajabarometri maakunnittain 2000, 2. neljännes
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- Zamudio D
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- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
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- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
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- Arnaoutoglou E
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- Arrandale L
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- Arshad H
- Arshad MA
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- Arustei M
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- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
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- Avila Sanchez FJ
- Avila EJD
- Avis J
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- Ayyaz H
- Azam UAA
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- Aziz FZ
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- Bairaktari A
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- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
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- Barnett A
- Baroselli A
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- Beloeil H
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- Benavent P
- Benevento A
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- Chetty RR
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- Chicken D-W
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- Chisbert Cuenca V
- Chlorou D
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- Chung CKE
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- Ciobotaru OR
- Cirstea E
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- Clarkson R
- Claxton A
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- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
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- Comptaer N
- Conde C
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- Copley E
- Copotoiu SM
- Coppens M
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- Costelloe H
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- Yeh E
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- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
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- Zhang J
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- Zhang Q
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- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London
The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections
- Author
- Aalinezhad Fatemeh
- Abdulwahed Eman
- Abed-Maillard S.
- Abello Anton
- Abidi Khalid
- Abillama Fayez
- Abousnina Fathi A.
- Abu-Sayf Natalia
- Acevedo José Oscar
- Adekola Oyebola O.
- Adeola Fowotade
- Agalar Canan
- Aguilar Candy Garcia
- Ahmadi Fatemeh
- Ahmed Abdullah Khudhur
- Ahmed Samiul
- Akdogan Ozlem
- Akova Murat
- Akova Murat
- Aksoy Firdevs
- Aktas Sabahat Cagan
- Akyol Ahmet
- Al-Jadaan Mohammad
- Aldhalia Amer
- Alfandari Serge
- Ali Fadi
- Ali Saedah
- AliAli Almajdoub Mohammed
- Aljabbary Ahmed
- Almekhlafi Ghaleb A.
- Almiqlash Bushray
- Almiroudi Mariota Panagiota
- Alsisi Adel
- Altin Nilgün
- Altintas Neriman Defne
- Alves Madalena
- Amerigo Joaquin Amador
- Amiri Fereshteh
- Amro Sarah
- Anderzhanova Anastasia
- Angell Hollie
- Antcliffe David
- Antrolikar Supriya
- Aparicio Christelle
- Apichatbutr Yutthana
- Aqeelah Ahmed
- Arbelot Charlotte
- Argaud Laurent
- Arias Mario
- Arias Sonia Sousa
- Armestar Fernando
- Arnillas Maria Pilar Gracia
- Artigas Ricard Mellado
- Arvaniti Kostoula
- Arvaniti Kostoula
- Asiyanbi Gabriel
- Aslan Abdullah Tarik
- Aslan Abdullah Tarık
- Athanasa Zoi
- Atobe Kaori
- Attokaran Antony George
- Attwood Ben
- Auchabie Johann
- Awad Ahmed K.
- Awad Maher
- Ayestaran J. Ignacio
- Azman Abd. Hamid
- Åkerlund Joyce
- Babashev Baurzhan
- Baby Sailaja K.
- Badre Gaëtan
- Baghbanian Reza
- Baig Nadia
- Baikady R. Rao
- Bajaj Manan
- Bakr Lubna
- Banach Dorota
- Barbier François
- Barbier François
- Baronia Arvind
- Barsoum Mina
- Bassetti Matteo
- Bassetti Matteo
- Batirel Ayse
- Battaglini Denise
- Baudry Thomas
- Baumer Tom
- Bayindir Yasar
- Baykam Nurcan
- Bazhykayeva Yelena
- Belkhadir Z.
- Bellina Davide
- Belman Daniel
- Belskiy Vladislav
- Bermudez Rosana Munoz
- Beuzelin M.
- Bhadange Neeraj
- Bilir Yeliz
- Bilkhayr Hala
- Biradar Vishwanath
- Bisanti Alessandra
- Biston Patrick
- Black E.
- Blasco-Navalpotro Miguel Angel
- Bloos Frank
- Bojko Jozef
- Borsi Seyed Hamid
- Bortolotti Perrine
- Bose Payel
- Botelho Isabel
- Bouaziz Mounir
- Bouhuwaish Ahmad
- Boukatta Brahim
- Bourenne Jérémy
- Bourgeois Marc
- Bracht Hendrik
- Brajkovic Ana Vujaklija
- Brewster David
- Broda Hanna
- Bruel Cédric
- Bubenek-Turconi Serban
- Buetti Niccolò
- Buetti Niccolò
- Buimsaedah Ahmad
- Burma Yaroslava
- C. Kampolis null
- Cakmak Rumeysa
- Carelli Simone
- Cartoze Nuno
- Casares Vanessa
- Castanera Jérémy
- Castillo Roberto Alejandro
- Catalan Beatriz
- Centeno Pablo
- Cerman Jaroslav
- Ceyhun Solakoğlu
- Chaaban Mohammad Karam
- Chandran Jagadish
- Chantziara Vasiliki
- Chatzis Marinos
- Chen Xiaomei
- Chiewroongroj Supattra
- Chikungwa Moses
- Chou Nai-Kuan
- Chukina Maria
- Cia Cong-Tat
- Cobb Katherine
- Cobilinschi Cristian
- Cole Stephen
- Conway Morris Andrew
- Cortegiani Andrea
- Cortegiani Andrea
- Costa Vasco
- Cotoia Antonella
- Coupez Elisabeth
- Covotta Marco
- Cowton Amanda
- Cunha Rui Pedro
- Custovic Aida
- Çolak Onur
- Çolak Sait
- da Costa Tito
- Dabiri Gholamreza
- Dahyot-Fizelier Claire
- Daroui Ivan
- Datta Avijatri
- Davalos-Alvarez Adrian
- De Bus Liesbet
- De Bus Liesbet
- de Figueiredo António Manuel Pereira
- De Geer Lina
- De La Rica Alejandro Suarez
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Elisabeth
- De Waele Jan
- De Waele Jan J.
