Projeto de Pesquisa Institucional Intercursos Escola Cidadã Com Responsabilidade Histórica e Social

Este trabalho de investigação científica, coordenado pela Faculdade Mauá, busca estratégias coletivas que viabilizem a proposta de uma Escola de Básica cidadã com responsabilidade social. Para desenvolver a pesquisa tornou-se necessário montar uma equipe interdisciplinar de pesquisadores e escolher um tema e problemas de pesquisa para cujas soluções os docentes e discentes dos cursos envolvidos - Administração, Serviço Social e Pedagogia - pudessem trazer contribuições significativas

Explorando o software geogebra

Trabalho apresentado no 31º SEURS - Seminário de Extensão Universitária da Região Sul, realizado em Florianópolis, SC, no período de 04 a 07 de agosto de 2013 - Universidade Federal de Santa Catarina.Ensino de Funções. as potencialidades do software, com explicações práticas e um Manual com todas as ferramentas

PLANEJAMENTO ESTRATÉGICO E PARTICIPATIVO: ELABORAÇÃO, FATORES FACILITADORES E DIFICULTADORES DE SUA IMPLANTAÇÃO NA UNIVERSIDADE

Definir o significado atribuído por estudiosos à ação acadêmico-administrativa da faculdade voltada ao atendimento das exigências da modernidade; conceituar Planejamento Estratégico detectando aspectos que geram a necessidade da sua implantação no todo da faculdade e, especificamente, na sua área acadêmica; identificar forças facilitadoras e impeditivas a sua implantação na faculdade como um todo e oferecer referências aos futuros planejadores estrategistas das instituições de ensino superior para discussão dos problemas que afetam a implantação do Planejamento Estratégico global e ao indicar alternativas para sua solução, de forma efetiva foram os objetivos maiores deste trabalho, realizado a partir de uma pesquisa bibliográfica

Training-related modulations of the autonomic nervous system in endurance athletes: is female gender cardioprotective?

The risk of sudden death is increased in athletes with a male predominance. Regular physical activity increases vagal tone, and may protect against exercise-induced ventricular arrhythmias. We investigated training-related modulations of the autonomic nervous system in female and male endurance athletes. Runners of a 10-mile race were invited. Of 873 applicants, 68 female and 70 male athletes were randomly selected and stratified according to their average weekly training hours in a low (≤4h) and high (>4h) volume training group. Analysis of heart rate variability was performed over 24h. Spectral components (high frequency [HF] and low frequency [LF] power in normalized units) were analyzed for hourly 5min segments and averaged for day- and nighttime. One hundred and fourteen athletes (50% female, mean age 42±7years) were included. No significant gender difference was observed for training volume and 10-mile race time. Over the 24-h period, female athletes exhibited a higher HF and lower LF power for each hourly time-point. Female gender and endurance training hours were independent predictors of a higher HF and lower LF power. In female athletes, higher training hours were associated with a higher HF and lower LF power during nighttime. In male athletes, the same was true during daytime. In conclusion, female and male athletes showed a different circadian pattern of the training-related increase in markers of vagal tone. For a comparable amount of training volume, female athletes maintained their higher markers of vagal tone, possibly indicating a superior protection against exercise-induced ventricular arrhythmia

The Ins and Outs of TAPBPR.

Peptide presentation on MHC class I molecules (MHC-I) is central to mounting effective antiviral and antitumoral immune responses. The tapasin-related protein TAPBPR is an MHC-I peptide editor which shapes the final peptide repertoire displayed on the cell surface. Here, we review recent findings which further elucidate the mechanisms by which TAPBPR performs peptide editing on a molecular level, and how glycosylation on MHC-I influences the interaction with TAPBPR and the peptide loading complex. We also explore how the function of TAPBPR can be utilized to promote exogenous peptide loading directly onto plasma-membrane expressed MHC-I. This has led to the development of new assays to investigate TAPBPR-mediated peptide editing and uncovered translational opportunities of utilizing TAPBPR to treat human disease.Wellcom

Crimping Tool Wear and Tear Analysis

This paper represents an investigation into spare parts longevity in the context of automotive production. By systematically examining the accuracy of the crimping process, our research unveils the potential for cost reduction by pushing the limits of the usage of crimping tooling, while maintaining production efficiency and quality. Preliminary findings reveal encouraging prospects, but underscore the necessity for further examinations, maintenance strategies, and the development of predictive models. Through the tests described in this paper and the obtained results, it has been concluded that the limits imposed by the procedure can be extended (thus reducing production interruptions and associated costs). Extending these limits cannot be determined by a universally applicable rule, therefore, additional analyses are necessary, analyses that will be the subject of further research

