296 research outputs found
Synthesis and characterisation of nanocrystalline ZrN PVD coatings on AISI 430 stainless steel
The nanocrystalline films of zirconium nitride have been synthesized using ion-plasma vacuum-arc deposition technique in combination with high-frequency discharge (RF) on AISI 430 stainless steel at 150oC. Structure examinations X-ray fluorescent analysis (XRF), X-ray diffraction analysis (XRD), scanning electron microscopy (SEM) with microanalysis (EDS), and transmission electron microscopy (TEM), nanoidentation method β were performed to study phase and chemical composition, surface morphology, microstructure and nanohardness of coatings. The developed technology provided low-temperature coatings synthesis, minimized discharge breakdown decreasing formation of macroparticles (MPs) and allowed to deposit ZrN coatings with hardness variation 26.6β¦31.5 GPa. It was revealed that ZrN single-phase coatings of cubic modification with finecrystalline grains of 20 nm in size were formed
Anti-corrosion ceramic coatings on the surface of Nd-Fe-B repelling magnets
The results of vacuum-arc deposition of thin ZrOβcoatings to protect the surface of Nd-Fe-B permanent magnets used as repelling devices in orthodontics are presented. The structure, phase composition and mechanical properties of zirconium dioxide films have been investigated by means of SEM, XRD, EDX, XRF and nanoindentation method. It was revealed the formation of polycrystalline ZrOβ films of monoclinic modification with average grain size 25 nm. The influence of the ZrOβ coating in terms of its barrier properties for corrosion in quasi-physiological 0.9 NaCl solution has been studied. Electrochemical measurements indicated good barrier properties of the coating on specimens in the physiological solution environment
ΠΠ΅ΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ 8 ΠΏΡΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΡ ΡΠ°ΡΡΠΈΠ½ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ N-(Π±Π΅Π½Π·ΠΈΠ»)-2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ² ΡΠΊ ΡΠΏΡΠΎΠ±Π° ΠΏΠΎΡΠΈΠ»Π΅Π½Π½Ρ ΡΡ Π°Π½Π°Π»Π³Π΅ΡΠΈΡΠ½ΠΈΡ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ
The chemical modification of the pyridine moiety of the molecule β displacement of the methyl group in position 8 ofΒ pyrido[1,2-a]pyrimidine nucleus has been considered as one of the possible versions to optimize the biological propertiesΒ of N-(benzyl)-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamides. The synthesis of the research targetsΒ was carried out by the reaction of the corresponding benzylamines and ethyl 2-hydroxy-8-methyl-4-oxo-4H-pyrido[1,2-a]Β pyrimidine-3-carboxylate, in its turn obtained by condensation of 2-amino-4-methylpyridine (i.e. the product with theΒ methyl group in the intentionally required position) and triethyl methanetricarboxylate. The structure of the compoundsΒ obtained has been confirmed by the data of