- Demeret Sophie
- Demiray Emine Kubra Dindar
- Dendane Pr Tarek
- Denys Wouter
- Desalu Ibironke
- Dessap Pr Armand Mekonted
- Di Gravio Valentina
- Di Guardo Andrea
- Diab Adei
- Dimopoulos Pr Georges
- Djanikian Flora
- Dolan Rachael
- Dominguez-Cherit Jose G.
- Dsilva Carol
- Duarte Tiago
- Dubler Simon
- Duburcq Thibault
- Dulac Thierry
- Duprey Matthieu
- Dwivedi Jyotsna
- D’herbon Vall
- Edin Alicia
- Efthymiou Anna
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
- Elbuzidi Abdurahaman
- Elhadi Muhammed
- Elhadidy Amr
- Elmandouh Omar
- Elrabi Omar
- Elsayed Ahmed
- Ercole Ari
- Erdoğan Cem
- Eremenko Aleksandr
- Eroglu Ahmet
- Eroglu Ege
- Erol Çiğdem
- Ersoy Yasemin
- Ersoz Gulden
- Escudier Etienne
- Espina Lorena Forcelledo
- Evik Guliz
- Fares Aya
- Fartoukh Muriel
- Faulkner Maria
- Fernández Rubén
- Ferrer Ricard
- Fildisis Georgios
- Filipescu Daniela Carmen
- Filipovic-Grcic Ina
- Finnis Mackenzie
- Fiorelli Silvia
- Flores Matias
- Fong Kean Khang
- Foucrier Arnaud
- Fourie Cheryl
- Francois Guy
- Franke Uwe
- Fujitani Shigeki
- Furman Mikhail
- Gaigolnik Denis
- Gainnier Marc
- Gallego Alberto Orejas
- Gamra Marwa
- Garcon Pierre
- Geng Nan
- Georgopoulou Maria
- Ghannam A.
- Ghosh Pralay
- Giacobbe Daniele
- Giacobbe Daniele Roberto
- Goh Ken Junyang
- Goh Qing Yuan
- Goksu Senay
- Gomà Gemma
- Gottschalk Antje
- Goyal Shraddha
- Graham Clive
- Gratarola Angelo
- Grigoras Ioana
- Grintescu Ioana Marina
- Gritsan Alexey
- Gritsan Alexey
- Guesdon Charlotte
- Guimarães Nádia
- Gundogan Kursat
- Gurjar Mohan
- Gurjar Mohan
- Guzeldag Seda
- Gürbüz Yunus
- Hachimi Abdelhamid
- Haentjens Lionel
- Haibo Qiu
- Hall Daniel
- Hamid Hytham K. S.
- Haney Michael
- Harara Belal
- Hasan Hayat Ben
- Hasan M. Shahnaz
- Hasan Rabab Shaban Ben
- Hasan Rajib
- Hashimoto Satoru
- Hayashi Yoshiro
- Hdada Aisha Khaled
- Hemead Hanan M.
- Henin Pierre
- Hermosillo Mariana
- Hernandez Aaron Mark
- Herrera Mara Ocotlan Gonzalez
- Hewer Tayne
- Hoheisen Sandra
- Hollevoet Isabelle
- Homaidan Ahmed Gaber Sadik
- Hosokawa Koji
- Houfi Ashraf El
- Housni Brahim
- Hssain Ali Ait
- Hu Chungfang
- Hu Ting-Yu
- Huang Min
- Hugill Keith
- Humphreys Miss Sally K.
- Huq Shihan Mahmud Redwanul
- Husain A.
- Iasonidou Cristina
- Ibrahim Rebecca
- Idowu Olusola
- Iliescu C. C.
- Imzi Nadia
- Ippolito Mariachiara
- Islam Mohammad Motiul
- Jackson Matthew
- Jain Nikhilesh
- Jakob Stephan
- Jamaluddin Muhamad Fadhil Hadi
- Janny Sylvie
- Jaramillo C’havala
- Javaherforoosh Fatemeh
- Jayyab Mustafa Abu
- Jeon Kyeongman
- Jhanji S.
- Jobran Rania
- Johnson Aimee
- Kagan Ilya
- Kaimakamis Evangelos
- Kalem Ayşe Kaya
- Kalfon Pierre
- Kaligozhin Zhannur
- Kanjaa Nabil
- Kannan Santhana
- Karaali Ridvan
- Karaiskos Ilias
- Karar Ali Adil Ali
- Karic Edin
- Karmakar Saurabh
- Karumai Toshiyuki
- Kashipazha Davood
- Kato Hideaki
- Kayaaslan Bircan
- Kayaaslan Bircan
- Keegan Allison
- Kent Melanie
- Khade Reena
- Kiani Arash
- Kipnis Eric
- Klouche Kada
- Kocagoz Sesin
- Kogkopoulos Evangelos
- Koksal Iftihar
- Komorowska Irmina Kaptur
- Kothari Nikhil
- Kotkowska Anna
- Kouroulas Pr Vasilios
- Koutsoukou Vasiliki
- Kovacevic Pedja
- Krystopchuk Andriy
- Ku Shih-Chi
- Kuo Li-Kuo
- Kuriyama Akira
- Kurt Ibrahim
- Kusoglu Hulya
- Kutsogiannis Demetrios J.
