Sub-threshold resonances in few-neutron systems

Three- and four-neutron systems are studied within the framework of the hyperspherical approach with a local S-wave nn-potential. Possible bound and resonant states of these systems are sought as zeros of three- and four-body Jost functions in the complex momentum plane. It is found that zeros closest to the origin correspond to sub-threshold (nnn) (1/2-) and (nnnn) (0+) resonant states. The positions of these zeros turned out to be sensitive to the choice of the $nn$--potential. For the Malfliet- Tjon potential they are E(nnn)=-4.9-i6.9 (MeV) and E(nnnn)=-2.6-i9.0 (MeV). Movement of the zeros with an artificial increase of the potential strength also shows an extreme sensitivity to the choice of potential. Thus, to generate ^3n and ^4n bound states, the Yukawa potential needs to be multiplied by 2.67 and 2.32 respectively, while for the Malfliet-Tjon potential the required multiplicative factors are 4.04 and 3.59.Comment: Latex, 22 pages, no PS-figures, submitted to J.Phys.

The Knee Osteoarthritis Grading System for Arthroplasty

Background: The aim of this study is to validate the Knee Osteoarthritis Grading System (KOGS) of progressive osteoarthritic degeneration for the tri-compartmental knee. This system defines the site and severity of osteoarthritis to determine a specific knee arthroplasty. Methods: The radiographic sequence for KOGS includes standing coronal (anteroposterior), lateral, 30° skyline patella, 15° and 45° Rosenberg and stress views in 20° of flexion. Cohen's kappa and related agreement statistical methods were used to assess the level of concordance of the 7 evaluators between A and B cohorts for each evaluator and also against the actual arthroplasty used. Sensitivity and specificity was also assessed for the KOGS in identifying true partial knee arthroplasties (PKAs) and total knee arthroplasties (TKAs) as decided from the cohort A evaluations. Results: From a cohort of 330 patients who were included in the study, 71 (22.5%) underwent a TKA procedure, 258 (78.2%) a PKA, and 1 (0.3%) was neither a TKA nor PKA. KOGS was able to identify true PKAs (sensitivity) in the range of 92.2%-98.5% across all the different evaluators. The KOGS method was able to identify a PKA or a TKA with an accuracy ranging from 92% to 98.8% across all different evaluators. The surgical results after 20 months are at least comparable with the expected average in the academic literature. Conclusion: The KOGS classification provides a reliable and accurate tool to assess suitability of an individual patient for undergoing PKA or TKA

Limb-Darkening of a K Giant in the Galactic Bulge: PLANET Photometry of MACHO 97-BLG-28

We present the PLANET photometric dataset for the binary-lens microlensing event MACHO 97-BLG-28 consisting of 696 I and V-band measurements, and analyze it to determine the radial surface brightness profile of the Galactic bulge source star. The microlensed source, demonstrated to be a K giant by our independent spectroscopy, crossed the central isolated cusp of the lensing binary, generating a sharp peak in the light curve that was well-resolved by dense (3 - 30 minute) and continuous monitoring from PLANET sites in Chile, South Africa, and Australia. Our modeling of these data has produced stellar profiles for the source star in the I and V bands that are in excellent agreement with those predicted by stellar atmospheric models for K giants. The limb-darkening coefficients presented here are the first derived from microlensing, among the first for normal giants by any technique, and the first for any star as distant as the Galactic bulge. Modeling indicates that the lensing binary has a mass ratio q = 0.23 and an (instantaneous) separation in units of the angular Einstein ring radius of d = 0.69 . For a lens in the Galactic bulge, this corresponds to a typical stellar binary with a projected separation between 1 and 2 AU. If the lens lies closer, the separation is smaller, and one or both of the lens objects is in the brown dwarf regime. Assuming that the source is a bulge K2 giant at 8 kpc, the relative lens-source proper motion is mu = 19.4 +/- 2.6 km/s /kpc, consistent with a disk or bulge lens. If the non-lensed blended light is due to a single star, it is likely to be a young white dwarf in the bulge, consistent with the blended light coming from the lens itself.Comment: 32 Pages, including 1 table and 9 postscript figures. (Revised version has slightly modified text, corrected typo, and 1 new figure.) Accepted for publication in 1999 Astrophysical Journal; data are now available at http://www.astro.rug.nl/~plane

