A numerical study of cell merger over Cuba ? Part II: sensitivity to environmental conditions

International audienceIn the first part of this study, an external 3-D ambient field (3d-field) was used to initiate a simulation (Sim1). In this paper, the influence of the 3-D field in the occurrence of the cloud merger simulated in Sim1 is studied. The surface convergence was very important to supply the lifting necessary for the development of new the convection. The interaction of the gust front from an old cloud with the environmental wind, as well as the interaction between the two gust fronts, were the main factors that enhanced the surface convergence. A favorable perturbation pressure gradient was also found to intensify this mechanism. The formation and development of a new cloud from the cloud bridge was the main feature for the occurrence of the cloud merger. The influence of the wind shear components and the relative humidity (RH) in the occurrence of the cloud merger was also analyzed. The parallel wind shear component and the large RH present in the zone of study had a positive contribution to the occurrence of the cloud merger. However, the perpendicular wind shear component did not provide the main forced lifting which would be capable of generating the new convection along the direction between interacting clouds. A high resolution simulation corroborated that the cloud merger was correctly simulated and it was not obtained by unrealistic effects due to the coarse resolution employed. It evidenced that when the horizontal resolution is improved, the life cycle of each cloud and the different processes related to their interactions are better described

A numerical study of cell merger over Cuba ? Part I: implementation of the ARPS/MM5 models

International audienceOn 21 July 2001 a number of severe storms developed over the region of Camaguey, Cuba, which were observed by radar. A numerical simulation was performed in order to realistically reproduce the development of the storms observed that day. The mesoscale model MM5 was used to determine the initial, boundary and update conditions for the storm-scale simulation with the model ARPS. Changes to the source code of ARPS were made in order to assimilate the output from the MM5 as input data and a new land-use file with a 1-km horizontal resolution for the Cuban territory was created. A case representing the merger between cells at different stages of development was correctly reproduced by the simulation and is in good agreement with radar observations. The state of development of each cell, the time when the merger occurred, starting from the formation of clouds, the propagation motion of the cells and the increase in precipitation, due to the growth of the area after the merger, were correctly reproduced. Simulated clouds matched the main characteristics of the observed radar echoes, though in some cases, reflectivity tops and horizontal areas were overestimated. Maximum reflectivity values and the heights where these maximum values were located were in good agreement with radar data, particularly when the model reflectivity was calculated without including the snow. The MM5/ARPS configuration introduced in this study, improved sensibly the ability to simulate convective systems, thereby enhancing the local forecasting of convection in the region

A novel presenilin 1 mutation (L174M) in a large Cuban family with early onset Alzheimer disease.

We studied a Cuban family with presenile dementia (autosomal dominant) consisting of 281 members within six generations, the proband descended from a Spanish founder. Mean age at onset was 59 years of age. Memory impairment was the main symptom in all patients, additionally, ischemic episodes were described in 4 (n = 18) patients. Neuropathological examination of brain material (1 patient) revealed neuronal loss, amyloid plaques, and neurofibrillary tangles. Thirty DNA samples were genotyped (regions on chromosome 1, 3, 10, 12, 14, 17, 19, 20, and 21). A maximum Lod score of 3.79 at theta = 0 was obtained for marker D14S43, located in a 9-cM interval in which all patients shared the same haplotype. Sequencing of the PSEN1 gene revealed a heterozygous base substitution, C520A (exon 6), which is predicted to cause an amino acid change from leucine to methionine in the TMIII of the presenilin 1 protein. The mutation was found to co-segregate with the disease phenotype and the associated disease haplotype. The C --> A change was not observed in 80 control chromosomes from the Cuban population. Leucine at position 174 is highly conserved among species and is identical in prese