- Kwa Andrea Lay Hoon
- Lance Marcus
- Larcher Romaric
- Lasic Hrvoje
- Laupland Kevin
- Layos Nathalie
- Le Guennec Loïc
- Le Meur Anthony
- Le Souhaitier Mathieu
- Leal Jesús Nicolás Pantoja
- Ledo Sara
- Ledtischke Anne
- Lee Sang-Min
- Lefrant Jean-Yves
- Lennard James
- Leone Marc
- Leone Pr Marc
- Lepper Philippe
- Leroy Olivier
- Levin Phillip
- Li Andrew Yunkai
- Lie Sui An
- Liew Mun Thing
- Lim Jia Yan
- Lim Sung Yoon
- Ling Lowell
- Lipman Jeffrey
- Litton Edward
- Lodi Giovanni
- Loftus S.
- Lomeli-Teran Manuel
- Longbottom Rebecca
- Lopez Patricia Mabel
- Louis Guillaume
- Lungu Olguta
- Luo Jili
- Macfie Caroline
- Magomedov Marat
- Mahmoodpoor Ata
- Makino Jun
- Malliotakis Polychronis
- Marchalot A.
- Marcu Alexandra
- Margetts Ben
- Marmanidou Kyriaki
- Marouli Diamantina
- Marques Ana Josefina Pinheiro
- Marsden Nicholas
- Martin-Loeches Ignacio
- Martinez Maria
- Maseda Emilio
- Masjedi Mansoor
- Massri Alexandre
- Matei Mariana Kristina
- Mateu Philippe
- Matsuyoshi Takeo
- Mazlan Mohd Zulfakar
- Mc Cree Melanie
- McCoshen Lorena
- Mcguigan Peter
- Mckee Rachel
- Mehraban Zahra
- Mehtap Selcuk
- Meleshkina Yulia
- Mendes António Carvalho
- Mer Mervyn
- Merenkov Yevgeniy
- Mesland Jean-Baptiste
- Metz Carlos
- Meyer Jason
- Mikstacki Adam
- Mingmin Chen
- Mira Jean-Paul
- Mirabella Michele
- Mishima Yuka
- Misra Krushna Chandra
- Misset Benoît
- Moldovan Leora
- Molinos Elena
- Mon Tomas
- Montefiore Pablo
- Montini Luca Maria
- Montravers Philippe
- Montravers Pr P.
- Montrucchio Giorgia
- Montrucchio Giorgia
- Moorthi Dhakshina
- Morris Andrew Conway
- Morris Andrew Conway
- Morvillo Lic Natalia
- Mostafa Tarek
- Mouhssine Doumiri
- Moura José Pedro
- Mugazov Miras
- Mukherjee Sudipta
- Mulhi Randeep
- Muzaffar Syed Nabeel
- N. Zappela null
- Nadeem Rashid
- Nafees Khalid Mahmood Khan
- Nagashima Michio
- Ng Kangqi
- Ng Louis Xiang Long
- Ng Shin Yi
- Nica Alexandru
- Nikolaou Charikleia
- Nikolic Mario
- Nissar Shaikh
- Noel Cindérella
- Noor Zuraini Md
- Novo Mariana
- Nowakowski Tomasz
- Nuccetelli Yanina
- null null
- Nunes Cristina
- Ñamendys-Silva Silvio A.
- Oikonomou Marina
- Oladimeji Motunrayo
- Olatosi John
- Omori Koichiro
- Ong Caroline Yu Ming
- Opdenacker Godelive
- Osman Nermin
- Ouhadian Maryam
- Ozair Ahmad
- Ozgen Cansu
- Ozturk Barcin
- Pagani Jl
- Pahuja Madhumati
- Paiva José Artur
- Paiva José-Artur
- Palermo Anna Maria
- Papageorgiou Eirini
- Papanikolaou M.
- Papathanakos A. /Pr Georgios
- Papoti Sofia
- Parcell Benjamin J.
- Park Seung Yong
- Park Sunghoon
- Pascoalinho Dulce
- Pasieka Bastian
- Paskalis Harry
- Patel Jamie
- Patel Mayur
- Patrier Juliette
- Paulet Rémi
- Peichota Mariusz
- Peije Li
- Pelagalli Lorella
- Pelosi Paolo
- Pereira Énio
- Pereira Tiago
- Perez-Nieto Orlando R.
- Perrigault Pierre-François
- Persec Jasminka
- Petros Sirak
- Pheng Lee See
- Philippart François
- Pietraszek-Grzywaczewska Iwona
- Pinto Ana Rios
- Pollock Hamish
- Popescu Mihai
- Porcile Elisa
- Póvoa Pedro
- Prazak Josef
- Predoi Cornelia Elena
- Prieto Emilio Garcia
- Psallida Vasiliki
- Qian Chuanyun
- Qin Bingyu
- Qiu Haibo
- Quah Jessica Lishan
- Queiró Joana
- Quesada María Dolores
- Rabbani Raihan
- Rabbani Raihan
- Radonic Radovan
- Raguer Laura
- Rahman Hamizah Bt Abdul
- Raj Ashok
- Ramanan Mahesh
- Rashid Nurhikmahtul Aqilah Haji Abd
- Rashidi Mahboobeh
- Rathod Darshana
- Razazi Keyvan
- Regli Adrian
- Renaud Paul Jean
- Renta Foteini
- Renuka M. K.