elemental analysis and NMR 1H spectroscopy, and in the case of opticallyΒ active 1-phenylethylamides additionally by polarimetry. The study of the analgesic properties of all N-(benzyl)-2-hydroxy-8-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamides was performed on the standard experimental βacetic acidΒ writhingβ model. At the same time, it has been found that our modification is accompanied with the increased biologicalΒ activity of exclusively para-substituted derivatives. For profound research 4-fluorobenzylamide exceeding Piroxicam andΒ Nabumetone by the level of the specific effect has been recommended as a potential new analgesic.Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² N-(Π±Π΅Π½Π·ΠΈΠ»)-2-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΠΈΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄ΠΎΠ² ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΡΠ°ΡΡΠΈ ΠΈΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ β ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ 8 ΠΏΠΈΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎΒ ΡΠ΄ΡΠ°. Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ΅Π»Π΅Π²ΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ ΡΠ΅Π°ΠΊΡΠΈΠ΅ΠΉ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
Π±Π΅Π½Π·ΠΈΠ»Π°ΠΌΠΈΠ½ΠΎΠ²Β Ρ ΡΡΠΈΠ»-2-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-8-ΠΌΠ΅ΡΠΈΠ»-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΠΈΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠΌ, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠΌ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ 2-Π°ΠΌΠΈΠ½ΠΎ-4-ΠΌΠ΅ΡΠΈΠ»ΠΏΠΈΡΠΈΠ΄ΠΈΠ½Π° (Ρ. Π΅. ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Ρ ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ Π² Π·Π°Π²Π΅Π΄ΠΎΠΌΠΎ ΡΡΠ΅Π±ΡΠ΅ΠΌΠΎΠΌ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ) Ρ ΡΡΠΈΡΡΠΈΠ»ΠΌΠ΅ΡΠ°Π½ΡΡΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠΌ. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ 1Π Π―ΠΠ , Π° Π² ΡΠ»ΡΡΠ°Π΅ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
1-ΡΠ΅Π½ΠΈΠ»ΡΡΠΈΠ»Π°ΠΌΠΈΠ΄ΠΎΠ² Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ Π΅ΡΠ΅ ΠΈ ΠΏΠΎΠ»ΡΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² Π²ΡΠ΅Ρ
N-(Π±Π΅Π½Π·ΠΈΠ»)-2-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-8-ΠΌΠ΅ΡΠΈΠ»-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΠΈΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄ΠΎΠ² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π½Π° ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉΒ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠΊΡΡΡΠ½ΠΎΠΊΠΈΡΠ»ΡΡ
ΠΊΠΎΡΡΠ΅ΠΉ. ΠΡΠΈ ΡΡΠΎΠΌ Π½Π°ΠΉΠ΄Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΡΡΠ°Ρ Π½Π°ΠΌΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ΠΌ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΡΠΊΠ»ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠ°ΡΠ°Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
. ΠΠ»Ρ ΡΠ³Π»ΡΠ±Π»Π΅Π½Π½ΡΡ
ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠ° ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½Β 4-ΡΡΠΎΡΠ±Π΅Π½Π·ΠΈΠ»Π°ΠΌΠΈΠ΄, ΠΏΡΠ΅Π²ΠΎΡΡ
ΠΎΠ΄ΡΡΠΈΠΉ ΠΏΠΎ ΡΡΠΎΠ²Π½Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° ΠΠΈΡΠΎΠΊΡΠΈΠΊΠ°ΠΌ ΠΈ ΠΠ°Π±ΡΠΌΠ΅ΡΠΎΠ½.Π―ΠΊ ΠΎΠ΄ΠΈΠ½ Π· ΠΌΠΎΠΆΠ»ΠΈΠ²ΠΈΡ
Π²Π°ΡΡΠ°Π½ΡΡΠ² ΠΎΠΏΡΠΈΠΌΡΠ·Π°ΡΡΡ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ N-(Π±Π΅Π½Π·ΠΈΠ»)-2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ² ΡΠΎΠ·Π³Π»ΡΠ½ΡΡΠΎ Ρ
ΡΠΌΡΡΠ½Ρ ΠΌΠΎΠ΄ΠΈΡΡΠΊΠ°ΡΡΡ ΠΏΡΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΡ ΡΠ°ΡΡΠΈΠ½ΠΈ ΡΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ β ΠΏΠ΅ΡΠ΅ΠΌΡΡΠ΅Π½Π½Ρ ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΡ Π³ΡΡΠΏΠΈ Ρ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ 8 ΠΏΡΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΄ΡΠ°. Π‘ΠΈΠ½ΡΠ΅Π· ΡΡΠ»ΡΠΎΠ²ΠΈΡ
Β ΠΎΠ±βΡΠΊΡΡΠ² Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π·Π΄ΡΠΉΡΠ½Π΅Π½ΠΎ ΡΠ΅Π°ΠΊΡΡΡΡ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΡ
Π±Π΅Π½Π·ΠΈΠ»Π°ΠΌΡΠ½ΡΠ² Π· Π΅ΡΠΈΠ»-2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-8-ΠΌΠ΅ΡΠΈΠ»-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠΌ, Ρ ΡΠ²ΠΎΡ ΡΠ΅ΡΠ³Ρ, ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠΌ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΡΡΡ 2-Π°ΠΌΡΠ½ΠΎ-4-ΠΌΠ΅ΡΠΈΠ»ΠΏΡΡΠΈΠ΄ΠΈΠ½ΡΒ (ΡΠΎΠ±ΡΠΎ ΠΏΡΠΎΠ΄ΡΠΊΡΡ Π· ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΡ Π³ΡΡΠΏΠΎΡ Π² Π·Π°Π²ΡΠ΄ΠΎΠΌΠΎ Π½Π΅ΠΎΠ±Ρ
ΡΠ΄Π½ΠΎΠΌΡ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ) Π· ΡΡΠΈΠ΅ΡΠΈΠ»ΠΌΠ΅ΡΠ°Π½ΡΡΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠΌ. ΠΡΠ΄ΠΎΠ²Ρ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠ΅ΡΠΎΠ²ΠΈΠ½ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½ΠΎ Π΄Π°Π½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ ΡΠ° ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΡΡ 1Π Π―ΠΠ ,Β Π° Ρ Π²ΠΈΠΏΠ°Π΄ΠΊΡ ΠΎΠΏΡΠΈΡΠ½ΠΎ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
1-ΡΠ΅Π½ΡΠ»Π΅ΡΠΈΠ»Π°ΠΌΡΠ΄ΡΠ² Π΄ΠΎΠ΄Π°ΡΠΊΠΎΠ²ΠΎ ΡΠ΅ ΠΉ ΠΏΠΎΠ»ΡΡΠΈΠΌΠ΅ΡΡΠΈΡΠ½ΠΎ. ΠΠΈΠ²ΡΠ΅Π½Π½Ρ Π°Π½Π°Π»Π³Π΅ΡΠΈΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΡΡΡΡ
N-(Π±Π΅Π½Π·ΠΈΠ»)-2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-8-ΠΌΠ΅ΡΠΈΠ»-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π½Π° ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΉ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΉ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΎΡΡΠΎΠ²ΠΎΠΊΠΈΡΠ»ΠΈΡ
ΠΊΠΎΡΡΡΠ². ΠΡΠΈ ΡΡΠΎΠΌΡ Π·Π½Π°ΠΉΠ΄Π΅Π½ΠΎ,Β ΡΠΎ Π·Π΄ΡΠΉΡΠ½Π΅Π½Π° Π½Π°ΠΌΠΈ ΠΌΠΎΠ΄ΠΈΡΡΠΊΠ°ΡΡΡ ΡΡΠΏΡΠΎΠ²ΠΎΠ΄ΠΆΡΡΡΡΡΡ ΠΏΠΎΡΠΈΠ»Π΅Π½Π½ΡΠΌ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΠΈΠΊΠ»ΡΡΠ½ΠΎ ΠΏΠ°ΡΠ°Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
. ΠΠ»Ρ ΠΏΠΎΠ³Π»ΠΈΠ±Π»Π΅Π½ΠΈΡ
Π²ΠΈΠΏΡΠΎΠ±ΠΎΠ²ΡΠ²Π°Π½Ρ ΡΠΊ Π½ΠΎΠ²ΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΠΉ Π°Π½Π°Π»Π³Π΅ΡΠΈΠΊ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½
Some aspects of periodontitis pathogenesis in children.
