618 research outputs found
Neoadjuvant therapy for breast cancer
Objective: To evaluate the frequency of neoadjuvant therapy (NT) in women with stage I–III breast cancer in Italy and whether it is influenced by biological characteristics, screening history, and geographic area. Methods: Data from the High Resolution Study conducted in 7 Italian cancer registries were used; they are a representative sample of incident cancers in the study period (2009–2013). Included were 3546 women aged <85 years (groups <50, 50–69, 70–64, and 75+) with stage I–III breast cancer at diagnosis who underwent surgery. Women were classified as receiving NT if they received chemotherapy, target therapy, and/or hormone therapy before the first surgical treatment. Logistic models were built to test the association with biological and contextual variables. Results: Only 8.2% of women (290 cases) underwent NT; the treatment decreases with increasing age (14.5% in age <50 and 2.2% in age 75+), is more frequent in women with negative receptors (14.8%), HER2-positive (15.7%), and triple-negative (15.6%). The multivariable analysis showed the probability of receiving NT is higher in stage III (odds ratio [OR] 3.83; 95% confidence interval [CI] 2.83–5.18), luminal B (OR 1.87; 95% CI 1.27–2.76), triple-negatives (OR 1.88; 95% CI 1.15–3.08), and in symptomatic cancers (OR 1.98; 95% CI 1.13–3.48). Use of NT varied among geographic areas: Reggio Emilia had the highest rates (OR 2.29; 95% CI 1.37–3.82) while Palermo had the lowest (OR 0.41; 95% CI 0.24–0.68). Conclusions: The use of NT in Italy is limited and variable. There are no signs of greater use in hospitals with more advanced care
Evolution of the cosmic ray anisotropy above 10^{14} eV
The amplitude and phase of the cosmic ray anisotropy are well established
experimentally between 10^{11} eV and 10^{14} eV. The study of their evolution
into the energy region 10^{14}-10^{16} eV can provide a significant tool for
the understanding of the steepening ("knee") of the primary spectrum. In this
letter we extend the EAS-TOP measurement performed at E_0 around 10^{14} eV, to
higher energies by using the full data set (8 years of data taking). Results
derived at about 10^{14} and 4x10^{14} eV are compared and discussed. Hints of
increasing amplitude and change of phase above 10^{14} eV are reported. The
significance of the observation for the understanding of cosmic ray propagation
is discussed.Comment: 4 pages, 3 figures, accepted for publication on ApJ Letter
Test of candidate light distributors for the muon (g2) laser calibration system
The new muon (g-2) experiment E989 at Fermilab will be equipped with a laser
calibration system for all the 1296 channels of the calorimeters. An
integrating sphere and an alternative system based on an engineered diffuser
have been considered as possible light distributors for the experiment. We
present here a detailed comparison of the two based on temporal response,
spatial uniformity, transmittance and time stability.Comment: accepted to Nucl.Instrum.Meth.
Measurement of the cosmic ray hadron spectrum up to 30 TeV at mountain altitude: the primary proton spectrum
The flux of cosmic ray hadrons at the atmospheric depth of 820 g/cm^2 has
been measured by means of the EAS-TOP hadron calorimeter (Campo Imperatore,
National Gran Sasso Laboratories, 2005 m a.s.l.). The hadron spectrum is well
described by a single power law : S(E_h) = (2.25 +- 0.21 +- 0.34(sys))
10^(-7)(E_h/1000)^(-2.79 +- 0.05) m^(-2) s^(-1) sr^(-1) GeV^(-1) over the
energy range 30 GeV-30 TeV. The procedure and the accuracy of the measurement
are discussed. The primary proton spectrum is derived from the data by using
the CORSIKA/QGSJET code to compute the local hadron flux as a function of the
primary proton spectrum and to calculate and subtract the heavy nuclei
contribution (basing on direct measurements). Over a wide energy range E_0 =
0.5-50 TeV its best fit is given by a single power law : S(E_0) = (9.8 +- 1.1
+- 1.6(sys)) 10^(-5) (E_0/1000)^(-2.80 +- 0.06) m^(-2) s^(-1) sr^(-1) GeV^(-1).
The validity of the CORSIKA/QGSJET code for such application has been checked
using the EAS-TOP and KASCADE experimental data by reproducing the ratio of the
measured hadron fluxes at the two experimental depths (820 and 1030 g/cm^2
respectively) at better than 10% in the considered energy range.Comment: 16 pages, 9 figures, accepted for publication in Astroparticle
Physic
The ARGO-YBJ Experiment Progresses and Future Extension
Gamma ray source detection above 30TeV is an encouraging approach for finding
galactic cosmic ray origins. All sky survey for gamma ray sources using wide
field of view detector is essential for population accumulation for various
types of sources above 100GeV. To target the goals, the ARGO-YBJ experiment has
been established. Significant progresses have been made in the experiment. A
large air shower detector array in an area of 1km2 is proposed to boost the
sensitivity. Hybrid detection with multi-techniques will allow a good
discrimination between different types of primary particles, including photons
and protons, thus enable an energy spectrum measurement for individual specie.