- Retselas Ioannis
- Reyes Luis Felipe
- Rigler Merav
- Rinka Hiroshi
- Ritzema Jenny
- Rizzo Anna Chiara
- Rocca Ricard Ferrer
- Rocca Ricard Ferrer
- Rocco Monica
- Roger Claire
- Roig Regina
- Rojo Roceld
- Romanou Vasiliki
- Romero-Gonzalez Juan P.
- Roshdy Ashraf
- Rosman Jérémy
- Routledge Matthew
- Rubina Noor Ahmedi
- Ruckly Stephane
- Ruckly Stéphane
- Ruppe Etienne
- Saber Ahmed
- Sabetian Golnar
- Saidahmed Elfayadh
- Saito Hiroki
- Sakagianni Aikaterini
- Sakan Sanja
- Sakkalis Anastasios
- Sales Gabriele
- Salgado Dra Maria
- Sallam Hend
- Saltoglu Nese
- Samdani Pratit
- Sanderson Amanda
- Sanousi Bashir El
- Santos Emilio Diaz
- Saracoglu Kemal Tolga
- Sari Ali
- Sarode Vineet
- Sarshad Hakimeh
- Sarton Benjamine
- Savaie Mohsen
- Saxena Manoj
- Sánchez-Hurtado Luis
- Schlevenin Maria Grazia
- Schmidt Karsten
- Seddiki Pr Rachid
- Segura Matías
- Sellami Pr Walid
- Serck Nicolas
- Serghini Issam
- Setti Nour
- Sharma Ankur
- Sharma Priya
- Shekhar Saurav
- Sheshala Kaladhar
- Shigemitsu Hidenobu
- Siami Shidasp
- Siddiqui Suhail Sarwar
- Silva Stein
- Singer Pierre
- Singh Ritu
- Sjovall Fredrik
- Sligl Wendy
- Sligl Wendy
- Sligl Wendy
- Smith Tim
- Smonig Roland
- Smyrniotis Dimitrios
- Soar Natalie
- Sokhan Anton
- Soltan Marina
- Soltani Farhad
- Soulountsi Vasiliki
- Souweine Bertrand
- Spahic Dzana
- Sridharan Dhadappa Damodar
- Sudhirchandra Shah
- Sulaiman Helmi
- Sungurtekin Hulya
- Svensson Carl Johan
- Szakmany Tamas
- Szczesniak Anna
- Tabah Alexis
- Tabah Alexis
- Tabatabaei Seyed Mohammad Nasirodin
- Taher Ahmed Sa
- Tajvidi Ramin
- Takaki Shunsuke
- Talan Leyla
- Tamowicz Barbara
- Tatham Kate
- Tejeda-Huezo Brigitte
- Telli Murat
- Temirov Talgat
- Templeton Maie
- Teresa Ana
- Theodorou Vasiliki
- Thomas-Rueddel Daniel
- Thompson Patricia
- Thyrault Martial
- Tilley Rebecca E.
- Timsit Jean-François
- Timsit Jean-François
- Timuroglu Arif
- Tinaslanidis George
- Tizard Kate
- Tomas Ernesto Deloya
- Tomescu Dana
- Tong Lee Kok
- Torlinski Tomasz
- Torre Valentina Della
- Tran Marc
- Tribulev Maksim
- Tunay Burcu
- Turki Olfa
- Tyler Steven
- Ubeda Alejandro
- Udy Andrew
- Ugwu Euphemia Mgbosoro
- Vaidyanathan R.
- Valeanu C. C. IliescuLiana
- Valeanu Liana
- Vanderhaeghen Sofie F. M.
- Vargas Joel
- Vasileiou Maria
- Vera Paula
- Vidal Gabriela
- Viderman Dmitriy
- Villafuerte Missael Vladimir Espinoza
- Vistovskaya Natala
- Visvalingam Sheshendrasurian
- Voiriot Guillaume
- Wajdi Maazouzi Ahmed
- Walczak-Wieteska Paulina
- Walid Haji Adi Muhamad Ibnu
- Walsham James
- Wang Hao
- Wang Jinfeng
- Wang Ruilan
- Wang Yan
- Wasowska Dominika
- Weeda. Elizabeth
- Wei-Hua Lu
- Weifeng Xie
- Weiss Emmanuel
- Wempe Carola
- Wittebole Xavier
- Wong Siong Ling Danny
- Wongsurakiat Phunsup
- Wusi Qiu
- Xie Jianfeng
- Xu Lei
- Yakubu Saidu Yusuf
- Yamasaki Masaki
- Yan Jing
- Yap Timothy
- Ye Jilu
- Ye Ling
- Yeh Tony Yu-Chang
- Yilmaz Mesut
- Yin Chengfen
- Yin Yongjie
- Ymbetzhanov Yerlan
- Yonan Aimee
- Yoshida Hideki
- Younes Oujidi
- Young Meredith
- Zaki Ahmed
- Zand Farid
- Zargar Mohammad Amin
- Zeggwagh Pr Amine Ali
- Zhang Min
- Zhao Juan
- Zhao Peng
- Zhen Wang
- Zhou Suming
- Zlojutro Biljana
- Zormpa Artemis
- Zubareva Nadezhda
- Zuccaro Francesco
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Purpose: The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process and outcome indicators in patients with hospital-acquired bloodstream infections (HABSI). Methods: We used data on HABSI from the prospective EUROBACT-2 study to evaluate the associations between centre/country factors on a process or an outcome indicator: adequacy of antimicrobial therapy within the first 24 h or 28-day mortality, respectively. Mixed logistical models with clustering by centre identified factors associated with both indicators. Results: Two thousand two hundred nine patients from two hundred one intensive care units (ICUs) were included in forty-seven countries. Overall, 51% (n = 1128) of patients received an adequate antimicrobial therapy and the 28-day mortality was 38% (n = 839). The availability of therapeutic drug monitoring (TDM) for aminoglycosides everyday [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.03-2.14] or within a few hours (OR 1.79, 95% CI 1.34-2.38), surveillance cultures for multidrug-resistant organism carriage performed weekly (OR 1.45, 95% CI 1.09-1.93), and increasing Human Development Index (HDI) values were associated with adequate antimicrobial therapy. The presence of intermediate care beds (OR 0.63, 95% CI 0.47-0.84), TDM for aminoglycoside available everyday (OR 0.66, 95% CI 0.44-1.00) or within a few hours (OR 0.51, 95% CI 0.37-0.70), 24/7 consultation of clinical pharmacists (OR 0.67, 95% CI 0.47-0.95), percentage of vancomycin-resistant enterococci (VRE) between 10% and 25% in the ICU (OR 1.67, 95% CI 1.00-2.80), and decreasing HDI values were associated with 28-day mortality. Conclusion: Centre/country factors should be targeted for future interventions to improve management strategies and outcome of HABSI in ICU patients
Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study
- Author
- Aalinezhad Fatemeh
- Abdulwahed Eman
- Abed-Maillard S.
