3-PHENACYLURIDINE-DERIVED HYPNOTICS: ANTHOLOGY, STRUCTUREACTIVITY RELATIONSHIPS AND SYNTHESIS OF SEVERAL ACYCLONUCLEOSIDE ANALOGUES

This work was supported by the Russian Foundation for Basic Research, project # 18-33-00421

Video-assisted thoracoscopic diagnosis of trapped lung in malignant pleural effusions

PURPOSE. The aim of this study is to present the role of video-assisted thoracoscopy to assess the ability of the lung to expand in malignant pleural effusions. METHODS. The survey was conducted for a 3-year period in 13 patients with histologically diagnosed malignant pleural effusion and trapped lung. In each of the patients video-assisted thoracoscopy was performed. RESULTS. Two reasons for trapped lung were identified. In 10 of the patients it was due to multiple metastatic nodules. In 3 cases the cause was a diffuse fibrotic involvement of the lung resulting from the metastatic process.CONCLUSIONS. Our research confirmed two causes of trapped lung in malignant pleural effusions: multiple metastases on the lung surface and diffuse lung fibrosis, induced by the metastatic process, with the increased role of multiple metastases on the lung surface

Aerosol Properties and Chemical Apportionment of Aerosol Optical Depth at Locations off the U.S. East Coast in July and August 2001

Airborne in situ measurements of vertical profiles of the aerosol light scattering coefficient, light absorption coefficient, and single scattering albedo (ω0) are presented for locations off the East Coast of the United States in July–August 2001. The profiles were obtained in relatively clean air, dominated by airflows that had passed over Canada and the Atlantic Ocean. Comparisons of aerosol optical depths (AODs) at 550 nm derived from airborne in situ and sun-photometer measurements agree, on average, to within 0.034 ± 0.021. A frequency distribution of ω0 measured in the atmospheric boundary layer off the coast yields an average value of ω0 = 0.96 ± 0.03 at 550 nm. Values for the mass scattering efficiencies of sulfate and total carbon (organic and black carbon) derived from a multiple linear regression are 6.0 ± 1.0 m2 (g SO=4)−1 and 2.6 ± 0.9 m2 (g C)−1, respectively. Measurements of sulfate and total carbon mass concentrations are used to estimate the contributions of these two major components of the submicron aerosol to the AOD. Mean percentage contributions to the AOD from sulfate, total carbon, condensed water, and absorbing aerosols are 38% ± 8%, 26% ± 9%, 32% ± 9%, and 4% ± 2%, respectively. The sensitivity of the above results to the assumed values of the hygroscopic growth factors for the particles are examined and it is found that, although the AOD derived from the in situ measurements can vary by as much as 20%, the average value of ω0 is not changed significantly. The results are compared with those obtained in the same region in 1996 under more polluted conditions

Intergenic interactions of SBNO1, NFAT5 AND GLT8D1 determine the susceptibility to knee osteoarthritis among Europeans of Russia

This study was conducted to examine the associations between genome-wide association studies (GWAS)-important single nucleotide polymorphisms (SNPs) and knee osteoarthritis (KOA) among Europeans of Russi

Quality Management System in Stavropol Research Anti-Plague Institute

The analysis of the structure of quality management system and the areas of its activity is presented. Trends for its further improvement are defined

Validation of Technological Process of Production of Liquid Brucellosis Diagnosticum for Agglutination Reaction, Suspension for Diagnostic Purposes

Presented are the results of validation of technological process of production of brucellosis diagnosticu

A critical evaluation of interlaboratory data on total, elemental, and isotopic carbon in the carbonaceous particle reference material, NIST SRM 1649a