Inflammatory processes in the tissues surrounding tooth root are frequent enough and develop as the direct complication of caries. As acute periodontitis is manifested with grinding toothache and violation of phΒyΒsioΒlogical act of chewing, symptoms of general intoxication, the continuous sluggish chronic periodontitis is harmful and dangerous to the organism as well. It forms the state of chronic ΠΎdontogenetic intoxication and chroneosepsis with wrong functioning of some internal organs and body systems. The like complications can cause significant disturbance to the function of kidneys, liver, heart, joints and their treatment without ablating focus of inflammation is often in- effective; this must be taken into account by doctors-interns. However, scanning of the oral cavity by conservative means has its difficulties mostly because of ignoring pathogenesis of such inflammation. That is why activity of ferments of blood dehydrogenases from the periapical tissues of the teeth affected with the chronic periodontitis was studied. The level of succinate dehydrogenase and alpha-glycerophosphate degydrogenase of lymphocytes of 110 schoolchildren aged 13-17 years old was studied. The main group of examined individuals included those of infected with tuberΒculousis β 50 individuals, and the control group (60 individuals) β clinically healthy ones without tuberculousis desease. All schoolchildren had 1 or 2 teeth affected with chronic periodontitis of the apical localization. The reΒsearchers found that a significant inhibition of activity of succinate dehydrogenase and alpha-glycerophosphate degydrogenase ferments occurs in the inflammatory periodontal tissues, which indicates to local immunity decline, and as a consequence, pathogenic bacteria activation. In people infected with tuberculousis these violations were Β more developed. Such features of periodontitis pathogenesis must be taken into account when providing a combined treatment
RF-Magnetron sputtering of silicon carbide and silicon nitride films for solar cells
RF-magnetron nonreactive sputtering method from solid-phase target in argon atmosphere was used for obtaining thin silicon carbide and silicon nitride films, that are used for constructing solar cells based on substrates of single crystal silicon of p-typ
Vascular mechanism in the formation of diclophenac induced gastrotoxicity: the association with the level of hydrogen sulfide
Department of Pharmacology, N. I. Pirogov National Medical University of Vinnitsa, UkraineBackground: Non-steroid anti-inflammatory drugs (NSAIDs)-induced gastrotoxicity arises as a result of imbalance between vasodilator and vasoconstrictor bioregulators. The influence of deficiency and excess of hydrogen sulfide on vascular mechanisms in the formation of NSAIDs-induced gastrotoxicity was investigated. Material and methods: Male nonlinear rats underwent preconditioning with donor of H2S (NaHS) and inhibitor of its synthesis (propargilglycine). Diclophenac sodium was introduced orally (8 mg/kg). In homogenates of ratsβ gastric mucosa was evaluated the activity of prostaglandin-H-synthase (PgH-synthase), NO-synthase, content