- Abello Anton
- Abilama Fayez
- Abousnina Fathi A.
- Abu-Sayf Natalia
- Acevedo José Oscar
- Adeola Fowotade
- Agalar Canan
- Aguilar Candy Garcia
- Ahmadi Fatemeh
- Ahmed Abdullah Khudhur
- Ahmed Samiul
- Akbas Türkay
- Akdogan Ozlem
- Akova Murat
- Aksoy Firdevs
- Aktas Sabahat Cagan
- Akyol Ahmet
- Al-Jadaan Mohammad
- Aldhalia Amer
- Alfandari Serge
- Ali Almajdoub Ali Mohammed
- Ali Fadi
- Ali Saedah
- Aljabbary Ahmed
- Almekhlafi Ghaleb A.
- Almiqlash Bushray
- Almiroudi Mariota Panagiota
- Alsisi Adel
- Altin Nilgün
- Altintas Neriman Defne
- Alves Madalena
- Amerigo Joaquin Amador
- Amiri Fereshteh
- Amro Sarah
- Anderzhanova Anastasia
- Angell Hollie
- Antcliffe David
- Antrolikar Supriya
- Aparicio Christelle
- Apichatbutr Yutthana
- Aqeelah Ahmed
- Arbelot Charlotte
- Argaud Laurent
- Arias Sonia Sousa
- Armestar Fernando
- Arnillas Maria Pilar Gracia
- Artigas Ricard Mellado
- Arvaniti Kostoula
- Asensio M. J.
- Asiyanbi Gabriel
- Aslan Abdullah Tarik
- Athanasa Zoi
- Atobe Kaori
- Attokaran Antony George
- Attwood Ben
- Auchabie Johann
- Awad Ahmed K.
- Awad Maher
- Ayestaran J. Ignacio
- Azman Abd. Hamid
- Åkerlund Joyce
- Babashev Baurzhan
- Baby Sailaja K.
- Badre Gaëtan
- Baghbanian Reza
- Baig Nadia
- Baikady R. Rao
- Bajaj Manan
- Bakr Lubna
- Banach Dorota
- Barbier François
- Baronia Arvind
- Barsoum Mina
- Batirel Ayse
- Battaglini Denise
- Baudry Thomas
- Baumer Tom
- Bayindir Yasar
- Baykam Nurcan
- Bazhykayeva Yelena
- Belkhadir Z.
- Bellina Davide
- Belman Daniel
- Belskiy Vladislav
- Bermudez Rosana Munoz
- Beuzelin M.
- Bhadange Neeraj
- Bilir Yeliz
- Bilkhayr Hala
- Biradar Vishwanath
- Bisanti Alessandra
- Biston Patrick
- Black E.
- Blasco-Navalpotro Miguel Angel
- Bloos Frank
- Bojko Jozef
- Borsi Seyed Hamid
- Bortolotti Perrine
- Bose Payel
- Botelho Isabel
- Bouaziz Mounir
- Bouhuwaish Ahmad
- Boukatta Brahim
- Bourenne Jérémy
- Bourgeois Marc
- Bracht Hendrik
- Brajkovic Ana Vujaklija
- Brewster David
- Broda Hanna
- Bruel Cédric
- Bubenek-Turconi Serban
- Buetti Niccolò
- Buimsaedah Ahmad
- Burma Yaroslava
- Cakmak Rumeysa
- Carelli Simone
- Cartoze Nuno
- Casares Vanessa
- Castanera Jérémy
- Castillo Roberto Alejandro
- Catalan Beatriz
- Centeno Pablo
- Cerman Jaroslav
- Ceyhun Solakoğlu
- Chaaban Mohammad Karam
- Chandran Jagadish
- Chantziara Vasiliki
- Chatzis Marinos
- Chen Xiaomei
- Chiewroongroj Supattra
- Chikungwa Moses
- Chou Nai-Kuan
- Chukina Maria
- Chuv Stephan Jakob
- Cia Cong-Tat
- Cobb Katherine
- Cobilinschi Cristian
- Cole Stephen
- Cortegiani Andrea
- Costa Vasco
- Coupez Elisabeth
- Covotta Marco
- Cowton Amanda
- Cunha Rui Pedro
- Custovic Aida
- Çolak Onur
- Çolak Sait
- da Costa Tito
- Dabiri Gholamreza
- Dahyot-Fizelier Claire
- Daroui Ivan
- Datta Avijatri
- Davalos-Alvarez Adrian
- De Almeida Jose
- De Bus Liesbet
- de Figueiredo António Manuel Pereira
- De Geer Lina
- De La Rica Alejandro Suarez
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Elisabeth
- De Waele Jan
- Demeret Sophie
- Demiray Emine Kubra Dindar
- Dendane Tarek
- Denys Wouter
- Desalu Ibironke
- Dessap Armand Mekonted
- Di Gravio Valentina
- Di Guardo Andrea
- Diab Adei
- Dimopoulos Georges
- Djanikian Flora
- Dolan Rachael
- Dominguez-Cherit Jose G.