Because of increased interest in the marine and atmospheric sciences in elemental carbon (EC), or black carbon (BC) or soot carbon (SC), and because of the difficulties in analyzing or even defining this pervasive component of particulate carbon, it has become quite important to have appropriate reference materials for intercomparison and quality control. The NIST "urban dust" Standard Reference Material? SRM 1649a is useful in this respect, in part because it comprises a considerable array of inorganic and organic species, and because it exhibits a large degree of (14C) isotopic heterogeneity, with biomass carbon source contributions ranging from about 2 % (essentially fossil aliphatic fraction) to about 32 % (polar fraction). A primary purpose of this report is to provide documentation for the new isotopic and chemical particulate carbon data for the most recent (31 Jan. 2001) SRM 1649a Certificate of Analysis. Supporting this is a critical review of underlying international intercomparison data and methodologies, provided by 18 teams of analytical experts from 11 institutions. Key results of the intercomparison are: (1) a new, Certified Value for total carbon (TC) in SRM 1649a; (2) 14C Reference Values for total carbon and a number of organic species, including for the first time 8 individual PAHs; and (3) elemental carbon (EC) Information Values derived from 13 analytical methods applied to this component. Results for elemental carbon, which comprised a special focus of the intercomparison, were quite diverse, reflecting the confounding of methodological-matrix artifacts, and methods that tended to probe more or less refractory regions of this universal, but ill-defined product of incomplete combustion. Availability of both chemical and 14C speciation data for SRM 1649a holds great promise for improved analytical insight through comparative analysis (e.g., fossil/ biomass partition in EC compared to PAH), and through application of the principle of isotopic mass balance.Carrie, L. A., Benner, B. A., Kessler, J. D., Klinedinst, D. B., Klouda, G. A., Marolf, J. V., . . . Schmid, H. (2002). A Critical Evaluation of Interlaboratory Data on Total, Elemental, and Isotopic Carbon in the Carbonaceous Particle Reference Material, NIST SRM 1649a. Journal of Research of the National Institute of Standards and Technology, 107(3), 279-298

Реокинетическое исследование процесса каталитического отверждения олигодиенуретанового форполимера глицерином в условиях избытка изоцианатных групп

For the first time the results of a rheokinetic study on the interaction of an oligodienuerethane prepolymer with glycerol under excessive content of isocyanate groups [NCO/OH = 1.5 (mol/mol)] are presented. It was found that, when conversion degree х ≈ 30 %, the interaction of isocyanate and hydroxyl groups is governed by the first order equation with adiabatic self-acceleration. Then (at х > 30 %) the curing process is described by the second order equation. A specific feature of the studied interactions is that, while temperature increases to 50 ° C, the role of the curing catalysts at the final stage is played by urethane and allophanate groups.Впервые представлены результаты реокинетических исследований процесса взаимодействия олигодиенуретанового форполимера с глицерином при избыточном содержании изоцианатных групп ( NCO / OH = 1.5 (моль / моль)). Установлено, что до степени превращения х ≈ 30% взаимодействие изоцианатных и гидроксильных групп подчиняется уравнению первого порядка с адиабатическим автоускорением, затем (при х > 30 %) процесс отверждения описывается уравнением второго порядка. Выявленной спецификой изученных взаимодействий является то, что с увеличением температуры до 50ºС роль катализаторов отверждения на завершающем этапе выполняют уретановые и аллофанатные группы

Dangerous human-made interference with climate: A GISS modelE study

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.We investigate the issue of "dangerous human-made interference with climate" using simulations with GISS modelE driven by measured or estimated forcings for 1880-2003 and extended to 2100 for IPCC greenhouse gas scenarios as well as the 'alternative' scenario of Hansen and Sato. Identification of 'dangerous' effects is partly subjective, but we find evidence that added global warming of more than 1 degree C above the level in 2000 has effects that may be highly disruptive. The alternative scenario, with peak added forcing ~1.5 W/m2 in 2100, keeps further global warming under 1 degree C if climate sensitivity is \~3 degrees C or less for doubled CO2. We discuss three specific sub-global topics: Arctic climate change, tropical storm intensification, and ice sheet stability. Growth of non-CO2 forcings has slowed in recent years, but CO2 emissions are now surging well above the alternative scenario. Prompt actions to slow CO2 emissions and decrease non-CO2 forcings are needed to achieve the low forcing of the alternative scenario

Climate simulations for 1880-2003 with GISS modelE

We carry out climate simulations for 1880-2003 with GISS modelE driven by ten measured or estimated climate forcings. An ensemble of climate model runs is carried out for each forcing acting individually and for all forcing mechanisms acting together. We compare side-by-side simulated climate change for each forcing, all forcings, observations, unforced variability among model ensemble members, and, if available, observed variability. Discrepancies between observations and simulations with all forcings are due to model deficiencies, inaccurate or incomplete forcings, and imperfect observations. Although there are notable discrepancies between model and observations, the fidelity is sufficient to encourage use of the model for simulations of future climate change. By using a fixed well-documented model and accurately defining the 1880-2003 forcings, we aim to provide a benchmark against which the effect of improvements in the model, climate forcings, and observations can be tested. Principal model deficiencies include unrealistically weak tropical El Nino-like variability and a poor distribution of sea ice, with too much sea ice in the Northern Hemisphere and too little in the Southern Hemisphere. The greatest uncertainties in the forcings are the temporal and spatial variations of anthropogenic aerosols and their indirect effects on clouds.Comment: 44 pages; 19 figures; Final text accepted by Climate Dynamic