of nitrites and nitrates, H2S and the activity of cystathionine-Ξ³-lyase. In vitro H2S-induced relaxation of mesenteric arteries was measured. Results: Diclophenac sodium decreased cystathionine-Ξ³-lyase enzyme activity, NO-synthase and PGH-synthase (by 17-24%), content of their H2S metabolites and nitrites/nitrates (by 20-22%) in gastric mucosa, and accompanied with the decrease of mesenteric artery sensitivity to vasodilatory action of H2S (EC50 increased to 27.5%). H2S deficiency β increases and excess of H2S β inhibits the negative influence of diclophenac on the production of vasoactive molecules and H2S-induced relaxation of mesenteric arteries. Conclusions: Excess of H2S in organism increases the content of vasoligating molecules and thus can prevent vascular disturbances caused by NSAIDs in rat stomach mucosa
Temperature influence on the properties of thin SiβNβ films
Applying Raman spectroscopy, small-angle x-ray scattering, and atomic force microscopy it were studied phase composition and surface morphology of nanoscale films SiβNβ (obtained by RF magnetron sputtering
N-ΡΠ΅Π½Π΅ΡΠΈΠ»-2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-Π°]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΠΈ ΡΠΊ ΠΌΠΎΠΆΠ»ΠΈΠ²Ρ ΠΏΡΠΎ- ΡΠΈΠ²ΡΡΡΡΠ½Ρ Π°Π³Π΅Π½ΡΠΈ
Based on the preliminary calculated screening performed by the PASS programme the synthesis of the group of the corresponding N-phenethyl-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamides as potential antiviral agents has been carried out by the interaction of ethyl esters of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids with 2-arylethylamines in boiling ethanol. Their structure has been confirmed by the data of elemental analysis and NMR 1H spectroscopy. Of the Herpesviruses family such viruses as Herpes Simplex Viruses Type 1 and 2, Varicella-Zoster Virus, Epstein-Barr Virus, as well as Cytomegalovirus have been involved in the screening research. Influenza Virus was presented by two types: A (subtypes H1N1, H3N2, H5N1) and B. The group of viruses affecting different sections of the respiratory tract included Parainfluenza Virus, SARS Virus, Rhinovirus, Adenovirus and Respiratory Syncytial Virus. Besides, Measles Virus, Vaccinia Virus and related Cowpox Virus, Hepatitis B and C Viruses, as well as Venezuelan Equine Encephalitis Virus were involved. The group of viruses causing febrile states of varying severity in human was presented by Rift Valley Fever Virus, West Nile Virus, Yellow Fever Virus, Dengue Virus and Tacaribe Virus. According to the results of the tests performed N-(4-chlorophenethyl)- 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide has been recommended for further research. Having a low cytotoxicity this compound revealed a high antiviral activity in relation to the West Nile fever virus agent.ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ PASS ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³Π° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ² Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΡΡΠΈΠ»ΠΎΠ²ΡΡ