- Dsilva Carol
- Duarte Tiago
- Dubler Simon
- Duburcq Thibault
- Dulac Thierry
- Duprey Matthieu
- Dwivedi Jyotsna
- Edin Alicia
- Efthymiou Anna
- El Houfi Ashraf
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
- Elbuzidi Abdurahaman
- Elhadidy Amr
- Elmandouh Omar
- Elrabi Omar
- Elsayed Ahmed
- Ercole Ari
- Erdoğan Cem
- Eremenko Aleksan
- Eroglu Ege
- Erol Çiğdem
- Ersoy Yasemin
- Ersoz Gulden
- Escudier Etienne
- Espina Lorena Forcelledo
- Evik Guliz
- Fares Aya
- Fartoukh Muriel
- Faulkner Maria
- Fernández Rubén
- Fildisis Georgios
- Filipescu Daniela Carmen
- Filipovic-Grcic Ina
- Finnis Mackenzie
- Fiorelli Silvia
- Flores Matias
- Fong Kean Khang
- Foucrier Arnaud
- Fourie Cheryl
- Francois Guy
- Franke Uwe
- Furman Mikhail
- Gaigolnik Denis
- Gainnier Marc
- Gallego Alberto Orejas
- Gamra Marwa
- Garcon Pierre
- Geng Nan
- Georgopoulou Maria
- Ghannam A.
- Ghosh Pralay
- Giacobbe Daniele Roberto
- Goh Ken Junyang
- Goh Qing Yuan
- Goksu Senay
- Gomà Gemma
- Gottschalk Antje
- Goyal Shraddha
- Graham Clive
- Gratarola Angelo
- Grigoras Ioana
- Grintescu Ioana Marina
- Gritsan Alexey
- Guesdon Charlotte
- Gundogan Kursat
- Gurja Mohan
- Guzeldag Seda
- Gürbüz Yunus
- Hachimi Abdelhamid
- Haentjens Lionel
- Haibo Qiu
- Hall Daniel
- Hamid Hytham K. S.
- Haney Michael
- Harara Belal
- Hasan Hayat Ben
- Hasan M. Shahnaz
- Hasan Rabab Shaban Ben
- Hasan Rajib
- Hashimoto Satoru
- Hayashi Yoshiro
- Hdada Aisha Khaled
- Hemead Hanan M.
- Henin Pierre
- Hermosillo Mariana
- Herrera Mara Ocotlan Gonzalez
- Hewer Tayne
- Hoffman Tomer
- Hoheisen Sandra
- Hollevoet Isabelle
- Homaidan Ahmed Gaber Sadik
- Hosokawa Koji
- Housni Brahim
- Hssain Ali Ait
- Hu Chungfang
- Hu Ting-Yu
- Huang Min
- Hugill Keith
- Humphreys Sally K.
- Huq Shihan Mahmud Redwanul
- Husain A.
- Iasonidou Cristina
- Ibrahim Rebecca
- Idowu Olusola
- Iliescu C. C.
- Imzi Nadia
- Ippolito Mariachiara
- Islam Mohammad Motiul
- Jackson Matthew
- Jain Nikhilesh
- Jamaluddin Muhamad Fadhil Hadi
- Janny Sylvie
- Jaramillo C'havala
- Javaherforoosh Fatemeh
- Jayyab Mustafa Abu
- Jeon Kyeongman
- Jhanji S.
- Jianfeng Xie
- Jobran Rania
- Johnson Aimee
- Kagan Ilya
- Kaimakamis Evangelos
- Kalem Ayşe Kaya
- Kalfon Pierre
- Kaligozhin Zhannur
- Kampolis C.
- Kanjaa Nabil
- Kannan Santhana
- Karaali Ridvan
- Karaiskos Ilias
- Karar Ali Adil Ali
- Karic Edin
- Karmakar Saurabh
- Kartal Ahmet Eroglu
- Karumai Toshiyuki
- Kashipazha Davood
- Kato Hideaki
- Kayaaslan Bircan
- Keegan Allison
- Kent Melanie
- Khade Reena
- Kiani Arash
- Kipnis Eric
- Kirdar Lutfi
- Kiwan Mazzeh
- Klouche Kada
- Kocagoz Sesin
- Kogkopoulos Evangelos
- Koksal Iftihar
- Komorowska Irmina Kaptur
- Kothari Nikhil
- Kotkowska Anna
- Kouroulas Vasilios
- Koutsoukou Vasiliki
- Kovacevic Pedja
- Krystopchuk Andriy
- Ku Shih-Chi
- Kuo Li-Kuo
- Kuriyama Akira
- Kurt Ibrahim
- Kusoglu Hulya
- Kutsogiannis Demetrios J.
