18,982 research outputs found
Tanaka-Tagoshi Parametrization of post-1PN Spin-Free Gravitational Wave Chirps: Equispaced and Cardinal Interpolated Lattices For First Generation Interferometric Antennas
The spin-free binary-inspiral parameter-space introduced by Tanaka and
Tagoshi to construct a uniformly-spaced lattice of templates at (and possibly
beyond) order is shown to work for all first generation interferometric
gravitational wave antennas. This allows to extend the minimum-redundant
cardinal interpolation techniques of the correlator bank developed by the
Authors to the highest available order PN templates. The total number of 2PN
templates to be computed for a minimal match is reduced by a
factor 4, as in the 1PN case.Comment: 9 pages, 8 figures, 3 tables, accepted for publication in Phys. Rev.
P-248 Futility and utility of two-stage hepatectomy
Meeting abstract in the European-Society-for-Medical-Oncology (ESMO) 21st World Congress on Gastrointestinal Cancer.info:eu-repo/semantics/publishedVersio
Metabolic and vascular effect of the mediterranean diet
Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic risk factors to increased risk of chronic degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with a lower degree of inflammation biomarkers and with a protective role on cardiovascular and cerebrovascular events. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. Recently, it has been reported a novel positive association between baseline plasma ceramide concentrations and cardiovascular events and how adherence to a Mediterranean Diet-style may influence the potential negative relationship between elevated plasma ceramide concentrations and cardiovascular diseases (CVD). Several randomized controlled trials (RCTs) showed the positive effects of the MeDi diet style on several cardiovascular risk factors, such as body mass index, waist circumference, blood lipids, blood pressure, inflammatory markers and adhesion molecules, and diabetes and how these advantages of the MeDi are maintained in comparison of a low-fat diet. Some studies reported a positive effect of adherence to a Mediterranean Diet and heart failure incidence, whereas some recent studies, such as the PREDIMED study, showed that the incidence of major cardiovascular events was lower among those assigned to MeDi supplemented with extra-virgin olive oil or nuts than among those assigned to a reduced-fat diet. New studies are needed to better understand the molecular mechanisms, whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases, but also discussing other related diseases. We review MedDiet composition and assessment as well as the latest advances in the genomic, epigenomic (DNA methylation, histone modifications, microRNAs, and other emerging regulators), transcriptomic (selected genes and whole transcriptome), and metabolomic and metagenomic aspects of the MedDiet effects (as a whole and for its most typical food components). We also present a review of the clinical effects of this dietary style underlying the biochemical and molecular effects of the Mediterranean diet. Our purpose is to review the main features of the Mediterranean diet in particular its benefits on human health, underling the anti-inflammatory, anti-oxidant and anti-atherosclerotic effects to which new knowledge about epigenetic and gut-microbiota relationship is recently added
A Gossip Algorithm based Clock Synchronization Scheme for Smart Grid Applications
The uprising interest in multi-agent based networked system, and the numerous
number of applications in the distributed control of the smart grid leads us to
address the problem of time synchronization in the smart grid. Utility
companies look for new packet based time synchronization solutions with Global
Positioning System (GPS) level accuracies beyond traditional packet methods
such as Network Time Proto- col (NTP). However GPS based solutions have poor
reception in indoor environments and dense urban canyons as well as GPS antenna
installation might be costly. Some smart grid nodes such as Phasor Measurement
Units (PMUs), fault detection, Wide Area Measurement Systems (WAMS) etc.,
requires synchronous accuracy as low as 1 ms. On the other hand, 1 sec accuracy
is acceptable in management information domain. Acknowledging this, in this
study, we introduce gossip algorithm based clock synchronization method among
network entities from the decision control and communication point of view. Our
method synchronizes clock within dense network with a bandwidth limited
environment. Our technique has been tested in different kinds of network
topologies- complete, star and random geometric network and demonstrated
satisfactory performance
Development of casein micellar pediatric formulations
Poster presented at the 1st European Conference on Pharmaceutics. 13-14 April 2015, Reims, France."The current need for medicines specifically designed for children, which consider ease of administration, dose flexibility, palatability, safety of excipients, stability and therapeutic equivalency of pediatric dosage forms, has driven the development of pediatric drug formulations.
In the present work casein (CN) based micellar formulations are evaluated as vehicles for the oral delivery of pediatric drugs, since caseins are nontoxic, biodegradable, GRAS materials and nanoencapsulation of drugs can improve their bioavailability. Chemical crosslinking of casein by carbodiimide (EDC) has been studied as an approach to improve the stability of the CN micelles and to tailor drug release."Fundação para a Ciência e a Tecnologia, Portugal (Research grant PTDC/DTPFTO/1057/2012
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