Castro Alves e Cecília Meireles: a África como espaço do exílio e da liberdade

Neste texto apresentamos uma reflexão sobre as imagens da África em poemas de Castro Alves e Cecília Meireles, demonstrando como esses poetas exploraram o tema do exílio e da liberdade em momentos distintos da literatura brasileira. Nos poemas “Vozes d´África”, “Navio Negreiro” e “Cachoeira de Paulo Afonso”, Castro Alves constrói várias imagens da África, país da liberdade, em contraponto com as Américas, espaço da escravidão e do desterro. No Romanceiro da Inconfidência, Cecília Meireles, ao recriar o espaço das Minas Gerais do século XVIII, traz à cena dos romances os povos africanos, seres marginalizados e excluídos pela sociedade, mas que ajudaram a construir a nossa história e também retrata o exílio e o desterro dos inconfidentes em Moçambique e Angola

Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules

Major histocompatibility complex (MHC) class I molecules present fragments of the cellular proteome, in the form of short peptides, to the cell surface for the inspection by cytotoxic T cells. This process is a crucial immunosurveillance mechanism used to induce appropriate immune responses against intracellular pathogens and cancer. In order to generate optimal T cell-mediated immune responses, prior to their export to the cell surface, MHC class I molecules undergo a process known as peptide selection. Optimal peptide selection is facilitated by two intracellular peptide editors, tapasin and TAPBPR. TAPBPR was shown to shape the peptide repertoire presented on MHC class I at the cell surface, either by directly catalysing peptide exchange on MHC class I molecules or by associating with the quality control enzyme UDP-glycoprotein glucosyltransferase 1 (UGT1), which selects optimally-loaded MHC class I molecules for export to the cell surface. Given that unlike tapasin, TAPBPR could catalyse peptide editing on MHC class I on its own in solution, I sought to test whether TAPBPR could also function as a peptide exchange catalyst on MHC class I molecules present on the surface of cells. By examining the artefactual expression of TAPBPR at the cell surface upon over-expression, I developed two novel cellular assays which allowed me to explore the function of TAPBPR as a peptide exchange catalyst on plasma membrane-expressed MHC class I molecules. I showed that, when given access the cell surface, TAPBPR can promote efficient peptide exchange on surface expressed MHC class I molecules. These assays allowed me to demonstrate that the 22-35 loop of TAPBPR was essential for its peptide exchange function. Moreover, I revealed that residue L30 within the loop was both necessary and sufficient for the efficient ability of TAPBPR to dissociate peptides from MHC class I molecules that typically accommodate hydrophobic anchor residues in their F pocket. This enabled me to propose a new mechanistic model for TAPBPR-mediated peptide editing. I further addressed the molecular basis governing the compatibility between TAPBPR and MHC class I molecules, by screening a wide panel of human leukocyte antigen (HLA) class I allotypes for their relative propensities to undergo peptide editing by TAPBPR. TAPBPR displayed a clear functional preference for HLA-A molecules, particularly for members of the A2 and A24 supertypes, over HLA-B and -C molecules. This preference appears to be driven by specific molecular features of the MHC class I F pocket, in particular residues H114 and Y116. Finally, I explored the potential translational applications of using TAPBPR as a peptide exchange catalyst on surface-expressed MHC class I molecules. I demonstrated that recombinant TAPBPR can be utilised to load immunogenic peptides of choice directly onto plasma-membrane expression MHC class I, thus overriding the internal antigen presentation pathway. Subsequently, I revealed that, TAPBPR can be used to induce T cell-mediated killing of tumour cells. These findings highlight a potential therapeutic application of TAPBPR in increasing the immune recognition of tumours.My PhD studentship was integrally funded by Wellcome

Identity affirmation in the text “Black dolls from the quilombo Conceição das Crioulas”

Neste artigo, sob a perspectiva da semiótica greimasiana, refletimos sobre a seguinte questão: O o que é e como se produz o efeito de sentido de afirmação da identidade? A partir de discussão teórica e de sua incidência na análise do texto bonecas pretas do Quilombo de Conceição das Crioulas, observamos que a identidade semiótica é um simulacro e para o efeito de sua afirmação são necessários elementos sintáxicos que produzam a repetição que, no discurso das bonecas, realiza-se, principalmente, com o recurso à isotopia, à aspectualização e à tensividade.In this article, from the perspective of greimasian semiotics, we reflect about the question: what is it and how is produced the effect of sense of the identity affirmation? From theoretical discussion and its impact on the analysis of the text black dolls from the Quilombo Conceição das Crioulas, we observe that the semiotic identity is a simulacrum and to the effect of its affirmation are necessary syntactic elements that can produce repeating that in the discourse of the dolls performs mainly with the use of isotope, aspectualization and tensivity