ΡΡΠΈΡΠΎΠ² 2-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΠΈΡΠΈΠ΄ΠΎ[1,2-Π°] ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Ρ 2-Π°ΡΠΈΠ»ΡΡΠΈΠ»Π°ΠΌΠΈΠ½Π°ΠΌΠΈ Π² ΠΊΠΈΠΏΡΡΠ΅ΠΌ ΡΡΠΈΠ»ΠΎΠ²ΠΎΠΌ ΡΠΏΠΈΡΡΠ΅ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ ΡΠΈΠ½ΡΠ΅Π· Π³ΡΡΠΏΠΏΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
N-ΡΠ΅Π½Π΅ΡΠΈΠ»-2-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΠΈΡΠΈΠ΄ΠΎ[1,2-Π°]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄ΠΎΠ². ΠΡ
ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π―ΠΠ 1Π. ΠΠ· ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° Π³Π΅ΡΠΏΠ΅ΡΠ²ΠΈΡΡΡΠΎΠ² Π² ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ΠΎΠ²ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
Π±ΡΠ»ΠΈ Π·Π°Π΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°Π½Ρ Π²ΠΈΡΡΡΡ ΠΏΡΠΎΡΡΠΎΠ³ΠΎ Π³Π΅ΡΠΏΠ΅ΡΠ° 1 ΠΈ 2 ΡΠΈΠΏΠΎΠ², Π²ΠΈΡΡΡ ΠΠ°ΡΠΈΡΠ΅Π»Π»Π°-ΠΠΎΡΡΠ΅ΡΠ°, Π²ΠΈΡΡΡ ΠΠΏΡΡΠ΅ΠΉΠ½Π°-ΠΠ°ΡΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΈΡΠΎΠΌΠ΅Π³Π°Π»ΠΎΠ²ΠΈΡΡΡ. ΠΠΈΡΡΡ Π³ΡΠΈΠΏΠΏΠ° Π±ΡΠ» ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ Π΄Π²ΡΠΌΡ ΡΠΈΠΏΠ°ΠΌΠΈ: Π (ΠΏΠΎΠ΄ΡΠΈΠΏΡ H1N1, H3N2, H5N1) ΠΈ Π. ΠΡΡΠΏΠΏΠ° Π²ΠΈΡΡΡΠΎΠ², ΠΏΠΎΡΠ°ΠΆΠ°ΡΡΠΈΡ
ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΎΡΠ΄Π΅Π»Ρ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, Π²ΠΊΠ»ΡΡΠ°Π»Π° Π²ΠΈΡΡΡ ΠΏΠ°ΡΠ°Π³ΡΠΈΠΏΠΏΠ°, Π²ΠΈΡΡΡ SARS, ΡΠΈΠ½ΠΎΠ²ΠΈΡΡΡ, Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡ ΠΈ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠΉ ΡΠΈΠ½ΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π²ΠΈΡΡΡ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π±ΡΠ»ΠΈ Π·Π°Π΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°Π½Ρ Π²ΠΈΡΡΡΡ ΠΊΠΎΡΠΈ, ΠΊΠΎΡΠΎΠ²ΡΠ΅ΠΉ ΠΎΡΠΏΡ, ΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΠΉ Π΅ΠΌΡ Cowpox Π²ΠΈΡΡΡ, Π²ΠΈΡΡΡΡ Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠ² Π ΠΈ Π‘, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΈΡΡΡ ΠΠ΅Π½Π΅ΡΡΡΠ»ΡΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΠΊΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ°. ΠΡΡΠΏΠΏΠ° Π²ΠΈΡΡΡΠΎΠ², Π²ΡΠ·ΡΠ²Π°ΡΡΠΈΡ
Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΎΡΠ½ΡΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° Π²ΠΈΡΡΡΠΎΠΌ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΊΠΈ Π΄ΠΎΠ»ΠΈΠ½Ρ Π ΠΈΡΡ, Π²ΠΈΡΡΡΠΎΠΌ ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠ³ΠΎ ΠΠΈΠ»Π°, Π²ΠΈΡΡΡΠΎΠΌ ΠΆΠ΅Π»ΡΠΎΠΉ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΊΠΈ, Π²ΠΈΡΡΡΠΎΠΌ ΠΠ΅Π½Π³Π΅ ΠΈ Π²ΠΈΡΡΡΠΎΠΌ Π’Π°ΠΊΠ°ΡΠΈΠ±Π΅. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ Π΄Π»Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½ N-(4-Ρ
Π»ΠΎΡΡΠ΅Π½Π΅ΡΠΈΠ»)-2-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-4- ΠΎΠΊΡΠΎ-4H-ΠΏΠΈΡΠΈΠ΄ΠΎ-[1,2-a]ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄. ΠΡΠΈ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ²ΠΈΠ»ΠΎ Π²ΡΡΠΎΠΊΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Ρ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΊΠΈ ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠ³ΠΎ ΠΠΈΠ»Π°.ΠΠ° ΠΏΡΠ΄ΡΡΠ°Π²Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎΠ³ΠΎ Π·Π° ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΎΡ PASS ΠΏΠΎΠΏΠ΅ΡΠ΅Π΄Π½ΡΠΎΠ³ΠΎ ΡΠΎΠ·ΡΠ°Ρ
