187 research outputs found

    About Possibility of Using Nanoparticles Based on Gadolinium Compounds in Preparations for Diagnostics of Oncological Diseases

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    The work was supported by D. Mendeleev University of Chemical Technology of Russia (Project № 013-2018)

    The QCD string and the generalised wave equation

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    The equation for QCD string proposed earlier is reviewed. This equation appears when we examine the gonihedric string model and the corresponding transfer matrix. Arguing that string equation should have a generalized Dirac form we found the corresponding infinite-dimensional gamma matrices as a symmetric solution of the Majorana commutation relations. The generalized gamma matrices are anticommuting and guarantee unitarity of the theory at all orders of v/cv/c. In the second quantized form the equation does not have unwanted ghost states in Fock space. In the absence of Casimir mass terms the spectrum reminds hydrogen exitations. On every mass level r=2,4,..r=2,4,.. there are different charged particles with spin running from j=1/2j=1/2 up to jmax=r1/2j_{max}=r-1/2, and the degeneracy is equal to dr=2r1=2jmaxd_{r}=2r-1 = 2j_{max}. This is in contrast with the exponential degeneracy in superstring theory.Comment: 11 pages LaTeX, uses lamuphys.sty and bibnorm.sty,; Based on talks given at the 6th Hellenic School and Workshop on Elementary Particle Physics, Corfu, Greece, September 19-26, 1998 and at the International Workshop "ISMP", Tbilisi, Georgia, September 12-18, 199

    Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells

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    The aim of this study was to simplify, improve and validate quantitative measurement of the mitochondrial membrane potential (ΔψM) in pancreatic β-cells. This built on our previously introduced calculation of the absolute magnitude of ΔψM in intact cells, using time-lapse imaging of the non-quench mode fluorescence of tetramethylrhodamine methyl ester and a bis-oxonol plasma membrane potential (ΔψP) indicator. ΔψM is a central mediator of glucose-stimulated insulin secretion in pancreatic β-cells. ΔψM is at the crossroads of cellular energy production and demand, therefore precise assay of its magnitude is a valuable tool to study how these processes interplay in insulin secretion. Dispersed islet cell cultures allowed cell type-specific, single-cell observations of cell-to-cell heterogeneity of ΔψM and ΔψP. Glucose addition caused hyperpolarization of ΔψM and depolarization of ΔψP. The hyperpolarization was a monophasic step increase, even in cells where the ΔψP depolarization was biphasic. The biphasic response of ΔψP was associated with a larger hyperpolarization of ΔψM than the monophasic response. Analysis of the relationships between ΔψP and ΔψM revealed that primary dispersed β-cells responded to glucose heterogeneously, driven by variable activation of energy metabolism. Sensitivity analysis of the calibration was consistent with β-cells having substantial cell-to-cell variations in amounts of mitochondria, and this was predicted not to impair the accuracy of determinations of relative changes in ΔψM and ΔψP. Finally, we demonstrate a significant problem with using an alternative ΔψM probe, rhodamine 123. In glucose-stimulated and oligomycin-inhibited β-cells the principles of the rhodamine 123 assay were breached, resulting in misleading conclusion
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