Fluorescence light detector array will extend the spectrum measurement above
100PeV where the second knee is located. An energy scale determined by balloon
experiments at 10TeV will be propagated to ultra high energy cosmic ray
experiments
Gamma ray flares from Mrk421 in 2008 observed with the ARGO-YBJ detector
In 2008 the blazar Markarian 421 entered a very active phase and was one of
the brightest sources in the sky at TeV energies, showing frequent flaring
episodes. Using the data of ARGO-YBJ, a full coverage air shower detector
located at Yangbajing (4300 m a.s.l., Tibet, China), we monitored the source at
gamma ray energies E > 0.3 TeV during the whole year. The observed flux was
variable, with the strongest flares in March and June, in correlation with
X-ray enhanced activity. While during specific episodes the TeV flux could be
several times larger than the Crab Nebula one, the average emission from day 41
to 180 was almost twice the Crab level, with an integral flux of (3.6 +-0.6)
10^-11 photons cm^-2 s^-1 for energies E > 1 TeV, and decreased afterwards.
This paper concentrates on the flares occurred in the first half of June.
This period has been deeply studied from optical to 100 MeV gamma rays, and
partially up to TeV energies, since the moonlight hampered the Cherenkov
telescope observations during the most intense part of the emission. Our data
complete these observations, with the detection of a signal with a statistical
significance of 3.8 standard deviations on June 11-13, corresponding to a gamma
ray flux about 6 times larger than the Crab one above 1 TeV. The reconstructed
differential spectrum, corrected for the intergalactic absorption, can be
represented by a power law with an index alpha = -2.1 extending up to several
TeV. The spectrum slope is fully consistent with previous observations
reporting a correlation between the flux and the spectral index, suggesting
that this property is maintained in different epochs and characterizes the
source emission processes.Comment: Accepted for publication on ApJ
INFN Camera demonstrator for the Cherenkov Telescope Array
The Cherenkov Telescope Array is a world-wide project for a new generation of
ground-based Cherenkov telescopes of the Imaging class with the aim of
exploring the highest energy region of the electromagnetic spectrum. With two
planned arrays, one for each hemisphere, it will guarantee a good sky coverage
in the energy range from a few tens of GeV to hundreds of TeV, with improved
angular resolution and a sensitivity in the TeV energy region better by one
order of magnitude than the currently operating arrays. In order to cover this
wide energy range, three different telescope types are envisaged, with
different mirror sizes and focal plane features. In particular, for the highest
energies a possible design is a dual-mirror Schwarzschild-Couder optical
scheme, with a compact focal plane. A silicon photomultiplier (SiPM) based
camera is being proposed as a solution to match the dimensions of the pixel
(angular size of ~ 0.17 degrees). INFN is developing a camera demonstrator made
by 9 Photo Sensor Modules (PSMs, 64 pixels each, with total coverage 1/4 of the
focal plane) equipped with FBK (Fondazione Bruno Kessler, Italy) Near
UltraViolet High Fill factor SiPMs and Front-End Electronics (FEE) based on a
Target 7 ASIC, a 16 channels fast sampler (up to 2GS/s) with deep buffer,
self-trigger and on-demand digitization capabilities specifically developed for
this purpose. The pixel dimensions of mm lead to a very compact
design with challenging problems of thermal dissipation. A modular structure,
made by copper frames hosting one PSM and the corresponding FEE, has been
conceived, with a water cooling system to keep the required working
temperature. The actual design, the adopted technical solutions and the
achieved results for this demonstrator are presented and discussed.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
Study of the diffuse gamma-ray emission from the Galactic plane with ARGO-YBJ
The events recorded by ARGO-YBJ in more than five years of data collection
have been analyzed to determine the diffuse gamma-ray emission in the Galactic
plane at Galactic longitudes 25{\deg} < l < 100{\deg} and Galactic latitudes .
The energy range covered by this analysis, from ~350 GeV to ~2 TeV, allows the
connection of the region explored by Fermi with the multi-TeV measurements
carried out by Milagro. Our analysis has been focused on two selected regions
of the Galactic plane, i.e., 40{\deg} < l < 100{\deg} and 65{\deg} < l <
85{\deg} (the Cygnus region), where Milagro observed an excess with respect to
the predictions of current models. Great care has been taken in order to mask
the most intense gamma-ray sources, including the TeV counterpart of the Cygnus
cocoon recently identified by ARGO-YBJ, and to remove residual contributions.
The ARGO-YBJ results do not show any excess at sub-TeV energies corresponding
to the excess found by Milagro, and are consistent with the predictions of the
Fermi model for the diffuse Galactic emission. From the measured energy
distribution we derive spectral indices and the differential flux at 1 TeV of
the diffuse gamma-ray emission in the sky regions investigated.Comment: 11 pages, 6 figures, published in AP
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