ΡΠ½ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠΊΡΠΈΠ½ΡΠ½Π³Ρ ΡΠΊ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½Ρ ΠΏΡΠΎΡΠΈΠ²ΡΡΡΡΠ½Ρ Π°Π³Π΅Π½ΡΠΈ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡΡ Π΅ΡΠΈΠ»ΠΎΠ²ΠΈΡ
Π΅ΡΡΠ΅ΡΡΠ² 2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-Π°]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ Π· 2-Π°ΡΠΈΠ»Π΅ΡΠΈΠ»Π°ΠΌΡΠ½Π°ΠΌΠΈ Ρ ΠΊΠΈΠΏΠ»ΡΡΠΎΠΌΡ Π΅ΡΠΈΠ»ΠΎΠ²ΠΎΠΌΡ ΡΠΏΠΈΡΡΡ Π·Π΄ΡΠΉΡΠ½Π΅Π½ΠΎ ΡΠΈΠ½ΡΠ΅Π· Π³ΡΡΠΏΠΈ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΡ
N-ΡΠ΅Π½Π΅ΡΠΈΠ»- 2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4Π-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-Π°]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄ΡΠ². ΠΡ
Π±ΡΠ΄ΠΎΠ²Π° ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½Π° Π΄Π°Π½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ ΡΠ° ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΡΡ Π―ΠΠ 1Π. Π ΡΡΠΌΠ΅ΠΉΡΡΠ²Π° Π³Π΅ΡΠΏΠ΅ΡΠ²ΡΡΡΡΡΠ² Ρ ΡΠΊΡΠΈΠ½ΡΠ½Π³ΠΎΠ²ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½ΡΡ
Π±ΡΠ»ΠΈ Π·Π°Π΄ΡΡΠ½Ρ Π²ΡΡΡΡΠΈ ΠΏΡΠΎΡΡΠΎΠ³ΠΎ Π³Π΅ΡΠΏΠ΅ΡΡ 1 ΡΠ° 2 ΡΠΈΠΏΡΠ², Π²ΡΡΡΡ ΠΠ°ΡΡΡΠ΅Π»Π»Π°-ΠΠΎΡΡΠ΅ΡΠ°, Π²ΡΡΡΡ ΠΠΏΡΡΠ΅ΠΉΠ½Π°-ΠΠ°ΡΡΠ°, Π° ΡΠ°ΠΊΠΎΠΆ ΡΠΈΡΠΎΠΌΠ΅Π³Π°Π»ΠΎΠ²ΡΡΡΡ. ΠΡΡΡΡ Π³ΡΠΈΠΏΡ Π±ΡΠ»ΠΎ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ Π΄Π²ΠΎΠΌΠ° ΡΠΈΠΏΠ°ΠΌΠΈ: Π (ΠΏΡΠ΄ΡΠΈΠΏΠΈ H1N1, H3N2, H5N1) ΡΠ° Π. ΠΡΡΠΏΠ° Π²ΡΡΡΡΡΠ², ΡΠΎ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΡΡ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΡΡΠ·Π½ΠΈΡ
Π²ΡΠ΄Π΄ΡΠ»ΡΠ² Π΄ΠΈΡ
Π°Π»ΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ, Π²ΠΊΠ»ΡΡΠ°Π»Π° Π²ΡΡΡΡ ΠΏΠ°ΡΠ°Π³ΡΠΈΠΏΡ, Π²ΡΡΡΡ SARS, ΡΠΈΠ½ΠΎΠ²ΡΡΡΡ, Π°Π΄Π΅Π½ΠΎΠ²ΡΡΡΡ ΡΠ° ΡΠ΅ΡΠΏΡΡΠ°ΡΠΎΡΠ½ΠΈΠΉ ΡΠΈΠ½ΡΠΈΡΡΠ°Π»ΡΠ½ΠΈΠΉ Π²ΡΡΡΡ. ΠΡΡΠΌ ΡΠΎΠ³ΠΎ, Π±ΡΠ»ΠΈ Π·Π°Π΄ΡΡΠ½Ρ Π²ΡΡΡΡΠΈ ΠΊΠΎΡΡ, ΠΊΠΎΡΠΎΠ²βΡΡΠΎΡ Π²ΡΡΠΏΠΈ, ΡΠΏΠΎΡΡΠ΄Π½Π΅Π½ΠΈΠΉ ΠΉΠΎΠΌΡ Cowpox Π²ΡΡΡΡ, Π²ΡΡΡΡΠΈ Π³Π΅ΠΏΠ°ΡΠΈΡΡΠ² Π Ρ Π‘, Π° ΡΠ°ΠΊΠΎΠΆ Π²ΡΡΡΡ ΠΠ΅Π½Π΅ΡΡΠ΅Π»ΡΡΡΠΊΠΎΠ³ΠΎ ΠΊΡΠ½ΡΡΠΊΠΎΠ³ΠΎ Π΅Π½ΡΠ΅ΡΠ°Π»ΡΡΡ. ΠΡΡΠΏΠ° Π²ΡΡΡΡΡΠ², ΡΠΎ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΡΡ Ρ Π»ΡΠ΄ΠΈΠ½ΠΈ Π»ΠΈΡ
ΠΎΠΌΠ°Π½ΠΊΠΈ ΡΡΠ·Π½ΠΎΠ³ΠΎ ΡΡΡΠΏΠ΅Π½Ρ ΡΡΠΆΠΊΠΎΡΡΡ, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° Π²ΡΡΡΡΠΎΠΌ Π»ΠΈΡ
ΠΎΠΌΠ°Π½ΠΊΠΈ Π΄ΠΎΠ»ΠΈΠ½ΠΈ Π ΠΈΡΡ, Π²ΡΡΡΡΠΎΠΌ ΠΠ°Ρ
ΡΠ΄Π½ΠΎΠ³ΠΎ ΠΡΠ»Ρ, Π²ΡΡΡΡΠΎΠΌ ΠΆΠΎΠ²ΡΠΎΡ Π»ΠΈΡ
ΠΎΠΌΠ°Π½ΠΊΠΈ, Π²ΡΡΡΡΠΎΠΌ ΠΠ΅Π½Π³Π΅ ΡΠ° Π²ΡΡΡΡΠΎΠΌ Π’Π°ΠΊΠ°ΡΡΠ±Π΅. ΠΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
Π²ΠΈΠΏΡΠΎΠ±ΠΎΠ²ΡΠ²Π°Π½Ρ Π΄Π»Ρ ΠΏΠΎΠ΄Π°Π»ΡΡΠΎΠ³ΠΎ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½ΠΎ N-(4-Ρ
Π»ΠΎΡΡΠ΅Π½Π΅ΡΠΈΠ»)- 2-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-4-ΠΎΠΊΡΠΎ-4H-ΠΏΡΡΠΈΠ΄ΠΎ[1,2-a]ΠΏΡΡΠΈΠΌΡΠ΄ΠΈΠ½-3-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΡΠ΄. ΠΡΠΈ Π½ΠΈΠ·ΡΠΊΡΠΉ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΡΡ ΡΠΏΠΎΠ»ΡΠΊΠ° Π²ΠΈΡΠ²ΠΈΠ»Π° Π²ΠΈΡΠΎΠΊΡ ΠΏΡΠΎΡΠΈΠ²ΡΡΡΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΠΎ Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ Π΄ΠΎ Π·Π±ΡΠ΄Π½ΠΈΠΊΠ° Π»ΠΈΡ
ΠΎΠΌΠ°Π½ΠΊΠΈ ΠΠ°Ρ
ΡΠ΄Π½ΠΎΠ³ΠΎ ΠΡΠ»Ρ
Effect of aluminium on redox-homeostasis of common buckwheat (Fagopyrum esculentum)