Limits on additional planetary companions to OGLE-2005-BLG-390L

We investigate constraints on additional planets orbiting the distant M-dwarf star OGLE-2005-BLG-390L, around which photometric microlensing data has revealed the existence of the sub-Neptune-mass planet OGLE-2005-BLG-390Lb. We specifically aim to study potential Jovian companions and compare our findings with predictions from core-accretion and disc-instability models of planet formation. We also obtain an estimate of the detection probability for sub-Neptune mass planets similar to OGLE-2005-BLG-390Lb using a simplified simulation of a microlensing experiment. We compute the efficiency of our photometric data for detecting additional planets around OGLE-2005-BLG-390L, as a function of the microlensing model parameters and convert it into a function of the orbital axis and planet mass by means of an adopted model of the Milky Way. We find that more than 50 % of potential planets with a mass in excess of 1 M_J between 1.1 and 2.3 AU around OGLE-2005-BLG-390L would have revealed their existence, whereas for gas giants above 3 M_J in orbits between 1.5 and 2.2 AU, the detection efficiency reaches 70 %; however, no such companion was observed. Our photometric microlensing data therefore do not contradict the existence of gas giant planets at any separation orbiting OGLE-2005-BLG-390L. Furthermore we find a detection probability for an OGLE-2005-BLG-390Lb-like planet of around 2-5 %. In agreement with current planet formation theories, this quantitatively supports the prediction that sub-Neptune mass planets are common around low-mass stars.Comment: 10 pages, 4 figures, accepted by A&

Discovery of the optical counterpart and early optical observations of GRB990712

We present the discovery observations of the optical counterpart of the gamma-ray burster GRB990712 taken 4.16 hours after the outburst and discuss its light curve observed in the V, R and I bands during the first ~35 days after the outburst. The observed light curves were fitted with a power-law decay for the optical transient (OT), plus an additional component which was treated in two different ways. First, the additional component was assumed to be an underlying galaxy of constant brightness. The resulting slope of the decay is 0.97+/-0.05 and the magnitudes of the underlying galaxy are: V = 22.3 +/- 0.05, R = 21.75 +/- 0.05 and I = 21.35 +/- 0.05. Second, the additional component was assumed to be a galaxy plus an underlying supernova with a time-variable brightness identical to that of GRB980425, appropriately scaled to the redshift of GRB990712. The resulting slope of the decay is similar, but the goodness-of-fit is worse which would imply that either this GRB is not associated with an underlying supernova or the underlying supernova is much fainter than the supernova associated with GRB980425. The galaxy in this case is fainter: V = 22.7 +/- 0.05, R = 22.25 +/- 0.05 and I = 22.15 +/- 0.05; and the OT plus the underlying supernova at a given time is brighter. Measurements of the brightnesses of the OT and the galaxy by late-time HST observation and ground-based observations can thus assess the presence of an underlying supernova.Comment: To appear in Ap

EXPRESS: Atomic Absorption Spectrometry Methods to Access the Metal Solubility of Aerosols in Artificial Lung Fluid

Recent studies to quantify the health risks that fine particulate matter with anaerodynamic lessthan 2.5 micrometers (PM2.5) poseuse in vitro approaches. One of these approaches is to incubate PM2.5in artificial lysosomal fluid for a given period at body temperature. These body fluids used have a high ionic strength and as such can be challenging samples to analyzewith atomic spectroscopy techniques. AsPM2.5isaprimary healthhazard because it is tiny enough to penetrate deep into the lungsand could, in addition, dissolve in the lung fluid it is important to quantify elements of toxic and/or carcinogenic concerns, reliably and accurately. Sophisticated instrumentation and expensive pre-treatment of challenging samples are not always available, especially in developing countries. Toevaluatethe applicability of GFAAS without Zeeman correction capability to detect trace quantities of heavy metals leached from PM2.5on to artificial lungfluid, uni-and multivariate approaches have been used for optimization purposes. The limits of quantification, LOQ,obtained by theoptimizedmethod were:2μgL-1(Cu), 3μg L-1(Cr), 1μg L-1(Mn) and 10μg L-1(Pb). The addition/recovery experiments had amean accuracy of: (Cu) 99 ± 7%; 110± 8% (Cr); 95 ± 9% (Mn) and 96 ± 11% (Pb). The average soluble fractions of PM2.5incubated in artificial lysosomal fluid (ALF)for 1 hour were:1.2 0.01ng m-3Cu, 0.40.01ng m-3Cr,0.60.01ng m-3Mnand4.8 0.03ng m-3Pb.Using historical elemental 2averagesof PM2.5 in Curitiba(Cu 3.3 ng m-3, Cr 2.1 ng m-3, Mn 6.1 ng m-3, Pb 21 ng m-3), the percentage bioaccessibility were determined to beCu 38%; Cr 20%; Mn 10%; and Pb 23%.The elemental values of the atmospheric soluble fraction of Cu, Cr and,Mn were below the inhalation risk concentrations.However, for Pb, the atmospheric soluble fraction exceeded the inhalation unit risk of 0.012 ng m-3.This robust and straightforward GF AASmethod is pivotal for low and middle-income countries were most air pollution adverse effects occur andestablished lower-costtechnologies are likelyunavailable

Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey

<p>Abstract</p> <p>Background</p> <p>Dimeticone 4% lotion was shown to be an effective treatment for head louse infestation in two randomised controlled trials in England. It is not affected by insecticide resistance but efficacy obtained (70-75%) was lower than expected. This study was designed to evaluate efficacy of dimeticone 4% lotion in a geographically, socially, and culturally different setting, in rural Turkey and, in order to achieve blinding, it was compared with a potential alternative formulation.</p> <p>Methods</p> <p>Children from two village schools were screened for head lice by detection combing. All infested students and family members could participate, giving access to treatment for the whole community. Two investigator applied treatments were given 7 days apart. Outcome was assessed by detection combing three times between treatments and twice the week following second treatment.</p> <p>Results</p> <p>In the intention to treat group 35/36 treated using dimeticone 4% had no lice after the second treatment but there were two protocol violators giving 91.7% treatment success. The alternative product gave 30/36 (83.3%) treatment success, a difference of 8.4% (95% CI -9.8% to 26.2%). The cure rates per-protocol were 33/34 (97.1%) and 30/35 (85.7%) respectively. We were unable to find any newly emerged louse nymphs on 77.8% of dimeticone 4% treated participants or on 66.7% of those treated with the alternative formulation. No adverse events were identified.</p> <p>Conclusion</p> <p>Our results confirm the efficacy of dimeticone 4% lotion against lice and eggs and we found no detectable difference between this product and dimeticone 4% lotion with nerolidol 2% added. We believe that the high cure rate was related to the lower intensity of infestation in Turkey, together with the level of community engagement, compared with previous studies in the UK.</p> <p>Trial Registration</p> <p>Current Controlled Trials ISRCTN10431107</p

Selection of Clostridium spp. in biological sand filters neutralizing synthetic acid mine drainage

In this study, three biological sand filter (BSF) were contaminated with a synthetic iron- [1500 mg L-1 Fe(II), 500 mg L-1 Fe(III)] and sulphate-rich (6000 mg L-1 SO2/4-) acid mine drainage (AMD) (pH = 2), for 24 days, to assess the remediation capacity and the evolution of autochthonous bacterial communities (monitored by T-RFLP and 16S rRNA gene clone libraries). To stimulate BSF bioremediation involving sulphate-reducing bacteria, a readily degradable carbon source (glucose, 8000 mg L-1) was incorporated into the influent AMD. Complete neutralization and average removal efficiencies of 81.5 (±5.6)%, 95.8 (±1.2)% and 32.8 (±14.0)% for Fe(II), Fe(III) and sulphate were observed, respectively. Our results suggest that microbial iron reduction and sulphate reduction associated with iron precipitation were the main processes contributing to AMD neutralization. The effect of AMD on BSF sediment bacterial communities was highly reproducible. There was a decrease in diversity, and notably a single dominant operational taxonomic unit (OTU), closely related to Clostridium beijerinckii, which represented up to 65% of the total community at the end of the study period.Web of Scienc

Fine Mapping of Posttranslational Modifications of the Linker Histone H1 from Drosophila melanogaster

The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine methylation and ADP-ribosylation. Their biological functions, however, remain largely unclear. This is in part due to the fact that most of the studies have been performed in organisms that have several H1 variants, which complicates the analyses. We have chosen Drosophila melanogaster, a model organism, which has a single H1 variant, to approach the study of the role of H1 PTMs during embryonic development. Mass spectrometry mapping of the entire sequence of the protein showed phosphorylation only in the ten N-terminal amino acids, mostly at S10. For the first time, changes in the PTMs of a linker H1 during the development of a multicellular organism are reported. The abundance of H1 monophosphorylated at S10 decreases as the embryos age, which suggests that this PTM is related to cell cycle progression and/or cell differentiation. Additionally, we have found a polymorphism in the protein sequence that can be mistaken with lysine methylation if the analysis is not rigorous