Agent-based simulation framework for airport collaborative decision making

Airport Collaborative Decision Making is based on information sharing. A better use of resources can be attained when the different stakeholders at airport operations share their more accurate and updated information. One of the main difficulties when dealing with this information sharing concept is the number of stakeholders involved and their different interest and behaviour: aircraft operators, ground handling companies, airport authority, air traffic control and the Central Flow Management Unit. It is paramount to quantify the benefit of an airport collaborative decision making strategy in order to involve all these different organisations. Simulations are required to analyse the overall system and its emerging behaviour. This paper presents the development and initial testing of an agent-based framework, which allows this behavioural analysis to be done. The simulator explicitly represents the different stakeholders involved in the A-CDM and the interactions between them from milestone 1 to 7. This framework allows independent gradual development of local behaviours and optimisation, and a gradual increase on complexity and fidelity on the simulations

Pilot Testing and Psychometric Validation of the Nijmegen Professionalism Scale for Spanish Nursing

Background and purpose: Professional commitment is frequently used as a humanistic care indicator. Thus, it is important to design and validate a tool which is able to measure professional commitment of nurses in Spain. In this study we aimed to analyze the psychometric properties of the Nijmegen Professionalism Scale for Spanish (NPS-S) nursing in order to verify its validity and reliability. Methods: We undertook the pilot testing and psychometric validation of the NPS-S. A total sample of 249 nursing professionals from a variety of areas of expertise took part in this study. The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) Statement was used for reporting this research. Results: The NPS-S achieved a high degree of content validity, construct validity, internal consistency, temporal stability, and usability; this version is, thus, equivalent to the Nijmegen Professionalism Scale in its original version. Implications for practice: Based on the results obtained from the validation of this tool, it is possible to affirm that the NPS-S is an effective instrument for measuring professional commitment in this population. The NPS-S will evaluate and thus contribute to the promotion of professional commitment in Spanish nursing. Additionally, it will serve to establish correlations between professional commitment and other variables including quality of care and patient satisfaction. Future studies should analyze the evaluation capacity of this tool

Inmigrantes extranjeros en España. Comentarios y respuesta

El artículo de Horacio Capel publicado en el número 81 de Scripta Nova correspondiente al 1 de febrero de 2001 (http://www.ub.es/geocrit/sn-81.htm) ( http://hdl.handle.net/2445/112896) ha dado lugar a diversos comentarios por parte de los miembros del Grupo de Trabajo sobre la inmigración convocado por el Centre de Cultura Contemporània de Barcelona. Publicamos aquí dichos comentarios así como la respuesta del autor del artículo

Biogeomorphological processes in an arid transgressive dunefield as indicators of human impact by urbanization

This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. This author accepted manuscript is made available following 24 month embargo from date of publication (August 2018) in accordance with the publisher’s archiving policyUrban and tourist developments can have long-lasting impacts on coastal environments and fundamentally alter the evolution of coastal dune systems. This is the case of the Maspalomas dunefield (Gran Canaria, Canary Islands), hosting one of the largest tourist resorts in Spain. The resort was built on top of a sedimentary terrace at 25 m above sea level (El Inglés) in the 1960s, and has subsequently affected local winds and therefore aeolian sediment transport patterns. Buildings on the terrace deflect the winds to the south of the dunefield, where the rate of sediment transport accelerated. A shadow zone appeared to the lee side of the resort with a consequent decrease in wind speed and aeolian sediment transport and an increase in vegetation cover. In this paper, first we characterize the environmental changes around El Inglés terrace in recent decades, and describe the changes in the shadow zone through an analysis of the evolution of sedimentary volumes and vegetation characteristics (density, spatial patterns, and plants communities). A series of historical aerial photographs, recent orthophotos and digital elevation models obtained by digital photogrammetry and LiDAR, as well as fieldwork were used to characterize plant communities and spatial-temporal changes in erosive landforms. Results show changes in the pattern and migration rates of dunes located at the southern edge of the urbanization, as well as the formation of blowouts and large deflation areas, where the vegetation increases in density and number of plant communities. We discuss eco-anthropogenic factors that have produced these environmental changes.This work is a contribution of projects CSO2013-43256-R and CSO2016-79673-R (National R & D & I Plan) co-financed with ERDF funds and a PhD contract of the Canary Islands Agency for Research, Innovation and Information Society and by the European Social Fund (ESF)

Brassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots

Brassinosteroids (BRs) play crucial roles in plant growth and development. Previous studies have shown that BRs promote cell elongation in vegetative organs in several plant species, but their contribution to meristem homeostasis remains unexplored. Our analyses report that both loss- and gain-of-function BR-related mutants in Arabidopsis thaliana have reduced meristem size, indicating that balanced BR signalling is needed for the optimal root growth. In the BR-insensitive bri1-116 mutant, the expression pattern of the cell division markers CYCB1;1, ICK2/KRP2 and KNOLLE revealed that a decreased mitotic activity accounts for the reduced meristem size; accordingly, this defect could be overcome by the overexpression of CYCD3;1. The activity of the quiescent centre (QC) was low in the short roots of bri1-116, as reported by cell type-specific markers and differentiation phenotypes of distal stem cells. Conversely, plants treated with the most active BR, brassinolide, or mutants with enhanced BR signalling, such as bes1-D, show a premature cell cycle exit that results in early differentiation of meristematic cells, which also negatively influence meristem size and overall root growth. In the stem cell niche, BRs promote the QC renewal and differentiation of distal stem cells. Together, our results provide evidence that BRs play a regulatory role in the control of cell-cycle progression and differentiation in the Arabidopsis root meristem.Fil: González García, Mary Paz. Centre for Research in Agricultural Genomics. Molecular Genetics Department; EspañaFil: Vilarrasa Blasi, Josep. Centre for Research in Agricultural Genomics. Molecular Genetics Department; EspañaFil: Zhiponova, Miroslava. Ghent University. Department of Plant Biotechnology and Genetics; Bélgica. Vlaams Instituut voor Biotechnologie; BélgicaFil: Divol, Fanchon. Centre for Research in Agricultural Genomics. Molecular Genetics Department; EspañaFil: Mora Garcia, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Centre for Research in Agricultural Genomics. Molecular Genetics Department; EspañaFil: Russinova, Eugenia. Ghent University. Department of Plant Biotechnology and Genetics; Bélgica. Vlaams Instituut voor Biotechnologie; BélgicaFil: Caño Delgado, Ana I. Centre for Research in Agricultural Genomics. Molecular Genetics Department; Españ

Increasing Vegetable Diversity Consumption Impacts the Sympathetic Nervous System Activity in School-Aged Children

Evidence about the impact of vegetable and fruit diversity consumption on the autonomic nervous system (ANS) functioning is scarce. In this cross-sectional study (513 participants, 49.9% girls aged 7 to 12 years), we evaluated the association between vegetable and fruit diversity consumption and the ANS in school-aged children. Dietary intake was collected using a single 24-h recall questionnaire. Fruit and vegetable diversity consumption was estimated by summing up all the different individual vegetables and fruits consumed in one day. Pupillometry was used to assess pupillary light response, which evaluated the ANS activity. Adjusted linear regressions estimated the association between vegetable and fruit diversity consumption with pupillary light response measures. There was a positive and significant association between vegetable diversity consumption and the average dilation velocity, a measure related to the sympathetic nervous system activity (beta-coefficient = 0.03, 95%CI: 0.002; 0.07). Our findings show that vegetable diversity consumption is associated with the ANS response, a possible early link between diet and health in school-aged children

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

Astrocytes have emerged as crucial regulators of neuronal network activity, synapse formation, and underlying behavioral and cognitive processes. Despite some pathways have been identified, the communication between astrocytes and neurons remains to be completely elucidated. Unraveling this communication is crucial to design potential treatments for neurological disorders like temporal lobe epilepsy (TLE). The BDNF and TrkB molecules have emerged as very promising therapeutic targets. However, their modulation can be accompanied by several off-target effects such as excitotoxicity in case of uncontrolled upregulation or dementia, amnesia, and other memory disorders in case of downregulation. Here, we show that BDNF and TrkB from astrocytes modulate neuronal dysfunction in TLE models. First, conditional overexpression of BDNF from astrocytes worsened the phenotype in the lithium-pilocarpine mouse model. Our evidences pointed out to the astrocytic pro-BDNF isoform as a major player of this altered phenotype. Conversely, specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of TLE. Regarding to the TrkB, we generated mice with a genetic deletion of TrkB specifically in hippocampal neurons or astrocytes. Interestingly, both lines displayed neuroprotection in the lithium-pilocarpine model but only the mice with genetic deletion of TrkB in astrocytes showed significantly preserved spatial learning skills. These data identify the astrocytic BDNF and TrkB molecules as promising therapeutic targets for the treatment of TLE

Distribution and Kinematics of the Circum-nuclear Molecular Gas in the Seyfert 1 Galaxy NGC 3227

We present new interferometric observations of the 12CO(1-0), 12CO(2-1) and HCN (1-0) molecular line emission in NGC 3227 obtained with the IRAM Plateau de Bure interferometer (PdBI). We achieved an unprecedented angular resolution in the 12CO(2-1) line of about 0.6'' corresponding to only about 80pc at a distance of 17.3Mpc. The mapped 12CO emission is concentrated in the inner 8'' and accounts for 20% of the total 30m CO line flux. The 12CO emission is resolved into an asymmetric nuclear ring with a diameter of about 3''. The HCN line emission is mostly unresolved at our resolution of ~2.4'' and contains all of the single dish flux. We have decomposed the observed molecular gas motions into a circular and non-circular component revealing that about 80% of the gas in the circum-nuclear region exhibits pure circular rotation. We find evidence for bar streaming onto the nuclear ring and a redshifted emission knot on the ring perimeter. In the central arcsecond the gas shows apparent counter rotation. This behavior can be best explained by a warping of the inner molecular gas disk rather than gas motion in a nuclear bar potential. We detected molecular gas at a distance from the nucleus of only ~13pc with a velocity of about 75 km/s with respect to the systemic velocity and find that within the central arcsecond the rotation curve is rising again. This is the first time that millimetric CO-line emission has been detected interferometrically at such small distances to the nucleus of a Seyfert galaxy. These measurements indicate a lower limit on the enclosed mass of about 2x10^7 M_solar in the inner 15pc.Comment: accepted for Ap.J. April issue, 54 pages, 22 figure