Common buckwheat is a significant culture in Ukraine, whose importance for food security has increased in recent decades. An important biological feature of buckwheat is the ability of the crop to grow on poor and especially acidic soils. Common buckwheat was sown in Ukraine on the area of 125,000 ha in 2020, mainly in the central part of the country and in the soil-climatic zone Polesie in the north of the country. At the same time, the area under buckwheat cultivation has been steadily decreasing in the last decade, which is due to the low profitability of cultivation on mainly acidic soils. The research was conducted in the field conditions during 2012β2018 in Kiev region, as well as in laboratory conditions. ICP analysis and biochemical methods were used. Yield of buckwheat on light soils of low fertility depends largely on the level of acidity of the soil. On acidic sod-podzolic soils with loam substrate, the aluminum content of the layer is 20β40 cm higher, compared to a layer of 0β20 cm. This is probably one of the reasons why, when the concentration of aluminum in the soil profile is increased, the root system is located mainly in the upper layer of soil with a lower content of aluminum. In this case, the study of the mechanisms of resistance to the action of aluminum on acidic soils is an important component of the cost-effectiveness of crop production in the region. In acidic soils with pH < 5.0, phytotoxic aluminum (Al3+) rapidly inhibits root growth and afterwards negatively affects water and nutrient uptake in plants. Acquiring phytotoxic capacities, in this connection Al ions affect a wide range of cellular and molecular processes, with a consequent reduction in plant growth. In most plant species, reactive oxygen species (ROS) production can also be induced by Al toxicity leading to oxidative damage of biomolecules and biological membranes. We have detected an accumulation of Al ions in leaf tissues of treatment plants after 10 days of exposure. Tissues of F. esculentum roots contained 155.4% of control level of Al and tissues of F. esculentum leaves β 186.2% of control level of Al ions. Significant intensification of O2β’β generation in roots and leaf tissues as a reaction to Al addition to nutrient solution was detected. Increase in antioxidant enzymes activities and non fixed products of lipids peroxidation was characterized as a biochemical defense reaction of F. esculentum over the 10 days of exposure to Al (50 ΞΌM). Thus, the results show that the action of 50 ΞΌM of Al ions activated antioxidant enzymes β SOD and CAT and decreased oxidative processes, thus promotes pro/antioxidant balance of common buckwheat. These mechanisms of redox homeostasis can be triggers of morphological changes in buckwheat plants, which lead to increased crop resistance when growing on acidic soils with high aluminum content. Thus, the resistance of culture to acid soils may be associated with the possibility of increased accumulation of aluminum in the plantβs tissues, as well as in changes in redox homeostasis with subsequent morphological changes, and primarily the formation of the root system in the top layer of soil with a reduced content of aluminum
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