- Kwa Andrea Lay Hoon
- Lance Marcus
- Larcher Romaric
- Lasic Hrvoje
- Laupland Kevin
- Layos Nathalie
- Le Guennec Loïc
- Le Meur Anthony
- Le Souhaitier Mathieu
- Leal Jesús Nicolás Pantoja
- Ledo Sara
- Ledtischke Anne
- Lee Sang-Min
- Lefrant Jean-Yves
- Lennard James
- Leone Marc
- Lepper Philippe
- Leroy Olivier
- Levin Phillip
- Li Andrew Yunkai
- Lie Sui An
- Liew Mun Thing
- Lim Jia Yan
- Lim Sung Yoon
- Ling Lowell
- Lipman Jeffrey
- Litton Edward
- Lodi Giovanni
- Loftus S.
- Lomeli-Teran Missael Vladimir Espinoza Villafuer
- Longbottom Rebecca
- Lopez Patricia Mabel
- Louis Guillaume
- Lungu Olguta
- Luo Jili
- Macfie Caroline
- Magomedov Marat
- Mahmoodpoor Ata
- Makino Jun
- Malliotakis Polychronis
- Marchalot A.
- Marcu Alexandra
- Margalit Ili
- Margetts Ben
- Marmanidou Kyriaki
- Marouli Diamantina
- Marques Ana Josefina Pinheiro
- Marsden Nicholas
- Martin-Loeches Ignacio
- Martinez Maria
- Maseda Emilio
- Masjedi Mansoor
- Massri Alexandre
- Matei Mariana Kristina
- Mateu Philippe
- Matsuyoshi Takeo
- Mazlan Mohd Zulfakar
- Mc Cree Melanie
- McCoshen Lorena
- Mcguigan Peter
- Mckee Rachel
- Mehraban Zahra
- Mehtap Selcuk
- Meleshkina Yulia
- Mendes António Carvalho
- Mer Mervyn
- Merenkov Yevgeniy
- Mesland Jean-Baptiste
- Metz Carlos
- Meyer Jason
- Mikstacki Adam
- Mingmin Chen
- Mira Jean-Paul
- Mirabella Michele
- Mishima Yuka
- Misra Krushna Chandra
- Misset Benoît
- Moldovan Leora
- Molinos Elena
- Mon Tomas
- Montefiore Pablo
- Montini Luca Maria
- Montravers P.
- Montravers Philippe
- Moorthi P. Dhakshina
- Morris Andrew Conway
- Mostafa Tarek
- Mouhssine Doumiri
- Moura José Pedro
- Mugazov Miras
- Mukherjee Sudipta
- Mulhi Randeep
- Muzaffar Syed Nabeel
- Nadeem Rashid
- Nafees Khalid Mahmood Khan
- Nagashima Michio
- Nasirodin Seyed Mohammad
- Ng Kangqi
- Ng Louis Xiang Long
- Ng Shin Yi
- Nica Alexandru
- Nikolaou Charikleia
- Nikolic Mario
- Nimbolkar Janardan
- Nissar Shaikh
- Noel Cindérella
- Noor Zuraini Md
- Novo Mariana
- Nowakowski Tomasz
- Nuccetelli Yanina
- null null
- Nunes Cristina
- Ñamendys-Silva Silvio A.
- Oikonomou Marina
- Oladimeji Motunrayo
- Olatosi John
- Omori Koichiro
- Ong Caroline Yu Ming
- Opdenacker Godelive
- Opolu Szpital Wojewodzki W.
- Osman Nermin
- Ouhadian Maryam
- Ozair Ahmad
- Ozgen Cansu
- Ozturk Barcin
- Pagani Jl
- Pahuja Madhumati
- Palermo Anna Maria
- Papageorgiou Eirini
- Papanikolaou M.
- Papathanakos Georgios
- Papoti Sofia
- Parcell Benjamin J.
- Park Seung Yong
- Park Sunghoon
- Pascoalinho Dulce
- Pasieka Bastian
- Paskalis Harry
- Patel Jamie
- Patel Mayur
- Patrier Mme Juliette
- Paulet Rémi
- Peichota Mariusz
- Peije Li
- Pelagalli Lorella
- Pelosi Paolo
- Pereira Énio
- Pereira Tiago
- Perez-Nieto Orlando R.
- Perm E. A. Vagner
- Perrigault Pierre-François
- Persec Jasminka
- Petros Sirak
- Pheng Lee See
- Philippart François
- Pietraszek-Grzywaczewska Iwona
- Pinto Ana Rios
- Pollock Hamish
- Popescu Mihai
- Porcile Elisa
- Póvoa Pedro
- Prazak Josef
- Predoi Cornelia Elena
- Prendki Virginie
- Prieto Emilio Garcia
- Psallida Vasiliki
- Qian Chuanyun
- Qin Bingyu
- Quah Jessica Lishan
- Queiró Joana
- Quesada María Dolores
- R Vaidyanathan
- Rabbani Raihan
- Radonic Radovan
- Raguer Laura
- Rahman Hamizah Bt Abdul
- Raj Ashok
- Ramanan Mahesh
- Rashid Nurhikmahtul Aqilah Haji Abd
- Rashidi Mahboobeh
- Rathod Darshana
- Razazi Keyvan
- Regli Adrian
- Renaud Paul Jean
- Renuka M. K.
- Retselas Ioannis
- Reyes Luis Felipe
- Rigler Merav
- Rinka Hiroshi
- Ritzema Jenny
- Rizzo Anna Chiara
- Rocca Ricard Ferrer
- Rocco Monica
- Rodriguez M.
- Roger Claire
- Roig Regina
- Rojo Roceld
- Romanou Vasiliki
- Romero-Gonzalez Juan P.
- Roshdy Ashraf
- Rosman Jérémy
- Routledge Matthew
- Rubina Noor Ahmedi
- Ruckly Stephane
- Ruckly Stéphane
- Ruppe Etienne
- Saber Ahmed
- Sabetian Golnar
- Saidahmed Elfayadh
- Saito Hiroki
- Sakagianni Aikaterini
- Sakan Sanja
- Sakkalis Anastasios
- Sales Gabriele
- Salgado Maria
- Sallam Hend
- Saltoglu Nese
- Samdani Pratit
- Sanderson Amanda
- Santos Emilio Diaz
- Saracoglu Kemal Tolga
- Sari Ali
- Sarode Vineet
- Sarshad Hakimeh
- Sarton Benjamine
- Savaie Mohsen
- Saxena Manoj
- Sánchez-Hurtado Luis
- Schlevenin Maria Grazia
- Schmidt Karsten
- Seddiki Rachid
- Segura Matías
- Sellami Walid
- Serck Nicolas
- Serghini Issam
- Sharma Ankur
- Sharma Priya
- Sheshala Kaladhar
- Shigemitsu Hidenobu
- Siami Shidasp
- Siddiqui Suhail Sarwar
- Silva Stein
- Singer Pierre
- Singh Ritu
- Sjövall Fredrik
- Sligl Wendy
- Smith Tim
- Smonig Roland
- Smyrniotis Dimitrios
- Soar Natalie
- Sokhan Anton
- Soltan Marina
- Soltani Farhad
- Souweine Bertrand
- Spahic Dzana
- Sridharan Dhadappa Damodar
- Sudhirchandra Shah
- Sungurtekin Hulya
- Svensson Carl Johan
- Szakmany Tamas
- Szczesniak Anna
- Tabah Alexis
- Taher Ahmed Sa
- Tajvidi Ramin
- Takaki Shunsuke
- Talan Leyla
- Tamowicz Barbara
- Tatham Kate
- Tejeda-Huezo Brigitte
- Telli Murat
- Temirov Talgat
- Templeton Maie
- Teresa Ana
- Theodorou Vasiliki
- Thomas-Rueddel Daniel
- Thompson Patricia
- Thyrault Martial
- Tilley Rebecca E.
- Timsit Jean-François
- Timuroglu Arif
- Tinaslanidis George
- Tizard Kate
- Tomas Ernesto Deloya
- Tomescu Dana
- Tong Lee Kok
- Torlinski Tomasz
- Torre Valentina Della
- Tran Marc
- Tribulev Maksim
- Tunay Burcu
- Turki Olfa
- Tyler Steven
- Ubeda Alejandro
- Udy Andrew
- Ugwu Euphemia Mgbosoro
- Umbetzhanov Yerlan
- Valeanu Liana
- Vargas Joel
- Vasileiou Maria
- Vera Paula
- Viderman Dmitriy
- Vistovskaya Natala
- Visvalingam Sheshendrasurian
- Voiriot Guillaume
- Wajdi Maazouzi Ahmed
- Walczak-Wieteska Paulina
- Walid Haji Adi Muhamad Ibnu
- Walsham James
- Wang Hao
- Wang Jinfeng
- Wang Ruilan
- Wang Yan
- Wasowska Dominika
- Weeda Elizabeth
- Wei-Hua Lu
- Weifeng Xie
- Weiss Emmanuel
- Wempe Carola
- Wittebole Xavier
- Wong Siong Ling Danny
- Wongsurakiat Phunsup
- Wusi Qiu
- Xu Lei
- Yahav Dafna
- Yakubu Saidu Yusuf
- Yamasaki Masaki
- Yan Jing
- Yap Timothy
- Ye Jilu
- Ye Ling
- Yeh Yu Chang
- Yilmaz Mesut
- Yin Chengfen
- Yin Yongjie
- Yonan Aimee
- Yoshida Hideki
- Younes Oujidi
- Young Meredith
- Zaki Ahmed
- Zand Farid
- Zappela N.
- Zargar Mohammad Amin
- Zeggwagh Amine Ali
- Zhang Min
- Zhao Juan
- Zhao Peng
- Zhen Wang
- Zhou Suming
- Zlojutro Biljana
- Zormpa Artemis
- Zubareva Nadezhda
- Zuccaro Francesco
- Publication venue
- Publication date
- 13/06/2024
- Field of study
Purpose: Older adults admitted to the intensive care unit (ICU) usually have fair baseline functional capacity, yet their age and frailty may compromise their management. We compared the characteristics and management of older (≥ 75 years) versus younger adults hospitalized in ICU with hospital-acquired bloodstream infection (HA-BSI). Methods: Nested cohort study within the EUROBACT-2 database, a multinational prospective cohort study including adults (≥ 18 years) hospitalized in the ICU during 2019-2021. We compared older versus younger adults in terms of infection characteristics (clinical signs and symptoms, source, and microbiological data), management (imaging, source control, antimicrobial therapy), and outcomes (28-day mortality and hospital discharge). Results: Among 2111 individuals hospitalized in 219 ICUs with HA-BSI, 563 (27%) were ≥ 75 years old. Compared to younger patients, these individuals had higher comorbidity score and lower functional capacity; presented more often with a pulmonary, urinary, or unknown HA-BSI source; and had lower heart rate, blood pressure and temperature at presentation. Pathogens and resistance rates were similar in both groups. Differences in management included mainly lower rates of effective source control achievement among aged individuals. Older adults also had significantly higher day-28 mortality (50% versus 34%, p < 0.001), and lower rates of discharge from hospital (12% versus 20%, p < 0.001) by this time. Conclusions: Older adults with HA-BSI hospitalized in ICU have different baseline characteristics and source of infection compared to younger patients. Management of older adults differs mainly by lower probability to achieve source control. This should be targeted to improve outcomes among older ICU patients